F N ifty eurological C ases from the N H ational ospital F N ifty eu r o lo g ic a l C ases fro m th e N H atio nal ospital Edited by Adrian Wills BSc (Hons) MB BS MD MRCP Locum Consultant Neurologist Department of Neurology Kings College Hospital London C David Marsden DSc FRCP FRS Dean and Professor of Neurology Institute of Neurology National Hospital for Neurology and Neurosurgery Queen Square London informa healthcare New York London CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 1998 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Version Date: 20130515 International Standard Book Number-13: 978-1-4822-1089-7 (eBook - PDF) This book contains information obtained from authentic and highly regarded sources. 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Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com C ontents List of contributors vii Preface xi Acknowledgements xiii Introduction XV Case 1 with commentary by Dr Mary M Reilly 1 Case 2 with commentary by Dr Nicholas W Wood 5 Case 3 with commentary by Mr H Alan Crockard 9 Case 4 with commentary by Professor P K Thomas 11 Case 5 with commentary by Dr Martin N Rossor 15 Case 6 with commentary by Dr Peter Rudge 17 Case 7 with commentary by Professor P K Thomas 21 Case 8 with commentary by Dr Michael G Hanna 23 Case 9 with commentary by Dr Nicholas Wood 27 Case 10 with commentary by Dr Peter Brown 31 Case 11 with commentary by Professor Alan J Thompson 33 Case 12 with commentary by Dr John A Morgan-Hughes 37 Case 13 with commentary by Dr Nicholas Wood 39 Case 14 with commentary by Dr Robert AH Surtees 41 Case 15 with commentary by Professor David H Miller 43 Case 16 with commentary by Dr Charles A Davie 47 Case 17 with commentary by Dr Adrian J Wills 51 Case 18 with commentary by Dr Wendy J Taylor 55 Case 19 with commentary by Dr Peter Rudge 59 Case 20 with commentary by Dr Christopher J Earl 63 Case 21 with commentary by Dr Nicholas A Losseff 67 Case 22 with commentary by Dr Michael G Hanna 71 Case 23 with commentary by Professor Michael J G Harrison 75 Case 24 with commentary by Dr John A Morgan-Hughes 79 Case 25 with commentary by Dr Andrew J Lees 83 V Contents Case 26 with commentary by Professor W Ian McDonald 85 Case 27 with commentary by Professor W Ian McDonald 89 Case 28 with commentary by Dr Peter Brown 93 Case 29 with commentary by Dr Gordon T Plant 97 Case 30 with commentary by Dr Hadi Manji 99 Case 31 with commentary by Dr Adrian J Wills 103 Case 32 with commentary by Professor Richard S J Frackowiak 105 Case 33 with commentary by Dr Kailash Bhatia 109 Case 34 with commentary by Dr Robert A H Surtees 111 Case 35 with commentary by Dr John M Land 113 Case 36 with commentary by Dr Adrian J Wills 117 Case 37 with commentary by Professor David H Miller 121 Case 38 with commentary by Professor Simon D Shorvon 125 Case 39 with commentary by Dr Raad AW Shakir 127 Case 40 with commentary by Dr Adrian J Wills & Dr John W Scadding 129 Case 41 with commentary by Dr Adrian J Wills 133 Case 42 with commentary by Professor Richard S J Frackowiak 137 Case 43 with commentary by Professor P K Thomas 139 Case 44 with commentary by Professor Peter J Goadsby 143 Case 45 with commentary by Professor David H Miller & Dr Nicholas A Losseff 145 Case 46 with commentary by Dr Gordon T Plant 149 Case 47 with commentary by Dr Peter Rudge 153 Case 48 with commentary by Dr Nicholas C Fox 155 Case 49 with commentary by Professor Francesco Scaravilli 157 Case 50 From the Archives — 1877 161 Index 163 vi L ist of C o n tributo rs Kailash Bhatia MB BS MD DM, Senior Hospital for Neurology and Neurosurgery, Lecturer and Consultant Neurologist, National Queen Square, London WC1N 3BG Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG Peter J Goadsby MB BS PhD DSc MD FRACP FRCP, Wellcome Research Fellow Peter Brown MB BChir MD MRCP, and Professor of Neurology, National Hospital Consultant Neurologist, National Hospital for for Neurology and Neurosurgery, Queen Neurology and Neurosurgery, Queen Square, Square, London WC1N 3BG London WC1N 3BG; and Middlesex Hospital and University College Hospital, London Michael G Hanna BSc (Hons) MB ChB WIN 8AA (Hons) MRCP MD, Consultant Neurologist and Senior Clinical Lecturer, National Hospital H Alan Crockard MB BCh BAO FRCS for Neurology and Neurosurgery, Queen FRCS Ed, Consultant Neurosurgeon, National Square, London WC1N 3BG Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG Michael J G Harrison MA BM BCh DM FRCP, Professor in Clinical Neurology, Charles A Davie MB ChB MRCP MD, University College and London School of