Abstracts International Academy of Cardiology Annual Scientific Sessions 2017 22nd World Congress on Heart Disease Vancouver, BC, Canada, July 14–16, 2017 Guest Editor Asher Kimchi, Los Angeles, CA, USA Basel • Freiburg • Paris • London • New York • Chennai • New Delhi • Bangkok • Beijing • Shanghai • Tokyo • Kuala Lumpur • Singapore • Sydney INTERNATIONAL ACADEMY OF CARDIOLOGY S. Karger Disclaimer All rights reserved. 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Th is is particularly important when the recommended agent is a new and/or infrequently employed drug. E-Mail [email protected] www.karger.com/crd 3 INTERNATIONAL ACADEMY OF CARDIOLOGY FOUNDER AND CONGRESS CHAIRMAN Asher Kimchi, USA SCIENTIFIC EXECUTIVE COMMITTEE John A. Elefteriades, USA (Chairman) Ali Ahmed, USA S. David Gertz, Israel Elena Aikawa, USA J. Rod Gimbel, USA Takashi Akasaka, Japan Sidney Goldstein, USA Martin A. Alpert, USA Jonathan Golledge, Australia Madhu B. Anand-Srivastava, Canada Mariann P. Gyöngyösi, Austria Francisco A. Arabía, USA Paul A. Heidenreich, USA Wilbert S. Aronow, USA Donald D. Heistad, USA Maciej Banach, Poland Charles H. Hennekens, USA Gregory Barsness, USA Ramon C. Hermida, Spain Lewis C. Becker, USA Roland Hetzer, Germany Daniel S. Berman, USA Brian D. Hoit, USA Deepak L. Bhatt, USA Daniela Jezova, Slovakia Robert W.W. Biederman, USA Maryl R. Johnson, USA Erik A.L. Biessen, The Netherlands Bodh I. Jugdutt, USA Yochai Birnbaum, USA Andreas Kalogeropoulos, USA Ron Blankstein, USA Edo Kaluski, USA Burns C. Blaxall, USA Tomoko S. Kato, Japan William Bommer, USA Amir Kazory, USA Jeffrey S. Borer, USA Ilan Kedan, USA Robert C. Bourge, USA Arthur L. Klatsky, USA Eugene Braunwald, USA Anne A. Knowlton, USA Sorin J. Brener, USA Wei Kong, China Samuel M. Butman, USA Santhosh K.G. Koshy, USA Michael E. Cain, USA Adarsh Kumar, India Hari P. Chaliki, USA Lih Kuo, USA Yzhar Charuzi, USA Stephanie Lehoux, Canada Changyi (Johnny) Chen, USA Gary Lopaschuk, Canada Yabing Chen, USA Avraham Lorber, Israel Anne B. Curtis, USA Alexandra Lucas, USA Lawrence S. Czer, USA John J. Mahmarian, USA Alexander H.J. Danser, The Netherlands Kenneth Maiese, USA Thomas Deneke, Germany Tadeusz Malinski, USA Naranjan S. Dhalla, Canada Roberto Manfredini, Italy Luc Djousse, USA James D. Marsh, USA Samuel C. Dudley, USA Jawahar L. Mehta, USA Abdou Elhendy, USA Dan M. Meyer, USA Michael Farkouh, Canada Leslie W. Miller, USA Michael A. Fifer, USA Freny V. Mody, USA Janos G. Filep, Canada Samia Mora, USA Gordon L. Fung, USA Mohammad-Reza Movahed, USA William H. Gaasch, USA Nandini Nair, USA Zorina S. Galis, USA Navin C. Nanda, USA Feng Gao, China Khurram Nasir, USA Julius M. Gardin, USA Mohamad Navab, USA A. Martin Gerdes, USA Demosthenes B. Panagiotakos, Greece Cardiology 2017;137(suppl 1) 1-349 International Academy of Cardiology, Annual Scientific Sessions 2017 22nd World Congress on Heart Disease 4 Kailash N. Pandey, USA Jamshid Shirani, USA Hakan Paydak, USA Mandeep S. Sidhu, USA Patricia A. Pellikka, USA Pawan K. Singal, Canada Louis