B:160 mm T:150 mm S:130 mm NOW APPROVED1 NOW APPROVED INTHE EU* E C N E R O L F 6 1 Final 0 2S T B Programme E :190 m :210 m :220 m m m m R U L I A F T R A VISIT BOOTH D10 TO LEARN MORE E H Please see Summary of Product Characteristics at Booth D10. This medicinal product is subject to additional monitoring. Healthcare professionals are asked to report any suspected adverse reactions. References: 1. Marketing authorization granted by the European Commission on 19 November 2015. Detailed information on this medicinal product, including the SmPC, is available on the website of the European Medicines Agency http://www.ema.europa.eu. 2. Roversi S, Tonelli R, Fabbri LM. Breakthroughs in internal and respiratory medicine. Lancet. 2015;3(8):600-602. ©2016 Novartis Pharma AG, CH-4002 Basel March 2016 GLCM/LCZ/0112 Promotional material submitted to AIFA on 13/04/2016. Printed in April 2016. 10522727_ESC_FinalPrgrm_M3.indd 1 4/6/16 11:36 AM PREPARED BY FCB Releasing as: PDFX1a Production: Barbara Grant x3946 Job #: 10522727 Colors: 4C AD: Kim Youri x2342 Client: Novartis Flat Size: 150mm w x 210mm h AE: Miquel Valiente Product: Entresto Bleed: 5mm all sides Producer: Kelli Currie Client Code: GLCM/LCZ/0112 Trim: 150mm w x 210mm h QC: L.Powell Date: April 6, 2016 11:35 AM Safety: 130mm w x 190mm h Digital Artist: gh, CL, CL Add’l Info: Proof: M3 M3 Spellcheck: Frank Episale FR Spellcheck: Path: PrePress:Novartis:LCZ696:10522727:10522727_ESC_FinalPrgrm_M3 4C Final Programme Ad Version 1 Congress organised by the Heart Failure association of the ESC BUILDING FLOOR PLAN Heart Failure 2017 and 4th World Congress on Acute Heart Failure ROME e-Library Members Press AGORA Lounge CPR Workshops PARIS Polveriera POSTER AREA EXHIBITION REGISTRATION LONDON Function Spaces Hands-on Tutorials SSperevaickee rCentre MEPoNArtTaIRN FAa eNnzCaE P BARCELONA aris ATHENS BERLIN France EXAM 29 April - 2 May ROOM Heart Failure: rendez-vous with the future www.escardio.org/HFA #heartfailure2017 HEART FAILURE ASSOCIATION OF THE ESC Working together for the future of heart failure Take out your membership for 2016 REGULAR SILVER GOLD FELLOW Access exclusive membership benefits Online European Journal of Heart Failure • CME online education programme • Slides from HFA congresses • Eligible for Board, Committees and Study Groups • Become Fellow of the HFA • And much more! To improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research. I’M AN HFA MEMBER. WE ARE THE ESC APPLY FOR MEMBERSHIP www.escardio.org/HFA-membership Inaugural Session SATURDAY 21 MAY 2016 17:45 – ROOM LONDON Chairpersons : G. Filippatos, G. Rosano, A. Maggioni, M. Piepoli Welcome from the President of the HFA G. Filippatos Welcome to Heart Failure 2016 G. Rosano Welcome to Florence M. Piepoli Welcome from the President of the ESC F. Pinto Announcement of the Philip Poole Wilson Lecturer A. Maggioni The HFA Eugene Braunwald Lecture F. Ruschitzka Introduction of Karl Swedberg E. Braunwald Eugene Braunwald Lecture: Treatment of heart failure: The success of neurohormonal and heart rate control K. Swedberg New elected Fellows of the HFA T. McDonagh Winners of the Heart Failure Awareness Days 2015 A. Mebazaa 19:00 Networking Reception in the Exhibition 3RD WORLD CONGRESS ON ACUTE HEART FAILURE www.escardio.org/HFA TABLE OF CONTENTS Welcome Address 4 ............................................................................................................................................................................................................................................................ Organising Committees 5 ......................................................................................................................................................................................................................................... Heart Failure Association (HFA) of the ESC 6 ..................................................................................................................................................................... Congress Information 8 ................................................................................................................................................................................................................................................ Congress Resources 9 ..................................................................................................................................................................................................................................................... About the Programme 10 ............................................................................................................................................................................................................................................ Don’t Miss 12 ..................................................................................................................................................................................................................................................................................... Abstract-based Programme 13 .......................................................................................................................................................................................................................... Programme at a Glance 14 ......................................................................................................................................................................................................................................... Congress Timetable 18 .................................................................................................................................................................................................................................................... Scientific Programme Saturday Morning Sessions 23 .................................................................................................................................................................................................................................................. Lunchtime Sessions 32 ........................................................................................................................................................................................................................................... Afternoon Sessions 36 .......................................................................................................................................................................................................................................... Inaugural Session 46 ................................................................................................................................................................................................................................................... Poster Session 1 48 ..................................................................................................................................................................................................................................................... Sunday Hands-On Tutorials 85 ......................................................................................................................................................................................................................................... Morning Sessions 89 .................................................................................................................................................................................................................................................. Lunchtime Sessions 100 ......................................................................................................................................................................................................................................... Afternoon Sessions 105 ........................................................................................................................................................................................................................................ Evening Sessions 116 .................................................................................................................................................................................................................................................... Poster Session 2 120 ................................................................................................................................................................................................................................................... Monday Hands-On Tutorials 153 ....................................................................................................................................................................................................................................... Morning Sessions 156 ................................................................................................................................................................................................................................................ Lunchtime Sessions 167 ......................................................................................................................................................................................................................................... Afternoon Sessions 171 ........................................................................................................................................................................................................................................ Evening Sessions 183 ................................................................................................................................................................................................................................................... Poster Session 3 186 ................................................................................................................................................................................................................................................... Tuesday Morning Sessions 225 ................................................................................................................................................................................................................................................ Poster Session 4 232 ................................................................................................................................................................................................................................................... Index of Sessions 257 ............................................................................................................................................................................................................................................................. Index of Chairpersons & Judges 262 ........................................................................................................................................................................................................... Index of Speakers 264 ........................................................................................................................................................................................................................................................... Index of Authors 268 ............................................................................................................................................................................................................................................................. 