Dr. Muhammad Fakhar-e-Alam Post-Doctoral Researcher, Ningbo Institute of Materials Technology & Engineering, CAS Ningbo Institute of Industrial Technology, No. 1219, Zhongguan West Road, Zhenhai District, Ningbo City, Zhejiang Province, 315201 P.R. China Email: [email protected], [email protected] Shype i.d: fakharphy Cell# +86-13-709070474 Father’s Name: Ghulam Abbas Designation: Assistant Professor Place of Birth: Muzaffar Garh, Pakistan Passport# AE8346773 Nationality: Pakistani Marital Status: Married Present Address: Ningbo Institute of Materials Technology & Engineering, CAS Ningbo Institute of Industrial Technology, No. 1219, Zhongguan West Road, Zhenhai District, Ningbo City, Zhejiang Province, 315201 P.R. China ACADEMIC QUALIFICATION Post-Doctoral Fellowship (December 2015 -16) Project Title: “Fabrication of Nano device by using individual and hybrid form of Novel Nanomaterials for Biosensing and Therapeutic Applications” Funding Resource: Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China Research Lab Address: : Institute of Fundamental and Frontier Sciences, North Jianshe Road, Section 2, Group 4, University of Electronic Science and Technology of China, Sichuan, Chengdu, China Research Responsibilities: Assembly of Nano-Device for Biosensing Applications and testing its working efficiency by applying advance possible techniques. For this purpose individual and hybrid form of different nanomaterials will be employed for betterment of bio-detecting applications. I worked on Indium and Indium Antimonide Nanowires for IR detector Doctor of Philosophy (PhD) (2008-2011) Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences (PIEAS) Thesis Title: “Photo sensitizer’s Dynamics Studies in different Biological Samples using Laser Irradiation” Supervisor: Prof. Muhammad Atif Master of Philosophy (M. Phil) (2003-2006) Department of Physics University of Agriculture, Faisalabad, Pakistan Thesis Title: “Electrical Resistivity of Copper and Aluminum at different Temperatures” Supervisor: Prof. Muhammad Anwar Chaudhary Master of Science (MSc) (1999-2001) Department of Physics, University of Agriculture, Faisalabad, Pakistan Thesis Title: “Controlling of system by using microcontroller through PC serial port” Supervisor: Prof. Hamid Sadiq RESEARCH EXPERIENCE PhD Fellowship (2008-2011) Project Title: “Photosensitizers Dynamic’s Study in Different Biological Model under Laser Irradiation” Funding Resource: High Education Commission of Pakistan Research Lab Address: Pakistan Institute of Engineering and Applied Sciences (PIEAS), Nilore, 45650, Islamabad, Pakistan Supervisor: Prof. Muhammad Atif Research Responsibilities: I conducted variety of experiments for improvement of PDT efficacy which might be significant contribution for cancer cure. Initially I focused on optimization of PDT parameters like photosensitizers uptake versus time, light dose, loss in cell viability, Reactive Oxygen Species test, Lipid Oxidation test towards various cancerous cell model e.g. RD cells, HEK293, HepG2, Hela, Hep2C, Foreskin Fibroblast, Melanoma, Bone marrow, MCF-7 and lung carcinoma cell model. At the end I analyzed and reported my data in peer review International Journals. Visiting Fellow at University of Lille, France (June 2011-December 2012) Project Title: “Organic Free Radicals