CONTENTS OF VOLUME 37 JANUARY 2001 VOLUME 37 NUMBER 1 REVIEW ARTICLES Editorial Comment Present-Day PTCR Versus CABG: A Should an Angiotensin-Converting Enzyme Inhibitor Randomized Comparison With a Different Focus and Be Standard Therapy for Patients With Atherosclerotic a New Result Thomas J. Ryan Disease? James H. O'Keefe, Mark Wetzel, Richard R. Moe, Impact of Coronary Artery Remodeling on Kathleen Brosnahan, Carl J. Lavie Clinical Presentation of Coronary Artery Disease: Shifting the Open-Artery Hypothesis Downstream: An Intravascular Ultrasound Study Mamoo Nakamura, The Quest for Optimal Reperfusion Matthew T. Roz, Hideo Nishtkawa, Set Mukai, Morimichi Setsuda, Kazuki E. Magnus Ohman, Arthur C. P. Maas, Nakajima, Hiroya Tamada, Hiroyuki Suzuki, Takahiro Robert H. Christenson, Kenneth W. Mahaffey, Ohnishi, Yutaka Kakuta, Takeshi Nakano, Alan C. Yeung Christopher B. Granger, Robert A. Harrington, Arterial Remodeling Influences the Development of Robert M. Calif; Mitchell W. Krucoff Intimal Hyperplasia After Stent Implantation Akihiro Endo, Haruo Hirayama, Osamu Yoshida, Tomoharu Arakawa, Takashi Akima, Takumi Yamada, CLINICAL STUDIES Mamoru Nanasato MYOCARDIAL INFARCTION Angioplasty Increases Coronary Sinus F,-Isoprostane Non-Q-Wave Myocardial Infarction Following Formation: Evidence for In Vivo Oxidative Stress Thrombolytic Therapy: A Comparison of Outcomes During PTCA Luigi Iuliano, Domenico Pratico, Cesare in Patients Randomized to Invasive or Conservative Greco, Enrico Mangiert, Giovanni Scibilia, Garret A. Post-Infarct Assessment Strategies in the Veterans FitzGerald, Francesco Violi Affairs Non-Q-Wave Infarction Strategies In-Hospital (VANQWISH) Trial Laura F. Wexler, Alvin S. CORONARY ARTERY DISEASE No Difference in Cardiac Event-Free Survival Between Blaustein, Philip W. Lavori, Kenneth G. Lehmann, Michael Positron Emission Tomography—Guided and Single- Wade, Wiliam E. Boden, for the Veterans Affairs Non—Q- Photon Emission Computed Tomography—Guided Wave Infarction Strategies in Hospital (VANQWISH) Trial Patient Management: A Prospective, Randomized Investigators Comparison of Patients With Suspicion of Jeopardized Editorial Comment Is ST Segment Elevation Non-Q- Myocardium Hans-Marc J. Siebelink, Paul K. Blanksma, Wave Myocardial Infarction After Thrombolytic Harry J. G. M. Crins, Jeroen J. Bax, Ad J. van Boven, Therapy a New Clinical Entity That Requires an Tyerk Kingma, D. Albertus Piers, Jan Pruim, Piet L. Jager, Invasive Management Strategy? Bernard R. Chaitman, Willem Vaalburg, Ernst E. van der Wall Saad R. Bitar Editorial Comment Testing Our Tests: Surrogate End Early Assessment of Regional Myocardial Blood Flow Points Versus Driving Patient Management and and Metabolism in Thrombolysis in Myocardial Infarc- Outcomes James E. Udelson tion Flow Grade 3 Reperfused Myocardial Infarction Enhanced External Counterpulsation Improves Using Carbon-11—Acetate Alex F. Maes, Frans Van de Werf, Liesbet V. Mesotten, Patrick B. Flamen, Exercise Tolerance, Reduces Exercise-Induced Myocardial Ischemia and Improves Left Ventricular Ronald S. Kuzo, Johan L. Nuyts, Luc Mortelmans Diastolic Filling in Patients With Coronary Artery Impact of Right Ventricular Involvement on Mortality Disease Hisashi Urano, Hisao Ikeda, Takafumi Ueno, and Morbidity in Patients With Inferior Myocardial Takahiro Matsumoto, Toyoakt Murohara, Infarction Shamir R. Mehta, John W. Eikelboom, Madhu Tsutomu Imaizumi K. Natarajan, Rafael Diaz, Cheelong Yi, Raymond J. Gibbons, Salim Yusuf Energy Stores and Metabolites in Chronic Reversibly and Irreversibly Dysfunctional Myocardium in Humans Course and Prognostic Implications of QT Interval Henrik Wiggers, Morten Noreng, Peter K. Paulsen, and QT Interval Variability After Primary Coronary Morten Bottcher, Henrik Egeblad, Torsten T. Nielsen, Angioplasty in Acute Myocardial Infarction Hendrik Hans Erik Batker Bonnemeier, Franz Hartmann, Uwe K. H. Wiegand, Frank Absolute Quantitation of Coronary Steal Induced by Bode, Hugo A. Katus, Gert Richardt Intravenous Dipyridamole Olakunle O. Akinboboye, Olajide Idris, Ru-Ling Chou, Robert R. Sciacca, Paul J. INTERVENTIONAL CARDIOLOGY Argentine Randomized Study: Coronary Angioplasty Cannon, Steven R. Bergmann With Stenting Versus Coronary Bypass Surgery in N-acetylcysteine Improves Coronary and Peripheral Patients With Multiple-Vessel Disease (ERACI II): Vascular Function Nei/ P. Andrews, Abhiram Prasad, 30-Day and One-Year Follow-up Results A/fredo Arshed A. Quyyumi Rodriguez, Victor Bernardi, Jose Navia, Juho Baldi, Liliana Grinfeld, Jorge Martinez, Daniel Vogel, Roberto Grinfeld, CORONARY PHYSIOLOGY Alejandro Delacasa, Marcelo Garrido, Raul Oliveri, Eduardo Myocardial Perfusion in Patients With Permanent Mele, Igor Palacios, Wiliam O'Neill, for the ERACI II Ventricular Pacing and Normal Coronary Arteries Investi gators Emmanuel I. Skalidis, George E. Kochiadakts, Sophia I. Koukouraki, Stavros I. Chrysostomakis, Ayan R. Patel, Jeffrey T. Kuvin, Natesa G. Pandian, John J. Nikolaos E. Igoumenidis, Nikolaos §. Karkavttsas, Smith, James E. Udelson, Michael E. Mendelsohn, Marvin Panos E. Vardas A. Konstam, Richard H. Karas Comparison of Myocardial Blood Flow During Dobutamine-Atropine Infusion With That After RHEUMATIC FEVER Dipyridamole Administration in Normal Men Eiji Left Ventricular Mechanics During and After Acute Tadamura, Hidehiro Iida, Keiichi Matsumoto, Marcelo Rheumatic Fever: Contractile Dysfunction Is Closely Mamede, Shigeto Kubo, Hiroshi Toyoda, Toshtki Shioxaki, Related to Valve Regurgitation Thomas L. Gentiles, Takahiro Mukai, Yasuhiro Magata, Junjt Konishi Steven D. Colan, Nigel J. Wilson, Renelle Biosa, John M. Neutze The Physiological Role of Endogenous Endothelin in the Regulation of Human Coronary Vasomotor Tone HYPERTROPHIC CARDIOMYOPATHY Philip A. MacCarthy, Nicholas C. Pegge, Bernard D. Echocardiographic Insights Into the Mechanisms of Prendergast, Ajay M. Shah, Peter H. Groves Relief of Left Ventricular Outflow Tract Obstruction After Nonsurgical Septal Reduction Therapy in