Increasingly, endogenous factors and processes are being emphasized as drivers in regional economic development and growth. This 15 chapter book is unique in that it commences by presenting five disciplinary takes on endogenous development from the perspectives of economics, geography, sociology, planning and organizational management. Several chapters demonstrate how researchers have developed operational models to investigate the roles played by endogenous factors in regional economic development, including the role of entrepreneurial rents. Further chapters provide empirical investigations of endogenous factors in regional development at various levels of spatial scale - from the supra-region to the nation, city and small town - and in a variety of situational settings, including the European Union, Asia and Australia. The book is an invaluable up-to-date resource for researchers and students in regional science, and regional economic development and planning.