Number 1 Editorial J. Rello, E. Quintana, B. Mirelis, M. Gurgui, J. Boldt, B. Zickmann, M. Benson, E. Schindler, M.R. Pinsky A. Net, G. Prats F. Dapper, G. Hempelmann The role of the right ventricle in determining Polymicrobial bacteremia in critically ill Does platelet size correlate with function in cardiac output in the critically ill 1 patients 22 patients undergoing cardiac surgery? 44 Originals B. Riou, A. Berdeaux, E. Pussard, M. J. Chapman, J.L. Moran, M.S. O’Fathartaigh, G. Red, P. Germann, H. Plattner, A. Hammerle J.-F. Giudicelli A.R. Peisach, D.N. Cunningham Right ventricular function in early septic shock Comparison of the hemodynamic effects Management of atrial tachyarrhythmias in states 3 of hydroxocobalamin and cobalt edetate at the critically ill: a comparison of intravenous equipotent cyanide antidotal doses in procainamide and amiodarone 48 T. Imai, M. Uchiyama, N. Maruyama, D. Yoshikawa, T. Fujita conscious dogs 26 Case reports Influence of constant sustained positive R. Fernandez, L. Blanch, A. Artigas C. Soravia, J.-A. Romand, M. Herrmann, airway pressure on right ventricular Inflation static pressure-volume curves of the J.-C. Chevrolet, B. Ricou, P.M. Suter performance 8 total respiratory system determined without any Group AB -haemolytic streptococcus instrumentation other than the mechanical septicaemia: the toxic strep syndrome 53 G.L.Chelucci, S. Boncinelli, M. Marsili, ventilator 33 F. Adlerfliegel, M. Leeman, Ph. Demaeyer, P. Lorenzi, A. Allegra, M. Linden, A. Chelucci, R. J. Kahn V. Merciai, F. Cresci, C. Rostagno, G. F. Gensini, G.R. Pesola, |. Akhavan, A. Madu, N.K. Shah, Sotalol poisoning associated with asystole 57 A. Lockhart, J. Milic-Emili G.C.Carlon Aspirin effect on early and late changes in acute Prediction equation estimates of creatinine Correspondence 59 lung injury insheep 13 clearance in the intensive care unit 39 Book review 60 Number 2 Editorial Originals H.M.Oudemans-van Straaten, G. J. Scheffer, G. Simbruner, J. Pfenninger D. Kietzmann, R. Kahl, M. Miller, H.B urchardi, L. Eysman, Ch. R. H. Wildevuur Neonatal and pediatric intensive care - anew D. Kettler Oxygen consumption after cardiopulmonary section in Intensive Care Medicine 61 Hydrogen peroxide in expired breath bypass — implications of different measuring Neonataalnd pediatric intensive care condensate of patients with acute respiratory methods 105 J. Tibballs failure and with ARDS 78 Bicarbonate and haemodynamicsinneonates 63 Brief reports T. lijima, R. Bauer, K.-A. Hossmann B. Roth, P.O. Grande, P. Nilsson-Ehle, |. Eliasson S. Fanconi, R. Burger, D. Ghelfi, J. Uehlinger, Brain resuscitation by extracorporeal Possible role of short-term parenteral nutrition A. Arbenz circulation after prolonged cardiac arrest in with fat emulsions for development of Hemodynamic effects of sodium bicarbonate in cats 82 haemophagocytosis with multiple organ failure critically illneonates 65 in a patient with traumatic brain injury 111 K. Tsuno, H. Terasaki, T. Otsu, T. Okamoto, M. J. Ball Y. Sakanashi, T. Morioka Parenteral nutrition in the critically ill: F.G. Lemesle, J.C. Gris, J. F. Schwed, C. Arich Newborn extracorporeal lung assist using a use of a medium chain triglyceride Rapid recovery of acquired purpura fulminans in novel double lumen catheter and a heparin- emulsion 89 a patient with familial C4DBP deficiency 115 bonded membrane lung 70 L.1.G. Worthley Forum A. Martinot, V. Hue, F. Leclerc, L. Vallee, Bronchial electrocardiography to determine C. Franklin SM.u dCdleosns edte, atJh. P.r ePvreuavloi ng Chiari type 1 left or right main bronchial placement of