M. Elena Renda · Miroslav Bursa Andreas Holzinger · Sami Khuri (Eds.) Information Technology 7 6 in Bio- and 2 9 S C Medical Informatics N L 6th International Conference, ITBAM 2015 Valencia, Spain, September 3–4, 2015 Proceedings 123 Lecture Notes in Computer Science 9267 Commenced Publication in 1973 Founding and Former Series Editors: Gerhard Goos, Juris Hartmanis, and Jan van Leeuwen Editorial Board David Hutchison Lancaster University, Lancaster, UK Takeo Kanade Carnegie Mellon University, Pittsburgh, PA, USA Josef Kittler University of Surrey, Guildford, UK Jon M. Kleinberg Cornell University, Ithaca, NY, USA Friedemann Mattern ETH Zurich, Zürich, Switzerland John C. Mitchell Stanford University, Stanford, CA, USA Moni Naor Weizmann Institute of Science, Rehovot, Israel C. Pandu Rangan Indian Institute of Technology, Madras, India Bernhard Steffen TU Dortmund University, Dortmund, Germany Demetri Terzopoulos University of California, Los Angeles, CA, USA Doug Tygar University of California, Berkeley, CA, USA Gerhard Weikum Max Planck Institute for Informatics, Saarbrücken, Germany More information about this series at http://www.springer.com/series/7409 M. Elena Renda Miroslav Bursa (cid:129) Andreas Holzinger Sami Khuri (Eds.) (cid:129) Information Technology in Bio- and Medical Informatics 6th International Conference, ITBAM 2015 – Valencia, Spain, September 3 4, 2015 Proceedings 123 Editors M.Elena Renda Andreas Holzinger Institute of Informatics andTelematics Medical University Graz Pisa Graz Italy Austria Miroslav Bursa Sami Khuri Czech TechnicalUniversity inPrague SanJose State University Prague SanJose, CA Czech Republic USA ISSN 0302-9743 ISSN 1611-3349 (electronic) Lecture Notesin Computer Science ISBN 978-3-319-22740-5 ISBN978-3-319-22741-2 (eBook) DOI 10.1007/978-3-319-22741-2 LibraryofCongressControlNumber:2015945607 LNCSSublibrary:SL3–InformationSystemsandApplications,incl.Internet/Web,andHCI SpringerChamHeidelbergNewYorkDordrechtLondon ©SpringerInternationalPublishingSwitzerland2015 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthe material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynow knownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublication doesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevant protectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthisbookare believedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsortheeditors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissionsthatmayhavebeenmade. Printedonacid-freepaper SpringerInternationalPublishingAGSwitzerlandispartofSpringerScience+BusinessMedia (www.springer.com) Preface Biomedical engineering and medical informatics represent challenging and rapidly growingareas.Applicationsofinformationtechnologyintheseareasareofparamount importance. Building on the success of ITBAM 2010, ITBAM 2011, ITBAM 2012, ITBAM 2013, and ITBAM 2014, the aim of the sixth ITBAM conference was to continue bringing together scientists, researchers, and practitioners from different dis- ciplines, namely, from mathematics, computer science, bioinformatics, biomedical engineering,medicine,biology,anddifferentfieldsoflifesciences,sotheycanpresent and discuss their research results in bioinformatics and medical informatics. We hope that ITBAM will continue serving as a platform for fruitful discussions between all attendees, where participants can exchange their recent results, identify future direc- tions and challenges, initiate possible collaborative research, and develop common languagesforsolvingproblemsintherealmofbiomedicalengineering,bioinformatics, and medical informatics. The importance of computer-aided diagnosis and therapy continues to draw attention worldwide and has laid the foundations for modern med- icine with excellent potential for promising applications in a variety offields, such as telemedicine, Web-basedhealthcare, analysisof genetic information, and personalized medicine. Following a thorough peer-review process, we selected nine long papers for oral presentation and two short papers for poster session for the sixth annual ITBAM conference. The organizing committee would like to thank the reviewers for their excellent job. The articles can be found in the proceedings and are divided into the following sections: Medical Terminology and Clinical Processes and Machine Learning in Biomedicine. The papers show how broad the spectrum of topics in applications of information technology to biomedical engineering and medical infor- matics is. The editors would like to thank all the participants for their high-quality contribu- tions and Springer for publishing the proceedings of this conference. Once again, our special thanks go to Gabriela Wagner for her hard work on various aspects of this event. June 2015 