Jarrah Ali Al-Tubaikh Internal Medicine An Illustrated Radiological Guide Second Edition Jarrah Ali Al-Tubaikh Department of Clinical Radiology Amiri Hospital – Kuwait City Kuwait City , Kuwait All illustrations marked with were drawn by the author. ISBN 978-3-319-39746-7 ISBN 978-3-319-39747-4 (eBook) DOI 10.1007/978-3-319-39747-4 Library of Congress Control Number: 2016954639 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland V Pref ace It is a privilege to write another introduction to investigate certain diseases. In the same fashion, this book. When I wrote this book in Munich in many radiologists are pleased with the variety of 2010, I knew I was writing a book with an uncom- images that detail the medical disorders and facili- mon combination, linking internal medicine to tate their detection. radiology. I can still remember the comment of my mentor Prof. Maximillian Reiser aft er he saw the Based on the past positive feedbacks, I aimed to manuscript’s content. He told me: “Why did you expand the range of the book by including three choose this layout and these disorders in particu- more medical fi elds, which are not directly linked lar?” I replied: “Th ey are the most commonly to internal medicine but however are important to encountered diseases daily in any busy medical know. Th e second edition of this book exposes the department.” reader to occupational medicine and toxicology, which are uncommonly seen as cases of attempt- Over the years, I have noticed how the chapter’s ing suicide and accidental intoxications. Th e download numbers are increasing in Springer’s radiological literature is fi lled with diff erent radio- offi cial website. Th is refl ects, to me at least, the con- logical signs reported by many researches detailing tinuous demand for such topics worldwide, espe- intoxications, which have become of great interest cially among newly coming radiologists. Th ey are since the data are accumulating over the years. the ones facing the fi re daily in duties and emer- gency calls from physicians and surgeons around Chiropractic and osteopathic medicine are two the clock. Moreover, radiology board teachings important fi elds that emerged more than a hun- concentrate more and more over emergency cases, dred years ago, and they are rarely, if ever, men- trauma cases, postoperative complications, and tioned or taught in medical schools or cancer screening and monitoring. I can assure you board-certifi cation programs, especially in spe- that almost 90 % of any radiologist’s daily routine cialties related to the orthopedics or the spine. lies within one or more of the past four areas in Although they are not considered part of conven- radiology. Internal medicine disorders and com- tional medicine, both specialties have very solid plications are considered extracurriculum, and neuroanatomical and neuropathophysiological maybe special interest radiology. basis. Chiropractic medicine in particular, founded by D. D. Palmar and perfected by B. J. Palmar, uses Within the past 5 years since the publication of radiology as an essential part of its diagnostic tech- this book, I have noticed a skyrocketing increase in niques. Th eir radiographic imaging techniques are the radiological referrals through my work in two known as “spinography.” Personally, I have been diff erent hospitals. Sometimes, we get radiological using their radiographic techniques in an exten- referral for simple disorders that do not need sive fashion to diagnose lower back pain and kine- radiological investigation, for example, more and siological disorders. Th eir radiological imaging more demands for ultrasound to exclude inguinal techniques proved to be very valid and very accu- hernias, ultrasound for lipoma, CT for acute rate in diagnosing lower back pain, especially lum- appendicitis suspicion, polytrauma PAN- CT, etc. bar spine MRI with almost normal fi ndings. As a radiologist, it is always nice to be needed; Unfortunately, such radiological knowledge is very however, technology can be a double- edged sword, rarely encountered in commonly known radiolog- reducing the clinical experience of both the refer- ical journals. I sincerely hope that the reader will ring clinician and the radiologist. Many physicians, fi nd the chapter of chiropractic medicine imaging unfortunately, started to use radiology as a substi- interesting and informative. tute for clinical examination and judgment. Although such a phenomenon is not necessarily Lastly, a very new medical specialty is arising widely found, it is there, no doubt about it. within the past 5 years: energy and quantum med- icine. Although it started with the book W hat Is I am pleased that the fi rst edition of my book has Life? (1944) by the Nobel Prize winner Austrian helped many physicians I know to change their physicist Erwin Schrödinger, many new medical perspective toward radiological investigations. I and biological researchers are now using quantum have been contacted by many physicians here in physics to defi ne life, including Robert O. Becker, Kuwait and outside of Kuwait who thank me for Jerry Tennant, Hans-Peter Dürr, Fritz-Albert detailing what they should order and how to Popp, Mae-Wan Ho, and so many others. Th eir VI Preface works have now evolved to so many applications, publishing the second edition of this book to emerging as unconventional therapies that use introduce the reader to a whole new world that waves and frequencies to heal, such as pulsed elec- uses therapies based on biophysics rather than bio- tromagnetic fi eld (PEMF) therapy, microcurrent chemistry for conventional, pharmacological therapy, phototherapy, and ultrasonic therapy. I medicine uses. have been personally using these devices for myself and my relatives and for special cases in the hospi- In conclusion, I hope for the reader an interesting tal, with a high success rate of controlling diseases journey through the book, and I hope that this and complications. I documented my fi ndings on book can help someone somewhere in the world radiological images, imaging patients before and save a life. aft er such unconventional, energetic therapy to fi nd out what has been changed in the disease sta- Jarrah Ali Al-Tubaikh , MD tus radiographically. I took the opportunity of Kuwait City, Kuwait VII Contents 1 Gastroenterology ............................................................................................................................................................ 1 1.1 Liver Cirrhosis......................................................................................................................................................................... 2 Types of Liver Cirrhosis ......................................................................................................................................................... 2 1.2 Fatty Liver Disease (Liver Steatosis) ............................................................................................................................. 15 Types of Liver Steatosis ......................................................................................................................................................... 15 1.3 Recurrent Epigastric Pain .................................................................................................................................................. 17 Gastroesophageal Refl ux Disease ..................................................................................................................................... 17 Diff erential Diagnoses and Related Diseases ................................................................................................................. 18 Peptic Ulcer Disease ............................................................................................................................................................... 24 Superior Mesenteric Artery Syndrome (Wilkie’s Syndrome) ..................................................................................... 27 Median Arcuate Ligament Syndrome (Celiac Trunk Compression Syndrome/Dunbar’s Syndrome) ........... 29 Recurrent Abdominal Pain of Childhood ........................................................................................................................ 29 1.4 Infl ammatory Bowel Diseases ......................................................................................................................................... 30 Crohn’s Disease ........................................................................................................................................................................ 31 Extraintestinal Manifestations of CD ................................................................................................................................ 