M Alcocer 2017 Food Allergy & Intolerance Marcos Alcocer Associate Professor ‘Food Waste Utilisation & Alternative School of Biosciences Proteins Workshop’ 28/11/2017 Sutton Bonington campus University of Nottingham,UK M Alcocer 2017 You tube animation: mp4 or media centre With the end of our own vegetable gardens… ..in our industrialised world… Quino Not everything is exactly under our control… EFA M Alcocer 2017 M Alcocer 2017 Classification M Alcocer 2017 Classification Adverse Reactions to Food Non toxic toxic Aversion Immune mediated Non immune mediated Unknown (psychosomatic) Proctocolitis, Non IgE mediated Enterocolitis, Enzymatic Intolerance to lactose, Coeliac disease Alcohol, galactosemia Eosinophilic esophagitis Anaphylaxis, Caffeine, acids,Tyramine IgE mediated Pharmacological Oral allergy syndrome Alkaloids, Histamine, Exercise induced anaphylaxis Monosodium glutamate, Salicylates, Benzoates Based on 2000, COT report and Skypala et al, food hypersensitivity. M Alcocer 2017 Classification Adverse Reactions to Food Non toxic toxic Food hypersensitivity Aversion Immune mediated Non immune mediated Unknown (psychosomatic) Proctocolitis, Non IgE mediated Enterocolitis, Enzymatic Intolerance to lactose, Coeliac disease Alcohol, galactosemia Eosinophilic esophagitis Anaphylaxis, caffeine, acids,Tyramine IgE mediated Pharmacological Oral allergy syndrome Alkaloids, Histamine, Exercise induced anaphylaxis Monosodium glutamate, Salicylates, benzoates Based on 2000, COT report and Skypala et al, food hypersensitivity. M Alcocer 2017 Classification Adverse Reactions to Food Non toxic toxic Food hypersensitivity Food allergy Aversion Immune mediated Non immune mediated Unknown (psychosomatic) Proctocolitis, Non IgE mediated Enterocolitis, Enzymatic Intolerance to lactose, Coeliac disease Alcohol, galactosemia Eosinophilic esophagitis Anaphylaxis, caffeine, acids,Tyramine IgE mediated Pharmacological Oral allergy syndrome Alkaloids, Histamine, Exercise induced anaphylaxis Monosodium glutamate, Salicylates, benzoates Based on 2000, COT report and Skypala et al, food hypersensitivity. M Alcocer 2017 What is Food allergy? It is “Immunity Gone Wrong” The Gut is Bombarded by Foreign Antigens •Eradication •Containment No Response • “Disease” (Tolerance) • Activation of mucosal mast cells • Release of inflammatory mediators  Transepithelial fluid loss  Smooth muscle contraction  Vomiting and diarrhoea Response (Immune Activation)  Anaphylaxis mucosal barrier The Gut sampling system Watch full Nature video in youTube: https://www.youtube.com/watch?v=gnZEge78_78