an Basic concepts and fundamental issues in endotracheal suction catheter tip 96 technology assessment 117 malformation in two children 73 M. Berner, M. Beghetti, B. Ricou, J.C. Rouge, F. Schneider, Ph. Lutun, A. Couchot, P. Bilbault, Correspondence 122 R. Prétre, B. Friedli J.D. Tempé Relief of severe pulmonary hypertension after Plasma cyclic guanosine 3'-5'monophosphate Book reviews 125 closure of a large ventricular septal defect using concentrations and low vascular resistance in low dose inhaled nitric oxide 75 human septic shock 99 Announcements 126 Number 3 Editorial E. M. Redi-Wenzi, C. Armbruster, G. Edelmann, Brief reports W.A. Knaus E. Fischi, M. Kolacny, A. Wechsler-Férdés, T. Takahara, C. Terai, Y. Okada, K. Mimura, Organ system dysfunction and risk P. Sporn M. Mukaida prediction 127 The effects of norepinephrine on hemodynamics Fatal traumatic subarachnoid hemorrhage due and renal function in severe septic shock to rupture of the vertebral artery 172 Review article J.W. Christman, R. W. McCain states 151 J.-P. Barras, P. Bigler, A. Czerniak Asensible approach to the nutritional support S. Walther, |. Jansson, S. Berg, L. Olsson Rex, Arare complication of the use of a finger cot to of mechanically ventilated critically ill S.Lennquist protect the cuff of a tracheal tube during patients 129 Corticosteroid by aerosol in septic pigs — effects nasotracheal intubation 174 on pulmonary function andoxygentransport 155 L. Fogli, P. Gorini, S. Belcastro Originals Conservative management of traumatic J.-¥. Fagon, J. Chastre, A. Novara, P. Medioni, A.Kropec, J. Huebner, M. Riffel, U. Bayer, chylothorax: acase report 176 C. Gibert A. Benzing, K. Geiger, F.D. Daschner Characterization of intensive care unit patients Exogeneous or endogeneous reservoirs of Expert panel report using a model based on the presence or nosocomial Pseudomonas aeruginosa and A.R. Aitkenhead, L. H. Booij, J. F. Dhainaut, absence of organ dysfunctions and/or infection: Staphylococcus aureus infections in a surgical K. Geiger, H. Haljamae, P.D. Lumb, the ODIN model 137 intensive care unit 161 W.B. Runciman, P.M. Suter, J.L. Vincent International standards for safety in the ICU. G. Guerrero Lopez, G. Vazquez Mata, M. Sydow, H. Burchardi, J. Zinserling, Developed by the International Task Force on A. Reina Toral, |. Rodriguez Bailén, Th. A. Crozier, T. Denecke, S. Zielmann Safety in the Intensive Care Unit 178 E. Fernandez Mondéjar, P. Aranegui Lasuen Intrinsic PEEP determined by static pressure- Thrombolytic treatment for massive thrombosis volume curves — application of a novel Correspondence 182 of prosthetic cardiac valves 145 automated occlusion method 166 Announcements 160 Number 4 Editorial D. Georgopoulos, E. Giannouli, D. Patakas Brief reports P. T. Schumacker Effects of extrinsic positive end-expiratory J. Schilling, M. Cakmakci, U. Battig, Pulmonary edema, shunt and blood flow pressure on mechanically ventilated patients S. Geroulanos distribution. Problems, progress and with chronic obstructive pulmonary disease and Anew approach in the treatment of hypotension perspectives 183 dynamic hyperinflation 197 in human septic shock by N°-monomethyI- L-arginine, an inhibitor of the nitric acid Originals K.L. Yang synthetase 227 F. Fredén, |. Cigarini, F. Mannting, Inspiratory pressure/maximal inspiratory A. Hagberg, F. Lemaire, pressure ratio: a predictive index of weaning K. Maruyama, Y. Setoguchi, J. Maruyama, G. Hedenstierna outcome 204 T. Shimizu, H. Chikusa, M. Takeuchi, Y. Ogihara, oDuetppeunt deinn ucnei loobfa rs huonleti c ona cicda rdeidaecm a A. Frutiger, J. X. Brunner