P. Perrault, Canada Dinender K. Singla, USA Christos Pitsavos, Greece Christopher S. Snyder, USA Maria Prokudina, Russia Laurence Sperling, USA Jeffrey J. Rade, USA Francis G. Spinale, USA Shahbudin H. Rahimtoola, UA Ashok K. Srivastava, Canada Nalini M. Rajamannan, USA Mitsuyasu Terashima, Japan Hanumanth K. Reddy, USA Udho Thadani, USA Clive Rosendorff, USA Takanobu Tomaru, Japan Robert S. Rosenson, USA Balwant S. Tuana, Canada Hani N. Sabbah, USA Yasunori Ueda, Japan Masood Sadiq, Paikistan Barry F. Uretsky, USA Maria J. Sanz, Spain George W. Vetrovec, USA Tiziano M. Scarabelli, USA Ronald Victor, USA Saul Schaefer, USA Nanette K. Wenger, USA Karlheinz Seidl, Germany Michel White, Canada Howard D. Sesso, USA Nathan D. Wong, USA Guo-Ping Shi, USA Ertan Yetkin, Turkey SCIENTIFIC ADVISORY BOARD Jun-ichi Abe, USA Harisios Boudoulas, Greece Mazen S. Abu-Fadel, USA Neil E. Bowles, USA Chris Adamopoulous, Greece Alexandros Briasoulis, USA Masanori Aikawa, USA T. Jared Bunch, USA Tolga Aksu, Turkey John C. Burnett, Jr., USA Kannayiram Alagiakrishnan, Canada Gianfranco Butera, Italy Mouaz H. Al-Mallah, Saudi Arabia Harpal S. Buttar, Canada Fernando Alfonso, Spain Hua Linda Cai, USA Aman Amanullah, USA Duncan J. Campbell, Australia Giuseppe Ambrosio, Italy Ugur Canpolat, Turkey Dominick J. Angiolillo, USA Feng Cao, China Charles Antzelevitch, USA Noel Caplice, Ireland Juan M. Aranda, Jr., USA Filip Casselman, Belgium Eloisa Arbustini, Italy Turgay Çelik, Turkey Pankaj Arora, USA Athanasios Chalkias, Greece Diana E. Ayala, Spain Subroto Chatterjee, USA Lina Badimon, Spain Farooq A. Chaudhry, USA Subhash Banerjee, USA Asim N. Cheema, Canada Giuseppe Barbaro, Italy Jaw-Wen Chen, Taiwan Philip Barter, Australia Shiyou Chen, USA Alexei G. Basnakian, USA Yi-Jen Chen, Taiwan Seth J. Baum, USA Yingjie Chen, USA Ronen Beeri, Israel Yucheng Chen, China Atta Behfar, USA Susan Cheng, USA Elise Belaidi-Corsat, France Xian Wu Cheng, Japan Jutta Bergler-Klein, Austria Yiu-Fai Cheung, China Luigi M. Biasucci, Italy Anand Chockalingam, USA Vera Bittner, USA Kee-Joon Choi, Korea Peter C. Block, USA Christina Chrysohoou, Greece Eduardo Bossone, Italy Shorena Chumburidze, Georgia Cardiology 2017;137(suppl 1) 1-349 International Academy of Cardiology, Annual Scientific Sessions 2017 22nd World Congress on Heart Disease 5 Quirino Ciampi, Italy Jihong Han, China Luciano Consuegra-Sánchez, Spain Yuchi Han, USA Leslie T. Cooper, USA Louise Harris, Canada Filippo Crea, Italy Babar S. Hasan, Pakistan Clifford L. Cua, USA Takekuni Hayashi, Japan Kaijun Cui, China Don Hayes, Jr., USA Luciano Daliento, Italy Michael Y. Henein, Sweden Michael Dandel, Germany Charles A. Henrikson, USA Ramprasad Dandillaya, USA Michel Henry, Luxembourg Anindita Das, USA Gerd Heusch, Germany Piroze Davierwala, Germany Jennifer E. Ho, USA Buddhadeb Dawn, USA Paul C. Ho, USA Natasja M.S. de Groot, The Netherlands David R. Holmes Jr., USA Giuseppe De Luca, Italy Gue-Ru Hong, South Korea Christopher DeSouza, USA Myeong-Ki Hong, Korea Prakash C. Deedwania, USA