This Manual provides a set of methods and approaches, and practical guidelines, on the safe handling and disposal of chemicals used in the illicit manufacture of different drugs. The Manual is aimed at all those, who are involved in, or confronted with the need for, the safe handling, transportation, storage and disposal of seized chemicals. The methods and approaches described reflect the breadth of circumstances under which illicit drug manufacture occurs worldwide, ranging from recycling to disposal at the site of seizure, for example, at a clandestine laboratory site.