EXERCISE TESTING When to Stress Patients After Coronary Artery Bypass Patients With Hypertrophic Obstructive Surgery? Risk Stratification in Patients Early and Late Cardiomyopathy Ramiro Flores-Ramirez, Nasser M. Post-CABG Using Stress Myocardial Perfusion SPECT: Lakkis, Katherine J. Middleton, Donna Killip, Wilham H. Implication of Appropriate Clinical Strategies Michael Spencer, III, Sherif F. Nagueh J. Zellweger, Howard C. Lewin, Shenghan Lai, Eric A. Dubois, John D. Friedman, Guido Germano, Xingping VENOUS THROMBOEMBOLISM Kang, Tali Sharir, Daniel S. Berman G20210A Mutation in the Prothrombin Gene and the Age-Predicted Maximal Heart Rate Revisited __ Risk of Recurrent Venous Thromboembolism /. Shawn Miles, Joseph P. Miletich, Samuel Z. Goldhaber, Charles H. Hirofumi Tanaka, Kevin D. Monahan, Douglas R. Seals Hennekens, Paul M. Ridker ELECTROPHYSIOLOGY Heart Rate Variability and Early Recurrence of Atrial AUTONOMIC DYSFUNCTION Ambulatory Norepinephrine Treatment of Severe Fibrillation After Electrical Cardioversion Federico Lombardi, Andrea Colombo, Barbara Basilico, Romana Autonomic Orthostatic Hypotension Olaf Oldenburg, Ravaglia, Massimo Garbin, Daniele Vergant, Pier Maria Anna Mitchell, Jens Niirnberger, Susanne Koeppen, Raimund Battezzati, Cesare Fiorentini Erbel, Thomas Philipp, Andreas Kribben HYPERTENSION ANABOLIC STEROIDS Should Diastolic and Systolic Blood Pressure Be Androgenic Anabolic Steroids and Arterial Structure Considered for Cardiovascular Risk Evaluation: and Function in Male Bodybuilders Mark A. Sader, A Study in Middle-Aged Men and Women Athanase Kaye A. Griffiths, Robyn J. McCredie, David J. Benetos, Frederique Thomas, Michel E. Safar, Kathryn E. Handelsman, David S. Celermajer Bean, Louis Guize Contrasting Clinical Properties and Exercise Responses PEDIATRIC CARDIOLOGY in Obese and Lean Hypertensive Patients Michael A. Inducibility of Intra-atrial Reentrant Tachycardia After Weber, Joel M. Neutel, David H. G. Smith the First Two Stages of the Fontan Sequence Effect of the Angiotensin II Type 2-Receptor Gene Ian H. Law, Peter S. Fischbach, Caren Goldberg, (+1675 G/A) on Left Ventricular Structure in Humans Ralph S. Mosca, Edward L. Bove, Thomas R. Lloyd, Roland E. Schmieder, Jeanette Erdmann, Christian Delles, Albert P. Rocchinit, Macdonald Dick IT Johannes Jacolt, Eckart Fleck, Karl Hilgers, Congenital Heart Block: Development of Late-Onset Vera Regitz-Zagrosek Cardiomyopathy, a Previously Underappreciated Sequela Jeffrey P. Moak, Karyl S. Barron, Thomas J. HEART FAILURE Hougen, Henry B. Wiles, Seshadri Balaji, Narayanswami Independent and Additive Prognostic Value Sreeram, Mark H. Cohen, Aaron Nordenberg, George F. Van of Right Ventricular Systolic Function and Hare, Richard A. Friedman, Maria Perez, Frank Cecchin, Pulmonary Artery Pressure in Patients With Daniel S. Schneider, Rodrigo A. Nehgme, Jill P. Buyon Chronic Heart Failure Stefano Ghio, Antonello Gavazzi, Late Rejection Is a Predictor of Transplant Coronary Carlo Campana, Corinna Inserra, Catherine Klersy, Artery Disease in Children Neda F. Mulla, Joyce K. Roberta Sebastiani, Eloisa Arbustini, Franco Recusant, Johnston, Laura Vander Dussen, W. Lawrence Beeson, Luigi Tavazzi Richard E. Chinnock, Leonard L. Bailey, Ranae L. Larsen HEART TRANSPLANT Reconstruction of Stenotic or Occluded [liofemoral Factors Affecting Long-Term Survival (>10 Years) Veins and Inferior Vena Cava Using Intravascular After Cardiac Transplantation in the Cyclosporine Era Stents: Re-establishing Access for Future Cardiac Ranjit John, Hiranya A. Rajasinghe, Silviu Itescu, Sanjeev Catheterization and Cardiac Surgery Frank F. Ing, Suratwalla, Katherine Lietz, Alan D. Weinberg, Alfred Thomas E. Fagan, Ronald G. Grifka, Sandra Clapp, Kocher, Donna M. Mancin1, Ronald E. Drusin, Mehmet C. Michael R. Nihill, Mark Cocalts, James Perry, James Oz, Craig R. Smith, Eric A. Rose, Niloo M. Edwards Mathewson, Charles E. Mullins Heart Failure Etiology Affects Peripheral Vascular The Amplatzer Duct Occluder: Experience in 209 Endothelial Function After Cardiac Transplantation Patients Aziz A. Bilkis, Mazeni Alwi, Samion Hasri, Abdul L. Haifa, Kandhavello Geetha, Muhammad A. Otto-Erich Brodde, Hans Michael Piper, Rehman, Ishak Hasanah Klaus-Dieter Schliiter Multiple Endothelial Injury in Epicardial Coronary Artery Induces Downstream Microvascular Spasm as EXPERIMENTAL STUDIES well as Remodeling Partly via Thromboxane A, Quantitative Assessment of Myocardial Perfusion Shu-tcht Saitoh, Futoshi Onogi, Kazuhiko Aikawa, Mitsuru During Graded Coronary Stenosis by Muto, Tomiyoshi Saito, Kazuhira Maehara, Real-Time Myocardial Contrast Echo Refilling Curves Yukio Maruyama Hisashi Masugata, Barry Peters, Stephane Lafitte, G. Monet Interaction Between Paracrine Tumor Necrosis Factor- Strachan, Koji Ohmori, Anthony N. DeMaria Alpha and Paracrine Angiotensin II During Improvement of Afterload Mismatch of Left Atrial Myocardial Ischemia Inna Frolkis, Jacob Gurevitch, Yael Booster Pump Function With Positive Inotropic Agent Yuhas, Adrian Taina, Yoram Wollman, Tamara Hisanori Sakai, Hideki Kunichika, Kazuya Murata, Cherntichovskti, Yosef Paz, Menachem Matsa, Dimitri Pevni, Kohzaburo Seki, Kazuhiro Katayama, Takafumt Hro, Amur Kramer, Itzhak Shapira, Rephael Mohr Toshiro Miura, Masunort Matsuzaki EDITOR’S PAGE Hemodynamic Determinants of the Mitral Annulus Why Did JACC Reject My Manuscript? Diastolic Velocities by Tissue Doppler William W. Parmley Sherif F. Nagueh, Huabin Sun, Helen A. Kopelen, Katherine J. Middleton, Dirar 8. Khoury SPECIAL SECTIONS Sildenafil Citrate (Viagra) Does Not Exacerbate Myocardial Ischemia in Canine Models of Coronary ACC News President’s Page: Enhancing the College’s Advocacy Artery Stenosis Karin Przyklenk, Robert A. Kloner Efforts George A. Beller Renin Angiotensin System-Dependent Hypertrophy as a Contributor to Heart Failure in Hypertensive Rats: LETTERS TO THE EDITOR Different Characteristics from Renin Angiotensin System-Independent Hypertrophy Yasushi Sakata, CORRECTIONS Tohru Masuyama, Kazuhiro