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Diet, Nutrition, and Cancer: Page nserte s. y i Directions for Research pesetting filen accidentall ye nal te be not from the origic errors may hav CommCitNotemaetm iooinns asDli oiRente ,os Nena uLrtcirfhiet iC oSoncu,i enannccidle sCancer book, graphi er po py pae t he original d, and som m tne oai ed fre ret creatnot b L files er, can Mv m Xowe oh d frng, posematti mor coc f n reecifi ep es ork has besetting-ution. wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p NATWIOaNshAinLg AtoCnA, DD.ECM. 1Y9 8P3RESS oe ue te th ii are trse us ks ea NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose mem- aPl bers are drawn from the Councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. bred. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. pesetting files. Page n accidentally inserte seaAtahinncsceccdta oie Ndnt rhTTaegdaenmhh taoi diensoyfs ccn tN mireeaaee csalnewp htAmationiio tfrcpbonhitarc el ahiodg rlvaasge eaRn smynot dee ebfyw s,r ee t eaneoinhaltnof gehrp n ci SrNontphehclera viieCeoecti irenfiAooieiwcntunsc,egn e aadss dcld cee ai eAoltlbnfme my-cwdrgay m maaotd'hss iveug n epeemnr erosNuidnytturaia i pepbonbtosi yfgloo.si sSntteImhhhtsac eee eliio sredmAA f n ta bhbccfcdyuaaeeam rndrsdtts, heieh htntmmehehii perseNyyi t na e cNaougurotfneai tr kohddEtpinno eoonjoarrorngs lawita i nhtAanlilt ecoeelAc cdyenaaocrg .udb iareTntedydh gmhai eobn nemiyrogn diC t ty otyhtooo hf of uA oeS pfan f cccr Edcioaoitviencdsnling eesdhCcidimuanneoucsesginr et ebe igstornseh rif a nceea 1ntosg ph9fsdm,pee1 i aodrti6ehornne evtdtsrahoa ee lIte lrdnhac vg psshebisotr caiyIoivetrnn uctesasecit r taetriRniop t tomoeu aetf flptht e e1hooeMn 8er optgt .6efe b o RdT3rMrvai,oehc etwvaeieirnnddi nhCege imicwc .oca oieTuh ngmCnn eheeto.cmne,s im cttlNuahy monbea fpil tiptoiietysoturrhe nabobeeatlfos eil c ctsstoh,c hinien-- ye Academy of Engineering and the Institute of Medicine were established in 1964 and 1970, respectively, under the charter of the National m the original ts may have be At oc CadoTenmhtreay cw ot ofN rSkoc .oi Nenn 0wc1eh-sCi.cPh- t0h5i6s 0p3u bwliictha ttihoen Nisa btiaosneadl wCaans cpeerr fIonrsmtiteudte p.ursuant not froc error book, graphi er po Library of Congress Catalog Card Number 83-61699 py pae t International Standard Book Number 0-309-03385-3 he original d, and som Available from m tne NATIONAL ACADEMY PRESS oai 2101 Constitution Ave., NW ed fre ret Washington, DC 20418 L files creater, cannot b Printed in the United States of America Mv m Xowe oh d frng, posematti mor coc f n reecifi ep es ork has besetting-ution. wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p oe ue te th iii are trse us ks ea bread. Pl Committee on Diet, Nutrition, and Cancer1 Page nserte CLIFFORD GROBSTEIN, Chairman pesetting files. n accidentally i JSTJOOE. HACLWONNL YCDINNA. G ICARUA.N SBMSSR,OP VOBWiIEcTeLM CLAhNairman ye LAURENCE N. KOLONEL nal te be DAVID KRITCHEVSKY m the origis may hav WAMNIACTLHHTAOEERNL YM J B.E P.R RMTIZVILALLER not froc error TLHEEO MWAAST TSELNABGEARG book, graphi TAKASHI SUGIMURA, Advisor er po py pae t National Research Council Staff: he original d, and som KSRUOUSBLHBEMRIRTA B HPAIALKLTSMOHENI,R, SR, tPaefsrfoe ajOercfcfthi cD Aeirsr esoctcoiar te om taine FRANCES M. PETER, Editor ed fre ret creatnot b L files er, can Mv m Xowe oh d frng, posematti mor coc f n reecifi ep es ork has besetting-ution. wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p 1 See Appendix A for further information on committee members and staff. oe ue te th iv are trse us ks ea aPl