Journal of Surgical Oncology Table of Contents Volume 90, Number Review Article: Cryoablation and Cryolocalization in the Management Pat W. Whitworth and John C. Rewcastle Cryotechnology has multiple applications in breast disease. Ap} cryolocalization will be discussed for use in diagnosing and treat ind breast cancer Review Article: Extremity Soft Tissue Sarcoma: Evidence-Based Multid nagement Charles R. Scoggins and Raphael E. Pollock Current management strategies for the treatment of primary ext emphasis on multidisciplinary care and protocol-based research Site-Select Procedure for Non-Palpable Breast Lesions: Feasibility Study um Cannula Emmanuel Barranger, Olivier Marpeau, Jocelyne Chopier, Mart This study demonstrates that the Site-Select procedure is an eff low complication rate, high patient satisfaction, and excellent es Prognostic Significance of Circumferential Margin Involvement in Rect noma Treated With Preoperative Chemoradiotherapy and Low Anterior Resection Pedro Luna-Pérez, Efrain Bustos-Cholico, Isabel Alvarado, Ant Marcos Gutiérrez de la Barrera, and Sonia Labastida Histologic examination of circumferential margins is an import { relapse in non-radiated rectal cancer. However, for patients who receive¢ py this role has not yet been addressed. In patients with rectal cancer treat mn plus total mesorectal excision and sphincter saving surgery, circumteren ated with high incidence of distant recurrence and cancer-related deat! Successful Use of Letrozole in Male Breast Cancer: A Case Report and monal Therapy for Male Breast Cancer Brent P. Zabolotny, Christian V. Zalai, and Sarkis H. Meterissiar Spontaneous Rupture of Adrenal Pheochromocytoma: Review and vostic Factors Takashi Kobayashi, Akira lwai, Ryo Takahashi, Yoshihiro Ide, K nor Hepatectomy Plus Intraoperative Radiofrequency Ablation and Chem at Technically Unresectable Multiple Colorectal Liver Metastases Dominique Elias, Olivier Baton, Lucas Sideris, Valérie Boige Marc Pocard, and Philippe Lasser The aim of this study was to assess the survival of patients wit! vy) unresectable liver metastases when undergoing a combination of liver resect hemothe rapy This treatment lead to a median survival of 36 months and t How | Do It: Bi-segmentectomy V-VIII as Alternative to Right Hepate« ahepatic Approach Marcel Autran C. Machado, Paulo Herman, Roberto F. Meirelle: Marcel C.C. Machado Volume 90, Number 2 Guest Editorial: Distinctive Biology of Pleomorphic Lobular Carcinoma Roger E. Moe and Benjamin O. Anderson Cytoreductive Surgery and Intraoperative Hyperthermic Chemoperfusi: iced Ovarian Carcinoma Trevor W. Reichman, Bernadette Cracchiolo, Jahir Sama, Margar Lillian Pliner and Lawrence E. Harrison The use of intraoperative hyperthermic chemopertusion (IHCP) c juction is a sate and effective treatment tor advanced ovarian carcinoma. Howe\ atients who will benefit most from the therapy is essential for the success of the treatment Commentary Paul H. Sugarbaker Detection of Peritoneal Micrometastasis by Reverse Transcriptase-Polymerase Chain Reaction for Heparanase mRNA and Cytology in Peritoneal Wash Samples Zhenning Wang, Xue Zhang, Huimian Xu, Xin Zhou, Li Jiang, and Chong Lu In this study, we have reported the clinical relevance of a new diagnostic method with RT-PCR assay using heparanase as a target gene tor detection of free cancer cells in peritoneal washes. It is suggested that heparanase could be ubiquitously