as potential contrast agent for MRI applications” Funding Resource: Split Ph. D in France via France Embassy at Pakistan Research Lab Address: Lille Insurm University Hospital, Unit 703, Anne-Marie Michel, Director International Relation Office, University of Lille, 59016 Lille Cedex, France Supervisor: Prof. Dr. Serge Mordon Research Responsibilities: I conducted series of experiment by using TEMPO-Glucose, TEEPO-Glucose as MRI contrast agent as reference data and pig-monkey which contributes a lot in field of Nano biomedicine especially towards nephrogenic/kidney disorder and ischemia patients. Visiting Fellow at Sweden (December 2010-April 2011) Project Title: “Potential Role of Nanoparticles for Glucose and Urea sensing and its toxicity towards cancer cell model” Funding Resource: Higher Education Commission of Pakistan Research Lab Address: Bredgatan 34, ITN-Campus Norrköping, Linköping University, Se-601 74, Norrköping, Sweden Supervisor: Prof. Magnus Willander Research Responsibilities: I explored potency of different Nanoparticles for Glucose and Urea sensing and its role towards commercialized Light Emitting Diodes (LEDs) Assembly. In Addition, I used Zinc Oxide Nanoparticles for Glucose Detection and Magnetic Nanoparticles for Urea sensing. Moreover, I explored bio- toxicity and photo toxicity of various nanoparticles after calibrating PDT parameters for different malignant cell model. At Lund University, Chemistry Department I employed the series of experiment to trace the absorption and emission peaks of various individual and complex from of Nanomaterial. Visiting Fellow at Brazil (November 2008-April 2009) Project Title: “Photodynamic Therapy and Laser Tissue Interaction” Funding Resource: Pakistan Institute of Engineering Applied Sciences Islamabad Pakistan Research Lab Address: Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil Supervisor: Prof. Vanderlei Salvandor Bagnato Research Responsibilities: I investigated the threshold dose and depth of necrosis for applying different PDT parameters like Diode Laser having 600 nm, 630 nm and 660 nm of visible light individual and combination of mention light wavelengths by using liver model of Wistar rat. Bio-distribution of Photofrin into Rat liver was confirmed by applying Fluorescence Spectroscopy y shape apparatus in which second harmonic Nd: Yag Laser was employed. M.Phil Project (2002-2005) Project Title: “Electrical Resistivity of Copper and Aluminum at different Temperatures” Funding Resource: University of Agriculture, Faisalabad, Pakistan Research Lab Address: Department of Physics, Faculty Basic Sciences, University of Agriculture, Faisalabad, Pakistan Supervisor: Prof. Muhammad Anwar Chaudhary M.Sc Project (1999-2001) Project Title: “Controlling of the system by using microcontroller through PC serial Port” Funding Resource: University of Agriculture, Faisalabad, Pakistan Research Lab Address: Department of Physics, Faculty Basic Sciences, University of Agriculture, Faisalabad, Pakistan Supervisor: Prof. Hamid Sadiq FUNDED RESEARCH PROJECTS  Project Approved from National Natural Science Foundation-CAS (about 0.2 Million RMB), Ningbo Institute of Materials Engineering and Technology-CAS, Ningbo, China -2017, Grant Number: 31750110454)  Interim Placement for fresh PhD’s startup Research Grant (about 0.5 million PKR) as PI, at IIU Islamabad ACADEMIC AWARDS  Indigenous Scholarship offered by HEC  Visiting fellowship at University of Sao Paulo, Brazil Funded by PIEAS, Pakistan  Visiting fellowship at Linkoping University, Norrkoping, Sweden, Funded by HEC, Pakistan  Split PhD Fellowship, French Embassy, Islamabad, Pakistan  Research Productivity Award 2012 offered by Pakistan Science Foundation  HEC Outstanding Research Award 2010-2011  Excellent Research Scholar Award 2017 by NIMTE-Chinese Academy of Sciences, P. R. China PROFESSIONAL EXPERIENCE  Worked as Visiting Research scholar at Fundamental and Frontier Sciences, UESTC, 610054, Jainshe Road, Chengdu, Sichuan, China (2015-16)  Working(On Leave) as Associate Professor, Department of Physics, G C University, Faisalabad (November 2012-Present)  Worked as Assistant Professor in IIU, Islamabad (December 2011-November 2012)  Adjunct Faculty of Center for Emerging Science and Engineering Technology (CESET), Islamabad (December 2011-Continue).  Worked as visiting Professor in Allama Iqbal Open University, Islamabad (AIOU), Islamabad (December 2011-November 2012).  Worked as a Lecturer in Physics, in Punjab Group of Colleges, Gujranwala, and Punjab, Pakistan. I taught Graduate (Degree) level courses (i.e. Modern Physics, Electricity and magnetism) in this duration.  Worked as a Lecturer in Physics, in Govt College Kot Addu, Punjab, Pakistan.  Worked as Lecturer Makkah Science Degree College, Talagang Chakwal  Worked as Subject Specialist in Orient Science Foundation, Talagang, Chakwal Teaching Experience I have about 9 years teaching Experience of Co-courses, elective and well as Basic Physics. I am confident I will show my ability up to the mark hopefully. PROFESSIONAL SKILLS  Supervised the thesis of 2 PhD, 10 MS, 20 MSc students  A seasoned result oriented professional who enjoys challenging role.  Skillful teacher, my experience & expertise can be utilized in taking institute to the next level of distinction and development.  Having conceptual understanding of research issues  Hands on technical expertise in performing experiments.  Experience in independently produce, analyze and present scientific data.  Proficient to write and publish independently.  Good English communication skills.  Skilled in Adobe Photoshop and Microsoft Excel, PowerPoint and Word.  Works effectively and efficiently independently or as a team.  Strong work ethic. LETTER OF APPRECIATION  Letter of appreciation from Professor Magnus Willander, Norrköping, Linköping University, Se-601 74, Norrköping, Sweden  Letter of appreciation from Professor Vanderlei Salvador Bagnato, Física de S. Carlos/USP e Inst. Física "Gleb Wataghin"/UNICAMP, University of Sao Paulo, Sao Carlos, Brazil  Omer Nur, Assistant Professor, Linköping University, Se-601 74, Norrköping, Sweden  Dr. Muhammad Atif, Senior Scientist, NILOP, 45650, NILORE, Islamabad, Pakistan. PUPLISHED BOOK CHAPTERS Title: “Potential Role of Drugs and Zinc Oxide nanoparticles in Photodynamic therapy” ISBN: 978-3-8484-2632-4 Book Chapter: “ZnO nanostructures (ZnO NRs, NPs, NPS, NWs) Toxicity and Phototoxicity Characteristics towards biological Samples”. JOURNALS PUBLICATIONS 1. Muhammad Fakhar-e-Alam, M. Zubair Iqbal, Aiguo Wu, “Malignant Targeted and Immune Booster Bipolymer Blend of Gd Doped Iron Nanostructures with Drugs towards MRI, PTT and PDT applications” submitted in Nanoletter (2017). 