The Official Journal of te The Royal Australasian fila College of Physicians 4 a a" published by 1 ‘ ) : es . se Blackwell Publishing Asia INTERNAL MEDICINE JOURNAL Formerly Australian & New Zealand Journal of Medicine Volume 34, 2004 Volume Contents Editor-in-Chief, Edward Byrne ISSN: 1444-903/2001 aims and scope disclaimer The J/nternal Medicine Journal, formerly known as the The Publisher, RACP and Editors cannot be held lustralian and N Zealand Fournal of Medicine, is the responsible for errors or any consequences arising from official journal of the Adult Medicine Division of The the use of information contained in this journal; the views Royal Australasian College of Physicians RACP). Its and opinions expressed do not necessarily reflect those of purpose is publish high-quality original medical the Publisher, RACP and Editors, neither does the research, both laboratory and clinical, relating to the study publication of advertisements constitute any endorsement and research of human disease Papers will be considered by the Publisher, RACP and Editors of the products from all areas of medical practice and science. The Journal advertised ae ilso has a major role in continuing medical education and publishes review articles relevant to physician education Except wh}e re otherwise stated,i articles are peer reviewed production editor publication frequency Marko Stechiwskyj I welve issues per year (two combined email: marko.stechiwskyj@ blackwellpublishingasia.com abstracting and indexing his journal is indexed by AIDS Abstracts, Australian Medical Index, Biological Abstracts (BIOSIS), Biomedical This journal ts printed on acid-free c pape r. EBSCO), Cambridge Scienti} ¢ Abstracts, Chemical Service, Current ( vical Medicine (AN LEMBASE/Ex rnational Pharmaceutical Abstract A, urn Ovid and © 2004 Royal Australasian College of Physicians. VMEDLINI address for editorial correspondence Editor-in-Chief, Jnternal Medicine Journal, The Royal his journal is also published online at Australasian College of Physicians, 145 Macquarie Street, www.blackwell-synergy.com Sydney, NSW 2000, Australia (tel: +61 2 9256 5431: fax: +61 2 9256 5485; email: virginia.savickis@ racp.edu.au ISSN 1444-0903 Print ISSN 1445-5994 Online For submission instructions, subscription and all other information visit www .blackwellpublishing.com/imj Volume Contents January/February, Issue 1/2 editorials clinical perspectives 1. The Journal in 2003 45 Ongoing controversies in the pharmacological E. BYRNE management of cancer pain P. GLARE, G. AGGARWAL and K. CLARK 3 Mitochondrial diseases: not so rare after all reviews D. R. THORBURN 50 Evidence-based guide to slowing the progression of 6 Renal failure is actually very common.. early renal insufficiency P.G. KERR D. W. JOHNSON commentary Ross River virus disease in Australia: epidemiology, socioecology and public health response 8 Capsule endoscopy review S. TONG I. D.N ORTON and W. S. SELBY ethics in medicine Original articles 61 Genetic testing: a round table conversation. Part | 10 Diagnostic screening of mitochondrial DNA P. A. KOMESAROFF, P. GREENBERG and mutations in Australian adults 1990-2001 L. PTTERMAN R. MAROTTA, J. CHIN, A. QUIGLEY, brief communication S. KATSABANIS, R. KAPSA, E. BYRNE and S. COLLINS 66 Cladribine followed by autologous stem-cell transplantation in progressive multiple sclerosis Renal impairment and anaemia in a population- A. GRIGG, N. J. TUBRIDY, J. SZER, P.