31 Ulcerative Colitis ..................................................................................................................................................................... 36 Extraintestinal Manifestations of UC ................................................................................................................................ 36 Diff erences Between Ulcerative Colitis and Crohn’s Disease .................................................................................... 39 Diff erential Diagnoses and Related Diseases ................................................................................................................. 39 1.5 Gastrointestinal Hemorrhage ......................................................................................................................................... 40 1.6 Pancreatitis .............................................................................................................................................................................. 41 Acute Pancreatitis ................................................................................................................................................................... 41 Diff erential Diagnoses and Related Diseases ................................................................................................................. 41 Chronic Pancreatitis ............................................................................................................................................................... 45 1.7 Jaundice .................................................................................................................................................................................... 48 Kernicterus ................................................................................................................................................................................ 50 Obstructive Jaundice ............................................................................................................................................................. 50 Bile Plug Syndrome ................................................................................................................................................................ 52 Infectious Ascending Cholangitis ...................................................................................................................................... 52 Choledochal Web .................................................................................................................................................................... 53 1.8 Diarrhea and Malabsorption ........................................................................................................................................... 54 Normal Anatomy ..................................................................................................................................................................... 54 Pathophysiology ..................................................................................................................................................................... 54 Common Causes of Diarrhea and Their Mechanism of Action ................................................................................. 54 Sprue ........................................................................................................................................................................................... 55 Whipple’s Disease (Intestinal Lipodystrophy) ................................................................................................................ 56 VIPoma (Werner–Morris Syndrome/Pancreatic Cholera) ........................................................................................... 57 2 Neurology ............................................................................................................................................................................ 59 2.1 Stroke (Brain Infarction) .................................................................................................................................................... 62 Diff erential Diagnoses and Related Diseases ................................................................................................................. 62 2.2 Stroke Diseases and Syndromes .................................................................................................................................... 66 Moyamoya Disease (Progressive Occlusive Arteritis) .................................................................................................. 66 Cerebral Amyloid Angiopathy ............................................................................................................................................ 68 CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukodystrophy) ............................................................................................................................................................. 69 MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes) ................. 70 Cortical Laminar Necrosis ..................................................................................................................................................... 71 Man-in-the-Barrel Syndrome .............................................................................................................................................. 72 Locked-In Syndrome .............................................................................................................................................................. 73 Brain Stem Infarction Syndromes ...................................................................................................................................... 73 Subclavian Steal Syndrome ................................................................................................................................................. 75 VIII Contents 2.3 Intracranial Hemorrhage ................................................................................................................................................... 76 Epidural Hematoma ............................................................................................................................................................... 77 Subdural Hematoma .............................................................................................................................................................. 78 Subarachnoid Hemorrhage ................................................................................................................................................. 79 Intracerebral/Intraparenchymal Hemorrhage ............................................................................................................... 80 Intraventricular Hemorrhage .............................................................................................................................................. 81 Hemorrhage into Malignancy ............................................................................................................................................. 82 2.4 Meningitis ................................................................................................................................................................................ 82 Diff erential Diagnoses and Related Diseases ................................................................................................................. 84 2.5 Encephalitis ............................................................................................................................................................................. 85 Limbic Encephalitis ................................................................................................................................................................ 85 Acute Demyelinating Encephalomyelitis (ADEM) ........................................................................................................ 87 Hashimoto’s Encephalitis...................................................................................................................................................... 88 Rasmussen Encephalitis (Rasmussen Syndrome) ......................................................................................................... 89 Measles Encephalitis .............................................................................................................................................................. 