Immunogenetics: Advances and Educatio n The First Congress of the Slovak Foundation NATO ASI Series Advanced Science Institutes Series A Series presenting the results of activities sponsored by the NATO Science Committee, which aims at the dissemination of advanced scientific and technological knowledge, with a view to strengthening links between scientific communities. The Series is published by an international board of publishers in conjunction with the NATO Scientific Affairs Division A Lif e Sciences Plenum Publishing Corporation B Physic s London and New York C Mathematica l and Physical Sciences Kluwer Academic Publishers D Behavioura l and Social Sciences Dordrecht, Boston and London E Applie d Sciences F Compute r and Systems Sciences Springer-Verlag G Ecologica l Sciences Berlin, Heidelberg, New York, London, H Cel l Biology Paris and Tokyo I Globa l Environmental Change PARTNERSHIP SUB-SERIES 1. Disarmamen t Technologies Kluwer Academic Publishers 2. Environmen t Springer-Verlag / Kluwer Academic Publishers 3. Hig h Technology Kluwer Academic Publishers 4. Scienc e and Technology Policy Kluwer Academic Publishers 5. Compute r Networking Kluwer Academic Publishers The Partnership Sub-Series incorporates activities undertaken in collaboration with NATO's Cooperation Partners, the countries of the CIS and Central and Eastern Europe, in Priority Areas of concern to those countries. NATOPCODATA BASE The electronic index to the NATO ASI Series provides full bibliographical references (with keywords and/or abstracts) to more than 50000 contributions from international scientists published in all sections of the NATO ASI Series. Access to the NATO-PCO-DATA BASE is possible in two ways: - via online FILE 128 (NATO-PCO-DATA BASE) hosted by ESRIN, Via Galileo Galilei, I-00044 Frascati, Italy. - via CD-ROM "NATO-PCO-DATA BASE" with user-friendly retrieval software in English, French and German (© WTV GmbH and DATAWARE Technologies Inc. 1989). The CD-ROM can be ordered through any member of the Board of Publishers or through NATO- PCO, Overijse, Belgium. 3. High Technology - Vol. 35 Immunogenetics: Advances an d Educatio n The First Congress of the Slovak Foundatio n edited by Alejandro J. Madrigal Anthony Nolan Research Institute, Royal Free Hospital, London, U.K. Margita Bencovä Slovak Foundation Education in Immunogenetics, Bratislava, Slovak Republic Derek Middleto n Northern Ireland Tissue Typing Centre, City Hospital, Belfast, Ireland, U.K. and Dominique Charro n HLA et M6decine, 12th IHWC Office, Institute des Cordeliers, Paris, France technical editor Tibor Nänäsi Slovak Academy of Sciences, Bratislava, Slovak Republic Springer Science+Business Media, B.V. Proceedings of the NATO Advanced Research Workshop on The First Congress of the Slovak Foundation Education in Immunogenetics Castä-PapierniCka, Bratislava, Slovak Republic September 5-9,1996 A C.I.P. Catalogue record for this book is available from the Library of Congress ISBN 978-94-010-6308-1 ISB N 978-94-011-5486-4 (eBook) DOI 10.1007/978-94-011-5486-4 Printed on acid-free paper All Rights Reserved © 199 7 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 1997 Softcover reprint of the hardcover 1st edition 1997 No part of the material protecte d by this copyright notic e may be reproduced or utilized in any form or by any means, electronic or mechanical, including photo- copying, recording or by any information storage and retrieval system, without written permission from the copyright owner. v CONTENTS Contents v Preface xi Acknowledgements xv Introduction XVll Report xix Haiku xxi Organizing Committee XXII List of Participants XXlll PART I Accreditation with European and American Histocompatibility Immunogenetics Organizations 1 The Slovak Foundation: Education in Immunogenetics M. Bencova, J. Benca and O. Nanasiova 3 Accreditation in Europe J. Hors and M. Jeannet 13 Accreditation - A Personal View D. Middleton 21 PART II HLA Diversity and Applications 25 HLA Diversity of Alleles and Haplotypes. The Contribution of the 12th International Histocompatibility Workshop R. Fauchet, C.M.Th. Schreuder, 5.C.E. Marsh and D. Charron 27 The Associated Polymorphism of HLA-DR2: Genotyping of DRB1, DRB5, DQBl loci in Slovakia Caucasian Population M. Bencova, J. Benca and A. Kimura 33 Paternity Testing -- Past, Present, Future M. Bohinjec 37 VI PART III HLA and Diseases 59 The Molecular Basis of the HLA Association in Celiac Disease. A Model Disease for Type1 Diabetes and other HLA Associated Disease L.M.Sollid, B.H. Johansen, K.E.A. Lundin, 0. Molberg, H. Scott, F. Vartdal and E. Thorsby 61 Immunogenetics of Graves' Disease - An Overview B.J. Manfras, P. Kiinl, G. Semana and B.D. Boehm 71 Assessing Prognosis in Rheumatoid Arthritis Using Monoclonal Antibodies and Flow Cytometry W.H. Marshall, S. Drover, B.A. Larsen, D. Codner, M.D. Copp, J. Gamberg, E. Keystone, D. Gladman and J. Wade 87 Hashimoto's Thyroiditis and HLA-DR-DQ Haplotypes Associated with