- MITCHELL, based study of oider people H. BUTZKUEVEN, P. SHUTTTTLEWORTH and R. G. CUMMING, P. MITCHELL, J. C CRAIG and I. KILPATRICK J. EFK NIGHT images in medicine Low prevalence of autoimmune diabetes markers in 69 Internal carotid artery dissection: never too old a mixed ethnic population of Singaporean diabetics P. BARLIS, P. JAMES, A. B. SUNDARAVINGAM, A. L. TODD, W.Y. NG, K. E LUI and A. C.’THAI P.R. COOMBS and K. LIM Audit of consultant physicians’ reply letters for letters to the editor referrals to clinics in a tertiary teaching hospital clinical-scientific notes I.A. SCOTT, C. A. MITCHELL and E. LOGAN 70 ~Prolonged survival after the diagnosis of metastatic Suspected white-tail spider bite and necrotic ulcers hepatic epitheliod haemangioendothelioma G. K. ISBISTER and IL. M. WHYTE A. M. JOSHUA, M. R. STOCKLER and M. J. BOYER ~ Blackwell Publishing Volume Contents Biliary hamartomas (von Mayenburg complex 102 Prevention of falls and fall-related fractures in magnetic resonance imaging 1n a Case report community-dwelling older adults: a meta-analysis S. NERI, B. MAUCERI, D. CILIO, ¢ SCIACCA, of estimates of effectiveness based on recent P. Di PRIMA and M. FINAZZO guidelines M. WEATHERALL general correspondence 72 Therapeutic drug monitoring of anti-tuberculous clinical perspectives drugs 109 Postmenopausal hormone therapy: the pros and cons G. SIMPSON and A. KONSTANTINOS L. M. RIVERA-WOLaLnd S. R. DAVIS books reviews 74 Books submitted 115 Delirium: current trends in prevention and abstracts treatment Al Abstracts presented at the 2003 Annual Scientific |. B.W EBER, J]. H. COVERDALE and M. E. KUNIK Meeting of the Stroke Society of Australasia ethics in medicine March, Issue 3 122 Genetic testing: a round table conversation. Part II P- KOMESAROFF, P. GREENBERG and editorials L. PTTERMAN brief communications 75 Ihe physician scientist: an endangered breed? E. BYRNI 126 Cytokine gene polymorphisms in idiopathic pulmonary fibrosis 76 Should we think before we treat delirium? R. L. RIHA, lL. A.Y ANG, G. C. RABNOTT, K. ROCK WOOD and R. BHAI A .M. TUNNICLIFFE, K. M. FONG and P.V. ZIMMERMAN Original articles Secondary prevention of fractures in older people: 79 Systematic genome-wide approach to positional evaluation of a protocol for the investigation and candidate cloning for identification of novel human treatment of Osteoporosis disease genes A. L SIDWELL, T. J. WILKINSON and H.C. HANGER H. KIYOSAWA, T. KAWASHIMA, D. SILVA, N. PETROVSKY, Y. HASEGAWA, K. SAKAI and Recurrence of Helicobacter pylori infection in adults Y. HAYASHIZAKI with intellectual disability R. A.W ALLACE, P. J. SCHLUTER and P. M. WEBB Community-acquired pneumonia: influence images in medicine of management practices on length of hospital Stay 134 Seroquel, Serzone and seizures R. LAING, C. COLES, S. CHAMBERS, D. L.W ORTHLEY, N. BURGESS, O. NIGRO and C. FRAMPTON, L. JENNINGS, N. KARALUS, S. SHAKIB G. MILLS and G. I. TOWN letters to the editor Oral versus intravenous ganciclovir for the prophylaxis of cytomegalovirus disease after clinical-scientific notes allogeneic bone marrow transplantation 135 Intracardiac thrombosis complicating J. SZER, S. DURRANT, A. P- SCHWARER, anuphospholipid