InHammation: Mechanisms and Treatment Proceedings of an International Meeting on Future Trends in Inflammation IV Organized by The European Biological Research Association under the auspices of The Royal Society of Medicine The Arthritis and Rheumatism Council The European League Against Rheumatism The Pathological Society of Great Britain & Ireland The British Immunology Society The British Pharmacology Society Held at the Royal College of Surgeons of England, 35-43 Lincolns Inn Fields, London WC2 3PN, 18th-22nd February 1980. InHammation: Mechanisms and Treatment Proceedings of the Fourth International Meeting on Future Trends in Inflammation Organized by the European Biological Research Association and held in London, 18th-22nd February 1980 Edited by D. A. Willoughby Professor, Department of Experimental Pathology and Rheumatology, St Bartholomew's Hospital, London 1. P. Giroud Professor, Department of Pharmacology, H6pital Cochin, Paris ~ MTP ~R ~SS LI M ITED /nter/wtiOlwl Mediad PI/bli her Published by MTP Press Limited Falcon House Lancaster, England Copyright © 1980 MTP Press Limited Softcover reprint ofthe hardcover 1st edition 1980 First Published 1980 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers. British Library Cataloguing in Publication Data International Meeting on Future Trends in Inflammation, 4th, London, 1980 Inflammation. 1. Inflammation - Congresses I. Title II. Willoughby, Derek Albert III. Giroud, J P IV. European Biological Research Association 616.07'2 RB131 ISBN-13: 978-94-010-9425-2 e-ISBN-13: 978-94-010-9423-8 DOl: 10.1007/978-94-010-9423-8 Contents ListoJContributors xvii Preface xxxiii SECTION I: FUTURE TRENDS Chairman: L. Chedid; Co-Chairman: Dame Honor Fell 1 The participation of mononuclear phagocytes in immune based inflammatory processes with special reference to their secretory responses P. Davies and R. J. Bonney 3 Discussion 2 Future trends in mechanisms of cartilage destruction (Abstract) J. T. Dingle 11 Discussion 3 New developments in leukocyte chemotaxis research: a survey P. C. Wilkinson 15 Discussion 4 Future trends in free radical studies W.Huber 27 Discussion 5 Future trends in the immunopathology of rheumatoid arthritis M.Ziff 43 Discussion 6 Future trends in anti-rheumatic drugs E. C. Huskisson 55 Discussion v INFLAMMATION: MECHANISMS AND TREATMENT SECTION II: REVIEW OF CURRENT DEVELOPMENTS Chairman: J. L. Turk; Co-Chairman: E. Munthe 7 A review of mechanism of action of steroid and non-steroid anti-inflammatory drugs S. Tsurufuji,K. Sugio, H. SatoandK. Ohuchi 63 Discussion 8 Review of immunotherapy in rheumatoid arthritis E. M. VeysandH. Mielants 79 Discussion 9 Crystal deposition disease G. Faure,A. Gaucher, P. Netter,J. PourelandJ. Duheille 99 Discussion 10 T-cell dependent inflammatory responses J.F.A.P.Miller 107 Discussion 11 Arachidonic acid peroxidation in inflammation and its inhi bition as a mechanism for anti-inflammatory activity G. A. Higgs and K. E. Eakins 115 12 GeneralDiscussion 129 SECTION III: ANTI-INFLAMMATORY AND ANTI-RHEUMATIC AGENTS Chairman: D. A. Willoughby; Co-Chairman: C. J. Dunn 13 Review of pathogenesis of adjuvant arthritis and its relation to rheumatoid arthritis (Abstract) C. M. PearsonandY.-H. Chang 133 14 The anti-inflammatory activity of aspirin: the active metabolite M.J.H.Smith 135 15 Indomethacin-sodium salicylate combinationiRGH-6705 as a new possibility in the treatment of inflammation (Abstract) E. Ezer, G. T. Hajos and L. Szporny 141 16 Tropesin: a new potential anti-rheumatic ester of indometacin J. Grimova, L. Fisnerova, Z. Roubal, J. Nemec, Z. TrnavskaandO. Nemecek 143 17 Development of an Arthus-like model of induced inflammation and its use in the anti-inflammatory characterization of orgotein (bovine Cu-Zn superoxide dismutase) L.D. Williams,M.G.Saifer,P.H.