Control of Disease Resistance M. Bencovci, J. Benca, A. Kimura and J. Podoba 99 Detection of the Tick Borne Encephalitis Virus in the Ticks and the Study of HLA Associations with the Tick Borne Encephalitis Onset M.L. Sartakova,V.I. Konekov, L.Q. Chernitsina, V.F. Prokofiev, S. Alekseenko and I. Yu. Korotkova 103 Immunogenetic Prognosis for Susceptibility to the Stomach Cancer Onset V.I. Konekov, G.A. Arzshba, K.V. Vardosanidze, I.Yu. Korotkova and M.L. Sartakova 105 PART IV Bone Marrow Transplantation 107 Permissible Mismatches, Acceptable Mismatches and Tolerance: New Trends in Decision Making J.J. van Rood, E.L. Lagaaij, I. Doxiadis, D. Roelen, G.G. Persijn and F.H.J. Claas 109 The Application of Cellular Tests in the Selection of Unrelated Donors for Bone Marrow Transplantation M.Oudshoorn, J.J. van Rood, D. Lio, J.L.W.T. Lie, B. Koene, M.B. Ruigrok, M.F.J.V.D. Voort Maarschalk and F.H.J. Claas 121 HLA Typing at the Molecular Level in the Process of Donor Selection for Bone Marrow Transplantation J.A. Madrigal 135 VB Bone Marrow Transplantation at Princess Margaret Hospital, University of Toronto J.n. Lipton 141 Transatlantic Bone Marrow Transplantation M. Bencova and J. Benca 149 PART V Transplantation, HLA and non-HLA Aspects 151 The Role ofHLA-DR, DQ, DP Subregions Compatibility in the Induction of Cytotoxic T Lymphocytes in Kidney Transplantation from Living Donor M. Bencova, A. Kimura, M. Yoshida, S. Hoshino, S. Porubska, M. Buc, J. Reznicek and T. Sasazuki 153 Microsatellite Testing of the Major Histocompatibility Complex in Human J. Wade and M. Carrington 159 NCOl Polymorphism within the TNFa Promotor Region and the First Intron of TNF,8 Gene in Association with DRB1 Specificities in Healthy Volunteers K. Bogunia-Kubik, C. Swider, M. Polak, T. Pacuszko and A. Lange 163 PART VI Solid Organ end Eye Cornea Transplantation 169 HLA in Kidney Transplantation D. Middleton 171 Facts and Figures of Eurotransplant G.G. Persijn and J.M.J. De Meester 175 Affect of ClassI and ClassII HLA Groups on Graft and Patient Survivals in Kidney Transplant Patients M. Turan, G. Moray, N. Bilgin and M. Haberal 193 The First Kidney Transplantation in Slovakia V. Zvara, J. Reznicek and J. Breza 201 HLA ClassI and ClassII Matched Donor Material for Improved Corneal Allograft Survival H.J. Volker-Dieben and J. D'Amaro 203 viii PARTVII HLA USERS 215 HLA Typing from Serology to Molecular Biology D. Middleton 217 HLA-DP Epitope Typing Using Monoclonal Antibodies W.H. Marshall, S. Drover, D. Codner, J. Gamberg, M.D. Copp, H-W. Liu, 1.T. Deng and H.B. Younghusband 223 Evolution of Molecular HLA Typing P. Merel 233 Internet Application in the Histocompatibility Laboratory P. Merel 243 Author's Index 255 Subject Index 257 I -~- 2@ NATO I ADVANCEDRESEARCHWORKSHOP THEFIRSTCONGRESSOFSLOVAKFOUNDATION EDUCATIONINIMMUNOGENETCS NationalCouncil ofSlovakia, Casta-Papiernicka Bratislava, SlovakRepublic 5-9September1996 1Jear1"rieruis %is 9{.9l.W.9l.2{Wwas he{tfin 'Bratisfava the Capita[oftheSfoval(1{epu6[ic on the river 1Janu6ewithan interestinganirichhistory ... T\! MargitaBencova, PresidentofSlovakEducationinImmunogenetics(1995-) Bratislava, CapitalofSlovakRepublic Devin, Castle,894,confluenfensofDanubeandMoraviarivers KingSvatopluk, (871-894) Xl PREFACE M.BENcovA Slovak Foundation Education in Immunogenetics Kopanice 25, 821 04 Bratislava Slovak Republic Short History of Slovakia After the end of the 5th century, the major part of Central Europe was dominated by Slavs (Slovaks). They had already in the 7th century settle ments in the vicinity oftowns Bratislava, Devin, Nitra to create the Slovak's state formation with the name "The Empire of Sam", territory of which corresponded to that of Slovakia of present. The Empire of Sam was also the first state formation in the Central Europe (as present states Czech Republic, Poland, Hungary, Slovakia etc.) Very important town of this state was Nitra, with the biggest Castle in the Central Europe with his Duke Pribina. The first Church of the Central Europe was built here in the year 830, and it is now considered to be the "Slovak Bethlehem". In the year 880, Nitra also became the first Office of Bishops. Later, the Slovak Duke Pribina and Moravian Duke Mojmir (Moravia corresponded to eastern part of the present Czech Republic) joined their formations to common state "Greate Moravian Empire". The strongest King ofthe Great Moravian Empire was Svatopluk (864 A.D.), who spread his empire over Czech Republic, Hungary and part of Poland, Ukraine and eastern Germany of present, which at that time still did not exist as state formations. His seat was in the southern Slovakia, at the Castle Devin on the river Danube. The near situated Bratislava Castle was one of the important centres of political and cultural life with the big church, too. It was also the seat ofone ofthe prominent Great Moravian princes, Braslav, Svatopluk's third-born son, which gave the castle its name "Braslavgrad" (today Bratislava).