Contents NUMBER 1 REVIEW PAPER 1 C^oniparative pharniacokiiietics ol aniinoglvcosicle aiitibiolics: S. A. BROWN & |. E. RIVIERE SCIENTIEIC PAPERS Pharmacokinetics, safety and tissue residues of sustained-release siilfainetha/.ine in sheep: M. S. BULGIN, V. M. LANE, T. E. ARCHER, J. D. BAG.G.OI & A. L. GRAK’.MILL 46 riiiamylal- and halothane-sparing effect of diazepam in <Iogs: W. W. MUIR in, L. BEDNARSKI & R. BEDNARSKI 51 Development of an analytical method for cephapirin and its metaljolite in lK)v ine milk and serum hy liquid chromatography with UV-VIS detection and confirmation hy thermospray mass spectrometry: K. L. TYC^ZKOWSKA, R. 1). VOYKSNER Sc A. L. ARONSON 61 Assessment of histamine, hradykinin, prostaglandins E| and E-j and carrageenin as vascular permeahilitv agents in the horse: 1). E. AUER, J. NG, ). S. REILLY & A. A. SEAWRIC'.Hf 70 Pharmacokinetics and elimination of salicylic acid in rahhits: G. R. SHOR E, C. A. NEEE- DAVIES, L. C. HSIEH, C.. U. KORITZ, M. S. MALBROUf’.H, S. A. BARKER & L. E. DAVIS 78 Pharmacokinetics and hioavailahility of ticarcillin and davulanate in foals after intravenous and intramuscular administration: W. D. WILSON, M. S. SPENSLEY, |. D. BAG.GO f, S. K. HIETALA Sc P. PRYOR 90 (ientamicin pharmacokinetics in diabetic dogs: S. A. BROWN, R. W. NELSON & G. SCO ! r-MONCRIEFF 96 Pharmacokinetics of gentamicin after intravenous and subcutaneous injection in obese cats: L. G. WRK’.HT, C. R. HORTON |r, A. D. JERNK'.AN, R. G. WILSON & C. H. CLARK 101 Pharmacokinetic profiles of netohimin metabolites after oral administration of zwitterion and trisamine formulations of netohimin to cattle: C. E. l^NUSSE, G. I'RUDEAU, S. RANJAN Sc R. K. PRICHARD SHORE COMMUNICATION 109 Evaluation of the anti-inllannnatory effects of a low dose of acetaminophen following surgery in dogs: D. N. MBURU 112 Notices NUMBER 2 RKV'IF.VV RAPKR 113 The rolt* of neutrophil-activating inecliatois in canine health and disease (with special lelerenee to the role of leukotrienes in iidlammator\ dermatoses): M. KRC)(’>S('>AARI) IHOMSKN scikn i ifk; faffrs 134 A comparative stuciv of the pharmacokinetics of thiopental in the rabbit, sheep and dog: |. F. ILKIW, J. A. BEN I HUYSEN, VV. E. EBEINU & 1). Mc NEAE 141 Ehe inlliience of chronic pain on the analgesic effects of the aj-adrenoceptor agonist, xylazine, in sheep: S. LEV, A. WA EERMAN & A. LIX'INUS fON 145 Disposition of human drug preparations in the horse. I. Rectallv administered inclometha- cin: E. E. DELBEKE, M. DEBACKERE & L. VVNC:KIER 1,50 An evaluation of the information given on veterinarv prescriptions in Norwav. Compliance with the legal regulations: K. CRAVE, M. BANf'.EN, M. ENCEL,SrAI) & N. E. S0ld 150 Ehe effect of isoprinosine aiicl levamisole on factot s relevant to protection of calves against respiratory disease: (i. MULC’.AHY, P. J. QUINN & J. HANNAN 170 Plasma protein binding of nitroxynil in several species: M. ALV'INERIE, R. FLO(]’H & P. C’.AL l lER 174 Fdfects of experimentally indnced Pasteurella hdemolytka infection in dairy calves on tbe pharmacokinetics of flnniet|uine: D. J. ME^VIUS, H. J. BREUKINK, A. S. J. P. A. M. \ .