antibody syndrome K. KF BRADSTOCK, J. GIBSON, C. ARTHUR, L.. B. TO,T. HUGHES and H. RAUNOW E. LIM, 1.W ICKS and L. J. ROBERTS Volume Contents 137 Thoracic spinal cord compression by a rheumatoid Original articles nodule 153 Impact of selective cyclooxygenase-2 inhibitors on Y. LEVY, P. STALLEY and J. BLEASE!] anti-ulcer medication and non-steroidal anti- general correspondence inflammatory drug use in patients with rheumatic disease 138 Giant cell arteritis, scalp necrosis and myocardial EE JOSHUA, S. P. OAKLEY and G. A. MAJOR infarction S. GRAN’! Intravenous pamidronate in the treatment and prevention of osteoporosis 139 Highly active antiretroviral therapy a misnomer in S. S.Y. CHAN, L. M. NERY, A. McELDUFE, HIV/AIDS terminology E.G. WILMSHURST, G. R. FULCHER, R. PHILPO' B. G. ROBINSON, J. N. STIEL, J. E. GUNTON and PB. CLIFTON-BLIGH 139 End-stage dementia: why treat at all? F FORMBY Long-term follow up of sequential mobilisation and autologous transplantation with CD34-selected 140 Reply cells in multiple myeloma: a multimodality J. A.L OW, D. K.Y. CHAN and R. CHYI approach N. HORVATH, U. HAHN, D. JOSHUA, P. DYSON, personal stories from eminent |. GIBSON, J. STEVENS, T. RAWLING, L. BARROW, physician scientists R. BROWN, S. STEPHENS, G. GOWER, J. NORMAN, B. MILLS and L. B. TO 141 Medical graduates and scientific research in Australia: a personal reflection Malnutrition screening in hospitalised patients and G. ADA its implication on reimbursement R. RAJA, A. V. LIM. Y. P. LIM,G . LIM,S . P. CHAN abstracts and C.K. EVI A17 Abstracts presented at the combined Annual Impact of hydroxychloroquine therapy on chronic Scientific Meeting of the Australasian Sleep Association and the Australasian Sleep urticaria: chronic autoimmune urticaria study and lechnologists Association, 2003 evaluation G. E. M. REEVES,M . J. BOYLE, J.B ONFIELD, April, Issue 4 P. DOBSON and M. LOEWENTHAI clinical perspectives editorials 187 Nonalcoholic fatty liver disease: is all the fat bad? 145 Impact of cyclooxygenase-2 inhibitors: are they A. D. CLOUSTON and E. E. POWELI fulfilling their promises? N. D.-YEOMANS reviews 147 Optimising antifungal therapy for individual 192 Guidelines for the use of antifungal agents in the patients treatment of invasive Candida and mould infections W.W. HOPE and D.W. DENNING M. A. SLAVIN, J.S ZER, A. P.G RIGG, A.W. ROBERTS, J. E SEYMOUR, J. SASADEUSZ, 150 HIV and tuberculosis: think local, act global K. THURSKY, S. C. CHEN, C. O. MORRISSEY, A.C. STREE] C. H. HEATH and ‘Tl. SORRELI 219 Reply 4 D. SPRIGGS 201 Chronic illness and the experience of surviving cancel A411 Award abstracts presented at the 2003 Annual M. LIVril Scientific Meeting of The Royal Australasian College of Physicians brief communications May, Issue 5 2U3 HIV and tuberculosis co-infection in south-western Sydney: experience from a case series S. LIMAYE, J. QUIN andR . H. STEELI editorial 206 Planned pregnancy n a heart transplant recipient 221 Bon santé: is wine good for your health? C. A. WASYWICH, P. N. RUYGROK, I I. MacG. DONALDSON WILKINSON, H. GIBBS andH . A. COVERDALI Original articles images in medicine 224 Effects of white and red wine on endothelial function in subjects with coronary artery disease 210 Left atrial myxoma: magnet or echo? A. P WHELAN, W. H. EF SUTHERLAND, K. C. ROBERTS-THOMSON, K. S. L.TEO, M. P, MeCORMICK, D. J. YEOMAN, S. A. de