Sanjay K. Jain Editor Imaging Infections From Bench to Bedside Imaging Infections Sanjay K. Jain Editor Imaging Infections From Bench to Bedside Editor Sanjay K. Jain Department of Pediatrics Johns Hopkins University School of Medicine Baltimore, MD, USA ISBN 978-3-319-54590-5 ISBN 978-3-319-54592-9 (eBook) DOI 10.1007/978-3-319-54592-9 Library of Congress Control Number: 2017941765 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. 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Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland This book is dedicated to all my amazing patients whose relentless battle with life- threatening infections has challenged me and nurtured my interest to develop new imaging technologies that could improve the care of future patients with infections. I also want to thank my family, who have instilled the values I hold and who have strongly supported me in all my endeavors. Contents 1 Introduction ............................................................................................ 1 Sanjay K. Jain 2 Clinical Imaging ..................................................................................... 17 Delphine L. Chen, Philip M. Scherer, and Christopher J. Palestro 3 Optical Imaging ...................................................................................... 43 Nathan K. Archer, Kevin P. Francis, and Lloyd S. Miller 4 Radiochemistry ...................................................................................... 77 Thomas Ebenhan, Carl Wagener, Lauren E. Bambarger, Alvin S. Kalinda, and Jan Rijn Zeevaart 5 Imaging the Host Response ................................................................... 133 Catherine A. Foss, Nada M.S. Hammouda, Chentian Shen, Jun Li, and H. Charles Manning 6 Bacterial Imaging ................................................................................... 149 Alvaro A. Ordonez, Lauren E. Bambarger, Niren Murthy, David M. Wilson, and Sanjay K. Jain 7 Fungal Imaging ...................................................................................... 173 Greetje Vande Velde and Stefan Wiehr 8 Neuroimaging ......................................................................................... 185 Dima A. Hammoud 9 Pharmacokinetic and Pharmacodynamics Relationships .................. 195 Zhuo Zhang, Kayla R. Gogarty, Fereidoon Daryaee, and Peter J. Tonge vii viii Contents 10 Biodistribution and Pharmacokinetics of Antimicrobials .................. 209 Alvaro A. Ordonez, Lauren E. Bambarger, Sanjay K. Jain, and Edward A. Weinstein 11 Image Analyses ....................................................................................... 223 Ziyue Xu, Georgios Z. Papadakis, Daniel J. Mollura, and Ulas Bagci 12 Imaging in the Developing World ......................................................... 239 Thomas Ebenhan and Mike Sathekge Index ................................................................................................................ 249 Contributors Nathan K. Archer Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Ulas Bagci Center for Research in Computer Vision, University of Central Florida, Orlando, FL, USA Lauren  E.  Bambarger Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA Delphine L. Chen Mallinckcrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA Fereidoon  Daryaee Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA Department of Radiology, Stony Brook University School of Medicine, Stony Brook, NY, USA Thomas  Ebenhan Department of Nuclear Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa Catherine A. Foss Russel H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA Kevin P. Francis Preclinical Imaging, Life Sciences, PerkinElmer, Inc., Hopkinton, MA, USA Department of Orthopedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA ix x Contributors Kayla R. Gogarty Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA Department of Radiology, Stony Brook University School of Medicine, Stony Brook, NY, USA Dima  A.  Hammoud Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, U.S. National Institutes of Health, Bethesda, MD, USA Nada M.S. Hammouda Icahn School of Medicine at Mount Sinai, New York, NY, USA Sanjay K. Jain Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Alvin S. Kalinda Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA Jun Li Vanderbilt Center for Molecular Probes and Molecular Imaging Research, Vanderbilt University, Nashville, TN, USA H. Charles Manning Department of Radiology, Vanderbilt Center for Molecular Probes and Molecular Imaging Research, Vanderbilt University, Nashville, TN, USA Lloyd S. Miller Department of Dermatology, Department of Medicine, Division of Infectious Diseases and Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA Daniel J. Mollura Center for Infectious Disease Imaging, U.S. National Institutes of Health, Bethesda, MD, USA Department of Radiology and Imaging Sciences, Clinical Center, U.S. National Institutes of Health, Bethesda, MD, USA Niren Murthy Department of Bioengineering, University of California at Berkeley, Berkley, CA, USA Alvaro A. Ordonez Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA Contributors xi Christopher J. Palestro Department of Radiology, Hofstra Northwell School of Medicine, Hempstead, NY, USA Georgios Z. Papadakis Center for Infectious Disease Imaging, U.S. National Institutes of Health, Bethesda, MD, USA Department of Radiology and Imaging Sciences, Clinical Center, U.S. National Institutes of Health, Bethesda, MD, USA Mike Sathekge Department of Nuclear Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa Philip M. Scherer Mallinckcrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA Chentian Shen U.S. National Institutes of Health, Bethesda, MD, USA Peter J. Tonge Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA Department of Radiology, Stony Brook University School of Medicine, Stony Brook, NY, USA Greetje Vande Velde Biomedical MRI Unit/MoSAIC, KU Leuven – University of Leuven, Leuven, Belgium Carl Wagener Radiochemistry Group, Department of Applied Chemistry, South African Nuclear Energy Corporation SOC Limited, Pelindaba, South Africa Edward A. Weinstein Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA Stefan Wiehr Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University Hospital Tuebingen, Tübingen, Germany David  M.  Wilson Department of Radiology, University of California, San Francisco, San Francisco, CA, USA Ziyue Xu Center for Infectious Disease Imaging, U.S. National Institutes of Health, Bethesda, MD, USA Department of Radiology and Imaging Sciences, Clinical Center, U.S. National Institutes of Health, Bethesda, MD, USA Jan Rijn Zeevaart Radiochemistry Group, Department of Applied Chemistry, South African Nuclear Energy Corporation SOC Limited, Pelindaba, South Africa Zhuo Zhang Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA Department of Radiology, Stony Brook University School of Medicine, Stony Brook, NY, USA