Masatsugu Hori, Japan Alessandro Della Corte, Italy Minoru Horie, Japan Yvan Devaux, Luxembourg Masatsugu Horiuchi, Japan Javier Díez, Spain John D. Horowitz, Australia Dobromir Dobrev, Germany Dan Hu, USA Gerald Dorros, USA Gang Hu, USA Rami Doukky, USA Heikki V. Huikuri, Finland Anique Ducharme, Canada Takafumi Ishida, Japan Daniel A. Duprez, USA Warren M. (Sonny) Jackman, USA Hamza Duygu, Cyprus Allan S. Jaffe, USA Mohaned Egred, UK Farouc A. Jaffer, USA Andrew J. Einstein, USA Deepak Jain, Germany Arif Elvan, The Netherlands Jesper K. Jensen, Denmark Marguerite M. Engler, USA Kai Jiao, USA Georg Ertl, Germany Xueting (Tina) Jin, USA Giovanni Esposito, Italy Hanjoong Jo, USA Melanie Everitt, USA James W. Jones, USA DeLisa Fairweather, USA Erik Jørgensen, Denmark Guo-Chang Fan, USA Boyoung Joung, Korea Mohamed Eid Fawzy, Egypt J. Wouter Jukema, The Netherlands Mark W. Feinberg, USA Hideo Kanaide, Japan Giuseppe Ferrante, Italy Duk-Hyun Kang, Korea Daniel Flammang, France Bharat K. Kantharia, USA Jerome L. Fleg, USA Samir Kapadia, USA Nicolas Foin, Singapore Navin K. Kapur, USA Michael Fu, Sweden Chandrasekharan C. Kartha, India Tohru Fukai, USA Masaya Kato, Japan Yoshihiro Fukumoto, Japan Demosthenes G. Katritsis, Greece Joel A. Garcia, USA Osami Kawarada, Japan Peter Gaskin, USA Henning Kelbaek, Denmark Jacob George, Israel Matyas Keltai, Hungary Guido Germano, USA Levon Khachigian, Australia Bernard J. Gersh, USA Rami N. Khouzam, USA Evaldas Girdauskas, Germany Jin Won Kim, Korea Robert J. Goldberg, USA Sang-Hyun Kim, Korea Jeffrey Goldberger, USA Yong-Jin Kim, Korea James A. Goldstein, USA Kwang Kon Koh, Korea Rajiv Gulati, USA Peter F. Kokkinos, USA Hyeon-Cheol Gwon, Korea Philippe Kolh, Belgium Arata Hagikura, Japan Igor E. Konstantinov, Australia Donald J. Hagler, USA Tatyana Korolenko, Russia Cardiology 2017;137(suppl 1) 1-349 International Academy of Cardiology, Annual Scientific Sessions 2017 22nd World Congress on Heart Disease 6 Smadar Kort, USA Eric Osborn, USA Ashok Krishnaswami, USA Noriyuki Ouchi, Japan Rungroj Krittayaphong, Thailand Gavin Y. Oudit, Canada Howard S. Kruth, USA Pasquale Pagliaro, Italy Rakesh C. Kukreja, USA Ramdas G. Pai, USA Sudhir Kurl, Finland John T. Parissis, Greece Fabien Labombarda, France Kaushik P. Patel, USA Roger J. Laham, USA Pranav M. Patel, USA Dhanunjaya Lakkireddy, USA Jan J. Piek, The Netherlands Gaetano A. Lanza, Italy Luc A. Pierard, Belgium Martin J. LaPage, USA Cristina Pislaru, USA Hwa Mu Lee, USA Laurent Pison, The Netherlands Stephan E. Lehnart, Germany Ygal Plakht, Israel Robert A. Levine, USA Sunny S. Po, USA Martin M. LeWinter, USA Don Poldermans, The Netherlands Qiangrong Liang, USA Rahul Potluri, UK Yulin Liao, China Sumanth D. Prabhu, USA Philip R. Liebson, USA Kailash Prasad, Canada Shing-Jong Lin, Taiwan Gregg S. Pressman, USA Steven E. Lipshultz, USA Karin Przyklenk, USA Tong Liu, China Paolo Emilio Puddu, Italy Douglas W. Losordo, USA Vijay Puri, UK Chaim Lotan, Israel Lu Qi, USA Amir S. Lotfi, USA Simon W. Rabkin, Canada Jincai Luo, China