JONG R. STUKLIS and S .G.W ORTHLEY ind M. J. A. WILLIAMS an occasional article Assessment and management of inpatients with acute diabetes-related foot complications: room for 211 The Wellcome Trust in Australasia: return on improvement investment S. M. LAWRENCE, P. R.WRAIGHT, \. WHITWORTH, M. PHILLIPS an D. A. CAMPBELL and P. G. COLMAN letters to the editor High rate of complications associated with peripherally inserted central venous catheters in clinical-scientific notes patients with solid tumours 214 Delayed pulmonary hypertension following K. CHEONG, D. PERRY, ¢ KARAPETIS and splenectomy for congenital spherocytosis B. KOCZWARA LD. L. JARDINE and A. D. LAING Can patients with dementia be assessed at a 216 Ascites, hypercalcaemia, diffuse peritoneal distance? The use of Telehealth and standardised thickening and elevated OM-M<A in a fifteen-vear- assessments old girl a case of peritoneal tuberculosis PK. LOH, P. RAMESH, S. MAHER, J. SALIGARI, O.'T. AYONRINDE and M. J. ZIMMERMAN L. FLICKER and P- GOLDSWAIN 217 Eosinophilic meningoencephalitis with permanent Neurological manifestations of cardiac myxoma: < neurological sequelae review of the literature and report of cases }. J.B ATMANIAN and J. H. O’NEILI E. 1.E XKINCI and G. A. DONNAN general correspondence Sensitivity and specificity of serology in determining recent acute Campylobacter infection 218 Guillain-Barré syndrome and hyponatraemia B. V. TAYLOR, J. WILLIAMSON, J. LUCK, B. M. COLLS D. COLEMAN, D. JONES and A. McGREGOR 218 Utility of medical ethics 259 Renal-related deaths in Australia 1997-1999 D. MEYERS S. Q. LI, J. CUNNINGHAM and A. CASS Volume Contents clinical perspectives 300 Book review 266 New concepts in breast cancer therapy 301 Corrigendum R. D. SNYDER June, Issue 6 reviews 270 Management of brain metastases editorials L. C. LIM, M. A. ROSENTHAL, N. MAARTENS and G. RYAN 303 The changing face of lupus 279 Kennedy’s disease: pathogenesis and clinical L. SCHRIEBER approaches Original articles K. J. GREENLAND and J. D. ZAJAC brief communications 305 Holter monitoring in the diagnosis of stroke mechanism 287 Black house spiders are unlikely culprits in necrotic S. SHAFQAT, P. J. KELLY and K. L. FURII arachnidism: a prospective study G. K. ISBISTER and M. R. GRAY No association between serum levels of insulin-like growth factor-I, vascular endothelial growth factor, 290 Arm position and blood pressure: an audit prolactin and clinicopathological characteristics of A. MOURAD and S. CARNEY breast carcinoma after surgery B. SANCAK, U. COSKUN, N. GUNEL, E. ONUK, images in medicine \. CIHAN, A. KARAMERCAN.Y. YILDIRIM and 292 Combined anatomical and functional imaging of S. OZKAN carcinoid metastases 5 Pilot study to determine the ability of health-care A. TING, N. POCOCK and B. McBRIDE professionals to undertake drug dose calculations a personal viewpoint G. J. OLDRIDGE, K. M. GRAY, I M. McDERMOT'! and C. M. J. KIRKPATRICK 294 ‘Tackling Australia’s future health problems: developing strategies to combat sarcopenia — Prospective audit of conversion from regular to age-related muscle wasting and weakness lispro insulin during routine clinical care G. S. LYNCH H. LUNT,D . KENDALL, M. P.