Yamamoto, Reiko Dot, Toshiaki Mano, Tsunehiko Kuzuya, Takeshi Miwa, Consensus Conference Report Hiroshi Takeda, Masatsugu Hort Mechanical Cardiac Support 2000: Beta-Adrenoceptor Stimulation Attenuates the Current Applications and Future Trial Design, Hypertrophic Effect of Alpha-Adrenoceptor June 15-16, 2000, Bethesda, Maryland Stimulation in Adult Rat Ventricular Cardiomyocytes Lynne Warner Stevenson, Conference Co-Chair, Matthias Schafer, Klaus Pénicke, Ingrid Hetnroth-Hoffmann, Robert L. Kormos, Conference Co-Chair FEBRUARY 2001 VOLUME 37 NUMBER 2 REVIEW ARTICLE Endothelial Dysfunction in Patients With Chronic Epidemiology and Natural History of Atrial Heart Failure: Systemic Effects of Lower-Limb Fibrillation: Clinical Implications Sumeet S. Chugh, Exercise Training Axe/ Linke, Nina Schoene, Stephan Gielen, Jiirgen Hofer, Sandra Erbs, Gerhard Schuler, Joseph L. Blackshear, Win-Kuang Shen, Rainer Hambrecht Stephen C. Hammill, Bernard J. Gersh Modulation of Alveolar-Capillary Sodium Handling as a Mechanism of Protection of Gas Transfer by Enalapril, and Not by Losartan, in Chronic Heart CLINICAL STUDIES Failure Marco Guazzi, Piergiuseppe Agostont, HEART FAILURE Maurizio D. Guazzi Utility of B-Type Natriuretic Peptide in the Diagnosis of Congestive Heart Failure in an Urgent-Care Setting CARDIOMYOPATHY Quyen Dao, Padma Krishnaswamy, Radmila Kazanegra, Dilated Cardiomyopathy in Dialysis Patients— Alex Harrison, Rambod Amirnovin, Leshe Lenert, Paul Beneficial Effects of Carvedilol: A Double-Blind, Clopton, Joel Alberto, Patricia Hlavin, Alan S. Maisel Placebo-Controlled Trial Gennaro Cice, Luigi Ferrara, Attilio Di Benedetto, Pina Elvira Russo, Giancarlo A Rapid Bedside Test for B-Type Peptide Predicts Marinelli, Francesco Pavese, Aldo Iacono Treatment Outcomes in Patients Admitted for Decompensated Heart Failure: A Pilot Study Van Effect of Beta-Blockers on Circulating Levels Cheng, Radmila Kazanagra, Alex Garcia, Leslie Lenert, of Inflammatory and Anti-Inflammatory Cytokines Padma Krishnaswamy, Nancy Gardetto, Paul Clopton, in Patients With Dilated Cardiomyopathy Alan Maisel Tomoaki Ohtsuka, Mareomi Hamada, Go Hiasa, Osamu Sasaki, Makoto Suzuki, Yuji Hara, Yuji Shigematsu, 485 Interaction Between Chemokines and Oxidative Stress: Kunio Hiwada Possible Pathogenic Role in Acute Coronary Syndromes Pé/ Aukrust, Rolf K. Berge, Thor Ueland, Autoantibodies Against the Second Extracellular Loop Ellinor Aaser, Jan Kristian Damas, Lisbeth Wikeby, of Beta,-Adrenergic Receptors Predict Ventricular Anne Brunsvig, Fredrik Miiller, Kolbjorn Forfang, Tachycardia and Sudden Death in Patients With Stig S. Froland, Lars Gullestad Idiopathic Dilated Cardiomyopathy Michikado Iwata, Tsutomu Yoshikawa, Akiyasu Baba, Toshihisa Anzat, Therapeutic Value of Eptifibatide at Community Hideo Mitamura, Satoshi Ogawa Hospitals Transferring Patients to Tertiary Referral Centers Early After Admission for Acute Coronary Syndromes Adam B. Greenbaum, Robert A. Harrington, ATHEROSCLEROSIS Michael P. Hudson, Cynthia M. MacAulay, Robert G. Estrogen-Induced Small Low Density Lipoprotein Wilcox, Maarten L. Simoons, Lisa G. Berdan, Alan Guerct, Particles May Be Atherogenic in Postmenopausal Dennis V. Cokkinos, Michael M. Kitt, A. Michael Lincof,; Women Akihiko Wakatsuki, Nobou Ikenoue, Yuji Okatanti, Eric J. Topol, Robert M. Calif, E.M agnus Ohman, for the Takao Fukaya PURSUIT Investigators Editorial Comment Estrogens, Lipids and Cardiovascular Disease: No Easy Answers Vera Bittner INTERVENTIONAL CARDIOLOGY The Effects of Contemporary Use of Coronary Stents Lipoprotein(a) Further Increases the Risk of Coronary on In-Hospital Mortality Stephen E. Kimmel, A. Russell Events in Men With High Global Cardiovascular Risk Localio, Ronald J. Krone, Warren K. Laskey, for the Registry Arnold von Eckardstein, Helmut Schulte, Paul Cullen, Gerd Assmann Committee of the Society for Cardiac Angiography and Interventions Irbesartan, an Angiotensin Type 1 Receptor Inhibitor, Regulates Markers of ENDOTHELIAL FUNCTION Inflammation in Patients With Premature Nitroglycerin Withdrawal Increases Endothelium- Atherosclerosis Sushant Navalkar, Sampath Dependent Vasomotor Response to Acetylcholine Parthasarathy, Nalini Santanam, Bobby V. Khan Eduardo R. Azevedo, Anne M. Schofield, Susan Kelly, Periodontal Disease and Risk of Subsequent John D. Parker Cardiovascular Disease in U.S. Male Physicians Platelet Inhibitory Effect of Nitric Oxide in the T. Howard Howell, Paul M. Ridker, Umed A. Ajani, Human Coronary Circulation: Impact of Endothelial Charles H. Hennekens, Wilham G. Christen Dysfunction Nei/ P. Andrews, Mohsin Husain, Nader Dakak, Arshed A. Quyyumt CORONARY ARTERY DISEASE Vascular Endothelial Function and Oxidative Stress Correlation of Coronary Calcification and Mechanisms in Patients With Behcet’s Syndrome Angiographically Documented Stenoses in Patients John C. Chambers, Dorian O. Haskard, Jaspal 8. Kooner With Suspected Coronary Artery Disease: Results of 1,764 Patients Ralph Haberl, Alexander Becker, Alexander BYPASS SURGERY Leber, Andreas Knez, Christoph Becker, Christine Lang, Early Mortality and Morbidity of Bilateral Versus Roland Briining, Maximilian Reiser, Gerhard Steinbeck Single Internal Thoracic Artery Revascularization: Enhanced Detection of Reversible Perfusion Defects Propensity and Risk Modeling John P. A. Ioannidis, by Tc-99m Sestamibi Compared to Tc-99m Othon Galanos, Demosthenes Katritsis, Chiff P. Connery, Tetrofosmin During Vasodilator Stress SPECT George E. Drossos, Daniel G. Swistel, Imaging in Mild-to-Moderate Coronary Artery Disease Constantine E. Anagnostopoulos Prem Soman, Raymond Taillefer, E. Gordon DePuey, Coronary Artery Revascularization in Patients With James E. Udelson, Avijit Lahiri Sustained Ventricular Arrhythmias in the Chronic Phase of a Myocardial Infarction: Effects on the MYOCARDIAL ISCHEMIA Electrophysiologic Substrate and Outcome Myocardial Perfusion Imaging Findings and the Role Josep Brugada, Luis Aguinaga, Llus Mont, Amadev Betriu, of Adenosine in the Warm-up