Mohan K. Raizada, USA Xin-Liang (Xin) Ma, USA Satish R. Raj, Canada Paolo Madeddu, UK Shahzad G. Raja, UK Mohammad Madjid, USA Dipak P. Ramji, UK Bernhard Maisch, Germany Tienush Rassaf, Germany Shaista Malik, USA Surendranath R.V. Reddy, USA Giuseppe Mancia, Italy Judith G. Regensteiner, USA Donna M. Mancini, USA Jun Ren, USA Antoni Martinez-Rubio, Spain Jeffrey Robbins, USA Akira Marui, Japan William C. Roberts, USA Takumi Matsubara, Japan Joe Rod, USA Nilanjana Maulik, USA Ariel Roguin, Israel Nicola Maurea, Italy Eric Rosenthal, UK Pascal McKeown, Ireland Yoram Rudy, USA Bruce M. McManus, Canada Martin H. Ruwald, Denmark Luisa Mestroni, USA Kerry-Anne Rye, Australia Antonio Miceli, Italy Rajesh Sachdeva, USA Hendrik Milting, Germany Christoph H. Saely, Austria Nader Moazami, USA Naritatsu Saito, Japan Henning Morawietz, Germany Fabian Sanchis-Gomar, Spain Daniel Moreira-Goncalves, Portugal Raul D. Santos, Brazil Ryuichi Morishita, Japan Hiroshi Sato, Japan Toshisuke Morita, Japan Heinrich R. Schelbert, USA Marjan Mujib, USA Ingolf Schimke, Germany Sreejayan Nair, USA Thomas H. Schindler, USA Francesco Nappi, France Paul Schoenhagen, USA Andrea Natale, USA Morten Schou, Denmark Arnold C.T. Ng, Australia Madhan Shanmugasundaram, USA Alexander Niessner, Austria Abhishek Sharma, USA Niels T. Olsen, Denmark Neeru Sharma, USA Elmir Omerovic, Sweden Rakesh K. Sharma, USA Torbjørn Omland, Norway Fayaz Shawl, USA Cardiology 2017;137(suppl 1) 1-349 International Academy of Cardiology, Annual Scientific Sessions 2017 22nd World Congress on Heart Disease 7 Michael Shechter, Israel Muthiah Vaduganathan, USA Jayaprakash Shenthar, India Héctor H. Valdivia, USA Win K. Shen, USA Hector O. Ventura, USA Avraham Shotan, Israel Josef Veselka, Czech Republic Rosa Sicari, Italy Francesco Violi, Italy Robert J. Siegel, USA Salim S. Virani, USA Horst Sievert, Germany Johannes Waltenberger, Germany Michael Simons, USA Lu Wang, USA David Snipelisky, USA Shi-Qiang Wang, China Elsayed Z. Soliman, USA Wenru Wang, Singapore Virend K. Somers, USA Xuejun Wang, USA Long-Sheng Song, USA Yanggan Wang, China Yiqing Song, USA S. Goya Wannamethee, UK Francis G. Spinale, USA Xander H.T. Wehrens, USA Deepak Srivastava, USA Giora Weisz, USA Komandoor Srivathsan, USA B. Daan Westenbrink, The Netherlands Christoph T. Starck, Germany Harvey D. White, New Zealand Paul Steendijk, The Netherlands Norbert Wilke, USA Martin Stockburger, Germany Martin C.S. Wong, Hong Kong Bodo E. Strauer, Germany Tom Wong, UK Kaihong Su, USA Scott Wright, USA Jianxin Sun, USA Mei-Hwan Wu, Taiwan Phyllis G. Supino, USA Bo Xu, USA Jesper Hastrup Svendsen, Denmark Zhong-Qun Yan, Sweden Masahiko Takagi, Japan Clyde W. Yancy, USA Masafumi Takahashi, Japan Qinglin Yang, USA Yida Tang, China Zequan Yang, USA Jean-Francois Tanguay, Canada Masafumi Yano, Japan Paramjit S. Tappia, Canada Yan Yao, China Luca Testa, Italy Jian (James) Ye, Canada David R. Thompson, Australia Hongki Yoo, South Korea Edward B. Thorp, USA Hiroshi Yoshida, Japan Dimitris Tousoulis, Greece Cheuk-Man