89 Subacute Sclerosing Panencephalitis (SSPE) ................................................................................................................. 90 Japanese Encephalitis ........................................................................................................................................................... 90 West Nile Encephalitis ........................................................................................................................................................... 90 Tick-Borne Encephalitis (Spring–Summer Encephalitis) ............................................................................................ 90 Murray Valley Encephalitis ................................................................................................................................................... 91 St. Louis Encephalitis ............................................................................................................................................................. 91 Encephalitis Lethargica ......................................................................................................................................................... 91 2.6 Epilepsy ..................................................................................................................................................................................... 92 Diff erential Diagnoses and Related Diseases ................................................................................................................. 93 2.7 Headache ................................................................................................................................................................................. 96 Migraine ..................................................................................................................................................................................... 96 Spontaneous Intracranial Hypotension (Schaltenbrand Syndrome) ..................................................................... 97 Idiopathic Intracranial Hypertension (Pseudotumor Cerebri) .................................................................................. 97 Temporal (Giant) Cell Arteritis ............................................................................................................................................ 98 2.8 Multiple Sclerosis and Other Demyelinating Diseases ........................................................................................ 99 Multiple Sclerosis .................................................................................................................................................................... 99 Neuromyelitis Optica (Devic’s Syndrome) ...................................................................................................................... 101 Marburg’s Type MS ................................................................................................................................................................. 102 Baló Concentric Sclerosis ..................................................................................................................................................... 103 Schilder’s Disease (Diff use Myelinoclastic Sclerosis) ................................................................................................... 103 Susac’s Syndrome ................................................................................................................................................................... 103 Guillain–Barré Syndrome ..................................................................................................................................................... 104 2.9 Parkinsonism .......................................................................................................................................................................... 106 Diff erential Diagnoses and Related Diseases ................................................................................................................. 107 2.10 Dementia .................................................................................................................................................................................. 108 Alzheimer’s Disease ................................................................................................................................................................ 108 Vascular Dementia .................................................................................................................................................................. 109 Frontotemporal Lobar Degeneration (Pick’s Disease) ................................................................................................. 109 Dementia with Lewy Bodies ................................................................................................................................................ 111 Progressive Supranuclear Palsy (Steele–Richardson–Olszewski Syndrome) ....................................................... 111 Multiple System Atrophy (Shy–Drager Syndrome) ...................................................................................................... 112 Subcortical Arteriosclerotic Encephalopathy (Binswanger’s Disease) ................................................................... 113 Prion Disease ............................................................................................................................................................................ 114 2.11 Huntington’s Disease .......................................................................................................................................................... 1 16 Diff erential Diagnoses and Related Diseases ................................................................................................................. 117 2.12 Heat Stroke (Pancerebellar Syndrome) ....................................................................................................................... 117 2.13 Aphasia ..................................................................................................................................................................................... 117 Neural Control of Speech ..................................................................................................................................................... 118 Aphasia Pathophysiology and Subtypes ......................................................................................................................... 118 2.14 Squint (Strabismus) ............................................................................................................................................................. 122 Neural Control of Ocular Muscles ...................................................................................................................................... 122 Pathophysiology ..................................................................................................................................................................... 122 Related Disorders .................................................................................................................................................................... 122 IX Contents 2.15 Nystagmus ............................................................................................................................................................................... 124 Neural Control of Eye Movement ...................................................................................................................................... 124 Nystagmus Subtypes ............................................................................................................................................................. 125 2.16 Erectile Dysfunction ............................................................................................................................................................ 126 Neural Control Human Sexual Behavior .......................................................................................................................... 126 Pathophysiology ..................................................................................................................................................................... 127 Erectile Dysfunction Diff erential Diagnoses................................................................................................................... 127 3 Endocrinology and Metabolism ............................................................................................................................ 