MIn.t rMautnheecyaulk ii njection of high-dose meglumine Distribution of ventilation and Computerized blood gas interpretation as tool amidotrizoate with complete recovery 232 for classroom andiCU 209 perfusion 185 W. Lorz, Chr. Cottier, E. imhof, N. Gyr C.L.de Champs, D. P. Gueion, FH.. KRoonmramde,l ,R . MW.a gGneoerrg,i eBf.f Neumeister, Multiple organ failure and coma as initial R.M. Garnier, M.C. Poupart, Studies on drug monitoring in thrice and once pparteiseenntt awtiitohn muolf tpiphleeo cenhdroocmroicney tnoemoap laisn iaa OJ..L .Y . SMiaronts oor, F. L. Dissait, daily treatment with aminoglycosides 215 (MEN) type IIA 235 Selective digestive decontamination by A.C. Day, A.P.N. Rankin, J.A. Judson Correspondence 239 erythromycin-base in a polyvalent intensive Grading asthma severity: using the APS care unit 191 component of the Apache lisystem 221 Announcements 242 Number 5 Neonatal and pediatric intensive care G. Nardi, U. Valentinis, A. Proietti, A.D e Monte, S. V. Baudouin, J. Wiggins, B. F. Keogh, J. Pfenninger A. Di Silvestre, R. Muzzi, R. Peressutti, C.J. Morgan, T. W. Evans Neurological intensive care in children 243 M.G. Troncon, F. Giordano Continuous veno-venous haemofiltration Epidemiological impact of prolonged following cardio-pulmonary bypass. J. Pfenninger, Ch. Aebi systematic use of topical SDD on bacterial Indications and outcome in 35 patients 290 Respiratory response to salbutamol (albuterol) in colonization of the tracheobronchial ventilator-dependent infants with chronic lung tree and antibiotic resistance. A three year U.M. Ingwersen, K. Richter Larsen, disease: pressurized aerosol delivery versus study 273 M. Thodberg Bertelsen, K. Kiil-Nielsen, intravenous injection 251 M. Laub, J. Sandermann, K. Bach, OS.r iCghienvarles t, M.H emmer, J. Carlet, M.L anger JL.. JM.i eLra,n oDr.e ,D reKy.f Dujsesd,a inBi. ,D aPr.c Wheyb,e r, P. Brun, HT.h rHeaen sdiefnf erent mask physiotherapy regimens and the European Cooperative Group on FI.s Cpoensitcei llin G an adequate initial treatment fcoorm pplriecvaenttiioonns oaff tpeor shte-aorpte raantdi vep ulpmuolnmaornya ry Nosocomial Pneumonia for aspiration pneumonia? A prospective surgery 294 Incidence and risk factors of pneumonia acquired in intensive care units. Results from a multicenter evaluation using a protected specimen brush C.-O. Pirttikangas, J. Perttila, M. Salo prospective study on 996 patients 256 and quantitative cultures 279 Propofol emulsion reduces proliferative responses of lymphocytes from intensive D. Pittet, B. Thiévent, R. P. Wenzel, N. Li, L. Marty, A. Flahault, B. Suarez, J. Caillon, C. Hill, care patients 299 G.Gurman, P.M. Suter A. Andremont importance of pre-existing co-morbidities Resistance to methicillin and virulence of Correspondence 303 for prognosis of septicemia in critically ill Staphylococcus aureus strains in bacteriemic patients 265 cancer patients 285 Announcements 306 Number 6 Editorials R. Bellomo, H. Teede, N. Boyce M. Croci, A. Elena, M. Soica C. Franklin Anticoagulant regimens in acute Performance of a hydrophobic heat and Elm Road and Hillsborough: tragedy, the law continuous hemodiafiltration: a comparative moisture exchanger at different ambient and medicine 307 study 329 temperatures 351 Ch. F. Bolton G.H. Sigurdsson, H.A. F. Youssef, D. Lichtenstein, O. Axier Neuromuscular abnormalities in critically ill A. Banic Intensive use of general ultrasound in the patients 309 Effects of ketoprofen on respiratory intensive care unit. Prospective study of and circulatory changes in endotoxic 150 consecutive patients 353 Review articles shock 333 