******ebook converter DEMO Watermarks******* ******ebook converter DEMO Watermarks******* COMPREHENSIVE REVIEW SERIES CLINICALS SURGERY For PG Medical Entrance ******ebook converter DEMO Watermarks******* Published by Delhi Academy of Medical Sciences (P) Ltd. HEAD OFFICE Delhi Academy of Medical Sciences (P.) Ltd. 4-B, Grovers Chamber, Pusa Road, Near Karol Bagh Metro Station, New Delhi-110 005 Phone : 011-4009 4009 http://www.damsdelhi.com Email: [email protected] ISBN: 978-93-89309-03-4 First Published 1999, Delhi Academy of Medical Sciences © 2020 DAMS Publications All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic, mechanical, including photocopying, recording, or any information storage and retrieval system without permission, in writing, from the author and the publishers. This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission. Reasonable efforts have been made to publish reliable data and information, but the authors and the publishers cannot assume responsibility for the validity of all materials. Neither the authors nor the publishers, nor anyone else associated with this publication, shall be liable for any loss, damage or liability directly or indirectly caused or alleged to be caused by this book. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming and recording, or by any information storage or retrieval system, without permission in writing from Delhi Academy of Medical Sciences. The consent of Delhi Academy of Medical Sciences does not extend to copying for general distribution, for promotion, for creating new works, or for resale. Specific permission must be obtained in writing from Delhi Academy of Medical Sciences for such copying. Trademark notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation, without intent to infringe. Typeset by Delhi Academy of Medical Sciences Pvt. Ltd., New Delhi (India). ******ebook converter DEMO Watermarks******* Contents Chapter 1 Breast Chapter 2 Thyroid and Parathyroid Chapter 3 Urology Chapter 4 GIT-1 - Esophagus, Stomach and Small and Large Intestine Chapter 5 GIT-2 - Hepatobiliary System and Pancreas Chapter 6 Adrenal Glands Chapter 7 Salivary Glands Chapter 8 Vascular Surgery Chapter 9 Hernia Chapter 10 Mediastinum Chapter 11 General Surgery Chapter 12 Plastic Surgery Chapter 13 Bariatric surgery Chapter 14 Fluid and Electrolytes Chapter 15 Total Parenteral Nutrition Chapter 16 Surgical Wounds and Infections Chapter 17 Sutures Chapter 18 Miscellaneous ******ebook converter DEMO Watermarks******* Embryology and Functional Anatomy of the Breast: Embryology: At the fifth or sixth week of fetal development, two ventral bands of thickened ectoderm (mammary ridges, milk lines) are evident in the embryo. In most mammals, paired breasts develop along these ridges, which extend from the base of the forelimb (future axilla) to the region of the hind limb (inguinal area). These ridges are not prominent in the human embryo and disappear after a short time, except for small portions that may persist in the pectoral region. Accessory breasts (polymastia) or accessory nipples (polythelia) may occur along the milk line when normal regression fails. Each breast develops when an ingrowth of ectoderm forms a primary tissue bud in the mesenchyme. The primary bud, in turn, initiates the development of 15 to 20 secondary buds. Epithelial cords develop from the secondary buds and extend into the surrounding mes enchyme. Major (lactiferous) ducts develop, which open into a shallow mammary pit. During infancy, a proliferation of mesenchyme transforms the mammary pit into a nipple. If there is failure of a pit to elevate above skin level, an inverted nipple results. This congenital malformation occurs in 4% of infants. At birth, the breasts are identical in males and females, demonstrating only the presence of major ducts. Important: Enlargement of the breast may be evident and a secretion, historically referred to as witch’s milk, may be produced. These transitory events occur in response to maternal hormones that cross the placenta. The breast remains undeveloped in the female until puberty, when it enlarges in response to ovarian estrogen and progesterone, which initiate proliferation of the epithelial and connective tissue elements. However, the breasts remain incompletely developed until pregnancy occurs. Absence of the breast (amastia) is rare and results from an arrest in mammary ridge development that occurs during the sixth fetal week. Poland’s syndrome consists of :hypoplasia or complete absence of the breastcostal cartilage and rib defects, hypoplasia of the subcutaneous tissues of the chest wall, and brachysyndactyly. Breast hypoplasia also may be iatrogenically induced before puberty by trauma, infection, or radiation therapy. Symmastia is a rare anomaly recognized as webbing between the breasts across the midline. Accessory nipples (polythelia) occur in <1% of infants and may be associated with abnormalities of the urinary tract (renal agenesis and cancer), abnormalities of the cardiovascular system (conduction disturbances, hypertension, congenital heart anomalies) and other conditions (pyloric stenosis, epilepsy, ear abnormalities, arthrogryposis). Supernumerary breasts may occur in any configuration along the mammary milk line but most frequently occur between the normal nipple location and the symphysis pubis. Turner’s syndrome(ovarian agenesis and dysgenesis) and Fleischer’s syndrome (displacement of the nipples and bilateral renal hypoplasia) may have polymastia as a component. Accessory axillary breast tissue is uncommon and usually is bilateral. Functional Anatomy: The breast is composed of 15 to 20 lobes , which are each composed of several lobules. Fibrous bands of connective tissue travel through the breast (Cooper’s suspensory ligaments), insert perpendicularly into the dermis. Cooper’s ligaments provide shape and structure to