INTERNATIONAL JOURNAL OF PHARMACEUTICS VOL. 68 NO. 1-3 CONTENTS 1 FEBRUARY 1991 Announcement from the Publisher Invited Review Vehicular influence on transdermal drug penetration H. Loth (Germany) Research Papers Pharmacokinetic interactions of norfloxacin with some metallic medicinal agents A.O. Okhamafe, J.O. Akerele and C.S. Chukuka (Nigeria) Effect of variables on the preparation of shellac microcapsules by solvent evaporation technique: Part 1 D.S. Sheorey, A.S. Shastri and A.K. Dorle (India) Some physicochemical properties of glassy felodipine J. Keré, S. Sréié, M. Mohar and J. Smid-Korbar (Yugoslavia) Investigation of piroxicam polymorphism F. Vreéer, S. Sréié and J. Smid-Korbar (Yugoslavia) Partition and transport of verapamil and nicotine through artificial membranes P. Santi, P.L. Catellani, P. Colombo, C. Ringard-Lefebvre, C. Barthélémy and A.-M. Guyot-Hermann (Italy, France) Moisture sorption and tensile strength of some tableted direct compression excipients S. Malamataris, P. Goidas and A. Dimitriou (Greece) Pharmacokinetics of 5-fluorouracil after intravenous infusion of 5-fluorouracil-acetic acid-human serum albumin conjugates to rabbits S.M. Chung, E.J. Yoon, S.H. Kim, M.G. Lee, H. Lee, M.K. Park and C.-K. Kim (Korea) Approaches to improve the association of amikacin sulphate to poly(alkylcyanoacrylate) nanoparticles M.J. Alonso, C. Losa, P. Calvo and J.L. Vila-Jato (Spain) Synthesis and enzymatic hydrolysis of aspirin-basic amino acid ethyl esters H. Tsunematsu, E. Ishida, S. Yoshida and M. Yamamoto (Japan) A new biodegradable implant consisting of waxy-type poly(e-caprolactone-co-5-valerolactone) and estramustine K. Imasaka, M. Yoshida, H. Fukuzaki, M. Asano, M. Kumakura, T. Mashimo, H. Yamanaka and T. Nagai (Japan) Disposition of ibuprofen enantiomers following the oral administration of a novel controlled release formulation to healthy volunteers A. Avgerinos, A. Noormohammadi and A.J. Hutt (U.K.) Complexation behaviour of azathioprine with metal ions S. Singh, M. Gulati and R.L. Gupta (India) (Contents continued on p. 294) © 1991 Elsevier Science Publishers B.V. (Biomedical Division). All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Elsevier Science Publishers B.V. (Biomedical Division), P.O. Box 1527, 1000 BM Amsterdam, The Netherlands. 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Cited in: Current Contents (Life Sciences; Clinical Practice); International Pharmaceutical Abstracts; Biological Abstracts; Chemical Abstracts; Excerpta Medica EMBASE; PASCAL M; Science Citation Index Printed in The Netherlands 294 (Contents continued from back cover) Nanoparticles of polyisohexylcyanoacrylate (PIHCA) as carriers of primaquine: formulation, physico-chemical characteriza- tion and acute toxicity R. Gaspar, V. Préat and M. Roland (Belgium) The effect of poloxamer-407 on liposome stability and targeting to bone marrow: comparison with polystyrene microspheres S.M. Moghimi, C.J.H. Porter, L. Illum and S.S. Davis (U.K.) Solvent effects on the harvesting of stratum corneum from hairless mouse skin through adhesive tape stripping in vitro J.-C. Tsai, M.J. Cappel, N.D. Weiner, G.L. Flynn and J. Ferry (U.S.A., Germany) The cytoskeleton of the cornea and its role in tight junction permeability Y. Rojanasakul and J.R. Robinson (U.S.A.) Permeability of latex membranes to anti-cancer drugs R.M. Mader, B. Rizovski, G.G. Steger, K. Moser, H. Rainer and C. Dittrich (Austria) Effects of molecular coatings on the compression and tableting of some pharmaceutical powders N. Pilpel, C.I. Igwilo and S. Malamataris (U.K.) Influence of dissolution rate on the extent and rate of bioavailability of metoprolol A. Sandberg, B. Abrahamsson and J. Sjégren (Sweden) Methotrexate: Existence of different types of solid H.-K. Chan and I. Gonda (Australia) Lipidic peptides. II. Synthesis, activity and transport of anti-inflammatory benzoquinolizine-lipidic peptide conjugates I. Toth, R.A. Hughes, M.R. Munday, C.A. Murphy, P. Mascagni and W.A. Gibbons (U.K.) Gastrointestinal transit of a multiparticulate tablet formulation in patients with active ulcerative colitis S.S. Davis, C. Robertson and I.R. Wilding (U.K.) Effect of water content on the microstructure of an 0/w cream L. Niemi and E. Laine (Finland) Synthesis, characterization and in vitro evaluation of various sulfonamide chemical delivery systems M.E. Brewster, M. Deyrup, K. Seyda and N. Bodor (U.S.A.) Effect of extracellular pH on cytoplasmic pH and mechanism of pH regulation in cultured bovine corneal endothelium: Possible importance in drug transport studies M.E. Dowty and P. Braquet (U.S.A., France) Influence of novel percutaneous absorption enhancers, cyclohexanone and piperidone derivatives, on histopathology of rat skin D. Quan, K. Takayama, T. Mitsuzono, K. Isowa and T. Nagai (Japan, China) A new type of a pH-independent controlled release tablet N. Kohri, H. Yatabe, K. Iseki and K. Miyazaki (Japan) Effect of uptake of albumin microspheres on cellular activity of mouse peritoneal macrophages J. Saunders, S.S. Davis, C.G. Wilson and A. Smith (U.K.) Effects of cyclodextrins on N-trifluoroacetyldoxorubicin-14-valerate (AD-32) stability and solubility in aqueous media O. Bekers, J.H. Beijnen, Y.A.G. Kempers, A. Bult and W.J.M. Underberg (The Netherlands) Lipid emulsion content and vitamin A stability in TPN admixtures D.P. Bluhm, R.S. Summers, M.M.J. Lowes and H.H. Diirrheim (Republic of South Africa) Notes Influence of container on vitamin A stability in TPN admixtures D.P. Bluhm, R.S. Summers, M.M.J. Lowes and H.H. Diirrheim (Republic of South Africa) Permeability characteristics of cultured mouse keratinocytes compared to hairless mouse skin P.K. Shah, R.L. Bartel and R.T. Borchardt (U.S.A.) Author index Noticeboard Rapid Communication A controlled release matrix using a mixture of hydrophilic and hydrophobic polymers H. Al-Hmoud, M. Efentakis and N.H. Choulis (Greece)