detected in peritoneal tree cancer cells and metastatic nodules, and the high sensitivity ot RT-PCR based heparanase assay made it a candidate molecular marker tor detecting peritoneal micrometastasis. Significance of Serum S-100B in Melanoma Patients Before and After Sentinel Node Biopsy Léonie H.M. Smit, Omgo E. Nieweg, Catharina M. Korse, Johannes M.G. Bonftrer, and Bin B.R. Kroon S-100B is not useful in predicting the presence of metastatic disease in the sentinel node. The biomarker has limited sensitivity but is highly specitic in pointing out previously unknown metastases during follow-up Commentary Mark B. Faries, Rishab K. Gupta, and Donald L. Morton Ductal Carcinoma In Situ in Core Biopsies Containing Invasive Breast Cancer: Correlation With Extensive Intraductal Component And Lumpectomy Margins Martin Dzierzanowski, Karen A. Melville, Penny J]. Barnes, Rebecca F. Macintosh, Judy S. Caines and Geoffrey A. Porter Until now, the signiticance of ductal carcinoma in situ (DCIS) tound in core biopsies (CB) containing invasive breast cancer was unclear. The objective of this study was to examine the implications of DCIS found in the original CB specifically related to the risk of extensive intraductal component and/or positive lumpectomy margins Quantification of Angiogenesis Induced in Rabbit Cornea by Breast Carcinoma of Women Treated With Tamoxifen Benedito Borges da Silva, Raimundo Gerdnimo da Silva Junior, Umbelina Soares Borges Marcos Antonio Guedes da Silveira Filho, Igor Clausius Carvalho Pimentel, Luiz Henrique Gebrim Manuel de Jesus Simdes, and Edmund Chada Baracat Tamoxiten inhibited angiogenesis induced by breast carcinoma in rabbit cornea. Activation of MMP-2 and MMP-9 in Patients With Oral Squamous Cell Carcinoma Beena P. Patel, Pankaj M. Shah, Upendra M. Rawal, Amisha A. Desai, Shakuntala V. Shah, Rakesh M. Rawal and Prabhudas S. Patel Expression of RCAS1 in Esophageal Squamous Cell Carcinoma Is Associated With a Poor Prognosis Hiroyuki Kato, Masanobu Nakajima, Norihiro Masuda, Ahmad Faried, Makoto Sohda, Yasuyuki Fukai Tatsuya Miyazaki, Minoru Fukuchi, Katsuhiko Tsukada, and Hiroyuki Kuwano Extended Multiorgan Resection for T4 Gastric Carcinoma: 25-Year Experience Fabio Carboni, Pasquale Lepiane, Roberto Santoro, Riccardo Lorusso, Pietro Mancini, Isabella Sperduti Massimo Carlini, and Eugenio Santoro Surgical management of locally advanced gastric carcinoma invading adjacent organs remains controversial However, the survival of patients can be improved with extended multiorgan resection, with acceptable postoperative morbidity and mortality rates, provided that a curative resection is pertormed Case Report: Extended Survival in a Patient With Recurrent and Metastatic Adrenal Cortical Carcinoma by Aggressive Transarterial Embolization—a Case Report Shau-Hsuan Li, Cheng-Hua Huang, Sheung-Fat Ko, Fong-Fu Chou, and Shun-Chen Huang Erratum Volume 90, Number 3, June 1, 2005 Seminars in Surgical Oncology: Gastric Cancer Walter Lawrence, Jr., mo, Guest Editor Intro: Walter Lawrence, jr.: A Tribute to a Surgical Oncologist. “Been There, Done That’’ Harry D. Bear Guest Editor Comment: Gastric Cancer: An Update Walter Lawrence, Jr. Gastric Cancer: New Genetic Developments Henry T. Lynch, William Grady, Gianpaolo Suriano, and David Huntsman COMMENT Walter Lawrence, Jr. New Strategies for the Prevention of Gastric Cancer: Helicobacter pyl Susceptibility Pelayo Correa COMMENT