1 31 3.1 Graves’ Disease (Hyperthyroidism) ............................................................................................................................... 132 3.2 Hyperparathyroidism ......................................................................................................................................................... 133 Diff erential Diagnoses and Related Diseases ................................................................................................................. 134 3.3 Growth Hormone Diseases ............................................................................................................................................... 138 Growth Hormone Insuffi ciency (Hypopituitarism)....................................................................................................... 139 Acromegaly and Gigantism ................................................................................................................................................. 140 Growth Hormone Insensitivity (Laron Syndrome) ....................................................................................................... 143 Carney’s Complex ................................................................................................................................................................... 143 3.4 Osteoporosis ........................................................................................................................................................................... 145 Primary Osteoporosis ............................................................................................................................................................ 145 Secondary Osteoporosis ....................................................................................................................................................... 148 Regional Migratory Osteoporosis of the Hip (Bone Marrow Edema Syndrome) ................................................ 148 3.5 Rickets and Osteomalacia ................................................................................................................................................. 149 Diff erential Diagnoses and Related Diseases ................................................................................................................. 150 3.6 Scurvy ........................................................................................................................................................................................ 152 3.7 Fluorosis ................................................................................................................................................................................... 154 3.8 Lead Poisoning (Plumbism) ............................................................................................................................................. 156 3.9 Adrenal Glands Abnormalities ....................................................................................................................................... 157 Cushing’s Syndrome ............................................................................................................................................................... 157 Conn’s Syndrome (Hyperaldosteronism) ......................................................................................................................... 158 Addison’s Disease.................................................................................................................................................................... 159 Pheochromocytoma .............................................................................................................................................................. 160 Neuroblastoma ........................................................................................................................................................................ 161 X-Linked Adrenoleukodystrophy ....................................................................................................................................... 161 Testicular Adrenal Rest Tumors .......................................................................................................................................... 162 3.10 Sex Hormone Abnormalities ........................................................................................................................................... 162 Polycystic Ovary Disease (Stein–Leventhal Syndrome) .............................................................................................. 163 Precocious Puberty ................................................................................................................................................................ 163 Van Wyk and Grumbach Syndrome .................................................................................................................................. 164 Gynecomastia .......................................................................................................................................................................... 165 Intersex Disorders ................................................................................................................................................................... 166 Diff erential Diagnoses and Related Diseases ................................................................................................................. 168 3.11 Sheehan Syndrome (Postpartum Hypopituitarism) ............................................................................................. 170 4 Nephrology ......................................................................................................................................................................... 1 73 4.1 Hypertension .......................................................................................................................................................................... 174 Renal Artery Stenosis ............................................................................................................................................................. 174 Coarctation of the Aorta ....................................................................................................................................................... 178 Polyarteritis Nodosa ............................................................................................................................................................... 179 Takayasu Arteritis .................................................................................................................................................................... 180 Midaortic Syndrome .............................................................................................................................................................. 181 Preeclampsia ............................................................................................................................................................................ 181 Reversible Posterior Leukoencephalopathy Syndrome (Hypertensive Encephalopathy) ..................................................................................................................................................................... 182 Nephroptosis (Floating Kidney) ......................................................................................................................................... 183 Riley–Day Syndrome (Familial Dysautonomia) ............................................................................................................. 183 Stafne’s Bone Defect of the Mandible .............................................................................................................................. 183 Hypertensive Heart Disease ................................................................................................................................................ 183 X Contents 4.2 Polycystic Kidney Disease ................................................................................................................................................. 185 Autosomal Dominant Polycystic Kidney Disease ......................................................................................................... 185 Autosomal Recessive Polycystic Kidney Disease .......................................................................................................... 186 Acquired Polycystic Kidney Disease.................................................................................................................................. 