Extreme Dose! Melatonin The Miracle Anti-Aging Hormone Anti-Alzheimer’s Hormone Anti-Baldness Hormone Menopause Reversal Hormone Jeff T. Bowles ((a previous version of this book is titled) ALZHEIMER’S TREATMENTS THAT ACTUALLY WORKED IN SMALL STUDIES BUT WILL NEVER BE TESTED & YOU WILL NEVER HEAR ABOUT FROM YOUR MD OR BIG PHARMA BECAUSE THEY ARE UNPATENTABLE, UNPROFITABLE, AND EASILY OBTAINABLE. This Book is Owned and published by Jeff T. Bowles Publishing LLC All Rights Reserved This book is dedicated to The pioneering research and theoretical works of Dr. Vladimir Dilman and Dr. Ward Dean. Preface (Don’t skip this!) Chapter 1. Foundations of the Theory Chapter Two—Lupron for Alzheimer’s disease. The Story behind the Story. Chapter 3—Treatments for Alzheimer’s that Work for Men and Women Chapter Four—Pharmaceuticals for Alzheimer’s? Chapter Five—More Treatment Regimens for Alzheimer’s that Work Chapter Six--Melatonin Chapter Seven—Origins of Aging: Evolution, Cells, Plants, and Animals— Influence of Hormones Chapter Eight—Anti-Aging Effects of Caloric… and Water Restriction Chapter Nine—LH Causes Alzheimer’s--History of the Theory The evolution of aging: a new approach to an old problem of biology. NIH News: New paper suggests elevated LH behind AD Appendices Appendix A: melatonin treatment on secretion of steroid hormones Appendix B: Two twins with Alzheimer’s Appendix C: Alzheimer’s Disease—Clinical Stages Apppendix D: Smoking Prevents Alzheimer’s Appendix E: Do Aricept and Namenda really help Alzheimer's symptoms? Appendix F: Voyager Pharmaceuticals Press Release Appendix G: Voyager Pharmaceuticals’ Therapeutic Approach to Alzheimer’s Appendix H: Lupron-Drug Facts Appendix I: Pregnenolone Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects. Appendix J: Scientists Pinpoint How Vitamin D May Help Clear Amyloid Plaques Found in Alzheimer's Appendix K: New Findings Contradict Dominant Theory in Alzheimer's Disease Book Overview About The Author Preface (Don’t skip this!) I will make this short and sweet. The first version of this book was primarily about Alzheimer’s, progesterone and melatonin. However, it has gone through a number of edits, including an edit by the well-known anti-aging and smart drug expert Dr. Ward Dean MD. It has become a better book, and while it still focuses quite a bit on Alzheimer’s in the beginning it now has become a go-to book to learn about the amazing results one might get from high dose melatonin. After the first edition of this book was published, it has come to the author’s attention that some women have been able to reverse the onset of menopause by taking melatonin. And although it is mentioned in the title, I will say no more about it in the original book that follows but rather direct you to review the following study- Melatonin and Menopause – Latest Research A six-month study conducted by the Menopause Center at the Madonna Del Grazie Health Institute in Rome Italy, identified a clear relationship between nocturnal melatonin production, a hormone that makes us sleepy, and menopause. Female subjects between the ages of 42 and 62 were given either a melatonin supplement or a placebo each night for six months. The subjects were either in the stages of perimenopause and experiencing missed menstrual cycles or post menopause and their menstrual cycles had ceased entirely. Over the course of the six-month study an amazing thing occurred. The subjects who received the daily melatonin supplement resumed menstrual cyclicity. Yes, even the women who were post-menopausal, regained their menstrual cycles. Symptoms typically associated with menopause such as depression, sleep disorders, hot flushes, fatigue, difficulty concentrating, appetite disorders and tremors related to anxiety and depression were remarkably reversed or significantly improved. Natural hormone levels were restored to youthful levels and the women receiving the melatonin became fertile again. One more item I should add, is that I describe in the high dose melatonin experiments of some of my friends, two of them had a shingles outbreak after taking melatonin. From what I know now, these outbreaks were surprisingly mild and very small, each about the size of a half dollar-sized circle of tiny oozing bumps, not anything near as scary as the awful shingles you see in television commercials for shingles vaccines. So please just keep that in mind. Introduction I apologize for not writing this book 15 years ago in 1997, when I first developed a novel, compelling theory about the cause of and potential treatments for Alzheimer’s disease. Why did I sit on this information for so long? Let me explain by giving you a little of