Angina Phenomenon Jaume Mulet, Ginés Sanz Peter Bogaty, John G. Kingma, Jean Guimond, Paul Poirier, Luce Boyer, Lyne Charbonneau, Gilles R. Dagenais ELECTROPHYSIOLOGY Different Patterns of Atrial Activation in Reduction of Exercise-Induced Myocardial Ischemia Idiopathic Atrial Fibrillation: Simultaneous During Add-On Treatment With the Angiotensin- Multisite Atrial Mapping in Patients With Paroxysmal Converting Enzyme Inhibitor Enalapril in Patients and Chronic Atrial Fibrillation Fiorenzo Gaita, Leonardo With Normal Left Ventricular Function and Optimal Calé, Riccardo Riccardi, Lucia Garberoglo, Marco Scaghione, Beta Blockade Ad F. M. van den Heuvel, Peter H. J. M. Giovanni Licciardello, Luisella Coda, Paolo Di Donna, Dunselman, Tyerk Kingma, Patrick Verhorst, Frans Mario Bocchiardo, Domenico Caponi, Renzo Antolint, Boomsma, Wiek H. van Gilst, Dirk J. van Veldhuisen Fulvio Orzan, GianPaolo Trevi Single Oral Loading Dose of Propafenone for ACUTE CORONARY SYNDROMES Pharmacological Cardioversion of Recent-Onset Effects of Long-Term, Moderate-Intensity Oral Atrial Fibrillation [jaz A. Khan Anticoagulation in Addition to Aspirin in Unstable Angina The Organization to Assess Strategies for Ischemic Efficacy and Safety of Out-of-Hospital Self- Syndromes (OASIS) Investigators Administered Single-Dose Oral Drug Treatment in the Management of Infrequent, Well-Tolerated Kaort Sato, Tiangen Wu, Roger J. Laham, Robert B. Paroxysmal Supraventricular Tachycardia Paolo Alboni, Johnson, Pamela Douglas, Jianyi Li, Frank W. Sellke, Corrado Tomasi, Carlo Menozzi, Nicola Bottoni, Nelly Stuart Bunting, Michael Simons, Mark J. Post Paparella, Giuseppe Fuca, Michele Brignole, Quantitative Assessment of Myocardial Perfusion Riccardo Cappato During Graded Coronary Artery Stenoses by Lack of Efficacy of Atenolol for the Prevention of Intravenous Myocardial Contrast Echocardiography Neurally Mediated Syncope in a Highly Symptomatic Elisabeth Leistad, Koji Ohmori, Thomas A. Peterson, Population: A Prospective, Double-Blind, Randomized Geir Christensen, Anthony N. DeMaria and Placebo-Controlled Study Antonio H. Madrid, Validation of a Digital Color Doppler Flow Javier Ortega, Jose G. Rebollo, Juan G. Manzano, Javier G. Measurement Method for Pulmonary Regurgitant Segovia, Andrés Sanchez, Gonzalo Pena, Concepcién Moro Volumes and Regurgitant Fractions in an In Vitro Editorial Comment Can We Assess the Efficacy of Therapy Model and in a Chronic Animal Model of in Neurocardiogenic Syncope? Jasdir S. Sra Postoperative Repaired Tetralogy of Fallot Yoshiki A Founder Mutation of the Potassium Channel Mori, Timothy Irvine, Michael Jones, Rosemary A. Rusk, Quynh Pham, Antoinette Kenny, David J. Sahn KCNQI1 in Long QT Syndrome: Implications for Estimation of Disease Prevalence and Molecular Mechanism of Ischemic Mitral Regurgitation With Diagnostics Kirsi Pippo, Heikki Swan, Michael Segmental Left Ventricular Dysfunction: Three- Pasternack, Hugh Chapman, Kristian Paavonen, Dimensional Echocardiographic Studies in Models of Matti Viitasalo, Lauri Toivonen, Kimmo Kontula Acute and Chronic Progressive Regurgitation Yutaka Otsuji, Mark D. Handschumacher, Noah Liel-Cohen, VALVE DISEASE Hiroaki Tanabe, Leng Jiang, Ehud Schwammenthal, Risks and Benefits of Adding Anti-Platelet Therapy to J. Luis Guerrero, Lort A. Nicholls, Gus J. Vlahakes, Warfarin Among Patients With Prosthetic Heart Robert A. Levine Valves: A Meta-Analysis David Massel, Impact Directly Over the Cardiac Silhouette Is Stephen H. Little Necessary to Produce Ventricular Fibrillation in Reoperation for Prosthetic Aortic Valve Obstruction in an Experimental Model of Commotio Cordis the Era of Echocardiography: Trends in Diagnostic Mark S. Link, Barry J. Maron, Brian A. VanderBrink, Testing and Comparison With Surgical Findings Masaaki Takeuchi, Natesa G. Pandian, Paul J. Wang, Steven E. Girard, Fletcher A. Miller, Jr., Thomas A. N. A. Mark Estes, II Orszulak, Charles J. Mullany, Samantha Montgomery, Adventitial Remodeling After Angioplasty Is William D. Edwards, Henry D. Tazelaar, Joseph F. Malouf, Associated With Expression of Tenascin mRNA by A. Jamil Tajik Adventitial Myofibroblasts Kurt Wallner, Behrooz G. Sharifi, Prediman K. Shah, Sumiko Noguchi, Hector DeLeon, ADULT CONGENITAL HEART DISEASE Josiah N. Wilcox Outcomes of Late Atrial Tachyarrhythmias in Adults After the Fontan Operation Akash Ghai, Louise Harris, Prevention of Aortic and Cardiac Fibrosis by Spironolactone in Old Normotensive Rats David A. Harrison, Gary D. Webb, Samuel C. Siu Patrick Lacolley, Michel E. Safar, Bernadette Lucet, Katia Ledudal, Carlos Labat, Athanase Benetos PEDIATRIC CARDIOLOGY Major Coronary Artery Anomalies in a Pediatric Soluble Substances Released From Postischemic Population: Incidence and Clinical Importance Reperfused Rat Hearts Reduce Calcium Transients Julie A. Davis, Frank Cecchin, Thomas K. Jones, and Contractility by Blocking the L-Type Calcium Michael A. Portman Channel Stephan B. Felix, Verena Stangl, Peter Pietsch, Peter Bramlage, Alexander Staudt, Sabine Bartel, Ernst- Editorial Comment Congenital Coronary Artery Anomalies Georg Krause, Jérn-Uwe Borschke, Klaus-Dieter Wernecke, in Young Patients: New Perspectives for Timely Gerrit Isenberg, Gert Baumann Identification Antonio Pelliccia Redox Regulation of MAPK Pathways and Cardiac Hypertrophy in Adult Rat Cardiac Myocyte EXPERIMENTAL STUDIES Koichi Tanaka, Masaaki Honda, Toshitkazu Takabatake Acute Ethanol Exposure Fails to Elicit Preconditioning-Like Protection in In Situ Rabbit EDITOR’S PAGE Hearts Because of Its Continued Presence During The Family Under Attack William W. Parmley Ischemia Maike Krenz, Christopher P. Baines, Xi-Ming Yang, Gerd Heusch, Michael V. Cohen, James M. Downey Hypercholesterolemia Impairs Myocardial Perfusion SPECIAL SECTIONS and Permeability: Role of Oxidative Stress and ACC News Endogenous Scavenging Activity Martin Rodriguez- President’s Page: Patient Satisfaction: A Personal Porcel, Amir Lerman, Patricia J.M. Best, James D. Krier, Perspective George