bred. Page nserte s. y i pesetting filen accidentall ye nal te be m the origis may hav not froc error book, graphi er po py pae t he original d, and som m tne oai ed fre ret creatnot b L files er, can Mv m Xowe oh d frng, posematti mor coc f n reecifi ep es ork has besetting-ution. wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p oe ue te th PREFACE v are trse us ks ea aPl bred. Preface Page nserte s. y i pesetting filen accidentall ye m the original ts may have be cspctooeunrmdtdiypnuI oenccnn to Jetam unt cnotmso ed mi (ti1ntepe9utre/8tenr 0hibue,eet nrtn ihtcstseioi ov anNnnes dtaasi ttnttuiuododtx netyihad cole tfc Coi ont hanccnetiaad crsmeercyrnii e cnIonenaut sniottft fiistt ch)cu alrtaieennte ecd( reN tanrat”Csuu;ktrI r(e)si2 : tac )i(bo o“1onmd)ua em“ltv rdfieeasilvescoiittpoe,o wnnraseu sdt…wer irhtt ihiietocehsnh e No, cfasaa tnrtaneidto ce bcno eaaom nlfc mcoRkemenern.osm Tedwauahlrtneeciio dhNcng aCCset e Iroad erun letnadoqtc euiitdlnhe sfe(totN oepr dmRdu ibtCaehltti)aiac otrt” noya; book, not frographic error arensde a(Tr3ch)h e “ rbeNacRsoemCd m Goenon vdteharetni oiannbgso vrBeeol aastrteaddt e at-osos fdi-gitenhteead-ray ra tcd oammpipnprioasnitsreaantlistvs eaa nnrdde s tnphuoetn risidtiibeoinnltiaitfyl i fcfaaoctrito otnrhs e oa fno dvg eatrhpae l ali rnpecraiosdj,ee dnctec vet oeol fot hpcea anE csxeeerr.ci”eusti voef er po Office of the Assembly of Life Sciences, now the Commission on Life Sciences. Subsequently, a 13-member pape ty Committee on Diet, Nutrition, and Cancer and one advisor were appointed to conduct the study. The committee's m the original ned, and som fCwcioraemsnrtec pt ewodrn.oe e Tftniahntsseek doss p fwi endce iiretfehti cicas obn modreu pptnhloederta ter,ed ite iwiosn hl ooJifcgu hytnh eeac 1 not9den8r crp2eirtn ewotvrriyaetht nes tudtihor evno e pnoyu febt dhcl ieauc nanrctdeieoelrarn.t itToohfhne e sagh 4reiepn9p e6obr-arpetlat wahgleeesa eordne ii pnntogchr letuo edfn nedutdiitet rlstie,te divnv eDuer tiareailttn i,ido nN nteun, rtoairmnnitdni o udcntiare,in ttaaicnvredyer oai guidelines for dissemination to the public. ed fre ret The committee responsible for the third task, i.e., the development of recommendations for research, included ML files creatver, cannot b 1abafs2ifo biolloiifoag tctyhiho,e en mm1s 3oais lnoetdrcryi umg,l ieaanmrja oglbr em rrnyeeeosmtelioacbgrsecy, rh,ns eiuanptntrieiddtr eieoomsnnties,o onalofud gttvhryiiest,i soeoerxn .c p Toeedmhriuemm cgaeirttnotieotuaenpl ,m oppenraomctvohbilodeolregosdyg a ,ya nm, d bpi rtcuohrbaeold biNc ir RaahlnC egga eseltnt ahoef,ftf ia ecanxsrde,p meptroritexcissrieecon obitlnieoo dsglou yingc. h yIA n,d psmitpsiocetulineptdicloiiuxnnl eaaAsrl m Xowe at the end of this report. posed fromatting, h oapnp deiaTrreh cient i CoAnopsmp femonrid titrxeee sB eoa. nrIc tD his i eaatnl,sd No t ugotr ratihttieoofsnue,l watonh dtoh Copsaaenr tcwiechri poias r teienvddi eeiwnb tetehdde s teoml etihcnteiec dmo nsafenecyrte isoncncisee nootfin st thfsui swt urhereop ocrreots naettar irtbchuhet. reTedqh tueheiersi trn oiadfm ethaeess comc for NRC. The committee particularly takes note of the excellent support received from the NRC staff headed by Dr. n reecifi Sushma Palmer and consisting of Dr. Kulbir Bakshi, Mrs. Frances Peter, Mr. ep es ork has besetting-ution. wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p oe ue te th PREFACE vi are trse us ks ea Robert Hilton, Ms. Susan Barron, and Mrs. Denise Belgrave. The support and assistance of Drs. Diane Fink, bread. Pl Andrew Chiarodo, and William DeWys, the past and present NCI project officers for this