187 Diff erential Diagnoses and Related Diseases ................................................................................................................. 188 4.3 Renal Failure ........................................................................................................................................................................... 188 Examples of Renal Parenchymal Disorders According to Their Anatomical Involvement ............................... 188 5 Cardiology ........................................................................................................................................................................... 1 93 5.1 Acute Chest Pain ................................................................................................................................................................... 194 Acute Coronary Syndrome ................................................................................................................................................... 194 Acute Pulmonary Embolism ................................................................................................................................................ 197 Aortic Dissection ..................................................................................................................................................................... 199 Aortic Intramural Hematoma .............................................................................................................................................. 201 Penetrating Atherosclerotic Ulcer ..................................................................................................................................... 202 5.2 Diseases of the Great Vessels .......................................................................................................................................... 202 Thoracic Aortic Aneurysm .................................................................................................................................................... 202 Pulmonary Hypertension ..................................................................................................................................................... 203 Coral Reef Aorta ...................................................................................................................................................................... 205 Superior Vena Cava Syndrome ........................................................................................................................................... 205 5.3 Myocardial Diseases (Cardiomyopathies) .................................................................................................................. 206 Hypertrophic Cardiomyopathy .......................................................................................................................................... 206 Dilated Cardiomyopathy ...................................................................................................................................................... 208 Restrictive Cardiomyopathy ................................................................................................................................................ 208 Arrhythmogenic Right Ventricular Dysplasia ................................................................................................................. 2 08 Noncompaction Cardiomyopathy (Spongy Myocardium) ........................................................................................ 209 Peripartum Cardiomyopathy (Cardiomyopathy of Pregnancy) ............................................................................... 210 5.4 Endocarditis ............................................................................................................................................................................ 210 Infective Endocarditis ............................................................................................................................................................ 211 Löffl er’s Endocarditis (Eosinophilic Endomyocardial Disease) ................................................................................. 213 Marantic Endocarditis (Nonbacterial Thrombotic Endocarditis) ............................................................................. 214 5.5 Pericardial Diseases ............................................................................................................................................................. 215 Diff erential Diagnoses and Related Diseases ................................................................................................................. 215 6 Rheumatology ................................................................................................................................................................... 2 19 6.1 Rheumatoid Arthritis .......................................................................................................................................................... 2 20 Diff erential Diagnoses and Related Diseases ................................................................................................................. 220 6.2 Ankylosing Spondylitis (Marie–Strümpell Disease) .............................................................................................. 228 Diff erential Diagnoses and Related Diseases ................................................................................................................. 231 6.3 Gout Arthritis ......................................................................................................................................................................... 232 Diff erential Diagnoses and Related Diseases ................................................................................................................. 233 6.4 CPPD and HADD .................................................................................................................................................................... 234 Calcium Pyrophosphate Dihydrate Crystal Deposition Disease .............................................................................. 234 Hydroxyapatite Crystal Deposition Disease ................................................................................................................... 235 6.5 Osteoarthritis ......................................................................................................................................................................... 237 6.6 Psoriasis and Psoriatic Arthritis ...................................................................................................................................... 241 Diff erential Diagnoses and Related Diseases ................................................................................................................. 241 6.7 Baastrup’s Disease (Spinout Process Impingement Syndrome) ...................................................................... 244 6.8 Scheuermann’s Disease (Juvenile Kyphosis Dorsalis)........................................................................................... 246 Criteria for Scheuermann’s Disease Diagnosis ............................................................................................................... 2 47 6.9 Sjögren Syndrome (Myoepithelial Sialadenitis) ..................................................................................................... 249 Criteria to Diagnose SS Include .......................................................................................................................................... 249 6.10 Behçet Disease ....................................................................................................................................................................... 252 Clinical Criteria to Diagnose BD Require a Combination of Three or More of the Following Findings..................................................................................................................................................... 252 XI Contents 6.11 Sharp Syndrome (Mixed Connective Tissue Disease) ........................................................................................... 253 6.12 Relapsing Polychondritis .................................................................................................................................................. 254 Diagnostic Criteria for Relapsing Polychondritis .......................................................................................................... 255 Diff erential Diagnoses and Related Diseases ................................................................................................................. 