Future Aspects in Contraception Part 1 Male Contraception Future Aspects in Contraception Part 1 Male Contraception Part 2 Female Contraception Future Aspects in Contraception Proceedings of an International Symposium held in Heidelberg, 5-8 September 1 984 Part 1 Male Contraception Edited by B. Runnebaum, T. Rabe and L. Kiesel WJ(Ap ARCHIEF .M.TP PRESS LI.M.ITED ..... 1985 a member of the KLUWER ACADEMIC PUBLISHERS GROUP -- n BOSTON / THE HAGUE / DORDRECHT / LANCASTER Published in the UK and Europe by MTP Press Limited Falcon House Lancaster, England British Library Cataloguing in Publication Data Future aspects in contraception: proceedings of an international symposium held in Heidelberg, September 5-8, 1 984. 1. Contraception I. Runnebaum, B. II. Rabe, T. III. Kiesel. L. 613.9'4 RG136 Published in the USA by MTP Press A division of Kluwer Boston Inc. 190 Old Derby Street Higham, MA 02043, USA Library of Congress Cataloging in Publication Data Main entry under title: Future aspects in contraception. Includes bibliographies and index. Contents: pt. 1. Male contraception-pt. 2. Female contraception. 1. Contraception-Addresses, essays, lectures. I. Runnebaum, B. (Benno), 1933- II. Rabe, T. III. Kiesel, L. [DNLM: 1. Contraception-trends. WP 630 F9961 RG136.F87 1985 613.9'432 85-11622 ISBN-13: 978-94-010-8675-2 e-ISBN-13: 978-94-009-4910-2 DOl: 10.1007/978-94-009-4910-2 Copyright © 1985 MTP Press Limited Softcover reprint of the hardcover 1s t edition 1985 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers. Contents of Part 1 Principal contributors to Parts 1 and 2 1 Future aspects in contraception: An overview T. Rabe, L. Kiesel and B. Runnebaum 2 Steroidal contraception-Experimental background 129 F. Neumann 3 Male contraception in the preclinical evaluation 145 K.-W. von Eickstedt 4 Long-acting steroids for male contraception 153 H. Kuhl, H.-J. Born, M. Schneider, J. Sandow, W. Singer and H.-D. Taubert 5 Relationship between ligand structure and affinity for androgen binding protein 167 T. J. LobI, G. R. Cunningham, J. A. Campbell and D. J. Tindall 6 Male contraception with LHRH agonists 179 A. Belanger, F. Labrie, Y. Tremblay, A. Dupont and R. St-Arnaud 7 The epididymis as a target for contraception: Role of testosterone metabolism 191 M. Motta, S. Zoppi and L. Martini 8 Effect of 6-month treatment with a gonadotrophin releasing hormone agonist analogue on endocrine and histological features of human testis tissue 199 I. Huhtaniemi, H. Nikula, M. Parvinen and S. Rannikko 9 The future of plant-derived chemicals as contracep- tive agents 205 N. R. Farnsworth and A. S. Bingel 10 Gossypol-the male fertility-regulating agent 219 N. R. Kalla v vi CONTENTS 11 Cottonseed oil for birth control 229 G.-Z. Liu 12 Antifertility activity of {-)-gossypol 237 S. A. Matlin and R. H. Zhou 13 Monoclonal antibodies directed against human sperm antigens 243 N. J. Alexander 14 Influence of psychotropic drugs. gossypol and acetylcholine receptor blockers on the motility of human spermatozoa in vitro 251 F. Krassnigg, R. Placzek, R. Engl, J. Frick and W.-B. Schill 15 Investigations on the spermicidal action of cellulose trisulphuric acid ester 257 W.-B. Schill and H. H. Wolff Index of contraceptive agents 267 Principal contributors to Parts 1 and 2 Nancy J. Alexander Marc Bygdeman Reproductive Biology and Behavior Department of Obstetrics and Gynecology Oregon Regional Primate Research Center Karolinska Hospital 505 North West 185th Ave S-1 04 01 Stockholm Beaverton, Oregon 97006 Sweden USA Andre Demoulin Hugh Allen Department of Obstetrics and Gynecology Department of Obstetrics and Gynecology University of Liege University of Western Ontario 81, Bd de la Constitution and B-4020 Liege Suite 201 Belgium 111 Waterloo Street London, Ontario Egon Diczfalusy Canada Reproductive Endocrinology Research Unit Karolinska Institute and Hospital Deborah J. Anderson Box 60500 Division of Immunogenetics S -1 04 01 Stockhol m Dana-Farber Cancer Institute and Depart- Sweden ment of Pathology Harvard Medical School 44 Binney Street H. Donat Boston, Massachusetts 0211 5 Department of Obstetrics and Gynecology USA Medical Academy of Magdeburg Gerhart-Hauptmann-Strasse 35 Etienne E. Baulieu 3060 Magdeburg Hormones Laboratory German Democratic Republic INSERM U33 94270 Bic6tre Klaus-Wolf von Eickstedt France Department of Pharmacology and Toxico- logy Alain Belanger Bundesgesundheitsamt Berlin Departments of Medicine and Molecular Gebweiler Strasse 1 5 Endocrinology Berlin 33 Le Centre Hospitalier de rUniversite Laval West Germany Quebec G1V 4G2 Canada Norman R. Farnsworth Professor Dr B. Beril: College of Pharmacy and PCR PS Department for Obstetrics and Gynecology The University of Illinois at Chicago Faculty of Medicine Room 310 University of Novi Sad 833 South Wood Street