IgE AND ANTI-IgE THERAPY IN ASTHMA AND ALLERGIC DISEASE Edited by Robert B. Fick, Jr. Stanford University School of Medicine, Palo Alto and Genentech, Inc. South San Francisco, California Paula M. Jardieu Genentech, Inc. South San Francisco, California Marcel Dekker, Inc. New York Basel • TM Copyright ©2002 by Marcel Dekker,Inc. All Rights Reserved. ISBN: 0-8247-0663-3 This bookisprinted onacid-freepaper. Headquarters MarcelDekker,Inc. 270 MadisonAvenue,New York,NY 10016 tel:212-696-9000;fax:212-685-4540 EasternHemisphereDistribution MarcelDekkerAG Hutgasse4,Postfach812, CH-4001Basel, Switzerland tel:41-61-261-8482;fax: 41-61-261-8896 World WideWeb http://www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright2002 byMarcelDekker,Inc. AllRights Reserved. Neitherthisbook norany partmay be reproducedortransmittedinany formorbyany means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Currentprinting (lastdigit): 10 9 8 7 6 5 4 3 2 1 PRINTEDINTHEUNITEDSTATESOFAMERICA LUNGBIOLOGYINHEALTHANDDISEASE ExecutiveEditor ClaudeLenfant Director,NationalHeart,Lung,andBloodInstitute NationalInstitutesofHealth Bethesda,Maryland 1. Immunologic and Infectious Reactions in the Lung, edited by C. H. KirkpatrickandH.Y.Reynolds 2. TheBiochemicalBasisofPulmonaryFunction,editedbyR.G.Crystal 3. BioengineeringAspectsoftheLung,editedbyJ.B.West 4. MetabolicFunctionsoftheLung,editedbyY.S.BakhleandJ.R.Vane 5. Respiratory Defense Mechanisms (in two parts), edited by J. D. Brain, D.F.Proctor,andL.M.Reid 6. DevelopmentoftheLung,editedbyW.A.Hodson 7. LungWaterandSoluteExchange,editedbyN.C.Staub 8. Extrapulmonary Manifestations of Respiratory Disease, edited by E. D. Robin 9. ChronicObstructivePulmonaryDisease,editedbyT.L.Petty 10. PathogenesisandTherapyofLungCancer,editedbyC.C.Harris 11. GeneticDeterminantsofPulmonaryDisease,editedbyS.D.Litwin 12. TheLungintheTransitionBetweenHealthandDisease,editedbyP.T. MacklemandS.Permutt 13. Evolution of Respiratory Processes: A Comparative Approach, edited byS.C.WoodandC.Lenfant 14. PulmonaryVascularDiseases,editedbyK.M.Moser 15. PhysiologyandPharmacologyoftheAirways,editedbyJ.A.Nadel 16. Diagnostic Techniques in Pulmonary Disease (in two parts), edited by M.A.Sackner 17. RegulationofBreathing(intwoparts),editedbyT.F.Hornbein 18. Occupational Lung Diseases: Research Approaches and Methods, editedbyH.WeillandM.Turner-Warwick 19. ImmunopharmacologyoftheLung,editedbyH.H.Newball 20. Sarcoidosis and Other Granulomatous Diseases of the Lung, edited by B.L.Fanburg 21. SleepandBreathing,editedbyN.A.SaundersandC.E.Sullivan 22. Pneumocystis carinii Pneumonia: Pathogenesis, Diagnosis, and Treat- ment,editedbyL.S.Young 23. Pulmonary Nuclear Medicine: Techniques in Diagnosis of Lung Dis- ease,editedbyH.L.Atkins 24. AcuteRespiratoryFailure,editedbyW.M.ZapolandK.J.Falke 25. Gas Mixing and Distribution in the Lung, edited by L. A. Engel and M. Paiva 26. High-Frequency Ventilation in Intensive Care and During Surgery, editedbyG.CarlonandW.S.Howland 27. Pulmonary Development: Transition from Intrauterine to Extrauterine Life,editedbyG.H.Nelson 28. ChronicObstructivePulmonaryDisease:SecondEdition,editedbyT.L. Petty 