-M OORE, R.S. SCOTD.T CO,LE , C. M. FRAMPTOaNn d letters to the editor M. CULLENS clinical-scientific notes clinical perspectives 297 Methysergide-induced retroperitoneal fibrosis and pericardial effusion 324 Management of chronic hepatitis C virus infection a new era of disease control FE Z. CAI, P’TESAR and A. KLESTO\ N. C. TEOH and G. C. FARRELI 298 Prevention of hepatotoxicity but loss of anti- melanoma effect with combined fotemustine and reviews anti-oxidant treatment 338 Update on the immunology, diagnosis and G. J. M.W EBSTER, J. KURTOVIC, management of systemic lupus erythematosus I. SINGH-GREWAL, M. FRIEDLANDER and S. M. RIORDAN G. E. M. REEVES 299 Neurosyphilis: not to be forgotten 348 Primary immunodeficiency diseases in adulthood L. J. BRITTON, B. E. JOYNER and A. H. EWAR1I D. S. RIMINTON and S. LIMAYE 370 Reply D. J. TOPLISS, R.W ONG and J. R. STOCKIG1I and practice Evolutionary ethic and embryonic stem-cell research R. BASCHETTI Reply G. CHI 360 Bool High-dose riboflavin for the prevention of migraine: can we afford to ignore it? brief communication |. S. DAVIS or rapid initiation of 373 Reply acute coronary syndromes DPLHITITL PDOp TT, S. CHANDY, R. MORRIS and PJ. GOADSBY |. Db. HOROWTTZ fast-track article — critically appraised articles images in medicine 373 Local thrombolysis or rapid transfer for primary vocardium angioplasty for patients presenting with ST segment elevation myocardial infarction to MISHRA NGER LD. HOROWTTZ hospitals without angioplasty facilities letters to the editor 1 SCOTT, J. CHAN, C. ARONEY and G. CARROL I abstracts clinical-scientific notes — ss A45 Proceedings of the Annual Scientific Meeting of 500 Milk—alkali syndrome: broadening the spectrum of the Australian Society for Geriatric Medicine, 2003 causes to allow early recognition 1. J. KLEINIG and D. J. TORPY July, Issue 7 367 Diverse presentation and clinical features of (Churg—Strauss syndrome: two cases from a editorial Melbourne teaching hospital I. JAYASURIYA, M. NIKPOUR, J. M. HUNT, 379 The long and short of the risk of antibiotic M. C.G. HOLMES andR . M. O'BRIEN treatment failure general correspondence Db. A. R. WATSON ane Original articles 368 Anaesthetic support for endoscopic retrograde cholangio pancreatograms in Australian teaching 383 Short course intravenous benzylpenicillin treatment hloossppiittaalls of adults with meningococcal disease S. LOUIS, M. BASSETT, A. CLARKE and S. BRIGGS, R. ELLIS-PEGLER, S. ROBERTS, PHOMSON M. THOMAS and A. WOODHOUSE 369 Plasmapheresis as a potential treatment option for 388 Positron emission tomography scanning in the amiodarone-induced thyrotoxicosis assessment of patients with lymphoma lH. DIAMOND, R. RAJAGOPAL, K. GANDA, S.S. FOO, P. L. MITCHELL, S. 0. BERLANGIERI, \. MANOHARAN and A. LUK C. L. SMITH and A. M. SCOTT Volume Contents 398 Analysis of clinical outcomes following in-hospital letters to the editor adult cardiac arrest clinical-scientific notes A. C. COHN,W . M. WILSON, B.YAN,S . B. JOSHI, M. HEILPY- M,O RLEP.Y- M,AR UFF, L. E. GRIGG ‘ 441 Hepatotoxicity possibly due to paracetamol with and A. E. AJANI carbamazepine Patient characteristics and quality of life among a S. PARIKH, L. C. DILLON and S. L. SCHARI sample of Australian chronic pain clinic attendees general correspondence S. KERR, G. FAIRBRO'THER, M. CRAWFORD, M. HOGG, D. FAIRBROTHER and K. E. KHOR 44A2t Ramipril: clinical and economic benefits Aciclovir or