2. M. Fakhar-e-Alam, M. Zubair Iqbal, Aiguo Wu “Malignant Battered and Healthy Shielded TEMPO Blend with Diverse form of Nanocomposites towards MRI applications” submitted in Journal of Physical Chemistry B (2017). 3. M. Fakhare-Alam, M. Zubair Iqbal, Aiguo Wu, Boron Nitride assisted Graphine Quantum Dots based Fluorescence Sensor for Cytokine Monitoring submitted in Nanoscale (2017). 4. M. Waseem Akram, M. Fakhare-Alam, et al. Temperature Dependent Toxic effects of Multifarious Assembly of Magnesium Oxide (MgO) Nanostructures in a Human Cervical Model in press in Scientific Report 7. (2017) 5. Fozia Shaheen, Muhammad Hammad Aziz, Muhammad Fakhar-e-Alam, et al. An In Vitro Study of the Photodynamic Effectiveness of GO-Ag Nanocomposites against Human Breast Cancer Cells; Nanomaterials; MDPI 2017, 7, 401; doi:10.3390/nano7110401 6. M. Fakhar-e-Alam, M. Waseem Akram, Seemab Iqbal, K. S. Alimgeer, M. Atif, K. Sultana, M. Willander, Zhiming M. Wang, “Empirical Modeling of Physiochemical Immune Response of Zinc Oxide Nanowires under UV Exposure to Melanoma and Foreskin Fibroblast. Sci. Rep. 7, 46603; doi: 10.1038/srep46603 (2017). 7. T. Munir, H. S. Munir, M.Kashif, M. Fakhar-E-Alam, A. Sajid, Synthesis and characterization of Copper Oxide nanoparticles by solution evaporation method. Journal of Optoelectronics and Advanced Materials (JOAM) in press (2017). 8. M. Fakhar-e-Alam, M. U. Farooq, Najeeb Abbas, Seemab Iqbal et al. “Pharmacokinetics and biodistribution of nickel oxide for liver cancer cure” Journal of Optoelectronics and Advanced Materials, 18, 414-418 (2016). 9. M. Fakhar-e-Alam, S. Kishwar, et al. “Anticancer effects of nanometallic oxides and their ligands with photosensitizers in osteosarcoma cells” Journal of Optoelectronics and Advanced Materials, 17, 1808-1815 (2015). 10. Muhammad Fakhar-e-Alam, Najeeb Abbas, Muhammad Imran, M. Atif, “Apoptotic Effect of TiO2 in HepG2 Cellular Model” Journal of Optoelectronics and Advanced Materials, 16, 1481-1486 (2014). 11. M. Fakhar-e-Alam, Shubana Rahim, et al. “ZnO Nanoparticles as drug delivery agent for Photodynamic Therapy” Laser Phys. Lett. 11 (2014) 025601 (7pp). 12. M. Fakhar-e-Alam, S. Kishwer, M. Willander, “Photodynamic Effects of Zinc Oxide Nanowires in skin Cancer and Fibroblast” Lasers Med Sci. 29, 1189-1194 (2014). 13. M. Fakhar-e-Alam, Mian Adnan Asghar, et al. “Thin Film Coating of Zinc Oxide (ZnO) by Thermal Evaporation Technique” Journal of Optoelectronics and Biomedical Materials, 6(2):35-40 (2014). 14. M. Fakhar-e-Alam, S. Kishwar, M. Siddique, Omer Nur, and Magnus Willander, The photodynamic effect of ZnO nanorods and their ligands with different Photosensitizers, Reviews in Nanoscience and Nanotechnology. 1, 40-51 (2012). 15. M. Fakhar-e-Alam, M. Atif, M. S. Alsalhi, M. Siddique, S. Kishwar, M. I. Qadir, and Magnus Willander, “Role of ALA Sensitivity in HepG2 Cell in the Presence of Diode Laser” Laser Phys. 21 (5), 982 (2011). 16. M. Fakhar-e-Alam, M. Atif, T. Rehman, H. Sadia, and S. Firdous, “The role of sensitivity of ALA (PpIX)-based PDT on human Embryonic Kidney Cell line (HEK293T)” Laser Phys. 21, 1-9 (2011). 