29. TheThorax(intwoparts),editedbyC.RoussosandP.T.Macklem 30. ThePleurainHealthandDisease,editedbyJ.Chrétien,J.Bignon,and A.Hirsch 31. Drug Therapy for Asthma: Research and Clinical Practice, edited by J. W.JenneandS.Murphy 32. PulmonaryEndotheliuminHealthandDisease,editedbyU.S.Ryan 33. The Airways: Neural Control in Health and Disease, edited by M. A. KalinerandP.J.Barnes 34. PathophysiologyandTreatmentofInhalationInjuries,editedbyJ.Loke 35. Respiratory Function of the Upper Airway, edited by O. P. Mathew and G.Sant'Ambrogio 36. Chronic Obstructive Pulmonary Disease: A Behavioral Perspective, editedbyA.J.McSweenyandI.Grant 37. Biology of Lung Cancer: Diagnosis and Treatment, edited by S. T. Rosen,J.L.Mulshine,F.Cuttitta,andP.G.Abrams 38. Pulmonary Vascular Physiology and Pathophysiology, edited by E. K. WeirandJ.T.Reeves 39. Comparative Pulmonary Physiology: Current Concepts, edited by S. C. Wood 40. Respiratory Physiology: An Analytical Approach, edited by H. K. Chang andM.Paiva 41. LungCellBiology,editedbyD.Massaro 42. Heart–Lung Interactions in Health and Disease, edited by S. M. Scharf andS.S.Cassidy 43. ClinicalEpidemiologyofChronicObstructivePulmonaryDisease,edited byM.J.HensleyandN.A.Saunders 44. SurgicalPathologyofLungNeoplasms,editedbyA.M.Marchevsky 45. The Lung in Rheumatic Diseases, edited by G. W. Cannon and G. A. Zimmerman 46. DiagnosticImagingoftheLung,editedbyC.E.Putman 47. Models ofLung Disease:Microscopyand StructuralMethods,editedby J.Gil 48. ElectronMicroscopyoftheLung,editedbyD.E.Schraufnagel 49. Asthma: Its Pathology and Treatment, edited by M. A. Kaliner, P. J. Barnes,andC.G.A.Persson 50. Acute Respiratory Failure: Second Edition, edited by W. M. Zapol and F.Lemaire 51. LungDiseaseintheTropics,editedbyO.P.Sharma 52. Exercise: Pulmonary Physiology and Pathophysiology, edited by B. J. WhippandK.Wasserman 53. Developmental Neurobiology of Breathing, edited by G. G. Haddad and J.P.Farber 54. Mediators of Pulmonary Inflammation, edited by M. A. Bray and W. H. Anderson 55. TheAirwayEpithelium,editedbyS.G.FarmerandD.Hay 56. Physiological Adaptations in Vertebrates: Respiration, Circulation, and Metabolism,edited by S.C.Wood,R.E.Weber,A.R.Hargens,andR. W.Millard 57. TheBronchialCirculation,editedbyJ.Butler 58. Lung Cancer Differentiation: Implications for Diagnosis and Treatment, editedbyS.D.BernalandP.J.Hesketh 59. PulmonaryComplicationsofSystemicDisease,editedbyJ.F.Murray 60. Lung Vascular Injury: Molecular and Cellular Response, edited by A. JohnsonandT.J.Ferro 61. CytokinesoftheLung,editedbyJ.Kelley 62. The Mast Cell in Health and Disease, edited by M.A.Kaliner and D.D. Metcalfe 63. PulmonaryDiseaseintheElderlyPatient,editedbyD.A.Mahler 64. CysticFibrosis,editedbyP.B.Davis 65. Signal Transduction in Lung Cells, edited by J. S. Brody, D. M. Center, andV.A.Tkachuk 66. Tuberculosis: A Comprehensive International Approach, edited by L. B. ReichmanandE.S.Hershfield 67. Pharmacology of the Respiratory Tract: Experimental and Clinical Re- search,editedbyK.F.ChungandP.J.Barnes 68. Prevention of Respiratory Diseases, edited by A. Hirsch, M. Goldberg, J.