3 WELCOME ADDRESS Dear friends and colleagues, It is with great pleasure that we welcome you to Florence for Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure. With this year’s spotlight ‘Heart Failure: state of the art’, we will consider the latest ways to make a heart failure diagnosis, predict patient outcomes, manage heart failure with drugs, devices, efficiently structured clinical services and lifestyle recommendations. The congress will be an exceptional event in the world of heart failure as we launch the latest ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. The track will start with an overview session on Saturday at 11:00 where the Task Force will reveal what is new in the 2016 Guidelines. Throughout the rest of the congress, the track will continue with four sessions that will go deeper into the content of the new Guidelines, by topic. In continuing our acclaimed scientific programme, expert faculty from around the globe will feature in the traditional symposia, debates, Meet the Experts, How-To and HFA Focus ‘Mobile App Interactive Voting’ sessions. In view of two successful previous editions, the HFA proudly hosts the 3rd World Congress on Acute Heart Failure with a full programme addressing an unmet need for professionals who care for and study patients suffering from acute heart failure. We are honoured to present this year’s HFA Lectures: Prof. Karl Swedberg will give the Honorary Eugene Braunwald Lecture on Saturday during the Inaugural session and Prof. Luigi Tavazzi will give the Honorary Philip Poole Wilson Lecture as a keynote of the Young Investigator Awards: Basic Science session on Sunday. State-of-the-art science will be presented during four days of oral and poster abstract sessions, a result of the record-breaking number of 2 010 abstracts and clinical cases received. Join us for the Awards Ceremony on Sunday on the HFA stand to congratulate the winners of the traditional Young Investigator and Nursing Investigator sessions and, new this year, the Clinical Case Competition! Make sure to also attend the Late Breaking Trials sessions that will unveil the latest results from clinical research. The congress is also an opportunity for you to visit the exhibition and attend the Industry Sponsored sessions to stay up to date with the recent advances in science and technology from our partners. The venue, Firenze Fiera, is housed in the monumental sixteenth century fortress ‘Fortezza da Basso’ located within walking distance of Florence’s historical centre with its unsurpassed renaissance art and architecture. Welcome to Florence, Welcome to Heart Failure 2016 & the 3rd World Congress on Acute Heart Failure, Heart Failure 2016 Scientific Chairpersons HFA President Prof. Aldo P. Maggioni (Florence, IT) Prof. Gerasimos S. Filippatos (Athens, GR) Prof. Massimo F. Piepoli (Piacenza, IT) Prof. Giuseppe M.C. Rosano (Rome, IT) 4 ORGANISING COMMITTEES Board of the Heart Failure Association of the ESC (2014 - 2016) Gerasimos Filippatos (GR) President Frank Ruschitzka (CH) President-Elect Stefan D. Anker (DE) Immediate Past-President Theresa McDonagh (UK) Chairperson of the Clinical Section Christoph Maack (DE) Chairperson of the Basic Science Section Alexandre Mebazaa (FR) Coordinator for National HF Societies & Working Groups Jillian Riley (UK) Secretary Arno Hoes (NL) Treasurer Clinical Section Basic Science Section Sui Generis Andrew Coats (UK) Johann Bauersachs (DE) Aldo Maggioni (IT) Marisa Crespo-Leiro (ES) Rudolf De Boer (NL) Piotr Ponikowski (PL) Veli-Pekka Harjola (FI) Stephane Heymans (NL) Ekaterini Lambrinou (CY) Adelino Leite-Moreira (PT) Mitja Lainscak (SI) Ex-officio Yuri Lopatin (RU) Burkert Pieske (DE) Massimo Piepoli (IT) Petar Seferovic (RS) Giuseppe Rosano (IT) Marco Metra (IT) Heart Failure 2016 Scientific Chairpersons Aldo Maggioni (IT) Massimo Piepoli (IT) Giuseppe Rosano (IT) Local Host Committee Local Track Committee Leonardo Bolognese (IT) Nadia Aspromonte (IT) Gian Franco Gensini (IT) Edoardo Gronda (IT) Luigi Padeletti (IT) Maurizio Volterrani (IT) Salvatore Di Somma (IT) Andrea Mortara (IT) Congress Ambassadors Roberto Ferrari (IT) Marco Metra (IT) Luigi Tavazzi (IT) 5 HEART FAILURE ASSOCIATION (HFA) OF THE ESC HFA Mission ‘To improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research’ HFA AT A GLANCE ADVOCACY The HFA has set up an exceptional international network across all continents and numerous activities with the support and close collaboration of more than 45 National Heart Failure Societies and Working Groups. Global Heart Failure Awareness Programme The HFA wishes to build a common approach across and beyond Europe to raise heart failure awareness and understanding: let HFA be your voice in the political arena! A White Paper is available on the HFA stand B10. Heart Failure Awareness Days Every year in May, with the participation of over 25 countries. Patient Website Heart failure matters explains all aspects of heart failure to patients, families and carers. Find more information on: www.heartfailurematters.org RESEARCH ISSN V1o3l8u8m-9e8 1462 ( PNriunmt)b IeSSr N1 1 8Ja7n9u-a0r8y4 