M. Elena Renda Miroslav Bursa Andreas Holzinger Sami Khuri Organization General Chair Christian Böhm University of Munich, Germany Program Committee Co-chairs Miroslav Bursa Czech Technical University Prague, Czech Republic Andreas Holzinger Medical University Graz, Austria Sami Khuri San José State University, USA M. Elena Renda IIT - CNR, Pisa, Italy, Honorary Chair Program Committee Werner Aigner FAW Tatsuya Akutsu Kyoto University, Japan Andreas Albrecht Queen’s University Belfast, UK Peter Baumann Jacobs University Bremen, Germany Veselka Boeva Technical University of Plovdiv, Bulgaria Roberta Bosotti Nerviano Medical Science s.r.l., Italy Miroslav Bursa Czech Technical University, Czech Republic Christian Böhm University of Munich, Germany Rita Casadio University of Bologna, Italy Sònia Casillas Universitat Autònoma de Barcelona, Spain Kun-Mao Chao National Taiwan University Vaclav Chudacek CzechTechnicalUniversityinPrague,CzechRepublic Hans-Dieter Ehrich Technical University of Braunschweig, Germany Christoph M. Friedrich University of Applied Sciences Dortmund, Germany Alejandro Giorgetti University of Verona, Italy Jan Havlik CzechTechnicalUniversityinPrague,CzechRepublic Volker Heun Ludwig-Maximilians-Universität München, Germany Larisa Ismailova NRNU MEPhI, Moscow, Russia Alastair Kerr University of Edinburgh, UK Sami Khuri San Jose State University, USA Michal Krátký Technical University of Ostrava, Czech Republic Vaclav Kremen CzechTechnicalUniversityinPrague,CzechRepublic Jakub Kuzilek Czech Technical University, Czech Republic Gorka Lasso CICbioGUNE Lenka Lhotska Czech Technical University, Czech Republic Roger Marshall Plymouth State University, USA Elio Masciari ICAR-CNR, Università della Calabria, Italy VIII Organization Erika Melissari University of Pisa, Italy Henning Mersch RWTH Aachen University, Germany Jean-Christophe Nebel Kingston University, UK Vit Novacek National University of Ireland, Galway Cinzia Pizzi Università degli Studi di Padova, Italy Clara Pizzuti Institute for High Performance Computing and Networking (ICAR)-National Research Council (CNR), Italy Nicole Radde Universität Stuttgart, Germany Maria Elena Renda CNR-IIT, Italy Stefano Rovetta University of Genoa, Italy Huseyin Seker De Montfort University, Uk Jiri Spilka CzechTechnicalUniversityinPrague,CzechRepublic Kathleen Steinhofel King’s College London, UK Karla Stepanova Czech Technical University, Czech Republic Roland R. Wagner University of Linz, Austria Viacheslav Wolfengagen Institute JurInfoR-MSU Borys Wrobel Polish Academy of Sciences, Poland Filip Zavoral Charles University in Prague, Czech Republic Songmao Zhang Chinese Academy of Sciences, China Qiang Zhu The University of Michigan, UK Contents Medical Terminology and Clinical Processes From Literature to Knowledge: Exploiting PubMed to Answer Biomedical Questions in Natural Language. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Pinaki Bhaskar, Marina Buzzi, Filippo Geraci, and Marco Pellegrini Using Twitter Data and Sentiment Analysis to Study Diseases Dynamics. . . . 16 Vincenza Carchiolo, Alessandro Longheu, and Michele Malgeri An Open Data Approach for Clinical Appropriateness. . . . . . . . . . . . . . . . . 25 Mario A. Bochicchio, Lucia Vaira, Marco Zappatore, Giambattista Lobreglio, and Marilena Greco Machine Learning in Biomedicine A Logistic Regression Approach for Identifying Hot Spots in Protein Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Peipei Li and Keun Ho Ryu The Discovery of Prognosis Factors Using Association Rule Mining in Acute Myocardial Infarction with ST-Segment Elevation . . . . . . . . . . . . . 49 Kwang Sun Ryu, Hyun Woo Park, Soo Ho Park, Ibrahim M. Ishag, Jang Hwang Bae, and Keun Ho Ryu Data Mining Techniques in Health Informatics: A Case Study from Breast Cancer Research. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 Jing Lu, Alan Hales, David Rew, Malcolm Keech, Christian Fröhlingsdorf, Alex Mills-Mullett, and Christian Wette Artificial Neural Networks in Diagnosis of Liver Diseases. . . . . . . . . . . . . . 71 JoséNeves,AdrianaCunha,AnaAlmeida,AndréCarvalho,JoãoNeves, António Abelha, José Machado, and Henrique Vicente How to Increase the Effectiveness of the Hepatitis Diagnostics by Means of Appropriate Machine Learning Methods. . . . . . . . . . . . . . . . . . . . . . . . . 81 Alexandra Lukáčová, František Babič, Zuzana Paraličová, and Ján Paralič Ant-Inspired Algorithms for Decision Tree Induction: An Evaluation on Biomedical Signals. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Miroslav Bursa and Lenka Lhotská X Contents Poster Session Microsleep Classifier Using EOG Channel Recording: A Feasibility Study. . . 109 Martin Holub, Martina Šrutová, and Lenka Lhotská Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115