S.V. Mark6vica 15 Box 6998 YU-21 000 Novi Sad Chicago, Illinois 60680 Yugoslavia USA vii viii PRINCIPAL CONTRIBUTORS TO PARTS 1 AND 2 David L. Gardner F. Krassnig Polymer Science and Technology Section Department of Dermatology Battelle University of Munich Columbus Laboratories Frauenlobstrasse 9-11 505 King Avenue D-8000 Munich 2 Columbus, Ohio 43201-2693 West Germany USA H. Kuhl A. A. Haspels U niversitiits-Frauenklinik Academische Kliniek Abteilung fur Gyniikologische Department of Gynecology Endokrinologie Catharijnesingel101 Theodor-Stern-Kai 7 Utrecht 3585 CP D-6000 Frankfurt am Main The Netherlands West Germany Walter L. Herrmann HOpital Cantonal Universitaire de Geneve F. Labrie Department de Gynecologie et d'Obstetrique Endocrinology of Reproduction 32 bis, Bd de la Cluse St Frant;:ois D'Assise Hospital CH-1211 Geneva 4 Department of Molecular Endocrinology Switzerland Laval Medical Center 10 Rue de I' Espinay IIpo Huhtaniemi Quebec G1 L 3L5 Department of Clinical Chemistry Canada University of Helsinki Meilahti Hospital Andre Lemay SF-00290 Helsinki Department of Gynecology/Obstetrics Finland Laval University HOpital St-Frant;:ois d'Assise Natwar R. Kalla 10 Rue de I'Espinay Department of Biophysics Quebec G1 L 3L5 Basic Medical Sciences Building Canada Panjab University Chandigarh 160014 Guo-Zhen Liu India Department of Urology Capital Hospital Louis G. Keith Peking Department of Obstetrics and Gynecology China The Medical School Northwestern University Thomas J. Lobi and Biopolymers Research Prentice Women's Hospital and Maternity The Upjohn Company Center Kalamazoo 333 East Superior Street Michigan 49001 Chicago, Illinois 60611 USA USA Ludwig Kiesel K. Loewit Division of Gynaecological Endocrinology Institute for Medical Biology and Genetics Department of Obstetrics and Gynaecology University of Innsbruck University of Heidelberg Sch6pfstrasse 41 D-6900 Heidelberg 1 A-6020 Innsbruck West Germany Austria Hans Kopera Marianne Mall-Haefeli Department of Experimental and Clinical Social-Medical Department Pharmacology University Clinic of Obstetrics and Gyne- University of Graz cology Universitiitsplatz 4 Schanzenstrasse 46 A-8010 Graz CH-4031 Basel Austria Switzerland PRINCIPAL CONTRIBUTORS TO PARTS 1 AND 2 ix H. G. Massouras Anand O. Prakash Obstetrician/Gynaecologist School of Studies in Zoology 3 Marasli St Jiwaji University Athens 106 76 Vidya Vihar Greece Gwalior-474011 India Stephen A. Matlin Department of Chemistry The City University T. Rabe Northampton Square Division of Gynaecological Endocrinology London EC1 V OH B Department of Obstetrics and Gynaecology UK University of Heidelberg D-6900 Heidelberg 1 Wolfgang E. Merz West Germany Department of Biochemistry II University of Heidelberg Subir Roy 1m Neuenheimer Feld 328 Department of Obstetrics and Gynecology D-6900 Heidelberg 1 University of Southern California School of West Germany Medicine 1240 North Mission Road Marcella Motta Los Angeles Department of Endocrinology California 90033 University of Milan USA Via Andrea del Sarto 21 1-20129 Milan Italy B. Runnebaum Division of Gynaecological Endocrinology Zvi Naor Department of Obstetrics and Gynaecology Department of Hormone Research University of Heidelberg The Weizmann Institute of Science D-6900 Heidelberg 1 P.O. Box 26 West Germany Rehovot 76 100 Israel J. Sandow Hoechst AG Mary V. Nekola Pharmacology H 821 Department of Medicine Postfach 80 03 20 Tulane Medical School D-6230 Frankfurt am Main 80 1430 Tulane Avenue West Germany New Orleans, Louisiana 70112 USA Joseph G. Schenker F. Neumann Department of Obstetrics and Gynecology Hauptdepartment Endokrinpharmakologie Hadassah University Medical School ScheringAG P.O. Box 12000 Mullerstrasse 170-178 91120 Jerusalem Postfach 65 03 11 Israel 1000 Berlin 65 West Germany Wolf-Bernhard Schill Dermatologische Klinik und Poliklinik der S. J. Nillius Un iversitiit Section for Reproductive Endocrinology Frauenlobstrasse 9-11 Department of Obstetrics and Gynaecology D-8000 Munich 2 Academic Hospital West Germany S-751 85 Uppsala Sweden P.Senanayake Willem A. A. van Os International Planned Parenthood Federa- St Elisabeth's Grote Gasthuis tion Boerhaavelaan 22, Postbus 417 18-20 Lower Regent Street 2000 AK Haarlem London SW1 Y 4PW The Netherlands UK x PRINCIPAL CONTRIBUTORS TO PARTS 1 AND 2 Vernon C. Stevens Lourens J. D. Zaneveld Department of Obstetrics and Gynecology Department of Obstetrics and Gynecology Ohio State University Hospitals Rush-Presbyterian-St Luke's Medical 41 0 West 1 Oth Street Center Columbus, Ohio 43210 and USA College of Pharmacy Health Sciences Center H.-D. Taubert 1753 West Congress Parkway Universitiits-Frauenklinik Chicago, Illinois 60612 Abteilung fur Gyniikologische USA Endokrinologie Theodor-Stern-Kai 7 0-6000 Frankfurt am Main West Germany