-P.Martin,andR.Masse 69. Pneumocystis carinii Pneumonia: Second Edition, edited by P. D. Walzer 70. Fluid and Solute Transport in the Airspaces of the Lungs, edited by R. M.EffrosandH.K.Chang 71. Sleep and Breathing: Second Edition, edited by N. A. Saunders and C. E.Sullivan 72. Airway Secretion: Physiological Bases for the Control of Mucous Hy- persecretion,editedbyT.TakishimaandS.Shimura 73. Sarcoidosis and Other Granulomatous Disorders, edited by D. G. James 74. EpidemiologyofLungCancer,editedbyJ.M.Samet 75. PulmonaryEmbolism,editedbyM.Morpurgo 76. SportsandExerciseMedicine,editedbyS.C.WoodandR.C.Roach 77. EndotoxinandtheLungs,editedbyK.L.Brigham 78. TheMesothelialCellandMesothelioma,editedbyM.-C.JaurandandJ. Bignon 79. Regulation of Breathing: Second Edition, edited by J. A. Dempsey and A.I.Pack 80. PulmonaryFibrosis,editedbyS.Hin.PhanandR.S.Thrall 81. Long-Term Oxygen Therapy: Scientific Basis and Clinical Application, editedbyW.J.O'Donohue,Jr. 82. Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure, edited by C. O. Trouth, R. M. Millis, H. F. Kiwull-Schöne, and M.E.Schläfke 83. AHistoryofBreathingPhysiology,editedbyD.F.Proctor 84. SurfactantTherapyforLungDisease,editedbyB.RobertsonandH.W. Taeusch 85. The Thorax: Second Edition, Revised and Expanded (in three parts), editedbyC.Roussos 86. SevereAsthma:PathogenesisandClinicalManagement,editedbyS.J. SzeflerandD.Y.M.Leung 87. Mycobacterium avium–Complex Infection: Progress in Research and Treatment,editedbyJ.A.KorvickandC.A.Benson 88. Alpha 1–Antitrypsin Deficiency: Biology · Pathogenesis · Clinical Mani- festations· Therapy,editedbyR.G.Crystal 89. Adhesion Molecules and the Lung, edited by P. A. Ward and J. C. Fantone 90. RespiratorySensation,editedbyL.AdamsandA.Guz 91. PulmonaryRehabilitation,editedbyA.P.Fishman 92. Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease, editedbyJ.-P.Derenne,W.A.Whitelaw,andT.Similowski 93. Environmental Impact on the Airways: From Injury to Repair, edited by J.ChrétienandD.Dusser 94. Inhalation Aerosols: Physical and Biological Basis for Therapy, edited byA.J.Hickey 95. Tissue Oxygen Deprivation: From Molecular to Integrated Function, editedbyG.G.HaddadandG.Lister 96. TheGeneticsofAsthma,editedbyS.B.LiggettandD.A.Meyers 97. Inhaled Glucocorticoids in Asthma: Mechanisms and Clinical Actions, editedbyR.P.Schleimer,W.W.Busse,andP.M.O’Byrne 98. NitricOxideandtheLung,editedbyW.M.ZapolandK.D.Bloch 99. PrimaryPulmonaryHypertension,editedbyL.J.RubinandS.Rich 100. LungGrowthandDevelopment,editedbyJ.A.McDonald 101. ParasiticLungDiseases,editedbyA.A.F.Mahmoud 102. Lung Macrophages and Dendritic Cells in Health and Disease, edited byM.F.LipscombandS.W.Russell 103. PulmonaryandCardiacImaging,editedbyC.ChilesandC.E.Putman 104. GeneTherapyforDiseasesoftheLung,editedbyK.L.Brigham 105. Oxygen, Gene Expression, and Cellular Function, edited by L. Biadasz ClerchandD.J.Massaro 106. Beta -Agonists in Asthma Treatment, edited by R. Pauwels and P. M. 2 O’Byrne 107. InhalationDeliveryofTherapeuticPeptidesandProteins,editedbyA.L. AdjeiandP.K.Gupta 108. AsthmaintheElderly,editedbyR.A.BarbeeandJ.W.Bloom 109. Treatment