RepRoductive Medicine RepRoductive Medicine & Assisted RM&ART RepRoductive techniques seRies IVF in the Medically Complicated Patient A Guide to Management, Second Edition E dited by Nick S Macklon, MB ChB, MD, FRCOG, Professor of Obstetrics and Gynaecology, Academic Unit of Human Development and Health/Faculty of Medicine, University of Southampton, and Director, Complete Fertility Centre Southampton, Princess Anne Hospital, Southampton, UK Each patient seeking assisted reproduction has a unique set of circumstances that affects the outcome of treatment. Particularly challenging are those patients with pre-existing medical conditions or those receiving medical therapies that may impact the safety and success of their IVF treatments. Prior identification and preparation of the patient at increased risk of com- plications will enable the clinician to avoid problems in advance, anticipate the necessary management, and optimize outcomes. This new expanded edition of a prize-winning text provides a readily accessible, authoritative, and didactic source of information to aid clinicians in this important field. From reviews of the first edition: “This is a very apt and concise book on the subject … but also provides evidence-based discussion of other complex situations such as managing hydrosalpinges and fibroids … This book should be read by every specialist dealing with large numbers of patients undergoing IVF as they will encounter these patients and will benefit from up-to-date and accurate data presented here.” —Highly Commended, Obstetrics & Gynaecology Category, 2006 BMA Medical Book Competition “This book attempts to highlight an important but neglected area of practice. It is highly original and a much-needed resource for clinicians working in IVF and infertility units.” —The Society of Authors and the Royal Society of Medicine Book Awards 2006 Markets: Reproductive Medicine, Gynaecology ES de ic K21521 tio on ISBN-13: 978-1-4822-0669-2 nd 90000 9 781482 206692 K21521_Cover_mech.indd All Pages 5/8/14 10:29 AM IVF in the Medically Complicated Patient REPRODUCTIVE MEDICINE AND ASSISTED REPRODUCTIVE TECHNIQUES SERIES David Gardner University of Melbourne, Australia Zeev Shoham Kaplan Hospital, Rehovot, Israel Kay Elder, Jacques Cohen Human Preimplantation Embryo Selection, ISBN: 9780415399739 Michael Tucker, Juergen Liebermann Vitrification in Assisted Reproduction, ISBN: 9780415408820 John D Aplin, Asgerally T Fazleabas, Stanley R Glasser, Linda C Giudice The Endometrium, Second Edition, ISBN: 9780415385831 Nick Macklon, Ian Greer, Eric Steegers Textbook of Periconceptional Medicine, ISBN: 9780415458924 Andrea Borini, Giovanni Coticchio Preservation of Human Oocytes, ISBN: 9780415476799 Steven R Bayer, Michael M Alper, Alan S Penzias The Boston IVF Handbook of Infertility, Third Edition, ISBN: 9781841848105 Ben Cohlen, Willem Ombelet Intra-Uterine Insemination: Evidence-Based Guidelines for Daily Practice, ISBN: 9781841849881 Adam H. Balen Infertility in Practice, Fourth Edition, ISBN: 9781841848495 Nick Macklon IVF in the Medically Complicated Patient, Second Edition: A Guide to Management, ISBN: 9781482206692 IVF in the Medically Complicated Patient Second Edition A Guide to Management Edited by Nick S Macklon, MB ChB, MD, FRCOG Professor of Obstetrics and Gynaecology, Academic Unit of Human Development and Health / Faculty of Medicine, University of Southampton, and Director, Complete Fertility Centre Southampton, Princess Anne Hospital, Southampton, UK Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2014 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Version Date: 20140304 International Standard Book Number-13: 978-1-4822-0671-5 (eBook - PDF) This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have been made to publish reliable data and information, neither the author[s] nor the publisher can accept any legal responsibil- ity or liability for any errors or omissions that may be made. The publishers wish to make clear that any views or opinions expressed in this book by individual editors, authors or contributors are personal to them and do not necessarily reflect the views/opinions of the publishers. The information or guidance contained in this book is intended for use by medical, scientific or health-care professionals and is provided strictly as a supplement to the medical or other professional’s own judgement, their knowledge of the patient’s medical history, relevant manufacturer’s instructions and the appropriate best practice guidelines. Because of the rapid advances in medical science, any information or advice on dosages, procedures or diagnoses should be independently verified. The reader is strongly urged to consult the drug companies’ printed instruc- tions, and their websites, before administering any of the drugs recommended in this book. This book does not indicate whether a particular treatment is appropriate or suitable for a particular individual. Ultimately it is the sole responsibility of the medical professional to make his or her own professional judgements, so as to advise and treat patients appropriately. The authors and publishers have also attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, micro- filming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www. copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750- 8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identi- fication and explanation without intent to infringe. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Contents Contributors ...............................................................................................................vii 1. The Patient with Cystic Fibrosis .......................................................................1 GCML Page-Christiaens, AJ Goverde, and F Teding van Berkhout 2. The Patient at Risk from Thrombosis ............................................................21 NS Macklon 3. The Patient with Hyperprolactinaemia ..........................................................31 AN Andersen, MP Lauritsen, and M Krog 4. The Patient with Autoimmune Disease ..........................................................39 D Galliano, A Pellicer, and J Bellver 5. The Patient with Epilepsy ................................................................................47 E Campbell and J Craig 6. The Patient with Inflammatory Bowel Disease .............................................59 SV Kane and JG Al Hashash 7. The Patient with Hypertension .......................................................................69 BB van Rijn and MA Coleman 8. The Patient with Obesity .................................................................................79 T Hardy and W Ledger 9. The Patient with Polycystic Ovary Syndrome ...............................................91 SMC De Sousa and RJ Norman 10. The Patient with Hydrosalpinx .....................................................................103 A Strandell 11. The Patient with Endometriosis ....................................................................119 Y Cheong 12. The Patient with Fibroids ..............................................................................129 Y Khalaf and SK Sunkara 13. The Patient with Congenital Uterine Abnormalities ..................................137 PK Heinonen v vi Contents 14. The Patient with Malignant Disease ............................................................147 RA Anderson 15. The Girl with Cancer .....................................................................................157 KT Schmidt 16. The Patient with Turner’s Syndrome ...........................................................163 O Hovatta and B Borgström 17. The Couple Testing Positive for Hepatitis B and C .....................................171 JG Lemmen, A Loft, and S Ziebe 18. The Couple Testing Positive for Human Immunodeficiency Virus ...........183 MV Sauer 19. The Couple with Sexual Dysfunction ...........................................................193 WL Gianotten 20. The IVF Patient, International Travel and Vaccinations ..........................205 H Tijani and NS Macklon Contributors JG Al Hashash Y Cheong Division of Gastroenterology, Academic Unit of Human Development Hepatology and Nutrition and Health University of Pittsburgh Medical Faculty of Medicine Center University of Southampton Pittsburgh, Pennsylvania, United Complete Fertility Centre States Southampton Princess Anne Hospital AN Andersen Southampton, United Kingdom The Fertility Clinic Copenhagen University Hospital MA Coleman Rigshospitalet, Copenhagen, Denmark University Hospitals Southampton NHS Foundation Trust RA Anderson Southampton, United Kingdom MRC Centre for Reproductive Health University of Edinburgh J Craig Queens Medical Research Institute Department of Neurosciences Edinburgh, United Kingdom Belfast Health and Social Care Trust Belfast, United Kingdom J Bellver Department of Obstetrics and SMC De Sousa Gynecology Royal Adelaide Hospital Faculty of Medicine Adelaide, South Australia, Australia University of Valencia and Instituto Valenciano de Infertilidad D Galliano Valencia, Spain Department of Reproduction Instituto Valenciano de Infertilidad B Borgström Barcelona, Spain Department of Clinical Science, Intervention and Technology WL Gianotten Karolinska Institutet Department of Medical Sexology Karolinska University Hospital University Medical Center Huddinge Utrecht, the Netherlands Stockholm, Sweden AJ Goverde E Campbell Department of Obstetrics and Department of Neurosciences Gynaecology Belfast Health and Social Care Trust University Medical Center Belfast, United Kingdom Utrecht, the Netherlands vii viii Contributors T Hardy JG Lemmen Royal Hospital for Women Fertility Clinic Rigshospitalet Randwick, New South Wales, Australia Copenhagen, Denmark PK Heinonen A Loft School of Medicine Fertility Clinic Rigshospitalet University of Tampere and Copenhagen, Denmark Department of Obstetrics and Gynecology NS Macklon Tampere University Hospital Academic Unit of Human Development Tampere, Finland and Health Faculty of Medicine O Hovatta University of Southampton Department of Clinical Science, Complete Fertility Centre Southampton Intervention and Technology Princess Anne Hospital Karolinska Institutet Southampton, United Kingdom Karolinska University Hospital Huddinge RJ Norman Stockholm, Sweden The Robinson Institute School of Pediatrics and Reproductive SV Kane Health Department of Gastroenterology University of Adelaide Mayo Clinic Adelaide, South Australia, Australia Rochester, Minnesota, United States GCML Page-Christiaens Y Khalaf Department Obstetrics and Gynaecology The Assisted Conception Unit University Medical Center Guy’s Hospital Utrecht, the Netherlands London, United Kingdom A Pellicer M Krog Department of Obstetrics and The Fertility Clinic Gynecology Copenhagen University Hospital Faculty of Medicine Rigshospitalet University of Valencia and Instituto Copenhagen, Denmark Valenciano de Infertilidad Valencia, Spain MP Lauritsen The Fertility Clinic MV Sauer Copenhagen University Hospital Department of Obstetrics and Rigshospitalet Gynecology Copenhagen, Denmark Columbia University New York, New York, United States W Ledger Department of Obstetrics and KT Schmidt Gynaecology Fertility Clinic School of Women’s and Children’s Health University Hospital of Copenhagen University of New South Wales Rigshospitalet Sydney, New South Wales, Australia Copenhagen, Denmark