Yu, China Dwight A. Towler, USA Maliha Zahid, USA Ronald J.A. Trent, Australia Jianyi Jay Zhang, USA Teresa S. M. Tsang, Canada Yingmei Zhang, China Masahiko Tsuchiya, Japan Youhua Zhang, USA Mark K. Urman, USA Shui-Ping Zhao, China Simon Urschel, Canada Xi-Long Zheng, Canada Masuko Ushio-Fukai, USA Yi Zhou, USA Gian Paolo Ussia, Italy Peter van der Meer, The Netherlands Niels van Royen, The Netherlands Cardiology 2017;137(suppl 1) 1-349 International Academy of Cardiology, Annual Scientific Sessions 2017 22nd World Congress on Heart Disease 8 ABSTRACTS PRESENTED AT THE INTERNATIONAL ACADEMY OF CARDIOLOGY ANNUAL SCIENTIFIC SESSIONS 2017 22nd WORLD CONGRESS ON HEART DISEASE Each abstract was graded by at least seven expert reviewers. Acceptance for presentation was based on the average score of all reviewers. A large number of excellent contributions were received and we thank both contributors and reviewers for their support, interest and effort. Asher Kimchi, MD Chairman SCIENTIFIC ABSTRACT REVIEW COMMITTEE Mazen S. Abu-Fadel, USA Anne B. Curtis, USA Chris Adamopoulos, Greece Alexander H.J. Danser, The Netherlands Ali Ahmed, USA Anindita Das, USA Takashi Akasaka, Japan Alessandro Della Corte, Italy Tolga Aksu, Turkey Naranjan S. Dhalla, Canada Kannayiram Alagiakrishnan, Canada Javier Diez, Spain Mouaz H. Al-Mallah, Saudi Arabia Luc Djousse, USA Martin A. Alpert, USA Samuel C. Dudley, USA Dominick J. Angiolillo, USA Hamza Duygu, Cyprus Eloisa Arbustini, Italy Abdou Elhendy, USA Wilbert S. Aronow, USA Marguerite M. Engler, USA Giuseppe Barbaro, Italy Melanie Everitt, USA Gregory Barsness, USA Guo-Chang Fan, USA Philip Barter, Australia Mark W. Feinberg, USA Alexei G. Basnakian, USA Giuseppe Ferrante, Italy Lewis Becker, USA Michael A. Fifer, USA Daniel S. Berman, USA Janos G. Filep, Canada Robert W.W. Biederman, USA William H. Gaasch, USA Yochai Birnbaum, USA Feng Gao, China Vera Bittner, USA Julius M. Gardin, USA Jeffrey S. Borer, USA Peter Gaskin, USA Eduardo Bossone, Italy S. David Gertz, Israel Sorin Brener, USA Robert J. Goldberg, USA Alexandros Briasoulis, USA James A. Goldstein, USA John C. Burnett, Jr, USA Jonathan Golledge, Australia Gianfranco Butera, Italy Arata Hagikura, Japan Michael E. Cain, USA Donald J. Hagler, USA Duncan J. Campbell, Australia Jihong Han, China Filip Casselman, Belgium Yuchi Han, USA Athanasios Chalkias, Greece Takekuni Hayashi, Japan Yzhar Charuzi, USA Charles H. Hennekens, USA Subroto Chatterjee, USA Charles A. Henrikson, USA Farooq A. Chaudhry, USA Michel Henry, Luxembourg Shiyou Chen, USA Brian D. Hoit, USA Yi-Jen Chen, Taiwan Myeong-Ki Hong, Korea Yucheng Chen, China Masatsugu Hori, Japan Anand Chockalingam, USA Masatsugu Horiuchi, Japan Kee-Joon Choi, Korea John D. Horowitz, Australia Luciano Consuegra-Sánchez, Spain Takafumi Ishida, Japan Clifford L. Cua, USA Warren M. (Sonny) Jackman, USA Cardiology 2017;137(suppl 1) 1-349 International Academy of Cardiology, Annual Scientific Sessions 2017 22nd World Congress on Heart Disease 9 Deepak Jain, Germany Arnold