INTERNATIONAL JOURNAL OF PHARMACEUTICS VOL. 97 NO. 1-3 CONTENTS 15 AUGUST 1993 Cited in: Current Contents (Life Sciences; Clinical Practice); International Pharmaceutical Abstracts; Biological Abstracts; Chemical Abstracts; Excerpta Medica EMBASE; PASCAL M; Science Citation Index; Current Awareness in Biological Sciences Announcement from the Publisher Invited Review The role of the gastrointestinal microflora in the metabolism of drugs M.A. Shamat (UK) Research Papers The application of canonical analysis to the evaluation of the influence of changes in components of standard direct compression tablet formulations F. Podezeck, G. Merkel and P. Révész (Germany, Hungary) The effect of dry granulation on the consolidation and compaction of crystalline lactose K.A. Riepma, H. Vromans, K. Zuurman and C.F. Lerk (The Netherlands) Solvent drag in ethanol/ethyl acetate enhanced skin permeation of d-norgestrel D.R. Friend and S.1. Smedley (USA) Total and regional lung deposition of terbutaline sulphate inhaled via a pressurised MDI or via Turbuhaler ™ L. Borgstrém and S. Newman (Sweden, UK) Determination of pyridostigmine and the main degradation product in tablets by high-performance liquid chromatography K. Wehler, P.O. Roksvaag and T. Waaler (Norway) Gastrointestinal transit and absorption of theophylline from a multiparticulate controlled release formulation K.H. Yuen, A.A. Deshmukh, J.M. Newton, M. Short and R. Melchor (UK) The influence of moisture content on spheronization of extrudate processed by a ram extruder K.E. Fielden, J.M. Newton and R.C. Rowe (UK) Comparison of in vitro dissolution profiles by calculating mean dissolution time (MDT) or mean residence time (MRT) F. Podezeck (UK) Contact angles and surface free energies of theophylline and salicylic acid powders determined by the Washburn method J. Kiesvaara, J. Yliruusi and E. Ahomaki (Finland) Aerosol solvent extraction system — a new microparticle production technique J. Bleich, B.W. Miller and W. WaBmus (Germany) The effect of aging on the dissolution of wet granulated tablets containing super disintegrants M.S. Gordon, V.S. Rudraraju, J.K. Rhie and Z.T. Chowhan (USA) Azo polymers for colon-specific drug delivery. I]: Influence of the type of azo polymer on the degradation by intestinal microflora G. Van den Mooter, C. Samyn and R. Kinget (Belgium) Effect of titrant concentration on pH-zero point of charge: verification by bootstrap technique W. Wongpoowarak and N. Worakul (Thailand) Optimization of pharmaceutical formulations based on response-surface experimental designs A.G. Gonzalez (Spain) Identification of stabilizing and destabilizing effects of excipient-drug interactions in solid dosage form design T. Diirig and A.R. Fassihi (USA) High levels of exopeptidase activity are present in rat and canine bronchoalveolar lavage fluid D.A. Wall and A.T. Lanutti (USA) Calcium alginate matrices for oral multiple unit administration: Il. Effect of process and formulation factors on matrix properties T. Ostberg, L. Vesterhus and C. Graffner (Norway, Sweden) A coherent matrix model for the consolidation and compaction of an excipient with magnesium stearate K.A. Riepma, H. Vromans and C.F. Lerk (The Netherlands) Cyclosporin A liposome aerosol: Particle size and calculated respiratory deposition J.C. Waldrep, P.W. Scherer, K. Keyhani and V. Knight (USA) (Contents continued on p. 0378-' 173¢ 19930815 )97:1/3;1-Y INTERNATIONAL JOURNAL OF PHARMACEUTICS VOL. 97 NO. 1-3 CONTENTS 15 AUGUST 1993 Cited in: Current Contents (Life Sciences; Clinical Practice); International Pharmaceutical Abstracts; Biological Abstracts; Chemical Abstracts; Excerpta Medica EMBASE; PASCAL M; Science Citation Index; Current Awareness in Biological Sciences Announcement from the Publisher Invited Review The role of the gastrointestinal microflora in the metabolism of drugs M.A. Shamat (UK) Research Papers The application of canonical analysis to the evaluation of the influence of changes in components of standard direct compression tablet formulations F. Podezeck, G. Merkel and P. Révész (Germany, Hungary) The effect of dry granulation on the consolidation and compaction of crystalline lactose K.A. Riepma, H. Vromans, K. Zuurman and C.F. Lerk (The Netherlands) Solvent drag in ethanol/ethyl acetate enhanced skin permeation of d-norgestrel D.R. Friend and S.1. Smedley (USA) Total and regional lung deposition of terbutaline sulphate inhaled via a pressurised MDI or via Turbuhaler ™ L. Borgstrém and S. Newman (Sweden, UK) Determination of pyridostigmine and the main degradation product in tablets by high-performance liquid chromatography K. Wehler, P.O. Roksvaag and T. Waaler (Norway) Gastrointestinal transit and absorption of theophylline from a multiparticulate controlled release formulation K.H. Yuen, A.A. Deshmukh, J.M. Newton, M. Short and R. Melchor (UK) The influence of moisture content on spheronization of extrudate processed by a ram extruder K.E. Fielden, J.M. Newton and R.C. Rowe (UK) Comparison of in vitro dissolution profiles by calculating mean dissolution time (MDT) or mean residence time (MRT) F. Podezeck (UK) Contact angles and surface free energies of theophylline and salicylic acid powders determined by the Washburn method J. Kiesvaara, J. Yliruusi and E. Ahomaki (Finland) Aerosol solvent extraction system — a new microparticle production technique J. Bleich, B.W. Miller and W. WaBmus (Germany) The effect of aging on the dissolution of wet granulated tablets containing super disintegrants M.S. Gordon, V.S. Rudraraju, J.K. Rhie and Z.T. Chowhan (USA) Azo polymers for colon-specific drug delivery. I]: Influence of the type of azo polymer on the degradation by intestinal microflora G. Van den Mooter, C. Samyn and R. Kinget (Belgium) Effect of titrant concentration on pH-zero point of charge: verification by bootstrap technique W. Wongpoowarak and N. Worakul (Thailand) Optimization of pharmaceutical formulations based on response-surface experimental designs A.G. Gonzalez (Spain) Identification of stabilizing and destabilizing effects of excipient-drug interactions in solid dosage form design T. Diirig and A.R. Fassihi (USA) High levels of exopeptidase activity are present in rat and canine bronchoalveolar lavage fluid D.A. Wall and A.T. Lanutti (USA) Calcium alginate matrices for oral multiple unit administration: Il. Effect of process and formulation factors on matrix properties T. Ostberg, L. Vesterhus and C. Graffner (Norway, Sweden) A coherent matrix model for the consolidation and compaction of an excipient with magnesium stearate K.A. Riepma, H. Vromans and C.F. Lerk (The Netherlands) Cyclosporin A liposome aerosol: Particle size and calculated respiratory deposition J.C. Waldrep, P.W. Scherer, K. Keyhani and V. Knight (USA) (Contents continued on p. 0378-' 173¢ 19930815 )97:1/3;1-Y 228 (Contents continued from back cover) Notes Dose-dependent pharmacokinetics of human granulocyte /macrophage colony-stimulating factor in rabbits E.J. Yoon, E.J. Bae, Y.N. Jeong, M.M. Kim, B. Kim, S.H. Lee and M.G. Lee (South Korea) Stability of ampicillin infusions in unbuffered and buffered saline M.C. Allwood and P.W. Brown (UK) Author index Noticeboard