\n MIERE, B. C;. E. KESSELS, A. S.'jOBSE & j. A‘ H. SMEE 185 (a)mparative in vitro susceptibility Barteroides and Fmohacterium isolated f rom f ootrot in sbeep to 28 antimicrobial agents: S. PIRIZ DURAN, R. (X’EN(]A VALERA, J. V'ALLE MANZANO & S. VADILIX) MACHOEA 103 Fdtenac, a new anti-inflammatory and analgesic drug for horses: clinical aspects: W. PRLX'.NER, R. HUBER & R. LUHMANN' SHORE COMMUNIUATIONS 200 Pharmacokinetics of cephaloridine in Bubalus huluilis: R. K. UHAUDHARY, A. K. SRIVAS EAVA & J. K. MALIK 20E) Mydriasis in pigeons (('.oluinbia livid domesliai) with t/-tubocurarine: topical instillation versus intracameral injection: U. P. VERSUHUELREN & |. E. LUMEIJ 200 Enantioselective A'-demethvlation of ketamine in the horse: P. DELA EOUR, P. |AUS- SAUD, D. C:OURE()E & I). EAU 213 Book reviews 21b In Memoriam 217 Notice 218 Erratum VI NUMBER 3 SCIENI IFIC PAPERS 219 Pharmacodynamics and pliarmokinetics of carprofen, a non-s(eroidal anli-inllammatory drug, in healthy cows and cows with Esdieiirhia coli endotoxin-induced mastitis: |. A. Cl. M. LOHUIS, T. VAN WERVKN, A. BRAND, A. S. |. P. A. M. VAN MIER i, K. ROHDE, B. LUDWIC;, P. HEIZMANN & \V. E. REHM 230 Purther studies on the antinociceptive activity and respiratorv ellects ol l)urenorphine in sheep: A. E. WAEERMAN, A. LIVINOSEON & A. AMIN 235 Studies of meclofenamic acid anti two metaholites in horses — pharmacokinetics and effects on exercise tolerance: I. M. JOHANSSON, P. KALLINOS & M. HAMMAREUND- UDENAES 243 Cllenhuterol plasma concentrations after repeated oral administration and its eifects on cardio-respiratory and blood lactate responses to exercise in healthy Standardhretl horses: P. KALLINCiS, C. INOVAS r-LARSSON, S. PERSSON, L.-E. APPEEOREN, H. J. EORSTER & K. L. ROMINC’.ER 250 Substance P: a neurogenic metliator of acute cellular inllammalion in the dog?: M. KROCiSC’.AARD EHOMSEN 257 Pharmacokinetics of tinidazole in dogs and cats: E. SARKIALA, A. JARVINEN, S. VALFULA & M. MERC) 203 Comparison of mucosal drug conjugative rates along the gastrointestinal tract ol female sheep: G. LARRIEU, M. KADDOURI & P. OALEIER ' 209 Pharmacokinetics of antipyrine and sulphadiniidine (sulfamethazine) in camels, sheep and goats: H. A. ELSHEIKH, B. H. ALI, A. M. HOMEIDA, 1. HASSAN & H. j. HAPKE 270 The effects of experimentally induced hronchopneumonia on the pharmacokinetics and tissue depletion of gentamicin in healthy and pneumonic calves: R. P. HUN TER, S. AN! HONY BROWN, j. K. ROLLINS & D. E. NELLIOAN 293 Alpha-2 adrenoceptors mediate clonitline-induced hypoinstilinaemia in sheep: E. E. A. OSMAN & T. NICHOLSON 300 Clinical investigations of halothane and isoflurane for induction and maintenance ol foal anesthesia: E. P. S TEEEEY, N. WILLIES, P. WONCL S. V. HILDEBRAND, J. D. WHEAT, D. M. MEAC'.HER, D. HODCSON, j. R. PASCOE, R. B. HEAEH & C. DUNLOP 310 Relaxant effects of theophylline and clenbuterol on tracheal smooth