A. Beller Claudio Napoli, Lilach O. Lerman Efficacy of Intracoronary or Intravenous VEGF ,,; in a Pig Model of Chronic Myocardial Ischemia LETTERS TO THE EDITOR MARCH 1, 2001 VOLUME 37 NUMBER 3 REVIEW ARTICLE Heterogeneity of Segmental Response and Correlation Role of Transesophageal Echocardiography-Guided With Plasma Oxidized Low Density Lipoprotein Cardioversion of Patients With Atrial Fibrillation Wiliam F. Penny, Ort Ben-Yehuda, Kenji Kuroe, John Allan L. Klein, R. Daniel Murray, Richard A. Grimm Long, Alan Bond, Valmik Bhargava, Joseph F. Peterson, Martin McDaniel, Joseph Juliano, Joseph L. Witztum, John CLINICAL STUDIES Ross, Jr.. Kirk L. Peterson MYOCARDIAL ISCHEMIA The Warm-Up Effect Protects Against Ischemic CORONARY ARTERY DISEASE Left Ventricular Dysfunction in Patients With Angina Clinical Significance of Antibody Against Oxidized Andrew D. Kelion, Terence P. Webb, Maureen A. Gardner, Low Density Lipoprotein in Patients With Oliver J. M. Ormerod, Adrian P. Banning Atherosclerotic Coronary Artery Disease Teruo Inoue, Failure to Precondition Pathological Human Toshihiko Uchida, Htrotoshi Kamishirado, Kan Takayanagi, Myocardium Sudip Ghosh, Nicholas B. Standen, Terumi Hayashi, Shigenori Morooka Manuel Galinanes History of Anxiety Disorders Is Associated With a Additive Effects of Nicorandil on Coronary Blood Decreased Likelihood of Angiographic Coronary Artery Flow During Continuous Administration of Disease in Women With Chest Pain: The WISE Nitroglycerin Atsunori Okamura, Hiromi Rakugi, Mitsuru Study Thomas Rutledge, Steven E. Reis, Marian Olson, Ohishi, Yoshihiro Yanagitani, Masumi Shimizu, Tadahiko Jane Owens, Sheryl F. Kelsey, Carl J. Pepine, Nathaniel Nishit, Yoshiaki Tantyama, Takashi Asai, Shin Takiuch, Reichek, William J. Rogers, C. Noel Bairey Merz, George Koichi Moriguchi, Masashi Ohkuro, Norio Komat, Kazuo Sopko, Carol E. Cornell, Barry Sharaf, Karen A. Matthews Yamada, Nozomu Inamoto, Atsuhiro Otsuka, Jitsuo Higaki, Toshio Ogihara Regional Myocardial Systolic Function During Acute MYOCARDIAL INFARCTION Myocarditis in Patients With Clinical Presentation Myocardial Ischemia Assessed by Strain Doppler of Myocardial Infarction and Normal Coronary Echocardiography Thor Edvardsen, Helge Skulstad, Svend Aakhus, Stig Urheim, Halfdan Ihlen Angiograms Laure Sarda, Patrice Colin, Franck Boccara, Doumit Daou, Rachida Lebtahi, Marc Faraggi, Charles Editorial Comment Myocardial Strain: Can We Finally Nguyen, Ariel Cohen, Michel S. Slama, Philippe G. Steg, Measure Contractility? T: P. Abraham, R. A. Nishimura Dominique Le Guludec Estradiol Supplementation Suppresses Prognostic Implications of Restrictive Left Ventricular Hyperventilation-Induced Attacks in Postmenopausal Filling in Reperfused Anterior Acute Myocardial Women With Variant Angina Hiroaki Kawano, Takeshi Motoyama, Nobutaka Hirai, Kiyotaka Kugtyama, Hsao Infarction Giampaolo Cerisano, Leonardo Bolognese, Ogawa, Hirofumi Yasue Prergiovannit Buonamici, Renato Valenti, Nazario Carrabba, Emulio Vincenzo Dovellini, Paolo Domenico Pucci, Giovanni STRESS TESTING Maria Santoro, David Antoniucci Real-Time Assessment of Myocardial Perfusion and Expression of an Endothelial-Type Nitric Oxide Wall Motion During Bicycle and Treadmill Exercise Synthase Isoform in Human Neutrophils: Modification Echocardiography: Comparison With Single Photon by Tumor Necrosis Factor-Alpha and During Acute Emission Computed Tomography Sarah Shimoni, Myocardial Infarction Trinidad de Frutos, Lourdes Wilham A. Zoghhi, Feng Xte, David Kricsfeld, Sherif Sanchez de Miguel, Jerénimo Farré, Juan Gomez, José Iskander, Lisa Gobar, Issam A. Mtkati, John Abukhalil, Romero, Pedro Marcos-Alberca, Antonio Nunez, Luis Rico, Mario S. Verani, Edward L. O'Leary, Thomas R. Porter Antonio Lépez-Farré Real-Time Perfusion Imaging With Low Mechanical Index Pulse Inversion Doppler Imaging Quantification of Regional Contractile Function After Infarction: Strain Analysis Superior to Wall Thomas R. Porter, Feng Xte, Mary Silver, David Kricsfeld, Edward O'Leary Thickening Analysis in Discriminating Infarct From Remote Myocardium Marco J. W. Gétte, Albert C. van Prediction of Mortality Using Dobutamine Rossum, Jos W. R. Twisk, Joost P. A. Kuijer, J. Tim Echocardiography Thomas H. Marwick, Colin Case, Marcus, Cees A. Visser Stephen Sawada, Curtis Rimmerman, Patricia Brenneman, Roxanne Kovacs, Leanne Short, Michael Lauer HEART FAILURE ENDOTHELIAL FUNCTION Left Ventricular Inotropic Reserve and Right Radiation Therapy Impairs Endothelium-Dependent Ventricular Function Predict Increase of Left Vasodilation in Humans Joshua A. Beckman, Ventricular Ejection Fraction After Beta-Blocker Avni Thakore, Barbara H. Kalinowski, Jay R. Harris, Therapy in Nonischemic Cardiomyopathy Tarik M. Mark A. Creager Ramahi, Marcella D. Longo, Arina R. Cadariu, Kate Improvement of Coronary Artery Endothelial Rohlfs, Stella A. Carolan, Kathryn M. Engle, Habib Dysfunction With Lipid Lowering Therapy: Samady, Frans J. Th. Wackers HEART TRANSPLANT Percutaneous Balloon Mitral Valvuloplasty in Detection and Prediction of Acute Comparison With Open Mitral Valve Heart Transplant Rejection With the Commissurotomy for Mitral Stenosis During Myocardial T, Determination Provided by a Pregnancy José A. M. de Souza, Eulogio E. Martinez Jr., Black-Blood Magnetic Resonance Imaging Sequence John A. Ambrose, Claudia M. R. Alves, Daniel Born, Enio Pierre Y. Marie, Michael Angioi, Jean P. Carteaux, Jean M. Buffolo, Antonio C. C. Carvalho Escanye, Sophie Mattei, Kiril Tzvetanov, Olivier Claudon, Nathalie Hassan, Nicolas Danchin, Gilles Karcher, Alain Bertrand, Paul M. Walker, Jean P. Villemot ELECTROPHYSIOLOGY Global Distribution of Atrial Ectopic Foci Triggering Recurrence of Atrial Tachyarrhythmia After Electrical INTERVENTIONAL CARDIOLOGY Cardioversion of Long-Standing Atrial Fibrillation: Unprotected Left Main Coronary Artery Stenting: A Bi-Atrial Basket Mapping Study Jivnn-Lee Lin, Correlates of Midterm Survival and Impact of Patient Ling-Ping Lat, Yung-Zu Tseng, Wen-Pin Lien, Selection