240 (1O4nline) European Journal of Heart Registry HHeeEuropaaMeEaMBnERr r OJFo TuHttE rEnSC a J OUlFR FNoAfL FAMaaILYiilluurree Failure Collaboration with the ESC EURObservational Research Journal of the Heart Failure Association of the ESC The world’s highest ranking Programme registries on Heart Failure and Perpartum CIHHmoei-gpamhorltori tgrRRabheanittcdtseI uWi mMt fryarropaoe soriar mnnsnkacet e t HnTRHt HrLohrFi ienoaoos feap knsgnf A pr a2s gDMtsRlit0 -atpiiFetaeaDs1teianeilrrin3oirriikaazkltnm nuesaWls Ja:rWreta. AF e iiSltv nudoini hPuneaHDrndPntEkierrn eedaF cisoCv l SpiHar t VothEigR uiiotvn.eonMutra rtre av lyo-enAr dtSiasel Honins.hE unen e-iispdFViuCnnr asciit:Geovihto isrooinioaaHHHecenelrsrhnsnngynfFFF?st:: hImeapratc tfa fialucrteo rj o=u r6n.5a2l.6 Cardiomyopathies. VEDodeliuptomurte-yi n 1E-, CdNihtuoimerfsb:: e SSrt te1ef panh aDn. vAonnk Heraehling (Clinical) & Zoltán Papp (Basic SMcieonncthe )2014 ESC Heart Failure – open access journal EDUCATION Online eLearning Programme Heart Failure Specialist Curriculum 20 CME-EBAC accredited modules available on: Provides a framework which can be used as a learn.escardio.org/heart-failure blueprint for training in Europe - written and assessed by the HFA. Postgraduate Course in Heart Failure Run in conjunction with the Zurich Heart House, the Patient Care Workshop ESC and the HFA, this Postgraduate Course in Heart To promote Best Practice in delivering Failure leads to a Certificate of Advanced Studies multiprofessional heart failure care through the (CAS) in heart failure. means of an interactive workshop. Heart Failure Clinical Practice Guidelines NEW! Individual Heart Failure Certification The new ESC Guidelines for the diagnosis and The HFA provides a brand new certification exam treatment of acute and chronic heart failure will be of professional excellence in heart failure, aiming presented during the congress and available on the to assess the knowledge base set out in the Heart HFA stand. Failure Specialist Curriculum. 6 HEART FAILURE ASSOCIATION (HFA) OF THE ESC CONGRESSES AND EVENTS Annual Heart Failure congress & World Congress on Acute Heart Failure A unique opportunity to learn, exchange and network. Winter Meeting on Translational Research Best basic and translational heart failure meeting in Europe, held every year in January with about 120 participants. HFA Summit Annual meeting with all National Heart Failure Societies to discuss pan-European objectives. MEMBERSHIP Choose the level that best fits your needs and access exclusive benefits! • Access the 20 CME accredited modules of the HFA eLearning programme • Direct access to the Heart Failure 2016 congress resources REGULAR SILVER GOLD FELLOW • Exclusive entrance to the HFA Member’s Lounge • Voting rights for electing the new HFA Board • Get your membership pin Fellows of the HFA Gold Members can become Fellows of the HFA. Candidates have to demonstrate their excellence in heart failure. All applications reviewed by the Credential Committee. Heart failure specialists of Tomorrow (HoT) Be part of our young community! A group of under 40’s (or those still in training) who aim to reach young professionals tackling the issue of heart failure. Don’t miss the HoT Cocktail on the ESC-HFA stand during the networking event. HEAROT FFA TIOLUMROE SRPREOCWIALISTS Visit the ESC-HFA stand B10 to learn more and join our leading community! I’M AN HFA MEMBER. WE ARE THE ESC HFA AT HEART FAILURE 2016 • ESC-HFA stand in the exhibition: come and see us during your coffee break! • Networking event in the exhibition after the Inaugural Session • The year’s best papers on heart failure session on Sunday 22 May at 14:15 • HFA General Assembly on Monday 23 May at 10:05: validation of new HFA Board 2016-2018 by HFA Members • HFA Member’s Lounge available for the HFA Gold and Fellows Members www.escardio.org/HFA 7 CONGRESS INFORMATION Heart Failure 2016 & the 3rd World Congress on Acute Heart Failure is the annual congress of the Heart Failure Association of the ESC. CME Accreditation The Heart Failure 2016 congress is accredited by the European Board for Accreditation in Cardiology (EBAC) for 21 hours of external CME credits. Each participant should claim only those hours of credit that have actually been spent in the educational activity. EBAC works in cooperation with the European Accreditation Council for Continuing Medical Education (EACCME) which is an institution of the European Union of Medical Specialists (UEMS). EBAC credits are recognised by the American Medical Association towards the Physician’s Recognition Award (PRA). Detailed instructions for converting these credits to AMA PRA Category 1 credits are available on the AMA website. EBAC Certificates will be available at the registration desks from Monday 23 May at 12:00. Industry Programme Follow us live Pick up your free copy of the Industry Programme Join the conversation on Twitter! with information on: #heartfailure2016 • Exhibition Floor Plan Look for your face in the crowd • List of Industry Partners on the Facebook photo album! • Industry Sponsored Sessions: Satellite Symposia, Experts on the Spot Wi-Fi and Hands-On Tutorials A free Wi-Fi network is available: • EBAC Accredited Educational Programmes • Notepad Name: hf-congress Password: hf-congress Language The official language during the congress is English. Apart from three sessions in the Local Track, all lectures and presentations will be held in English only. No translation is available. Programme Changes / Date of print The date of print is 18 April 2016. The organisers cannot be held liable for any changes in the programme due to external or unforeseen circumstances. 8