17. M. Fakhar-e-Alam, S. Kishwar, Y. Khan, M. Siddique, M. Atif, O. Nur and M. Willander, “Tumoricidal Effects of Nanomaterials in HeLa cell line” Laser Phys. 21, 1978-1988 (2011). 18. M. Fakhar-e-Alam, Y. Khan, et al. “The potential applications of ZnO nanoparticles conjugated with ALA and Photofrin® as a biomarker in HepG2 cells” Laser Phys. 21, 2156-2164 (2011). 19. M. Fakhar-e-Alam, Syed M. Usman Ali, Zafar Hussain Ibupoto, M. Atif, and M.Willander, “Role of ALA Sensitivity in HepG2 Cell in the Presence of Diode Laser” Laser Phys. 21, 2165-2170 (2011). 20. M. Fakhar-e-Alam, Syed M. Usman Ali, et al. “Role of Sensitivity of Zinc Oxide nanoporous (ZnO-NPRs) complexed with Photofrin® in Human Lung cancer cells (A- 549)” Laser Med. Sci. DOI: 10.1007/s10103-011-0989-8, (2011). 21. M. Fakhar-e-Alam, S. Roohi, M. Atif, S. Firdous, N. Amir, R. Zahoor, “Labeling and Optimization of Photofrin® with 99mTc.” Radiochim Acta. 98, 813-818 (2010). 22. M. Atif, M. Fakhar-e-Alam, et al. “Study of the efficacy of 5ALA-mediated photodynamic therapy on human Rhabdomyosarcoma cell line (RD)” Laser Phys. Lett. 7, 757–764 (2010). 23. Muhammad Hammad Aziz, M. Fakhar-e-Alam, Mahvish Fatima, et al., “Photodynamic Effect of Ni Nanotubes on an HeLa cell line” PLOS one, DOI:10.1371/journal.pone.0150295; 1/13 (2016). 24. Muhammad Atif, M. Fakhar-e-Alam, “In Vitro Cytotoxicity of Mesoporous SiO2 @Eu(OH)3 Core-Shell Nanospheres in MCF-7” Hindawi Publishing Corporation: Journal of Nanomaterials (2016). 25. Mu uhammad Shafa, Sadaf Akbar, Lei Gao, Muhammad Fakhar-e-Alam, Zhiming M. Wang, “Indium Antimonide Nanowires: Synthesis and Properties” Nanoscale Research Letters, 11, 2-20 (2016). 26. Muhammad Shakeel, Farhat Jabeen, Naureen Aziz Qureshi, Muhammad Fakhar-E-Alam, Toxic Effects of Titanium Dioxide Nanoparticles and Titanium Dioxide Bulk Salt in the Liver and Blood of Male Sprague Dawley Rats Assessed by Different Assays” Biol. Trace Elem. Res. 173(2):405-26 (2016). 27. Smmi Khan, Farhat Jabeen, Naureen Aziz Qureshi, Muhammad Fakhar-e-Alam, “Eco- Friendly Synthesis of Silver Nanoparticles Through Economical Methods and Assessment of Toxicity Through Oxidative Stress Analysis in the Labeo Rohita” Biol. Trace Elem. Res. 176 (2), 416-28 (2016). DOI: 10.1007/s12011-016-0838-5 28. Muhammad Nadeem Shakoor, Muhammad Fakhar-e-Alam, et al. “Photodynamic effect of NiO in HepG2 cellular Model” Journal of Nanoelectronics and Optoelectronics, 10, 1-4 (2015). 29. Mahvish Fatima, Muhammad Fakhar-e-Alam, et al. “Apoptotic effect of α-Fe O and SiO 2 3 2 nanoparticles in human Rhabdomyosarcoma cell line” Laser Phys. 24 (2014) 125602 (5pp): DOI:10.1088/1054-660X/24/12/12560. 30. T. Munir, M. Fakhar-e-Alam, et al. “Breakdown Analysis of Normally-Off 4H-SiC Trenched and Implanted VJFET” Journal of Optoelectronics and Advanced Materials, 16, 1400- 1404 (2014). 31. Akbar Ali, M. Fakhar-e-Alam, et al. “Silver-Chitosan Nanobiocomposite as Urea Biosensor” Optoelectronics and advanced Materials-Rapid Communications, 8 (11) 1238-1242 (2014). 32. T. Munir, M. Fakhar-e-Alam, et al. “DC and switching performance of normally-off 4H-SiC TI- VJFET” Journal of Optoelectronics and Advanced Materials, 8, 1187-1190 (2014). 33. Najma Zia, M. Fakhar-e-Alam, et al. “Designing of sophisticated automatic lead shielding to reduce radiation dose of 99mTc.” Journal of Optoelectronics and Advanced Materials, 16, 443-450 (2014).