F. Vandenesch, B. Lina, Ch. Lebeau, E. Spencer, C. Pycock, J. Lytle Th. B. Greenland, J. Etienne Brief reports Phaeochromocytoma presenting as Epidemiologicai markers of coagulase- T. Vassal, N.G.D. Anh, J. B. Gabillet, B. Guidet, acute circulatory collapse and abdominal negative staphylococci 311 F. Staikowsky, G. Offenstadt pain 356 Prospective evaluation of self-extubations in D. Teres a medical intensive care unit 340 M. Seyr, W. Hasibeder, W. Furtwaengler, Trends from the United States with end of life H. Antretter, N. J. Mutz decisions in the intensive care unit 316 D. Balogh, E. Kittinger, A. Benzer, Multiple organ failure after mitral valve J.M. Hackl repair with intravascular hemolysis Originals Noise intheICU 343 and its recovery due to mitral valve J.H. Coakley, K.N agendran, M. Honavar, replacement 358 C.J. Hinds Ch. Santré, O. Leroy, M. Simon, H. Georges, Preliminary observations on the neurcmuscular B. Guery, C. Beuscart, G. Beaucaire Correspondence 361 abnormalities in patients with organ failure and Pharmacokinetics of vancomycin during sepsis 323 continuous hemodiafiltration 347 Announcements 364 Number 7 Editorials J.J. Rouby, T. Lherm, E. Martin de Lassale, M.E. Berner, M. Cauderay, P.M. Suter G. Hedenstierna P. Poéte, L. Bodin, J. F. Finet, P. Callard Assessment of lung volume and alveolar The recording of FRC — is it of importance and Histologic aspects of pulmonary barotrauma pressure during combined high-frequency jet can it be made simple? 365 in critically ill patients with acute respiratory ventilation in a child with adult respiratory failure 383 distress syndrome 411 CM.i cBrroubnio-lBougiiscsaoln diagnosis of ventilator- RP.. GF. .DJeo reJnosn,g h,F. JW. .v aAn. DOev erBavcekledr , R. Mohan, CDl.é tRyo,s siF., WeJ.s ed,e VFi.l lVee ydec kGeomyaents,, S.P .C Clleampeunytt , de associated pneumonia: to direct or not to Angiotensin-converting enzyme activity in D. Moulin direct samplings? 367 serum and bronchoalveolar lavage fluid after Management of intra-abdominal organ damage to the alveolo-capillary barrier in the injury following blunt abdominal trauma in A.S. Slutsky humanlung 390 children 415 Barotrauma and alveolar recruitment 369 M. Kristiansson, M. Soop, L. Saraste, K.-G. Sundavist B. Schmitt, B. Simma, R. Burger, Originals Post-operative circulating cytokine patterns — G. Dumermuth R. Fretschner, H. Deusch, A. Weitnauer, the influence of infection 395 Resuscitation after severe hypoxia in a young J.X. Brunner child: temporary isoelectric EEG and loss of Asimple method to estimate functional Neonatal and pediatric intensive care BAEP components 420 residual capacity in mechanically ventilated A. Piotrowski Comparison of atracurium and pancuronium in Technique patients 372 mechanically ventilated neonates 401 H. Stjernstr6ém, T. Karisson, U. Ungerstedt, L. Hillered R. Jorda, F. Parras, J. ibafiez, J. Reina, A. Pardou, D. Vermeylen, M. F. Muller, Chemical monitoring of intensive care patients J. Bergada, J.M.Raurich D. Detemmerman using intravenous microdialysis 423 Diagnosis of nosocomial pneumonia High-frequency ventilation and conventional in mechanically ventilated patients mechanical ventilation in newborn babies with Correspondence 429 by the blind protected telescoping respiratory distress syndrome: a prospective, catheter 377 randomized trial 406 Announcements 419 Number 8 Editorials R. Fernandez, LI. Blanch, J. Valles, F. Baigorri, A. Delhumeau, X. Moreau, C. Chapotte, L. Brochard A. Artigas N. Houi, J.C. Bigorgne Non-invasive ventilation: practical issues 431 Pressure support ventilation via face mask in