the breast as they course from the overlying skin to the underlying deep fascia. Because these ligaments are anchored into the skin, infiltration of these ligaments by carcinoma commonly produces tethering, which can cause dimpling or subtle deformities on the otherwise smooth surface of the breast. ******ebook converter DEMO Watermarks******* Extent: The mature female breast extends from the level of the second or third rib to the inframammary fold at the sixth or seventh rib. It extends transversely from the lateral border of the sternum to the anterior axillary line. The deep or posterior surface of the breast rests on the fascia of the pectoralis major, serratus anterior, and external oblique abdominal muscles, and the upper extent of the rectus sheath. The retro- mammary bursa may be identified on the posterior aspect of the breast between the investing fascia of the breast and the fascia of the pectoralis major muscles. The axillary tail of Spence extends laterally across the anterior axillary fold. The upper outer quadrant of the breast contains a greater volume of tissue than do the other quadrants. Shape: The breast has a protuberant conical form. The base of the cone is roughly circular, measuring 10 to 12 cm in diameter. Considerable variations in the size, contour, and density of the breast are evident among individuals. The nulliparous breast has a hemispheric configuration with distinct flattening above the nipple. With the hormonal stimulation that accompanies pregnancy and lactation, the breast becomes larger and increases in volume and density, whereas with senescence, it assumes a flattened, flaccid, and more pendulous configuration with decreased volume. Microscopic Anatomy: The mature breast is composed of three principal tissue types: (1) glandular epithelium, (2) Fibrous stroma and supporting structures and (3) adipose tissue. The breast also contains lymphocytes and macrophages. In adolescents, the predominant tissues are epithelium and stroma. In postmenopausal women, the glandular structures involute and are largely replaced by adipose tissue. The glandular apparatus of the breast is composed of a branching system of ducts, organized in a radial pattern spreading outward and downward from the nipple-areolar complex. It is possible to cannulate individual ducts and visualize the lactiferous duct. Each major duct has a dilated portion (lactiferous sinus) below the nipple- areolar complex. These ducts converge through a constricted orifice into the ampulla of the nipple. lactiferous sinus is lined with stratified squamous epithelium. Each of the major ducts has progressive generations of branching and ultimately ends in the terminal ductules or acini. Acini are the milk-forming glands of the lactating breast and, together with their small efferent ducts or ductules, are known as lobular units or lobules. Lobules are the structural units of breast. Terminal Duct Lobular Unit(TDLU) is the composite assembly of terminal portion of the duct and the various lobules attached to it. TDLU are the Functional units of breast. The entire ductal system is lined by epithelial cells, which are surrounded by specialized myoepithelial cells that have contractile properties and serve to propel milk formed in the lobules toward the nipple. Outside the epithelial and myoepithelial layers, the ducts of the breast are surrounded by a continuous basement membrane containinglaminin, type IV collagen, and proteoglycans. The basement membrane layer is an important boundary in differentiating in situ from invasive breast cancer. Continuity of this layer is maintained in ductal ******ebook converter DEMO Watermarks******* carcinoma in situ (DCIS), also termed noninvasive breast cancer. Invasive breast cancer is defined by penetration of the basement membrane by malignant cells invading the stroma. Inactive and Active Breast: Each lobe of the breast terminates in a major (lactiferous) duct (2–4 mm in diameter), which opens through a constricted orifice (0.4–0.7 mm in diameter) into the ampulla of the nipple. Major ducts are lined with two layers of cuboidal cells, whereas minor ducts are lined with a single layer of columnar or cuboidal cells. In the inactive breast, the epithelium is sparse and consists primarily of ductal epithelium. In the early phase of the menstrual cycle, minor ducts are cord- like with small lumina. With estrogen stimulation at the time of ovulation, alveolar epithelium increases in height, duct lumina become more prominent, and some secretions accumulate. When the hormonal stimulation decreases, the alveolar epithelium regresses. With pregnancy, the breast undergoes proliferative and developmental maturation. As the breast enlarges in response to hormonal stimulation, lymphocytes, plasma cells, and eosinophils accumulate within the connective tissues. The minor ducts branch and alveoli develop. Development of the alveoli is asymmetric, and variations in the degree of development may occur within a single lobule. With parturition, enlargement of the breasts occurs via hypertrophy of alveolar epithelium and accumulation of secretory products in the lumina of the minor ducts. Alveolar epithelium contains abundant endoplasmic reticulum, large mitochondria, Golgi complexes, and dense lysosomes. Two distinct substances are produced by the alveolar epithelium: (a) the protein component of milk, which is synthesized in the endoplasmic reticulum (merocrine secretion); and (b) the lipid component of milk (apocrine secretion), which forms as free lipid droplets in the cytoplasm. Milk released in the first few days after parturition is called colostrum and has low lipid content but contains considerable quantities of antibodies. The lymphocytes and plasma cells that accumulate within the connective tissues of the breast are the source of the antibody component. With subsequent reduction in the number of