of the Hospitalized Cystic Fibrosis Patient, edited by D. M. OrensteinandR.C.Stern 110. Asthma and Immunological Diseases in Pregnancy and Early Infancy, editedbyM.Schatz,R.S.Zeiger,andH.N.Claman 111. Dyspnea,editedbyD.A.Mahler 112. ProinflammatoryandAntiinflammatoryPeptides,editedbyS.I.Said 113. Self-ManagementofAsthma,editedbyH.KotsesandA.Harver 114. Eicosanoids, Aspirin, and Asthma, edited by A. Szczeklik, R. J. Gryglewski,andJ.R.Vane 115. FatalAsthma,editedbyA.L.Sheffer 116. PulmonaryEdema,editedbyM.A.MatthayandD.H.Ingbar 117. Inflammatory Mechanisms in Asthma, edited by S. T. Holgate and W. W.Busse 118. Physiological Basis of Ventilatory Support, edited by J. J. Marini and A. S.Slutsky 119. Human Immunodeficiency Virus and the Lung, edited by M. J. Rosen andJ.M.Beck 120. Five-Lipoxygenase Products in Asthma, edited by J. M. Drazen, S.-E. Dahlén,andT.H.Lee 121. Complexity in Structure and Function of the Lung, edited by M. P. HlastalaandH.T.Robertson 122. BiologyofLungCancer,editedbyM.A.KaneandP.A.Bunn,Jr. 123. Rhinitis: Mechanisms and Management, edited by R.M.Naclerio,S.R. Durham,andN.Mygind 124. Lung Tumors: Fundamental Biology and Clinical Management, edited byC.BrambillaandE.Brambilla 125. Interleukin-5: From Molecule to Drug Target for Asthma, edited by C.J. Sanderson 126. PediatricAsthma,editedbyS.MurphyandH.W.Kelly 127. Viral Infections of the Respiratory Tract, edited by R. Dolin and P. F. Wright 128. AirPollutantsandtheRespiratoryTract,editedbyD.L.SwiftandW.M. Foster 129. GastroesophagealRefluxDisease and AirwayDisease,edited byM.R. Stein 130. Exercise-InducedAsthma,editedbyE.R.McFadden,Jr. 131. LAM and Other Diseases Characterized by Smooth Muscle Prolifera- tion,editedbyJ.Moss 132. TheLungatDepth,editedbyC.E.G.LundgrenandJ.N.Miller 133. Regulation of Sleep and Circadian Rhythms, edited by F.W.Turek and P.C.Zee 134. Anticholinergic Agents in the Upper and Lower Airways, edited by S. L. Spector 135. Control of Breathing in Health and Disease, edited by M. D. Altose and Y.Kawakami 136. ImmunotherapyinAsthma,editedbyJ.BousquetandH.Yssel 137. Chronic Lung Disease in Early Infancy, edited by R. D. Bland and J. J. Coalson 138. Asthma's Impact on Society: The Social and Economic Burden, edited byK.B.Weiss,A.S.Buist,andS.D.Sullivan 139. New and Exploratory Therapeutic Agents for Asthma, edited by M. YeadonandZ.Diamant 140. MultimodalityTreatmentofLungCancer,editedbyA.T.Skarin 141. Cytokines in Pulmonary Disease: Infection and Inflammation, edited by S.NelsonandT.R.Martin 142. DiagnosticPulmonaryPathology,editedbyP.T.Cagle 143. Particle–LungInteractions,editedbyP.GehrandJ.Heyder 144. Tuberculosis: A Comprehensive International Approach, Second Edi- tion, Revised and Expanded, edited by L. B. Reichman and E. S. Hershfield 145. Combination Therapy for Asthma and Chronic Obstructive Pulmonary Disease,editedbyR.J.MartinandM.Kraft 146. Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Di- sease,editedbyT.D.BradleyandJ.S.Floras 147. Sleep and Breathing in Children: A Developmental Approach, edited by G.M.Loughlin,J.L.Carroll,andC.L.Marcus 148. PulmonaryandPeripheralGasExchangeinHealthandDisease,edited byJ.Roca,R.Rodriguez-Roisen,andP.D.Wagner 149. LungSurfactants:BasicScienceandClinicalApplications,R.H.Notter 150. NosocomialPneumonia,editedbyW.R.Jarvis 151. FetalOriginsofCardiovascularandLungDisease,editedbyDavidJ.P. Barker 152. Long-TermMechanicalVentilation,editedbyN.S.Hill 153. EnvironmentalAsthma,editedbyR.K.Bush 154. AsthmaandRespiratoryInfections,editedbyD.P.Skoner 155. Airway Remodeling, edited by P. H. Howarth, J. W. Wilson, J. Bous- quet,S.Rak,andR.A.Pauwels 156. Genetic Models in Cardiorespiratory Biology, edited by G. G. Haddad andT.Xu 157. Respiratory-Circulatory Interactions in Health and Disease,edited by S. M.Scharf,M.R.Pinsky,andS.Magder 158. Ventilator Management Strategies for Critical Care, edited by N. S. Hill andM.M.Levy 159. Severe Asthma: Pathogenesis and Clinical Management, Second Edition, Revised and Expanded, edited by S. J. Szefler and D. Y. M. Leung 160. Gravity and the Lung: Lessons from Microgravity, edited by G.K.Prisk, M.Paiva,andJ.B.West 161. High Altitude: An Exploration of Human Adaptation, edited by T. F. HornbeinandR.B.Schoene 162. Drug Delivery to the Lung, edited by H. Bisgaard, C. O’Callaghan, and G.C.Smaldone 163. InhaledSteroidsinAsthma:OptimizingEffectsintheAirways,editedby R.P.Schleimer,P.M.O’Byrne,S.J.Szefler,andR.Brattsand 164. IgE and Anti-IgE Therapy in Asthma and Allergic Disease, edited by R. B.Fick,Jr.,andP.M.Jardieu 165. ClinicalManagementofChronicObstructivePulmonaryDisease,edited byT.Similowski,W.A.Whitelaw,andJ.-P.Derenne 166. Sleep Apnea: Pathogenesis, Diagnosis, and Treatment, edited by A. I. Pack 167. Biotherapeutic Approaches to Asthma, edited by J. Agosti and A. L. Sheffer 168. Proteoglycans in Lung Disease, edited by H. G. Garg, P. J. Roughley, andC.A.Hales 169. GeneTherapyinLungDisease,editedbyS.M.Albelda 170. DiseaseMarkersinExhaledBreath,editedbyN.Marczin,S.A.Kharito- nov,M.H.Yacoub,andP.J.Barnes 171. Sleep-Related Breathing Disorders: Experimental Models and Thera- peuticPotential,editedbyD.W.CarleyandM.Radulovacki 172. Chemokines in the Lung, edited by R. M. Strieter, S. L. Kunkel, and T. J.Standiford 173. Respiratory Control and Disorders in the Newborn, edited by O. P. Mathew 174. The Immunological Basis of Asthma, edited by B. N. Lambrecht, H. C. Hoogsteden,andZ.Diamant 175. Oxygen Sensing: Responses and Adaptation to Hypoxia, edited by S. Lahiri,G.L.Semenza,andN.R.Prabhakar 176. Non-NeoplasticAdvancedLungDisease,editedbyJ.Maurer ADDITIONALVOLUMESINPREPARATION Therapeutic Targets in Airway Inflammation, edited by N. T. Eissa and D.Huston RespiratoryInfectionsinAsthmaandAllergy,editedbyS.Johnstonand N.Papadopoulos AcuteRespiratoryDistressSyndrome,editedbyM.A.Matthay Upper and Lower Respiratory Disease, edited by J. Corren, A. Togias, andJ.Bousquet VenousThromboembolism,editedbyJ.E.Dalen Acute Exacerbations of Chronic Obstructive Pulmonary Disease, edited byN.Siafakas,N.Anthonisen,andD.Georgopolous Lung Volume Reduction Surgery for Emphysema, edited by H. E. Fessler,J.J.Reilly,Jr.,andD.J.Sugarbaker Theopinionsexpressedinthesevolumesdonotnecessarilyrepresent theviewsoftheNationalInstitutesofHealth.