Alexander Black, Jr, Rosario Cortina, Irene Bossi, Shoei K. Stephen Huang Rémi Choussat, Jean Fajadet, Jean Marco Sympathetic Stimulation Produces a Greater Increase Preprocedural C-Reactive Protein Levels and in Both Transmural and Spatial Dispersion of Cardiovascular Events After Coronary Stent Repolarization in LQT1 Than LQT2 Forms of Implantation Dirk H. Walter, Stephan Fichtlscherer, Marc Congenital Long QT Syndrome Yasuko Tanabe, Masashi Sellwig, Wolfgang Auch-Schwelk, Volker Schachinger, Inagaki, Takashi Kurita, Noritoshi Nagaya, Atsushi Tagush1, Andreas M. Zether Kazuhiro Suyama, Naohtko Athara, Shiro Kamakura, Kenji Administration of Abciximab to Patients Receiving Sunagawa, Kazufumi Nakamura, Tohru Ohe, Jeffrey A. Tirofiban or Eptifibatide: Effect on Platelet Function Towbin, Silvia G. Priori, Wataru Shimizu El I. Lev, Julio I. Osende, Merwin F. Richard, The Repolarization-Excitability Relationship in the Jonathan A. Robbins, Jenny A. Delfin, Oswaldo Rodriguez, Human Right Atrium Is Unaffected by Cycle Length, Samin K. Sharma, Tim Jayasundera, Juan J. Badimon, Recording Site and Prior Arrhythmias Frank Bode, Jonathan D. Marmur Michael Kilborn, Pamela Karasik, Michael R. Franz Coronary Artery Stenting in the Aged Manish S. Chauhan, Richard E. Kuntz, Kalon K. L. Ho, David J. Alterations in Potassium Channel Gene Expression in Atria of Patients With Persistent and Paroxysmal Cohen, Jeffrey J. Popma, Joseph P. Carrozza, Jr, Donald S. Baim, Donald E. Cutlip Atrial Fibrillation: Differential Regulation of Protein and mRNA Levels for K* Channels Bianca J. J. M. Brundel, Isabelle C. Van Gelder, Robert H. Henning, E. HYPERTENSION Tuinenburg, Mirian Wietses, Jan G. Grandjean, Arthur Effect of the Angiotensin-Converting Enzyme A. M. Wilde, Wiek H. Van Gilst, Harry J. G. M. Crijns Inhibitor Imidapril on Reactive Hyperemia in Patients With Essential Hypertension: Relationship Between Treatment Periods and Resistance Artery Endothelial PEDIATRIC CARDIOLOGY Function Yukihito Higashi, Shota Sasaki, Keigo The Fontan Procedure for Tricuspid Atresia: Nakagawa, Hideo Matsuura, Goro Kajtyama, Early and Late Results of a 25-Year Experience With Tetsuya Oshima 216 Patients Douglas D. Mair, Francisco J. Puga, Gordon K. Danielson Hyperinsulinemia and Hemostatic Abnormalities Are Associated With Silent Lacunar Cerebral Infarcts in Balloon Angioplasty for Obstructed Modified Elderly Hypertensive Subjects Kazuomi Kario, Takefumi Systemic-Pulmonary Artery Shunts and Pulmonary Matsuo, Hiroko Kobayashi, Satoshi Hoshide, Artery Stenoses Jou-Kou Wang, Mei-Hwan Wu, Kazuyuki Shimada Chung-I Chang, Ing-Sh Chiu, Hung-Chi Lue Aldosterone Synthase (CYP11B2) —344 C/T Editorial Comment Concurrent Balloon Dilation of Polymorphism Is Associated With Left Ventricular Stenosed Aortopulmonary Gore-Tex Shunts and Structure in Human Arterial Hypertension Christian Branch Pulmonary Arteries P. Syamasundar Rao Delles, Jeanette Erdmann, Johannes Jacobi, Karl F. Hilgers, Eckart Fleck, Vera Regitz-Zagrosek, Roland E. Schmieder EXPERIMENTAL STUDIES VALVE DISEASE Alpha-Methylnorepinephrine, a Selective Alpha,- Adrenergic Agonist for Cardiac Resuscitation Prediction of Operative Mortality After Valve Replacement Surgery Fred H. Edwards, Eric D. Shijie Sun, Max Harry Weil, Wanchun Tang, Peterson, Laura P. Coombs, Elizabeth R. DeLong, W. R. Takashi Kamohara, Kada Klouche Eric Jamieson, A. Laurie W. Shroyer, Frederick L. Grover Mitochondrial ATP-sensitive K* Channels Play a Role The Effect of Valvular Heart Disease on Maternal and in Cardioprotection by Na*-H* Exchange Inhibition Fetal Outcome of Pregnancy Afshan Hameed, Ilyas S. Against Ischemia/Reperfusion Injury Tetsuji Miura, Karaalp, Padmint P. Tummala, Omar R. Wani, Menahem Yongge Liu, Mahiko Goto, Akihito Tsuchida, Takayuki Miki, Canetti, Mohammed W. Akhter, Murphy Goodwin, Natalia Atsushi Nakano, Yasuhiro Nishino, Yoshito Ohnuma, Zapadinsky, Uri Elkayam Kazuaki Shimamoto EDITOR’S PAGE LETTERS TO THE EDITOR Reflections on Attending on the Cardiology Service William W. Parmley ADDENDUM SPECIAL SECTIONS ACC News President’s Page: Health Care and the 107th Congress George A. Beller CORRECTIONS MARCH 15, 2001 VOLUME 37 NUMBER 4 REVIEW ARTICLE Marc Kollum, Balram Bhargava, Roxana Mehran, Pulse Pressure—A Review of Mechanisms and Clinical Rosanna C. Chan, Gary S. Mintz Relevance Anthony M. Dart, Bronwyn A. Kingwell Preintervention Arterial Remodeling Affects Clinical Outcome Following Stenting: An Intravascular Ultrasound Study Hiroyuki Okura, Yoshihiro Morino, Akio CLINICAL STUDIES Oshima, Motoya Hayase, Michael R. Ward, Jeffrey J. Popma, MYOCARDIAL INFARCTION Richard E. Kuntz, Heidi N. Bonneau, Paul G. Yock, Stenting Versus Thrombolysis in Acute Myocardial Peter J. Fitzgerald Infarction Trial (STAT) Michel R. Le May, Marino Labinaz, Richard F. Davies, Jean-Frangois Marquis, Louise STRESS TESTING A. Laramée, Edward R. O’Brien, William L. Willams, Prognostic Value of Exercise Echocardiography in Rob S. Beanlands, Graham Nichol, Lyall A. Higginson 2,632 Patients =65 Years of Age Adelaide M. Arruda, Development and Validation of the Ontario Acute Mini K. Das, Veronique L. Roger, Kyle W. Klarich, Myocardial Infarction Mortality Prediction Rules Douglas W. Mahoney, Patricia A. Pellikka Jack V. Tu, Peter C. Austin, Randy Walld, Leshe Roos, Jean Agras, Kathryn M. McDonald HEART FAILURE Editorial Comment Measuring the Effectiveness of Predictive Value of Systolic and Diastolic Function for Incident Congestive Heart Failure in the Elderly: Medical Care Delivery James G. Jollis The Cardiovascular Health Study Gerard P. ACUTE CORONARY SYNDROMES Aurigemma, John §. Gottdiener, Lynn Shemanski, Reactivation of Ischemic Events in Acute Coronary Julius Gardin, Dalane Kitzman Syndromes: Results From GUSTO-IIb Maria Cecilia Prognostic Value of Doppler Echocardiographic Mitral Bahit, Eric J. Topol, Robert M. Califf; Paul W. Armstrong, Inflow Patterns: Implications for Risk Stratification in Douglas A. Criger, Vic Hasselblad, Amadeo Betriu, Patients With Chronic