Walter Lawrence, Jr. Biologic and Clinical Variations of Adenocarcinoma at the Esophago Relevance of a Topographic-Anatomic Subclassification J. Riidiger Siewert, Marcus Feith, and Hubert J. Stein COMMENT Walter Lawrence, Jr. Recent Advances in Sentinel Node Navigation for Gastric Cancer: A Pa f Surgical Management Yuko Kitagawa, Hirofumi Fujii, Koichiro Kumai, Tetsuro Kubota Masashi Yoshida, Atsushi Kubo, and Masaki Kitajima COMMENT Walter Lawrence, Jr. Status of Extended Lymph Node Dissection: Locoregional Control Is the Survive Gastric Cancer Henk H. Hartgrink and Cornelis J.H. van de Velde Role of Post-Operative Chemoradiation in Resected Gastric Cancer John S. Macdonald Invited Commentary: Eliminating and Suppressing Local-Regional Dis« in Gastric Cancer Scott A. Hundahl COMMENT Walter Lawrence, Jr. Perioperative Adjunctive Treatment in the Management of Operable ¢ Howard Silberman COMMENT Walter Lawrence, Jr. Minimally Invasive Treatment for Gastric Cancer: Approaches and Sel« Sung Hoon Noh, Woo Jin Hyung, and Jae-Ho Cheong COMMENT Walter Lawrence, Jr. Gastric Gl Stromal Tumors (GISTs): The Role of Surgery in The Era of 1 Michael C. Heinrich and Christopher L. Corless COMMENT Walter Lawrence, Jr. Volume 90, Number 4 Prospective Non-Randomized Trial Comparing Esophagectomy-Followed-t radiotherapy Versus Chemoradiotherapy-Followed-By-Esophagectomy for T4 Esophageal Can Hirmasa Fujita, Susumu Sueyoshi, Toshiaki Tanaka, Yuichi Tanak onmirouzu Gen Suzuki, Naofumi Hayabuchi, and Hiroki Inutsuka Forty-three patients with a T4 esophageal cancer were enrolled zed study in which each patient decided on which treatment arm to receive: chem« sopnhagectomy or esophagectomy-followed-by-chemoradiotherapy. This trial conclt yf treatment for such patients was prior chemoradiotherapy rather than prior esophage« Impact of the Extent and Duration of Cytoreductive Surgery on Postopera \atological Toxicity After Intraperitoneal Chemohyperthermia for Peritoneal Carcinomatosis Dominique Elias, Bruno Raynard, Valérie Boige, Agnes Laplanch« ilka, and Marc Pocard Surgical Results for Hepatocellular Carcinoma With Bile Duct Invasion pathologic Comparison Between Macroscopic and Microscopic Tumor Thrombus Minoru Esaki, Kazuaki Shimada, Tsuyoshi Sano, Yoshihiro Sakamot nd Hidenori Ojima Expression of L-Type Amino Acid Transporter 1 (LAT1) in Esophageal Carcinoma Hideaki Kobayashi, Yukimoto Ishii, and Tadatoshi Takayama Predictive Value of Lymph Node and Tumor Matrix Metalloproteinase Expression in the Analysis of Metastatic Periampullary Tumors Gregory J. McKenna, Adam Meneghetti, Yong Liang Chen, Alice L.F. Mui, Christopher Ong, Charles H. Scudamore, W. Robert McMaster, David A. Owen, and Stephen W. Chung 16 patients with periampullary malignancies were followed prospectively to determine the whether there was a correlation between expression of matrix metalloproteinases and clinical outcomes. How | Do It: A Modified Technique for Insertion of Intraperitoneal Port for Chemotherapy Wen-Shiung Liou, Nelson N.H. Teng, and John K. Chan Review Article: Apoptotic and Anti-Angiogenic Strategies in Liver and Gastrointestinal Malignancies Jannis Kountouras, Christos Zavos, and Dimitrios Chatzopoulos Inducing the apoptotic process in various ways and targeting fundamental play-markers of the angiogenic process can be applied as novel strategies to cancer management Author Index to Volume 90 Subject Index to Volume 90