-C.DangandW.Huber 149 18 The inhibition of macrophage accumulation in rats following injection of complete Freund's adjuvant (Abstract) M.J. Thomson,A. P. GreenandF. R. Mangan 157 vi CONTENTS 19 Possible synergism between ovariectomy and oestradiol in preventing Freund's adjuvant arthritis in the rat A. Sfikakis, K. Karamanis, Ch. Laiou, P. Sfikakis and D. Varonos 159 20 Anti-inflammatory actions of an immunomodulator: therafectin 1 ,2-0-isopropylidene-3-0-3'-(N' ,N'-dimethlyamino n-propyl)-D-gluco-furanose, HCl P. Gordon 169 21 Effects of benoxaprofen on macrophage function (Abstract) G. W. Civil, D. Hillman, E. A. Kitchen, S. C. R. Meacock andW.Dawson 181 22 Some 'anti-arthritic' properties of an oversulphated glycos aminoglycan in degenerative joint disease G. Verbruggen,E.M. Veys,F. P. LuytenandS. S. Suykens 183 23 Anti-arthritic properties of ICI 55897 ('Clozic') (Abstract) M. E. J. Billingham 193 24 Effect of ICI 55897 ('Clozic'), indomethacin and dexamethas- one on collagenase and prostaglandin production by cultured rheumatoid synovial tissue (Abstract) D. E. Woolley, S. J. Gadher, S. J. Foster and M. E. J. Bill- ingham 195 25 The use of thymopoietin as an anti-inflammatory agent (Abstract) A. D. Sedgwick, P. A. Thrower, D. A. Willoughby and E. C. Huskisson 197 26 Production of hydrogen peroxide from neutrophils of rats (Abstract) E. M. Glenn,B.J. BowmanandN.A. Rohloff 199 27 Effects of D-penicillamine on granulation tissue and connective tissue of skin, aorta and bone in rats (Abstract) lb. LorenzenandP. Junker 201 28 D-penicillamine in rheumatoid arthritis: fixed versus variable regimes D. R. Blake,E. F. J. Ring,R. C. BucknallandP. A. Bacon 203 29 Effects of anti-inflammatory drugs on polymorphonuclear leukocyte aggregation (Abstract) F.M.CunninghamandM.J.H.Smith 209 30 Aggregation of rat polymorphonuclear leukocytes in vitro by chemotactic factors (Abstract) M. E. Shipley,F. M. CunninghamandM.J. H. Smith 211 Vll INFLAMMATION: MECHANISMS AND TREATMENT 31 Preliminary report on the effect of a new derivative of acetyl salicylic acid on tissue-algogen component due to damaging stimulation of cutis L. Vecchiet, O. Pontano, G. Obletter and L. Carratelli 213 Discussion SECTION IV: PHARMACOLOGICAL MEDIATORS Chairman: G. P. Lewis; Co-Chairman: P. Bacon 32 Changes in the inflammatory mediator content in the colonic mucosae of immune colitides in guinea pigs (Abstract) I. J. Zeitlin, A. A. NorrisandA. J. Lewis 235 33 Simultaneous continuous monitoring of blood volume and per meability in rabbit synovium: action of histamine H.A.AI-HaboubiandL.J.Zeitlin 237 34 Leukotriene B: a biologically active release product of poly morphonuclear leukocytes A. W. Ford-Hutchinson, M. A. Bray, M. E. Shipley, M. V. DoigandM.J.H.Smith 241 35 Arachidonic acid metabolism by lipoxygenase in leukocytes of different species and the chemokinetic activity of some products (Abstract) R. M. J. Palmer, J. A. Salmon, S. N arumiya, G. A. Higgs and K. E. Eakins 249 36 Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carra- geenin pleural exudates (Abstract) M. I. Siegel, R. T. McConnell, N. A. Porter, J. L. Selph, J. E. Truax, R. Vinegar and P. Cuatrecasas 251 37 The possible role of divalent cations, microtubules and cyclic nucleotides in lymphokine induced macrophage aggregation P. Badenoch-Jones,B. RouveixandJ. L. Turk 253 38 Inhibitory effect of benoxaprofen and BW 755C on rabbit PMN leukocyte lipoxygenase (Abstract) 1.R.WalkerandW.Dawson 259 39 Mechanism of inhibition of prostaglandin biosynthesis by anti inflammatory steroids M. DiRosa,P. Persico,R. CarnuccioandA. Pinto 261 40 Selective control of formation of 1 and 2 series prostaglandins: a new concept in the regulation