Congestive Heart Failure Jack Hirsh, Diego Ardissino, Christopher B. Granger Alexander Hansen, Markus Haass, Christian Zugck, Carsten Krueger, Kristina Unnebrink, Rainer Zimmermann, INTERVENTIONAL CARDIOLOGY Wolfgang Kuebler, Helmut Kuecherer Survival of Patients With Diabetes and Multivessel Angiotensin Converting Enzyme (ACE) and Non-ACE Coronary Artery Disease After Surgical or Dependent Angiotensin II Generation in Resistance Percutaneous Coronary Revascularization: Results of a Arteries From Patients With Heart Failure and Large Regional Prospective Study Nathaniel W. Niles, Coronary Heart Disease Mark C. Petrie, Paul D. McGrath, David Malenka, Hebe Quinton, Neal Padmanabhan, John E. McDonald, Chris Hiller, David Wennberg, Samuel J. Shubrooks, Joan F. Tryzelaar, John M. C. Connell, John J. V. McMurray Robert Clough, Michael J. Hearne, Felix Hernandez, Jr, Preservation of Venous Endothelial Function in the Matthew W. Watkins, Gerald T. O’Connor, for the Northern Forearm Venous Capacitance Bed of Patients With New England Cardiovascular Disease Study Group Chronic Heart Failure Despite Arterial Endothelial Editorial Comment Coronary Artery Bypass Graft or Dysfunction Angus K. Nightingale, Daniel J. Blackman, Percutaneous Coronary Interventions in Patients With Gethin R. Ellis, Matthias Schmitt, Jayne A. Morris- Diabetes: Another Nail in the Coffin or “Too Close to Thurgood, Elizabeth A. Jones, Michael P. Frenneaux Call?” Spencer B. King, III Predictors of Diffuse and Aggressive Intra-Stent ENDOCARDITIS Restenosis Steven L. Goldberg, Arthur Loussararian, Echocardiography Predicts Embolic Events in Joseph De Gregorio, Carlo Di Mario, Remo Albiero, Infective Endocarditis Giovanni Di Salvo, Gilbert Antonio Colombo Habib, Valeria Pergola, Jean-Frangots Avierinos, Emmanuel Edge Stenosis and Geographical Miss Following Philip, Jean-Paul Casalta, Jean-Marie Vailloud, Genevieve Intracoronary Gamma Radiation Therapy for In-Stent Derumeaux, Joany Gouvernet, Pierre Ambrosi, Marc Restenosis Han-Soo Kim, Ron Waksman, Yves Cottin, Lambert, Ange Ferracct, Didier Raoult, Roger Lucctont 1077 Editorial Comment Echocardiography Predicts Embolic NEW METHODS Events in Infective Endocarditis Shelley Shapiro, Ultrafast Three-Dimensional Contrast-Enhanced Leon Irt Kupferwasser Magnetic Resonance Angiography and Imaging in the Diagnosis of Partial Anomalous Pulmonary Venous Drainage Victor A. Ferrari, Craig H. Scott, VALVE DISEASE Cardiocyte Cytoskeleton in Patients With Left George A. Holland, Leon Axel, Martin St. John Sutton Ventricular Pressure Overload Hypertrophy PEDIATRIC CARDIOLOGY Michael R. Zile, G. Randall Green, Gregg T. Schuyler, Dilated Cardiomyopathy in Isolated Congenital Gerard P. Aurigemma, D. Craig Miller, George Cooper, IV Complete Atrioventricular Block: Early and Long- Term Risk in Children Floris E. A. Udink ten Cate, PULMONARY HYPERTENSION Johannes M. P. J. Breur, Mitchell I. Cohen, Nicole Pulmonary Artery Pulse Pressure and Wave Reflection Boramanand, Livia Kapusta, Jane E. Crosson, Joel I. in Chronic Pulmonary Thromboembolism and Primary Brenner, Louise J. Lubbers, Alan H. Friedman, Pulmonary Hypertension Vincent Castelain, Philippe Victoria L. Vetter, Erik J. Metjboom Hervé, Yves Lecarpentier, Pierre Duroux, Gerald Simonneau, Denis Chemla EXPERIMENTAL STUDIES Quantification of Renal Blood Flow With ELECTROPHYSIOLOGY Contrast-Enhanced Ultrasound Kevin Wei, Patients at Lower Risk of Arrhythmia Recurrence: Elizabeth Le, Jian-Ping Bin, Matthew Coggins, A Subgroup in Whom Implantable Defibrillators May Jerrel Thorpe, Sanjiv Kaul Not Offer Benefit A/fred P. Hallstrom, John H. McAnulty, Regional Asynchrony During Acute Myocardial Bruce L. Wilkoff, Dean Follmann, Merritt H. Raitt, Mark Ischemia Quantified by Ultrasound Strain Rate D. Carlson, Anne M. Gillis, Hue-Teh Shih, Judy L. Powell, Imaging Cristina Pislaru, Marek Belohlavek, Hank Duff; Blair D. Halperin, and the Antiarrhythmics Richard Y. Bae, Theodore P. Abraham, Versus Implantable Defibrillator (AVID) Trial Investigators James F. Greenleaf, James B. Seward Pause-Dependent Polymorphic Ventricular Atherosclerotic Aortic Component Quantification by Tachycardia During Long-Term Treatment With Noninvasive Magnetic Resonance Imaging: An In Vivo Dofetilide: A Placebo-Controlled, Implantable Study in Rabbits Gérard Helft, Stephen G. Worthley, Cardioverter-Defibrillator-Based Evaluation Alexander Valentin Fuster, Azfar G. Zaman, Clyde Schechter, Julio I. Mazur, Mark E. Anderson, Sharon Bonney, Dan M. Roden Osende, Oswaldo J. Rodriguez, Zahi A. Fayad, John T. Editorial Comment Dofetilide: Is the Treatment Worse Fallon, Juan J. Badimon Than the Disease? Michael R. Lauer SPECIAL SECTIONS Up-Regulation of Inositol 1,4,5 Trisphosphate ACC News Receptor Expression in Atrial Tissue in Patients With President’s Page: Cardiologists Under Stress: The Chronic Atrial Fibrillation Jutaro Yamada, Tomoko Response of the American College of Cardiology Obkusa, Tomoko Nao, Takeshi Ueyama, Masafumi Yano, George A. Beller Shigeki Kobayasht, Kimikazu Hamano, Kensuke Esato, Masunori Matsuzaki Newly Elected Members APRIL 2001 VOLUME 37> NUMBER 5 BETHESDA CONFERENCE REPORT 1214 Beneficial Effects of Ramipril on Left Ventricular End-Diastolic and End-Systolic Volume Indexes After 32nd Bethesda Conference: Care of the Adult With Congenital Heart Disease Gary D. Webb, Conference Co- Uncomplicated Invasive Revascularization Are Associated With a Reduction in Cardiac Events in Chair, Roberta G. Williams, Conference Co-Chair Patients With Moderately Impaired Left Ventricular Function and No Clinical Heart Failure Lars Kjoller- CLINICAL STUDIES Hansen, Rolf Steffensen, Peer Grande HEART FAILURE Effects of Intravenous Brain Natriuretic Peptide Surgical Anterior Ventricular Endocardial Restoration on Regional Sympathetic Activity in Patients With (SAVER) in the Dilated Remodeled Ventricle After Chronic Heart Failure as Compared With Healthy Anterior Myocardial Infarction Control Subjects Hans P. Brunner-La Rocca, Constantine