ganciclovir universal prophylaxis of G. LAKING and J. LORD cytomegalovirus infection in liver transplantation an economic analysis 44A2’ Management of spontaneous pneumothorax R.W. L. LEONG, D. W. SMITH, G. GARAS, G. SIMPSON J. M. BEAMAN, A.W. MICHELL, D. 1. HEATH A. K. HOUSE and G. P. JEFFREY 443| Reply, clinical perspectives H. VEDAM and D. BARNES 416 Repetitive strain injuries: has the Australian 4A 4/ 4 Genetic testing: a round table conversation epidemic burnt out? G. SUTHERS M. AWERBUCH J. KIRK review J. CORNWALI 420 Obstructive sleep apnoea and cardiovascular disease B. KOCZWARA G. S. HAMILTON, P. SOLIN and M.'T. NAUGHTON 446 Reply brief communications P KOMESAROF! 427 Scorpion stings in Australia: five definite stings 447 Changing face of colonoscopy: a comparison a review between audits of colonoscopy at Wellington G. K. ISBISTER, E. S.V OLSCHENK and Hospital from 1987 to 2002 J. E.S EYMOUR S.J. INNS and J. W. WYETH Staged autologous peripheral blood progenitor cell transplantation for Ewing sarcoma and August, Issue 8 rhabdomyosarcoma D. S. RITCHIE, A. P.G RIGG, A. ROBERTS, M. ROSENTHAL, R. FOX and J. SZER editorials ethics in medicine 449 Where to for occupational medicine? 435 Ethics and public health D. GORMAN S. R. LEEDER 450 A good death down unde images in medicine J. R. HARDY and R. VORA 440 Displaced colon: Chilaiditi’s sign P. E.WESTERWEEL and J. M. HEMMER Volume Contents Original articles 507 Improving the implementation of community- acquired pneumonia guidelines 493 Percutaneous pulmonary vein isolation fot A. A.W RIGHT and B.W. MAYDOM nt of atrial fibrillation S. P THOMAS. A. ¢ BOYD, G. AGGARWAL. Y. JIN 510 Rate of nosocomial transmission of vancomycin- ilb.] ROSS resistant enterococci from isolated patients A. C. CHENG, G. HARRINGTON, P. RUSSO, ng metastatic non-small cell lung L. LIOLIOS and D. SPELMAN hing hospital images in medicine ROSEN THAI R. deBOER, 1 R. M. FOX 513 Thyroid acropachy meningococcal disease in H. A. TRAN (00) 00) personal stories from eminent IL] d M. M. YOUNG physician scientists ited and measured maximal ing in patients 515 Excitement of research disease P. KINCAID-SMITH VINTCH letters to the editor clinical-scientific notes management of pancreatic carcinoma 517 Beware the thin, deaf ‘type 2’ diabetic: maternally LD. GOLDSTEIN, S. CARROLL, M. APTI inherited diabetes and deafness with systemic G. KEOGH mitochondrial) manifestations review LD. L. JONES and Tl. M. GREENAWAY ilmopathy: a practical 518 Sudden blindness following acute pancreatitis , natural history and Y. J. TAL, A. G. TESTRO and P.M. HOFFMAN MAN and J. R. WALI general correspondence improving clinical practice 519 Cutaneous reactions to interferon and ribavirin \. J. CHAMBERLAIN and E. POON lowards more effective use of decision support in clinical practice: what guidelines for guidelines 520 Book reviews 1. A. SCOTT, C. P-D ENARO, C. J.B ENNI September/October, Issue 9/10 \. M. MUDGI ethics in medicine editorials 501 Non-heart beating organ donation 521 The impact factor and the Internal Medicine G. 1.S NELL. B. |.L EVVEY and T. J.W ILLIAMS Tournal brief communications E. BYRNI 504 Reproducibility of tilt-table test result in patients 521 Coeliac disease: against the grain with malignant neurocardiogenic syncope G. E. M. REEVES R. OMAR, K.-S. NG. W.-L. NG a1 1A. SUTANDAR