Table Of Content

Author index A Becquemont L (see Tennezé et al). 1999;66:582-8 Belz GG, Butzer R, Kober S, Mang C, Mutschler E. Time course Aarons L (see Simpson et al). 1999;66:474-84 and extent of angiotensin [I antagonism after irbesartan, losartan, Abernethy DR (see Donahue et al). 1999;66:563-68 and valsartan in humans assessed by angiotensin II dose response Abiose AK (see Tangphao et al). 1999;66:232-8 and radioligand receptor assay. 1999;66:367-73 Adams WP (see Singh et al). 1999;66:346-57 Benowitz NL (see Gelal et al). 1999;66:123-35 Agler D (see Swanson et al). 1999;66:294-305 Bergquist C, Lindegard L. Dosing recommendations in liver dis- Agren JJ (see Vidgren et al). 1999;66:3 15-22 ease. 1999;66:201 (Letter) Ahonen J (see Palkama et al). 1999;66:33-9 Bertilsson L (see Mirghani et al). 1999;66:454-60 Ajayi F (see Yuan et al). 1999;66:9-15 Bertino JS (see Streetman et al). 1999;66:535-41 Aljada A (see Dandona et al). 1999;66:58-65 Bialer M (see Volosov et al). 1999;66:547-53 Allen J (see Johnson et al). 1999;66:492-500 Bickel WK (see Petry et al). 1999;66:306-14 Alvarez JC, Gluck N, Arnulf I, Quintin P, Leboyer M, Pecquery R, Bieglmayer C (see Pernerstorfer et al). 1999:66:51-7 Launay JM, Perez-Diaz F, Spreux-Varoquaux O. Decreased Blaschke TF (see Tangphao et al). 1999;66:232-8 platelet serotonin transporter sites and increased platelet inositol Blouin RA (see Poloyac et al). 1999;66:554-62 triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine. 1999;66:617-24 Blum RA (see Rogers et al). 1999;66:358-66 Amin RD (see Rogers et al). 1999;66:358-66 Boissel JP (see Nony et al). 1999;66:173-84 Antonijoan R (see Barbanoj et al). 1999;66:485-91 Bozkurt A (see Aynaciouglu et al). 1999;66:185-92 Aoyama N (see Tanigawara et al). 1999;66:528-34 Brahmadevara N (see Mamidi et al). 1999;66:193-200 Arnulf I (see Alvarez et al). 1999;66:617-24 Breivik EK, Barkvoll P, Skovlund E. Combination of diclofenac Asada A (see Hamaoka et al). 1999;66:110-7 with acetaminophen or acetaminophen-codeine after oral surgery Atkinson AJ, Moore KE, Peck CC. Dr Marcus M. Reidenberg, a randomized, double-blind, single-dose study. 1999;66:625-35 recipient of the 1999 Harry Gold Award. 1999;66:1 BrockmillerJ (see Johne et al). 1999;66:338-45 (Commentary) BrockmillerJ (see Sachse et al). 1999;66:431-8 Aynacioglu AS, Sachse C, Bozkurt A, Kortunay S, Nacak M, Brockmiller J. (see Aynaciouglu et al). 1999;66:185-92 SchrédeTr, Kayaalp O, Roots I, Brockméller J. Low frequency of Brgsen K (see Sindrup et al). 1999;66:636-41 defective alleles of cytochrome P450 enzymes 2C19 and 2D6 in Brown MT (see Herman et al). 1999;66:374-9 the Turkish population. 1999;66:184-92 Brunner HR (see Rossat et al). 1999;66:76-84 Bulzer R (see Belz et al). 1999;66:367-73 Bundschuh D (see Hartung et al). 1999;66:415-24 B Burnett A (see Yuan et al). 1999;66:9-15 Burnier M (see Rossat et al). 1999;66:76-84 Backman JT (see Kivist6 et al). 1999;66:444-53 Burry AE (see Tan et al). 1999;66:275-81 Backman JT, Wang JS, Wen X, Kivisté KT, Neuvonen PJ. Mibeferadil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam. 1999; c 66:401-7 Badger GJ (see Petry et al). 1999;66:306-14 Cadarso C (see de la Serna and Cadarso). 1999;66: 166-72 Balian JD (see Yuan et al). 1999;66:9-15 Cai WM, Chen B, Zhou Y, Zhang YD. Fluoxetine impairs the Ball SE, Scatnia JA, Kao J, Ferron GM, Fruncillo R, Mayer P, CYP2D6-mediated metabolism of propafenone enantiomers in Weinryb I, Guida M, Hopkins PJ, Warner N, Hall J. Population healthy Chinese volunteers. 1999;66:516-21 distribution and effects on drug metabolism of a genetic variant in the 5° promoter region of CYP3A4. 1999;66:288-94 Capparelli E (see Mirochnick et al). 1999;66: 16-24 Barbanoj M, Antonijoan R, Morte A, Grinyé JM, Sola R, Vallés J, Chalon S (see Tangphao et al). 1999;66:232-8 Peraire C, Cordero JA, Mufioz A, Jané F, Obach R Chavluvdi MR (see Mamidi et al). 