these cells, the production of colostrum decreases and lipid-rich milk is released. Blood Supply, Innervation, and Lymphatics: The breast receives its principal blood supply from: a. Perforating branches of the internal mammary artery; b. Lateral branches of the posterior intercostal arteries; and c. Branches from the axillary artery, including the highest thoracic, lateral thoracic, and pectoral branches of the thoracoacromial artery. The second, third, and fourth anterior intercostal perforators and branches of the internal mammary artery arborize in the breast as the medial mammary arteries. The lateral thoracic artery gives off branches to the serratus anterior, pectoralis major and pectoralis minor, and subscapularis muscles. It also gives rise to lateral mammary branches. The veins of the breast and chest wall follow the course of the arteries, with venous drainage being toward the axilla. The three principal groups of veins are: a. Perforating branches of the internal thoracic vein. b. Perforating branches of the posterior intercostal veins, and c. Tributaries of the axillary vein. Batson’s vertebral venous plexus, which invests the vertebrae and extends from the base of the skull to the sacrum, may provide a route for breast cancer metastases to the vertebrae, skull, pelvic bones, and central nervous system. Lymph vessels generally parallel the course of blood vessels. Lateral cutaneous branches of the third through sixth intercostal nerves provide sensory innervation of the breast (lateral mammary branches) and of the anterolateral chest wall. These branches exit the intercostal spaces between slips of the serratus anterior muscle. Cutaneous branches that arise from the cervical plexus, specifically the anterior branches of the supraclavicular ******ebook converter DEMO Watermarks******* nerve, supply a limited area of skin over the upper portion of the breast. Important: The intercostobrachial nerve is the lateral cutaneous branch of the second intercostal nerve and may be visualized during surgical dissection of the axilla. Resection of the intercostobrachial nerve causes loss of sensation over the medial aspect of the upper arm. This is the most common nerve injured during mastectomy: Six axillary lymph node groups recognized by surgeons are: a. The axillary vein group (lateral), which consists of four to six lymph nodes that lie or posterior to the vein and receive most of the lymph drainage from the upper extremity. b. The external mammary group (anterior or pectoral group), which consists of five to six lymph nodes that lie along the lower border of the pectoralis minor muscle contiguous with the lateral thoracic vessels and receive most of the lymph drainage from the lateral aspect of the breast. c. The scapular group (posterior or subscapular), which consists of five to seven lymph nodes that lie along the posterior wall of the axilla at the lateral border of the scapula contiguous with the subscapular vessels and receive lymph drainage principally from the lower posterior neck, the posterior trunk, and the posterior shoulder. d. The central group, which consists of three or four sets of lymph nodes that are embedded in the fat of the axilla lying immediately posterior to the pectoralis minor muscle and receive lymph drainage both from the axillary vein, external mammary, and scapular groups of lymph nodes, and directly from the breast. e. The subclavicular group (apical), which consists of six to twelve sets of lymph nodes that lie posterior and superior to the upper border of the pectoralis minor muscle and receive lymph drainage from all of the other groups of axillary lymph nodes. f. The inter- pectoral group (Rotter’s lymph nodes), which consists of one to four lymph nodes that are interposed between the pectoralis major and pectoralis minor muscles and receive lymph drainage directly from the breast. The lymph fluid that passes through the interpectoral group of lymph nodes passes directly into the central and subclavicular groups. Levels of Lymph Nodes: Levels are decided according to their anatomic relationship to the pectoralis minor muscle. Lymph nodes located lateral to or below the lower border of the pectoralis minor muscle are referred to as level I lymph nodes, which include the axillary vein, external mammary, and scapular groups. Lymph nodes located superficial or deep to the pectoralis minor muscle are referred to as level II lymph nodes, which include the central and interpectoral groups. Lymph nodes located medial to or above the upper border of the pectoralis minor muscle are referred to as level III lymph nodes, which consist of the subclavicular group. group of lymph nodes. The axillary lymph nodes usually receive >75% of the lymph drainage from the breast. The rest is derived primarily from the medial aspect of the breast, flows through the lymph vessels that accompany the perforating branches of the internal mammary artery, and enters the parasternal (internal mammary) group of lymph nodes. Gynecomastia (very important topic for exams): Gynecomastia refers to an enlarged breast in the male. In the nonobese male, breast tissue measuring at least 2 cm in diameter must be present before a diagnosis of gynecomastia may be made: Physiologic gynecomastia usually occurs during three phases of life: a. The neonatal period, : Neonatal gynecomastia is caused by the action of placental estrogens on neonatal breast tissues. b. Adolescence: in adolescence, there is an excess of estradiol relative to testosterone. c. Senescence: with senescence, the circulating testosterone level falls, which results in relative hyperestrinism. Common to each of these phases is an excess of circulating estrogens in relation to circulating testosterone. In gynecomastia, the ductal structures of the male breast enlarge, elongate, and branch with a concomitant ******ebook converter DEMO Watermarks*******