Ng, Australia Jesper K. Jensen, Denmark Niels Thue Olsen, Denmark Daniela Jezova, Slovakia Gavin Y. Oudit, Canada Xueting (Tina) Jin, USA Demosthenes Panagiotakos, Greece Maryl R. Johnson, USA Kailash N. Pandey, USA Bodh I. Jugdutt, USA Hakan Paydak, USA Andreas Kalogeropoulos, USA Louis P. Perrault, Canada Edo Kaluski, USA Ygal Plakht, Israel Hideo Kanaide, Japan Sunny Po, USA Duk-Hyun Kang, Korea Don Poldermans, The Netherlands Masaya Kato, Japan Rahul Potluri, UK Amir Kazory, USA Kailash Prasad, Canada Ilan Kedan, USA Gregg S. Pressman, USA Henning Kelbaek, Denmark Maria Prokudina, Russia Matyas Keltai, Hungary Karin Przyklenk, USA Levon Khachigian, Australia Lu Qi, USA Jin Won Kim, Korea Jeffrey J. Rade, USA Arthur L. Klatsky, USA Shahzad G. Raja, UK Anne A. Knowlton, USA Nalini M. Rajamannan, USA Wei Kong, China Dipak P. Ramji, UK Tatyana Korolenko, Russia Hanumanth K. Reddy, USA Ashok Krishnaswami, USA Surendranath R V. Reddy, USA Howard Kruth, USA Jeffrey Robbins, USA Takashi Kubo, Japan Robert S. Rosenson, USA Lih Kuo, USA Hanni N. Sabbah, USA Sudhir Kurl, Finland Rajesh Sachdeva, USA Martin J. LaPage, USA Naritatsu Saito, Japan Hwa Mu Lee, USA Fabian Sanchis-Gomar, Spain Stephanie Lehoux, Canada Maria J. Sanz, Spain Philip R. Leibson, USA Hiroshi Sato, Japan Qiangrong Liang, USA Tiziano M. Scarabelli, USA Shing-Jong Lin, Taiwan Ingolf Schimke, Germany Gary Lopaschuk, Canada Howard D. Sesso, USA Jincai Luo, China Madhan Shanmugasundaram, USA Xin-liang Ma, USA Win-Kuang Shen, USA Mohammad Madjid, USA Guo-Ping Shi, USA Kenneth Maiese, USA Jamshid Shirani, USA Bernhard Maisch, Germany Rosa Sicari, Italy Tadeusz Malinski, USA Mandeep S. Sidhu, USA Giuseppe Mancia, Italy Pawan K. Singal, Canada Roberto Manfredini, Italy Elsayed Z. Soliman, USA James D. Marsh, USA Francis G. Spinale, USA Antoni Martínez-Rubio, Spain Bodo E. Strauer, Germany Akira Marui, Japan Jianxin Sun, USA Pascal McKeown, Ireland Masahiko Takagi, Japan Jawahar L. Mehta, USA Paramjit S. Tappia, Canada Antonio Miceli, Italy Mitsu Terashima, Japan Leslie W. Miller, USA Luca Testa, Italy Freny Vaghaiwalla Mody, USA Udho Thadani, USA Samia Mora, USA Edward B. Thorp, USA Henning Morawietz, Germany Takanobu Tomaru, Japan Daniel Moreira-Gonçalves, Portugal Masahiko Tsuchiya, Japan Mohammad-Reza Movahed, USA Barry F. Uretsky, USA Nandini Nair, USA Gian Paolo Ussia, Italy Francesco Nappi, France Niels van Royen, The Netherlands Andrea Natale, Italy Hector O. Ventura, USA Cardiology 2017;137(suppl 1) 1-349 International Academy of Cardiology, Annual Scientific Sessions 2017 22nd World Congress on Heart Disease 10 Josef Veselka, Czech Republic Qinqling Yang, USA Yanggan Wang, China Zequan Yang, USA Nanette K. Wenger, USA Jian (James) Ye, Canada Harvey D. White, New Zealand Hongki Yoo, South Korea Martin C.S. Wong, Hong Kong Maliha Zahid, USA Mei-Hwan Wu, Taiwan Xi-Long Zheng, Canada Bo Xu, USA Yi Zhou, USA Cardiology 2017;137(suppl 1) 1-349 International Academy of Cardiology, Annual Scientific Sessions 2017 22nd World Congress on Heart Disease