Advances in Experimental Medicine and Biology Volume 850 Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy Advances in Experimental Medicine and Biology presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. The series also provides scientists with up to date information on emerging topics and techniques. 2014 Impact Factor: 1.958 More information about this series at http://www.springer.com/series/5584 Stephen P. Schoenberger · Peter D. Katsikis · Bali Pulendran Editors Crossroads Between Innate and Adaptive Immunity V 1 3 Editors Stephen P. Schoenberger Bali Pulendran Laboratory of Cellular Immunology Yerkes National Primate Research Center La Jolla Institute for Allergy and Immun Emory University Emory Vaccine Center & La Jolla Atlanta USA Georgia USA Peter D. Katsikis Department Microbiology & Immunology Drexel University College of Medicine Philadelphia Pennsylvania USA ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-319-15773-3 ISBN 978-3-319-15774-0 (eBook) DOI 10.1007/978-3-319-15774-0 Library of Congress Control Number: 2015948173 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com) Contents 1 T ype III interferons (IFNs): Emerging Master Regulators of Immunity .............................................................................................. 1 Ioanna E. Galani, Ourania Koltsida and Evangelos Andreakos 2 Stability of Regulatory T Cells Undermined or Endorsed by Different Type-1 Cytokines ..................................................................... 17 Silvia Piconese and Vincenzo Barnaba 3 T he Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses ...................................................... 31 Gabriel R. Starbeck-Miller and John T. Harty 4 Functional Diversity of Human Dendritic Cells .................................... 43 Eynav Klechevsky 5 Selective Dependence of Kidney Dendritic Cells on CX CR1—Implications for Glomerulonephritis Therapy ................... 55 3 Katharina Hochheiser and Christian Kurts 6 Mechanisms of Memory T Cell Activation and Effective Immunity .................................................................................................. 73 Grégoire Lauvau and Saïdi M’Homa Soudja 7 Molecular Programming of Immunological Memory in Natural Killer Cells .................................................................................. 81 Aimee M. Beaulieu, Sharline Madera and Joseph C. Sun 8 Induction of Immune Tolerance to Dietary Antigens ........................... 93 Kwang Soon Kim and Charles D. Surh v vi Contents 9   The Role of p110δ in the Development and Activation of B  Lymphocytes ............................................................................................. 119 Rebecca Newman and Martin Turner 10 I mmune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model ............................................................. 137 D. Zehn and E. J. Wherry Index ................................................................................................................ 153 Contributors Evangelos Andreakos Department of Immunology, Center for Translational and Clinical Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece Vincenzo Barnaba Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy Istituto Pasteur -Fondazione Cenci Bolognetti, Rome, Italy Aimee M. Beaulieu Memorial Sloan Kettering Cancer Center, New York, NY, USA Ioanna E. Galani Department of Immunology, Center for Translational and Clinical Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece John T. Harty Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA Department of Microbiology, University of Iowa, Iowa City, IA, USA Katharina Hochheiser Institute of Experimental Immunology(IMMEI), Rheinische Friedrich-Wilhelms University, Bonn, Germany Kwang Soon Kim Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, Republic of Korea Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea Eynav Klechevsky Washington University School of Medicine, St. Louis, USA Ourania Koltsida Department of Immunology, Center for Translational and Clinical Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece Christian Kurts Institute of Experimental Immunology(IMMEI), Rheinische Friedrich-Wilhelms University, Bonn, Germany vii viii Contributors Grégoire Lauvau Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA Sharline Madera Memorial Sloan Kettering Cancer Center, New York, NY, USA Rebecca Newman Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, UK Silvia Piconese Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy Saïdi M’Homa Soudja Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA Gabriel R. Starbeck-Miller Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA Joseph C. Sun Memorial Sloan Kettering Cancer Center, New York, NY, USA Charles D. Surh Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, Republic of Korea Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea Division of Developmental Immunology, La Jolla institute for Allergy and Immunology, La Jolla, CA, USA Martin Turner Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, UK E. J. Wherry Department of Microbiology, Institute for Immunology, Philadelphia, PA, USA D. Zehn Division of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland Chapter 1 Type III interferons (IFNs): Emerging Master Regulators of Immunity Ioanna E. Galani, Ourania Koltsida and Evangelos Andreakos Abstract Lambda interferons (IFN-λs), type III interferons or interleukins 28 and  29 are the latest addition to the class II cytokine family. They share low homology with the interferon (IFN) and IL-10 cytokine families, yet they exhibit common and unique activities, the full spectrum of which still remains incompletely understood. Although initially described for their antiviral functions, it is now appreciated that IFN-λs also mediate diverse antitumor and immune-modulatory effects, and are key  determinants of innate immunity at mucosal sites such as the gastrointestinal and respiratory tracks. Here, we are reviewing the biological functions of IFN-λs, the  mechanisms controlling their expression, their downstream effects and their role in the maintenance of homeostasis and disease. We are also exploring the potential application of IFN-λs as novel therapeutics. Keywords Lambda interferons (IFN-λs) · Type III interferons · Interleukin 28 · Interleukin 29 · Antiviral activity · Mucosal immunity Type III IFNs or Lambda IFNs: A Unique Interferon Family Interferons (IFNs) were originally described over 50 years ago as anti-viral pro- teins. However, they have since been shown to regulate multiple other biological processes including cell proliferation and survival, inflammation and immunity. They have also been implicated in many pathological situations including infec- tions, cancer and autoimmunity. The diversity and functional organization of this family became obvious in the 1980s with the cloning of the IFN-β gene and several  isoforms of IFN-α. This led to the realization that most of these molecules are part  of a single family, the type I IFN or IFN-α/β family, and signal through the same  heterodimeric receptor comprising the IFNαR1 and IFNαR2 chains. In humans,  E. Andreakos () · I. E. Galani · O. Koltsida Department of Immunology, Center for Translational and Clinical Research, Biomedical Research Foundation, Academy of Athens, Athens 11527, Greece e-mail: [email protected] © Springer International Publishing Switzerland 2015 1 S. P. Schoenberger et al. (eds.), Crossroads Between Innate and Adaptive Immunity V, Advances in Experimental Medicine and Biology 850, DOI 10.1007/978-3-319-15774-0_1