muscle from horse and rat in I'itio: C. INCVAS'E-LARSSON 317 The pharmacokinetics and locomotor activity of alfentanil in the horse: P. j. PASC.OE, W. D. BLACK, J. M. CLAX EON & R. E. SANSOM SHORT COMMUNICATIONS 326 Plasma thiamphenicol concentrations in calves after intratracheal administration: G. C. SlGNORINl, E. QUINEAVALLA, E. SCARDUELLl, A. LONC.O & M. C.ABRIELLl 330 C^oncentrations of phenvlhutazone and oxyphenhutazone in post-parturient mares and their neonatal foals: M. V. C:R1SMAN, j. R. WILCKE, R. A. SAMS & 1). E. GERKEN 335 Disposition kinetics of gentamicin in buffalo calves {Bubalus hithalis) following single intravenous administration: SA EISH K. GARG, S. P. VERMA & B. D. GARG 341 E?ffect of some organic vehicles on the rate of elimination of intravenously administered ronidazole in pigeons: L. BAER 1, H. VERMEERSCH & j. P. REMON NUMBER 4 SCIKM IFIC 1‘Al’KRS 345 riie aiitoradiograpliic biiuting of [ *H] (|iiiniKliclinvl Ijen/.ilate to miistarinit: receptors in the spinal cord of the sheep: (). BOUCHENAFA & A. LI VINC’.S ION 351 IMiannacokinetic and tissue distril)ntion study ofOxytetracycline in rainl)o\v trout following lK)his intravenous administration: \V. 1). BLA(]FL H. W. FERCiL'SON, P. BVRNF & M. ). CLAX ION 359 Intramuscular and oial disposition of enrofloxacin in Af rican grey parrots following single and multiple doses: K. FLAMMFR, I). P. AL'ClOIN & I). A. WHI P 1 3()7 Pharmacokinetics of intravenous and oral methimazole following single- and multiple-dose administration iu normal cats: L. A. I RFPANIFR, M. F. PF PERSON & 1). P. AL’COIN 374 IMiai inacokinetics and hioavailabilitv of 2-mercaptoproj>ionvlgIvcine administered intra- venouslv and orallv in dogs: A. HOPPE, I. DFNNFBFRO', B.-M. FMANUELSSON, B. kA(;FI)AL & S. LINIX’.RFN 3S5 Distribution of Oxytetracycline to tissue cages and granuloma pouches in calves and effect of acute innammation ou distribution to tissue cages: B. BPLNO'I SSON, J. LL'1 HMAN, S.-O. JACOBSSON & S. FKMAN 395 On the constmction of shortest confidence intervals and Bavesian higfiest posterior density intervals: A. P. C.RIFVF 490 (finical pharmacokinetics of parenterallv administered danofloxacin in cattle: C7 J. (ilLFS, R. A. ma(;oni(;lf, W. l. r. crimshavv. a. C. l ANNFR, ). f. risk, m. j. lynch &: |. R. RICE 411 P'urosemide-induced changes in plasma and blood volume of horses: K. W. HINCHC’.LIFF, K. H. McKFFVFR & VV. W. MUIR, 111 SIIOR 1 COMMUNICA 1 IONS 418 Fnautioselectivitv in the anaesthetic effect of ketamine in dogs: j. DP'.LFP'ORCP^, |. L. DAVOP, B. BOISRAMF & P. DFLAIOUR 421 1‘razosin and propranolol and the stress response to trans|)ort in male goats: a preliminary study: A. A. SANHOURI, R. S. JONES & H. DOBSON 42() Serum disposition of oral clorazepate from regular-release and sustained-deliverv tablets in dogs: S. A. BROWN & S. 1). FORRES PER 430 Pestosterone disposition after intramuscular injection in castrated thoroughbred race horses: R. MAR I INEZ, B. URQUIE I A, E. AL I lERI, L. C.ARZON & E. CID 435 Notice 437 Index ft