its history. I personally have seen the toll that Alzheimer’s can take on a great mind. My grandfather got the disease in his 60’s, when he was a very well-respected lawyer/real estate investor/ politician. When it first hit him, we noticed he would keep driving with the turn indicator on. After he was diagnosed, we noticed his vocabulary started a rapid decline, when he would look out the window and talk about the birds he would like to feed, and would refer to them as tails. He would drive my grandmother crazy by getting up at night and being all agitated. They finally sent him to a nursing home. I remember that when I went to visit him (when I was 14), he would just sit in a wheel chair and could not hold his head up, could not speak, and would drool a lot. He looked terrible! He died of pneumonia not too long after I saw him like that. They probably decided not to treat him. 1997 was the year when I was the first who theorized that the dramatic increases of human Luteinizing Hormone (LH) that occurs in aging people (by up to 1,000’s of percent) is the culprit that causes Alzheimer’s disease. At the time, this was quite a radical idea that had never been seen before in print or even mentioned by anyone, sane or insane! You see, Luteinizing Hormone (LH) was supposed to be a hormone that only affected, controlled, and acted upon sex-related tissues. By June, 1997, I had finished a theoretical paper describing this crazy idea, and it was accepted for publication by the British journal, Medical Hypotheses, and eventually made it into print in September, 1998. The theory was still quite speculative at the time, but little by little, supporting facts started trickling in. About a year after my paper was published, LH receptors were found all over the body (and in the brain), not just in the sex tissues. About a year after that, the Mayo clinic found that autopsied brains of Alzheimer’s victims were loaded with LH, with the heaviest concentrations being found in the most damaged parts of the brain. Just last year, a paper by a scientist at the NIH (the conservative US government-run National Institutes of Health) agreed that he (and they) now believe the premise is correct--that LH does cause Alzheimer’s! Quite a turnaround from the initial ridicule I got from various Alzheimer’s researchers to whom I’d mentioned the LH idea. I remember one researcher from Northwestern University, standing in front of his highly complicated amyloid beta poster, telling me, “I wish it were that easy,” and then smugly turning his back on me. But that is typical behavior when you are proposing unfamiliar ideas to most scientists. In my experience, I have not found much difference in my dealings with scientists and with autistic children. How are scientists like autistic children? They both usually share these characteristics: they are socially awkward they have and concentrate intensely on peculiar interests they are usually pedantic (enjoy correcting others and demonstrating their detailed knowledge of a topic) they love repetition and sameness (thus, they’re not particularly creative) and, they get really upset when the furniture is rearranged! Another researcher, after reading my paper at my suggestion, said that even though he wasn’t exactly sure about all the ideas presented in it, his initial opinion was that if it was a painting instead of a science article, it seemed more like something his granddaughter might have created, as opposed to a Jackson Pollock. Several times I got letters back from well-known, evolution professors that started with something like, “Unfortunately you do not understand how evolution works.” It used to make me angry, and I would go into a tirade showing them how wrong they were--but now it just makes me laugh. The mainstream science community cannot be convinced of anything new, no matter how much proof you push into their faces. That is why I no longer write papers for scientists--only for those who might be able to fairly evaluate the facts and theories I present. Today’s mainstream professional scientists will be the last to accept any changes to their beliefs. It really is a sad situation, because it leads to a snail’s pace of scientific and medical advancement on which countless suffering humans are waiting. In this book, I will discuss how the entire medical, evolutionary, biology, and science communities are all trapped in a self-policed and self-reinforced logical box which prevents them from coming up with proper, simple, approaches for treating the diseases of aging which today would be considered “outside the box.” I will also explain how to get out of the box without violating the rules of logic.