255 6.13 Refl ex Sympathetic Dystrophy ....................................................................................................................................... 260 6.14 Polymyalgia Rheumatica ................................................................................................................................................... 264 6.15 Systemic Lupus Erythematosus...................................................................................................................................... 266 Diff erential Diagnoses and Related Diseases ................................................................................................................. 267 7 Pulmonology ...................................................................................................................................................................... 2 73 7.1 Pleural Diseases .................................................................................................................................................................... 275 Pleural Eff usion ........................................................................................................................................................................ 275 Pneumothorax ......................................................................................................................................................................... 278 Pleural Calcifi cation ................................................................................................................................................................ 280 7.2 Alveolar Lung Diseases ...................................................................................................................................................... 282 Types of Alveolar Lung Diseases ........................................................................................................................................ 282 How to Diff erentiate Between Cardiogenic Edema from ARDS on Plain Chest Radiographs? ...................... 284 Types of Pneumonias ............................................................................................................................................................. 284 7.3 Atelectasis (Lung Collapse) .............................................................................................................................................. 287 Types of Pulmonary Atelectases ........................................................................................................................................ 287 7.4 Sarcoidosis............................................................................................................................................................................... 290 Pulmonary Sarcoidosis .......................................................................................................................................................... 291 Hepatic, Splenic, and Gastric Sarcoidosis ........................................................................................................................ 292 Dermatological Sarcoidosis ................................................................................................................................................. 292 Cardiac Sarcoidosis ................................................................................................................................................................. 293 Neurosarcoid ............................................................................................................................................................................ 293 Musculoskeletal Sarcoidosis ................................................................................................................................................ 295 Head and Neck Sarcoidosis .................................................................................................................................................. 295 Genitourinary Sarcoidosis .................................................................................................................................................... 296 7.5 Emphysema ............................................................................................................................................................................. 297 7.6 Idiopathic Interstitial Pneumonias ............................................................................................................................... 300 Idiopathic Pulmonary Fibrosis ............................................................................................................................................ 300 Nonspecifi c Interstitial Pneumonia ................................................................................................................................... 3 02 Cryptogenic Organizing Pneumonia ................................................................................................................................ 302 Respiratory Bronchiolitis-Associated Interstitial Lung Disease ................................................................................ 303 Desquamative Interstitial Pneumonia.............................................................................................................................. 303 Lymphoid Interstitial Pneumonia ...................................................................................................................................... 303 Acute Interstitial Pneumonia (Hamman–Rich Syndrome) ......................................................................................... 304 7.7 Histiocytoses .......................................................................................................................................................................... 304 Langerhans Cell Histiocytosis ............................................................................................................................................. 305 Infection-Associated Hemophagocytic Syndrome ...................................................................................................... 307 Omenn Syndrome .................................................................................................................................................................. 307 Chédiak–Higashi Disease ..................................................................................................................................................... 307 Diff erential Diagnoses and Related Diseases ................................................................................................................. 307 Rosai–Dorfman’s Disease (Sinus Histiocytosis).............................................................................................................. 308 Xanthoma Disseminatum (Montgomery Syndrome) .................................................................................................. 308 Erdheim–Chester Disease (Lipogranulomatosis) .......................................................................................................... 309 7.8 Hemoptysis ............................................................................................................................................................................. 310 Bronchopulmonary Sequestration .................................................................................................................................... 311 Anomalous Systemic Artery Supplying Normal Lung Parenchyma ....................................................................... 312 Pulmonary Vasculitis .............................................................................................................................................................. 312 Cardiac Bronchus .................................................................................................................................................................... 314 Dieulafoy Disease.................................................................................................................................................................... 314 7.9 Cystic Fibrosis (Mucoviscidosis) ..................................................................................................................................... 315 Pulmonary Manifestations of Cystic Fibrosis ................................................................................................................. 315 Nasal and Sinus Manifestations of Cystic Fibrosis ........................................................................................................ 316