L. Athanasuleas, Alfred W. H. Stanley, Jr., David M. Kaye, Robyn L. Woods, Jacqueline Hastings, Gerald D. Buckberg, Vincent Dor, Marissa DiDonato, Murray D. Esler Eugene H. Blackstone, and the RESTORE group Editorial Comment Is It Time for a Randomized Trial of Effect of Spironolactone on Plasma Brain Natriuretic Surgical Treatment of Ischemic Heart Failure? Peptide and Left Ventricular Remodeling in Patients Robert H. Jones With Congestive Heart Failure Takayoshi Tsutamoto, Atsuyukt Wada, Keiko Maeda, Naoko Mabuchi, Comparison With Two-Dimensional Dobutamine Masaru Hayashi, Takashi Tsutsui, Masato Ohnishi, Stress Echocardiography Masood Ahmad, Tianrong Xie, Masahide Sawaki, Masanori Fujii, Takehiro Matsumoto, Marti McCulloch, Gerard Abreo, Marschall Runge Toshiki Matsui, Masahiko Kinoshita Physiologic Assessment of Coronary Artery Stenosis Aspirin Inhibits the Acute Venodilator Response to by Coronary Flow Reserve Measurements With Furosemide in Patients With Chronic Heart Failure Transthoracic Doppler Echocardiography: Pardeep S. Jhund, Andrew P. Davie, John J. V. McMurray Comparison With Exercise Thallium-201 Postinfarctional Remodeling: Increased Dye Intensity Single-Photon Emission Computed Tomography in the Myocardial Risk Area After Angioplasty of Masao Daimon, Hiroyuki Watanabe, Hiroyuki Yamagishi, Infarct-Related Coronary Artery Is Associated With Takashi Muro, Kaname Akioka, Kumiko Htrata, Reduction of Ventricular Volumes Gianni Destro, Paolo Kazuhide Takeuchi, Junichi Yoshtkawa Marino, Enrico Barbieri, Andrea Zorzi, Giovanna Brighetti, Fractional Flow Reserve, Absolute and Relative Massimiliano Maines, Monica Carletti, Piero Zardini Coronary Blood Flow Velocity Reserve in Relation Evidence for Functional Presynaptic Alpha-2 to the Results of Technetium-99m Sestamibi Adrenoceptors and Their Down-Regulation in Human Single-Photon Emission Computed Tomography Heart Failure Anuradha Aggarwal, Murray D. Esler, in Patients With Two-Vessel Coronary Artery Flora Socratous, David M. Kaye Disease Steven A. J. Chamuleau, Martijn Meuwissen, Berthe L. F. van Eck-Smit, Karel T. Koch, Angelina de HEART TRANSPLANT Jong, Robbert J. de Winter, Carl E. Schotborgh, Matthis Angiography of Potential Cardiac Donors Bax, Hein J. Verberne, Jan G. P. Tijssen, Jan J. Piek Paul J. Hauptman, Kevin J. O'Connor, Robert E. Wolf, Barbara J. McNeil INTERVENTIONAL CARDIOLOGY Antiplatelet Effects of Abciximab, Tirofiban and ACUTE CORONARY SYNDROMES Eptifibatide in Patients Undergoing Coronary Stenting Ticlopidine Versus Aspirin After Myocardial Infarction Franz-Josef Neumann, Wilhibald Hochholzer, (STAMI) Trial Domenico Scrutinio, Claudio Cimminiello, Gisela Pogatsa-Murray, Albert Schémig, Meinrad Gawaz Ettore Marubini, Maria Vittoria Pitzalis, Matteo Di Biase, Paolo Rizzon, on behalf of the STAMI Group Long-Term Vessel Response to a Self-Expanding The Effect of Aspirin on C-Reactive Protein as a Coronary Stent: A Serial Volumetric Intravascular Marker of Risk in Unstable Angina Simon Kennon, Ultrasound Analysis From the ASSURE Trial Christopher P. Price, Peter G. Mills, Kulasegaram Yoshiki Kobayashi, Yasuhiro Honda, Leonard G. Christie, Ranyjadayalan, Jackie Cooper, Heather Clarke, Paul S. Teirstein, Steven R. Bailey, Charles L. Brown, LI, Adam D. Timmis Ray V. Matthews, Anthony C. De Franco, Robert S. Schwartz, Sheldon Goldberg, Jeffrey J. Popma, Paul G. Yock, Recurrent Unstable Angina After Directional Coronary Peter J. Fitzgerald Atherectomy Is Related to the Extent of Initial Coronary Plaque Inflammation Martijn Meuwissen, Treatment of No-Reflow and Impaired Flow With Jan J. Piek, Allard C. van der Wal, Steven A. J. Chamuleau, the Nitric Oxide Donor itroprusside Following Karel T. Koch, Peter Teeling, Chris M. van der Loos, Percutaneous Coronary Interventions: Initial Human Jan G. P. Tyssen, Anton E. Becker Clinical Experience William B. Hillegass, Neal A. Dean, Increased Local Temperature in Human Coronary Laurence Liao, Rodney G. Rhinehart, Paul R. Myers Atherosclerotic Plaques: An Independent Predictor of Clinical Outcome in Patients Undergoing a ENDOTHELIAL FUNCTION Percutaneous Coronary Intervention Improved Endothelial Function With Metformin in Christodoulos Stefanadis, Konstantinos Toutouzas, Type 2 Diabetes Mellitus Kieren J. Mather, Subodh Eleftherios Tstamis, Costas Stratos, Manolis Vavuranakis, Verma, Todd J. Anderson Ioannis Kallikazaros, Dimosthenis Panagiotakos, Rapid Improvement of Nitric Oxide Bioavailability Pavlos Toutouzas After Lipid-Lowering Therapy With Cerivastatin Extensive Development of Vulnerable Plaques as a Within Two Weeks Stefan John, Christian Delles, Pan-Coronary Process in Patients With Myocardial Johannes Jacobi, Markus P. Schlaich, Markus Schneider, Infarction: An Angioscopic Study Masanori Asakura, Gerd Schmitz, Roland E. Schmieder Yasunori Ueda, Osamu Yamaguchi, Takayoshi Adachi, Atsushi Hirayama, Masatsugu Hori, Kazuhisa Kodama Effects of Mental Stress on Coronary Epicardial Vasomotion and Flow Velocity in Coronary Artery Randomized Trial of a Noninvasive Strategy to Reduce Hospital Stay for Patients With Low-Risk Myocardial Disease: Relationship With Hemodynamic Stress Infarction Peter Bogaty, Serge Dumont, Gilles E. O'Hara, Responses Willem J. Kop, David S. Krantz, Luce Boyer, Lucie Auclair, Jean Jobin, Jean-Roch Boudreault Robert H. Howell, Michael A. Ferguson, Vasilios Papademetriou, David Lu, Jeffrey J. Popma, Risk of Acute First Myocardial Infarction and John F. Quigley, Marina Vernalis, John S. Gottdiener Use of Nicotine Patches in a General Population Stephen E. Kimmel, Jesse A. Berlin, Carolyn Miles, Attenuation of Endothelin-1 Induced Vasoconstriction Jane Jaskowiak, Jeffrey L. Carson, Brian L. Strom by 17B Estradiol Is Not Sustained During Long-Term Therapy in Postmenopausal Women With Coronary MYOCARDIAL ISCHEMIA Heart Disease Pardeep S. Jhund, Nuala Dawson, Real-Time Three-Dimensional Dobutamine Stress Andrew P. Davie, Naveed Sattar, John Norrie, Echocardiography in Assessment of Ischemia: Kevin P. J. O’Kane, JohnJ . V. McMurray