of inflammation and immunity D. F. Horrobin,M. S. Manku,M. OkaandS. C. Cunnane 267 viii CONTENTS 41 Human haptoglobin: an endogenous inhibitor of prostaglandin synthase S. A. Saeed, P. A. Denning-Kendall, W. J. McDonald- GibsonandH. O. J. Collier 285 42 Release of thromboxane B2 and PGE2 by rabbit polymorpho- nuclear leukocytes (Abstract) E.M. Davidson,M.J. H.SmithandA. W.Ford-Hutchinson 301 43 Prostaglandin and thromboxane production by rat macro- phages (Abstract) M. V. DoigandA. W. Ford-Hutchinson 303 44 Specificity of glucocorticoid inhibition of synovial prosta- glandin synthesis R. M. McMillan, C. E. Brinckerhoffand E. D. Harris, Jr. 305 45 Collagenase release from synovial fibroblasts: relationship to fatty acid release and prostaglandin synthesis R. M. McMillan, C. E. BrinckerhoffandE. D. Harris,Jr. 313 46 Observations on the influence of anti-oxidant compounds on prostaglandin biosynthesis (Abstract) M. V. Torrielli, J. S. Franzone, T. Natale, R. Cirillo and L.Sena 321 47 Preliminary data on the influence of thyroid function on prostaglandin biosynthesis (Abstract) J. S. Franzone, T. Natale, L. SenaandM. V. Torrielli 323 Discussion SECTION v: EXPERIMENTAL MODELS OF INFLAMMATION AND CHEMO TAXIS Chairman: L. E. Glynn; Co-Chairman: J. P. Giroud 48 Effect of pharmacologic agents on macrophage accumulation N. R. Ackerman, A. J. Tomolonis, L. Miram, J. B. Kheifits, S. MartinezandA. C. Carter 335 49 The histology of cotton pellet and polyvinyl sponge induced granulomas in rats (Abstract) E.A.BoyleandF.R.Mangan 343 50 A biochemical and morphological study of the cotton pellet granuloma in the rat: effects of dexamethasone and indometha- cin (Abstract) P. J. Bailey, A. Stunp. and B. Lopez-Ramos 345 51 Neutrophil interactions with particulate materials: an in vitro model for inflammatory arthritides R. Turner ,G. Counts, J. Johnson, E. A. West and W. Treadway 347 ix INFLAMMATION: MECHANISMS AND TREATMENT 52 An in vitro mouse macrophage model for use in assessing the effects of anti-inflammatory drugs D. D. White,P. K.FoxandP. Livingston 355 53 Monosodium urate monohydrate stimulates release of lysoso- mal enzymes and prostaglandins from macrophages R. M. McMillan, P. Hasselbacher and E. D. Harris (J r) 365 54 Comparison between calcium pyrophosphate and monosbdic urate induced inflammations of the palatal connective tissue J. L.JouvinandA. Daniel 373 55 Intracellular killing of micro-organisms by phagocytic cells: the effect of extracellular stimuli (Abstract) P. C. J. Leijh, M. Th. van den Barselaar, Th. L. vanZwetand R. van Furth 387 56 In vivo studies on the influence of antigen induced joint inflam- mation on patellar hyaline articular cartilage W. B. van den Berg, M. W. M. Kruijsen and L. B. A. van de Putte 389 57 A stereo logical analysis of collagen phagocytosis in a model of chronic inflammation in rats (Abstract) D. A. Deporter 395 58 Modification of chemotaxis and peptide binding during pathophysiological state of polymorphonuclear leukocytes M. Roch-Arveiller, J.-P. Abita, D. Bradshaw and J. P. Giroud 397 59 Diverging effects of chemotactic serum peptides and synthetic f-Met-Leu-Phe on neutrophil locomotion and adhesion (Abstract) H. U. Keller,J. H. WisslerandB. Damerau 405 60 Correlation between aggregative and chemotaxis inducing ac- tivities of five chemotactic peptides (Abstract) B. Damerau, E. Griinefeld and W. Vogt 407 61 On the mechanism of human polymorphonuclear leukocyte deactivation of chemotaxis by the synthetic peptide formyl-methiony-leucyl-phenylalanine J.-P. Abita 409 62 Dynamics of membranes in viable leukocytes associated with cellular recognition and biological memory in chemotaxis and promotion of locomotion in chemokinesis (Abstract) J. H. WisslerandE. Logemann 417 Discussion x