study, are also Page nserte acknowledged. s. y i pesetting filen accidentall ye nal te be CLIFFORD GROBSTEIN m the origis may hav CCHOAMIMRMITATNEE ON DIET, NUTRITION, AND CANCER not froc error book, graphi er po py pae t he original d, and som m tne oai ed fre ret creatnot b L files er, can Mv m Xowe oh d frng, posematti mor coc f n reecifi ep es ork has besetting-ution. wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p oe ue te th CONTENTS vii are trse us ks ea aPl bred. Contents Page nserte s. y i pesetting filen accidentall ye m the original ts may have be CChhaapptteerr 12 -- OAvpSeprrtvroaiaetcewhg iatcon Odth bMej eSacjttouivrd eyRse acnodm Pmrieonrditaietiso nfosr Research 135 book, not frographic error Chapter 3 - DieRt easneda rtchhe RMeeccohmanmisemndsa otifo Cnsarcinogenesis 119 er po pape ty Chapter 4 - Epidemiological Methods 12 m the original ned, and som ResATAeynsapsraecelyshss s oRmisfe e oEcnfopt mDiodfmae tDmaeniieodtlaaotrgiyoi cnEasxl pSotsuudryes 11115567 oai ed fre ret Chapter 5 - Laboratory Methods 19 ML files creatver, cannot b MMMReeeestttehhhaooordddcsssh fffRooorrer cAIIoddsmeesnnemttsiisffeyyinniidnngagg tt hiDMoeni aeEsrtfkafreeyrcs tI sRn ioetfila aNttoeudrts r tiaoen nNdts eM oopnol daCisfaiiarec riisnn ooHfg uCemnaerascniissnogenesis 22220123 m Xowe Initiators and Modifiers of Carcinogenesis 23 posed fromatting, h TMhaer kEefrfse cRtse loafte Nd utotr iNenetosp olans iCaa irnc iHnougmeannessis 2233 comc for Chapter 6 - Macroconstituents 25 en repecifi FParotstein 2257 es ork has besetting-ution. CDaierbtaorhyy Fdirbaeters 2288 wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p oe ue te th CONTENTS viii are trse us ks ea Alcohol 30 bread. Pl Total Caloric Intake 30 Page nserte ResGeeanrcehra Rl eRceocmommmenednadtaiotinosns for Epidemiological Research 3311 s. y i General Recommendations for Laboratory Research 32 ypesetting fileen accidentall Chapter 7 - VitVamitSainmpse,ic nMisf,ii cnC eRarreaocltsoe, mnaenmsd,e aNnndodan tRniouenttrisnitoivides Inhibitors of Carcinogenesis 333662 nal te be Vitamin A, Carotenes, and Retinoids 36 m the origis may hav SelVVeniittiaaummmii nnan ECd (OAtshceor rTbrica cAe cMidi)nerals 333788 not froc error SMeolelynbiudmenum, Zinc, Iron, Iodine, and Arsenic 3491 book, graphi NGoennenruatlr iRtievsee Ianrchhib Riteocrso mofm Ceanrdcaintioognesnesis 4412 er po Specific Research Recommendations 43 py pae t Vitamin A and Carotenes 44 he original d, and som VVSeiitltaeamnmiiuinnm EC a (nAd sOcothrberic T Araccide )Elements 444445 m tne Nonnutritive Inhibitors of Carcinogenesis 46 oai ed fre ret Chapter 8 - Food Additives, Contaminants, Carcinogens, and Mutagens 47 creatnot b Research Recommendations 50 L files er, can Mv m Xowe oh d frng, posematti mor coc f n reecifi ep es ork has besetting-ution. wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p oe ue te th CONTENTS ix are trse us ks ea bread. Pl Chapter 9 - Consumer Behavior 52 Page nserte Research Recommendations 56 s. y i References 58 ypesetting fileen accidentall AAppppeennddiixx AB -- ACockmnmowittleeed gomn eDnitest, Nutrition, and Cancer--Affiliations and Major Research Interests 6697 nal te be m the origis may hav not froc error book, graphi er po py pae t he original d, and som m tne oai ed fre ret creatnot b L files er, can Mv m Xowe oh d frng, posematti mor coc f n reecifi ep es ork has besetting-ution. wpb nal er tyattri e origind othon for entation of thding styles, aoritative versi his new digital represhs, word breaks, heaublication as the auth About this PDF file: Tthe original; line lengtprint version of this p