Heparin-associated thrombocytopenia acute respiratory failure in hypercapnic COPD syndrome: an underestimated etiology of W. Zapol patients 456 adrenal hemorrhage 475 Minidose inhaled nitirc oxide: less is better 433 M. Chiaranda, L. Verona, O. Pinamonti, G.G.Collee, D. M. Lomax, C. Ferguson, Review article L. Dominioni, G. Minoja, G. Conti G.C. Hanson D.K. Heyland, D. J.C ook, G.H. Guyatt Use of heat and moisture exchanging (HME) Bedside measurement of intra-abdominal Enteral nutrition in the critically ill patient: a critical review of the evidence 435 filters in mechanically ventilated ICU patients: pressure (IAP) via an indwelling naso- influence on airway flow-resistance 462 gastric tube: clinical evaluation of the Originals technique 478 H. Gerlach, D. Pappert, K. Lewandowski, M. Sydow, T.A. Crozier, S. Zielmann, J. Radke, R. Rossaint, K. J. Falke H. Burchardi Correspondence 481 Long-term inhalation with evaluated low doses High-dose intravenous magnesium sulfate of nitric oxide for selective improvement of in the management of life-threatening status Announcements 449 oxygenation in patients with adult respiratory asthmaticus 467 distress syndrome 443 List ofreferees 483 Brief reports M. Vitacca, F. Rubini, K. Foglio, S. Scaivini, T. Kasai, T. Nakatani, K. Hirosawa, Author index 484 S. Nava, N. Ambrosino K. Kobayashi Non-invasive modalities of positive pressure Benign stricture of the extra-hepatic bile duct Subject index 486 ventilation improve the outcome of acute following hepatectomy for traumatic hepatic exacerbations in COLD patients 450 rupture 472 Contents of Volume 19 Supplement 1 Inhibitor substitution in septicemia Guest editors: A. Artigas, Sabadell; C.E. Hack, Amsterdam Editorial L.G. Thijs, J. P.d e Boer, M.C.M.de Groot, C.E. Hack, A.C. Ogilvie, B. Eisele, C.E. Hack C.E. Hack A. J.M. Eerenberg, J. Wagstaff, L.G. Thijs Inhibitor substitution insepsis S 1 Coagulation disorders in septic C1-inhibitor substitution therapy in septic shock shock S8 and in the vascular leak syndrome induced by Originals high doses of interleukin-2 S19 N. Sala, J. Fontcuberta, M. LL. Rutllant H.-P. Schuster New biological concepts on coagulation AT Ill in septicemia with E. F. Mammen inhibitors S3 DIC $16 Perspectives for the future S29 Supplement 2 Neuromuscular blocking agents in Intensive Care Guest editors: B.J. Pollard; J. F. Bion J. F. Bion, B. J.P ollard R. J. M. Ross, J. Rodriguez-Arnao, J. Bentham, N. J. N. Harper Neuromuscular blocking drugs in the Intensive J.H. Coakley Neuromuscular blocking drugs: practical Care Unit: Introductory remarks S 35 The role of insulin, growth hormone and IGF-I as aspects of research in the Intensive Care anabolic agents in the critically ill S 54 Unit S80 B. J. Pollard Neuromuscular blocking agents in intensive C.F. Bolton B. J. Pollard care S36 Neuromuscular complications of sepsis S 58 Which drug — steroid or benzylisoquinolinium? S 86 M. J. Murray, R. A. Strickland, C. Weiler M. Aubier J.M. Hunter The use of neuromuscular blocking drugs in the Respiratory muscles: working or wasting? S 64 Atracurium and laudanosine pharmacokinetics intensive Care Unit: AUS perspective S 40 in acute renal failure S91 F. Lemaire W.C. Bowman Difficult weaning S 69 J.F. Bion, M. 1. Bowden, B. Chow, L. Honisberger, Physiology and pharmacology of B.C. Weatherley neuromuscular transmission, with special J. Viby-Mogensen Atracurium infusions in patients with reference to the possible consequences of Monitoring neuromuscular function in the fulminant hepatic failure awaiting liver prolonged blockade S 45 Intensive Care Unit S 74 transplantation S94