IMMUNOLOGY AND BLOOD TRANSFUSION DEVELOPMENTS IN HEMATOLOGY AND IMMUNOLOGY Volume 28 The titles published in this series are listed at the end of this volume. Immunology and Blood Transfusion Proceedings of the Seventeenth International Symposium on Blood Transfusion, Groningen 1992, organized by the Red Cross Blood Bank Groningen-Drenthe edited by C. Th. SMIT SIBINGA and P. C. DAS Red Cross Blood Bank Groningen-Drenthe, The Netherlands and T. H. THE Professor of Clinical Immunology, University of Groningen, The Netherlands SPRINGER SCIENCE+BUSINESS MEDIA, B.V. Library of Congress Cataloging-in-Publication Data Immunology and blood transfusion / edited by C.Th. Smit Sibinga and P.C. Das and T.H. The. p. cm. Includes index. ISBN 978-1-4613-6352-1 ISBN 978-1-4615-3094-7 (eBook) DOI 10.1007/978-1-4615-3094-7 1. Blood—Transfusion—Congresses. 2. Immunohemato1ogy- -Congresses. I. Smit Sibinga, C. Th. II. Das, P. C. III. The, T. H. [DNLM: 1. Blood Transfusion—congresses. 2. Blood Cells- -immunology—congresses. 3. Blood Groups—immunology—congresses. W1 DE997VZK v. 28 1993 / WB 356 335 1993] RM171.I455 1993 615' .39—dc20 DNLM/DLC for Library of Congress 93-5012 ISBN 978-1-4613-6352-1 Printed on acid-free paper All Rights Reserved © 1993 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 1993 Softcover reprint of the hardcover 1st edition 1993 No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without written permission from the copyright owner. Baxter Acknowledgement Thispublicationhas beenmadepossiblethroughth~ supportofBaxter,whichis gratefullyacknowledged. VII CONTENTS ModeratorsandSpeakers XI Foreword 'xIII I. PrinciplesandFundamentals CytokinesandCellMediatedImmunology 3 W.H.A. Dokter Transfusion-inducedImmuneTolerance .1l H.T. Meryman PotentialInvolvementofFreeRadicalReactionsinInactivatingAntigen PresentingCellsbyUltraviolet-B Irradiation 2l T.A.Takahashi AlloimmunizationandPlateletTransfusionRefractoriness .37 A. Brand Graft-versus-hostDisease 45 J.Jansen Anti-idiotypicRegulationoftheAlloimmuneResponseinPatients TransfusedwithPlateletConcentrates : 57 lW. Semple Discussion 65 II. ProcessingAspects OptionsforPreventionofTCellAlloactivationbyBloodTransfusions 77 F.H.J.Claas UseofMonoclonalAntibodiesforImmunePurginginBoneMarrow Transplantation 85 E.Racadot VIII ReductionoftheImmunogenicCapacityofBloodComponentsfor thePreventionofAlloimmunizationtoWhiteCells 99 P.Rebulla TheEffectofPlateletsinRedCellConcentratesontheLeukocyte DepletionCapacityofLeukocyteDepletionFilters .109 I. Steneker LeukocyteDepletionofRedCellPreparations: FourthFilterGeneration Leadsto410gReduction. HowFarCan/ShouldWeGo? .121 E.Richter ImmuneTargetingofT-lymphocytes .129 L.deLeij HumoralFunctionsofImmunoglobulin: RelationshiptoPurification TechnologyofIntravenousImmunoglobulin .137 P.L.Yap ImmuneAdsorptionChromatographyforProteinPurification 151 J.P. Tharakan Discussion .161 III. LaboratoryAspects ImmunologicalPrinciplesinRoutineQualityControlImmunocharacteristics andFunctionTests .173 J.G. Huisman TheEmergingRoleofMHCMoleculesasSignalTransducingReceptors.....187 T.A. Chatila FlowCytometryinTransfusionMedicine .195 B.Houwen NewApplicationsofMolecularDiagnosticsinLaboratoryTestSystems 219 L.R.Overby Discussion 231 IV.ClinicalImmunologyandBloodTransfusion ProspectsandLimitationsofAdoptiveImmunotherapyandGene Therapy 239 M.Cottier-Fox ClinicalStrategiesforthePreventionofPlateletAlloimmunization 245 EJ.Lee IX ImmuneMediatedTransfusionReactions: BystanderImmuneCytolysis- AFrequentlyOverlookedMechanismofHemolysis? .255 B.A. van Dijk BloodTransfusionandCancer: ModulationorTolerance? 261 lG.A.Houbiers BloodProductInducedImmunomodulationandItsClinicalConsequences...275 H.G. Watson TransfusionMedicineandImmunologicalResearch: Perspectiveforthe Future 285 T.H. The Discussion 289 Index 297 XI MODERATORS AND SPEAKERS Moderators T.H.The(chairman) UniversityHospitalGroningen,Groningen, NL P.c. Das RedCrossBloodBankGroningen-Drenthe, Groningen,NL L.deLeij - UniversityHospitalGroningen,Groningen,NL H.T. Meryman - JeromeH. HollandLaboratory,Rockville, MD, USA L.c. Overby Alamo,CA,USA P.Rebulla BloodTransfusionCentre,Milan,I C.Th. SrnitSibinga RedCrossBloodBankGroningen-Drenthe, Groningen,NL Speakers A. Brand RedCrossBloodBankLeiden,Leiden, NL T.Chatila HarvardMedicalSchool,Boston,MA,USA F.H.J.Claas - UniversityHospitalLeiden,Leiden, NL M.Cottier-Fox - NationalInstituteofHealth,Bethesda,MD, USA B.A. van Dijk BloodTransfusionService,UniversityHospital Nijmegen,Nijmegen,NL W.N.Drohan JeromeH. HollandLaboratory,Rockville, MD,USA J.G.A. Houbiers - RedCrossBloodBankLeiden,Leiden, NL B.Houwen LornaLindaUniversitySchoolofMedicine, LornaLinda,CA,USA H. Huisman CentralLaboratoryoftheNetherlandsRedCross BloodTransfusionService,Amsterdam,NL J.Jansen - MethodistHospitalofIndiana,Indianapolis,IN,USA XII EJ.Lee - UniversityofMarylandCancerCenter,Baltimore,MD, USA E.Racadot - RegionalBloodTransfusionCentre,Besan~on, F E. Vellenga - UniversityHospitalGroningen,Groningen,NL H. Watson - RoyalInfirmaryofEdinburgh,Edinburgh, UK P.L. Yap - Edinburgh& SouthEastScotlandBloodTransfusion Service,Edinburgh, UK Prepareddiscussants E.Richter - InstituteforTransfusionMedicine,Berlin,D T.Takahashi HokkaidoRedCrossBloodCenter,Sapporo,J J.W. Semple - BloodBankSt. Michael'sHospital,Toronto,C I.Steneker - RedCrossBloodBankAmsterdam, Amsterdam, NL