Lecturer, National Hospital for Neurology and Medicine; Consultant Neurologist, National Neurosurgery, Queen Square, London WC1N Hospital for Neurology and Neurosurgery, 3BG Queen Square, London WC1N 3BG Christopher J Earl MB BS MD FRCP, John M Land BSc PhD BM BCh MBA, Honorary Consultant Physician in Neurology, Consultant Chemical Pathologist, National Moorfields Eye Hospital, Middlesex Hospital Hospital for Neurology and Neurosurgery, and National Hospital for Neurology and Queen Square, London WC1N 3BG Neurosurgery, Queen Square, London WC1N 3BG Andrew J Lees MB BS MD FRCP, Consultant Neurologist, National Hospital for Nicholas C Fox MRC Clinician Scientist, Neurology and Neurosurgery, Queen Square, Dementia Research Group, National Hospital London WC1N 3BG; and Middlesex Hospital for Neurology and Neurosurgery, Queen and University College Hospital, London Square, London WC1N 3BG WIN 8AA Richard S J Frackowiak MA MD DSc Nicholas A Losseff MB BS MRCP, FRCP, Dean, Institute of Neurology, Professor Neurology Specialist Registrar, King’s College and Head, Wellcome Department of Cognitive Hospital, London SES 9RS Neurology, Institute of Neurology, Queen Square; Consultant Neurologist, National List of Contributors Hadi Manji MB BChir MA MD FRCP, Martin N Rossor MB BChir MA MD FRCP, Consultant Neurologist, National Hospital for Consultant Neurologist, National Hospital for Neurology and Neurosurgery, Queen Square, Neurology and Neurosurgery, Queen Square, London WC1N 3BG London WC1N 3BG C David Marsden DSc FRCP FRS, Dean Peter Rudge MB BS FRCP, Consultant and Professor of Neurology, Institute of Neurologist, MRC Neuro-otology Unit, Neurology, National Hospital for Neurology National Hospital for Neurology and and Neurosurgery, Queen Square, London Neurosurgery, Queen Square, London WC1N WC1N 3BG 3BG; Northwick Park Hospital, Harrow HA1 3UJ W Ian McDonald MB ChB PhD FRCP FRCOphth FRACP, Professor and Head, John W Scadding MB BS MD FRCP, University Department of Clinical Neurology, Consultant Neurologist, National Hospital for Institute of Neurology; Honorary Consultant Neurology and Neurosurgery, Queen Square, Physician, National Hospital for Neurology and London WC1N 3BG Neurosurgery, Queen Square, London WC1N 3BG, and Moorfields Eye Hospital, London Francesco Scaravilli MD PhD FRCPath, EC IV 2PD Professor of Neuropathology and Honorary Consultant Neuropathologist, Institute of David H Miller MD FRACP FRCP, Neurology, National Hospital for Neurology Professor of Clinical Neurology, Department and Neurosurgery, Queen Square, London of Clinical Neurology, Institute of Neurology, WC1N 3BG National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N Raad A W Shakir MB ChB MSc FRCP, 3BG Consultant Neurologist, Regional Neurosciences Centre, Charing Cross John A Morgan-Hughes BA MB BChir MD Hospital, London W6 8RF; Central Middlesex FRCP, Consultant Physician Emeritus; and Hospital, London NW10 7NS Honorary Research Fellow, Institute of Neurology and National Hospital for Simon D Shorvon MB BChir MD FRCP, Neurology and Neurosurgery, Queen Square, Professor of Clinical Neurology, Institute of London WC1N 3BG Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London Gordon Plant MB BChir MA MD FRCP, WC1N 3BG Consultant Neurologist, National Hospital for Neurology and Neurosurgery, Queen Square, Robert A H Surtees BM BCh PhD FRCP, London WC1N 3BG Senior Lecturer in Paediatric Neurology, Institute of Child Health and Honorary Mary M Reilly MB BCh BAO MD MRCPI, Consultant Paediatric Neurologist, Great Senior Registrar in Neurology, Department of Ormond Street Hospital for Children, London Neurology, Guy’s Hospital, London SE1 9RT WC1N 3JH viii List of Contributors Wendy J Taylor MB ChB FRCR FRCP, Alan J Thompson MD FRCP FRCPI, Consultant Neuroradiologist, Hospital for Sick Professor of Clinical Neurology and Children and National Hospital for Neurology Rehabilitation, Department of Clinical and Neurosurgery, Queen Square, London Neurology, Institute of Neurology, Queen WC1N 3BG Square, London WC1N 3BG P K Thomas CBE MD DSc MRCS FRCP Adrian J Wills MB BS MD MRCP, Locum FRCPath, Emeritus Professor and Honorary Consultant Neurologist, King’s College Consultant, Royal Free Hospital School of Hospital, London SES 9RS Medicine, London NW3 2QG and National Hospital for Neurology and Neurosurgery, Nicholas W Wood MB ChB PhD MRCP, Queen Square, London WC1N 3BG, and Senior Lecturer and Honorary Consultant Royal National Orthopaedic Hospital, London Neurologist, National Hospital for Neurology W1P8AQ and Neurosurgery, Queen Square, London WC1N 3BG