Handbook of Dermatology Handbook of Dermatology A Practical Manual SeconD eDition Margaret W. Mann, MD Associate Professor and Director of Aesthetic Dermatology University Hospitals, Case Western School of Medicine Cleveland, OH, USA Co-Founder Innova Dermatology Hendersonville, TN, USA Daniel L. Popkin, MD PhD Assistant Chief of Dermatology, Louis Stokes VA Medical Center Assistant Professor of Dermatology University Hospitals, Case Western School of Medicine Cleveland, OH, USA Co-Founder Innova Dermatology Hendersonville, TN, USA This edition first published 2020 © 2020 by John Wiley & Sons Ltd Edition History [1e, 2009] All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions. 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Subjects: | MESH: Skin Diseases–diagnosis | Skin Diseases–therapy | Dermatologic Agents–therapeutic use | Handbook Classification: LCC RL74 (ebook) | LCC RL74 (print) | NLM WR 39 | DDC 616.5–dc23 LC record available at https://lccn.loc.gov/2019003278 Cover Design: Wiley Cover Images: © STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY/Getty Images Set in 7.5/9.5 Frutiger by SPi Global, Pondicherry, India 10 9 8 7 6 5 4 3 2 1 Dedication This second edition is dedicated to our son Samuel. Without you, completing this second edition would have been so much faster and less fun. Contents Preface, xv Acknowledgments, xvii Part 1 General Dermatology, 1 Common Work-uPs, signs, And mAnAgement, 3 dermatologic differential Algorithm, 3 direct immunofluorescence (dif), 3 False positive/negative diFs, 3 Workup Quick reference orders, 4 Acne, 6 Alopecia Workup, 7 telogen effluvium, 10 Androgenic alopecia, 10 Alopecia areata, 11 other alopecia treatments, 12 Aphthosis Workup and treatment, 13 dermatologic signs, 15 Folliculitis, 21 melasma, 22 immunology And immunologiC diseAse, 24 lupus erythematosus, 24 Autoantibody, 26 sensitivities and specificities, 26 in connective tissue diseases, 28 Anti‐nuclear antibodies, 29 AnCA (Anti‐neutrophil cytoplasmic antibodies), 30 treatment of AnCA‐associated vasculitis, 30 Vasculitis, 31 small vessel vasculitis, 31 medium vessel vasculitis, 33 large vessel vasculitis, 34 Cryoglobulinemia, 34 Bullous disorders, 36 intracorneal/subcorneal, 36 intraepidermal, 36 suprabasilar, 37 subepidermal with little inflammation, 37 epidermolysis bullosa, 39 major bullous diseases – clinicopathologic findings, 42 vii Complement, 46 Angioedema and complement levels, 46 Complement deficiencies, 47 gVHd, 47 HlA associations, 48 th profiles, 50 sPeCiAl sites: glAnds, nAil, Bone, muCosA, 51 glands, 51 nail terminology, 53 disorders or drugs associated with nail, bone, or ocular findings, 57 genital ulcers, 67 inFeCtion And inFestAtions, 68 Fungal disease / mycoses, 68 laboratory tests, 68 superficial mycoses, 68 Cutaneous mycoses, 69 subcutaneous mycoses, 71 systemic mycoses, 73 opportunistic mycoses, 75 Viruses and diseases, 78 Human papilloma virus, 79 other viral diseases, 80 infections/Bugs, 83 Vector‐borne diseases, 83 Creatures in dermatology, 88 ContACt And PlAnt dermAtitis, 93 Patch testing, 93 Common contact allergens, 95 Allergic vs. irritant contact dermatitis, 104 Allergens – location specific, 105 Features suggestive of specific irritant/toxin, 106 Plants and dermatoses, 106 tumors snd inFiltrAtes, 109 Cutaneous t Cell lyphoma, 109 Cutaneous B‐cell lymphoma, 113 leukemia cutis, 113 monoclonal gammopathies in dermatology, 114 tumors and gene associations, 115 For melanoma, BCC, and sCC, see skin Cancer, 221 viii