1999;66: 193-200 Pharmacokinetics of the somatostatin analog lanreotide in Chen B (see Cai et al). 1999;66:516-21 patients with severe chronic renal insufficiency. 1999;66:485-91 Chiba K (see Ikeda et al). 1999;66:265-74 Barbey JT, Sale ME, Woosley RL, Shi J, Melikian AP, Hinderling Chiu HFK (see Lam et al). 1999;66:647 (Letter) PH. Pharmacokinetic, pharmacodynamic, and safety evaluation Chongsuphajaisiddhi T (see Simpson et al). 1999;66:474-84 of an accelerated dose titration regimen of sotalol in healthy mid- Chorazyczewski J (see Tan et al). 1999;:66:275-81 dle-aged subjects. 1999;66:91-9 Chow L (see Lam et al). 1999;66:647 (Letter) Barkvoll P (see Breivik et al). 1999;66:625-35 Clark AL (see Muir et al). 1999;66:85-90 Barnas CR (see Krecic-Shepard et al). 1999;66:40-50 ConnorJ (see Mirochnick et al). 1999;66:16-24 Bauer S (see Johne et al). 1999;66:338-45 Cordero JA (see Barbanoj et al). 1999;66:485-91 Bauer S (see Sachse et al). 1999;66:431-8 Cucherat M (see Nony et al). 1999;66:173-84 July, pp. 1-104; August, pp. 105-210; September, pp. 211-332; D October, pp. 333-444; November, pp. 445-546; December, pp. 547-674. Index to the ASCPT meeting abstracts is located in the d’ Athis P (see Pariente-Khayat et al). 1999;66:136-9 February issue. Damodarram G (see Mamidi et al). 1999;66:193-200 CLINICAL PHARMACOLOGY & THERAPEUTICS DECEMBER 1999 659 CLINICAL PHARMACOLOGY & THERAPEUTICS 660 Author index DECEMBER 1999 Dandona P, Mohanty P, Hamouda W, Aljada A, Kumbkarni Y, Garg Geus WP (see Mathét and Geus). 1999;66:140-51 R. Effect of dexamethasone on reactive oxygen species genera- Gluck N (see Alvarez et al). 1999;66:617-2 tion by leukocytes and plasma interleukin-10 concentrations: a Gorski JC (see Krecic-Shepard et al). 1999;66:40-50 pharmacodynamic study. 1999;66:58-65 Gotschall R (see Streetman et al). 1999;66:535-41 Danish University Antidepressant Group. Clomipramine dose-effect Gramatté T, Oertal R. Intestinal secretion of intravenous talinolol is study in patients with depression: clinical end points and phar- inhibited by luminal R-verapamil. 1999;66:239-45 macokinetics. 1999;66:152-65 Greenblatt DJ (see Tsunoda et al). 1999;66:461-71 Davis DB (see Mould et al). 1999;66:246-57 Griny6é JM (see Barbanoj et al). 1999;66:485-91 de la Serna G, Cadarso C. Fenofibrate decreases plasma fibrinogen, Groopman JD (see Kinirons et al). 1999;66:224-31 improves lipid profile, and reduces uricemia. 1999;66: 166-72 Guerret M (see Kovarik et al). 1999;66:391-400 de Meijer A, Vollaard H, de Metz M, Verbruggen B, Thomas C, Guida M (see Ball et al). 1999;66:288-94 Novakova I. Meloxicam, 15 mg/day, spares platelet function in Guinta D (see Swanson et al). 1999;66:294-305 healthy volunteers. 1999;66:425-30 Gupta V (see van Agtmael et al). 1999;66:408-14 de Metz M (see de Meijer et al). 1999;66:425-30 Gustafsson LL (see Mirghani et al). 1999;66:454-60 Deinum HT (see van Lingen et al). 1999;66:509-15 Denolle T, Pellizzoni C, Jannuzzo G, Poggesi I. Hemodynamic effects of reboxetine in healthy male volunteers. 1999;66:282-7 H Desel H (see Nau et al). 1999;66:25-32 Dettling M (see Sachse et al). 1999;66:431-8 Haefeli WE (see Romerio et al). 1999;66:522-7 Doecek WD (see Hartung et al). 1999;66:415-24 Donahue S, Flockhart DA, Abernethy DR. Ticlopidine inhibits Hall J (see Ball et al). 1999;66:288-94 Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, phenytoin clearance. 1999;66:563-68 Asada A. Propofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study. 1999;66:110-7 Hamouda W (see Dandona et al). 1999;66:58-65 Hanai H (see Ikeda et al). 1999;66:265-74 Echizen H (see Takahashi et al). 1999;66:569-81 Hartung T, Doecek WD, Bundschuh D, Foote MA, Fantner F, Eichler HG (see Pernerstorfer et al). 1999;66:51-7 Hermann C, Lenz A, Milwee S, Rich B, Simon B, Vook HD, von Elliott MJ(see Mould et al). 1999;66:246-57 Aulock S, Wendel A. Effect of filgrastim treatment on inflamma- Ellis RE (see Streetman et al). 1999;66:535-41 tory cytokines and lymphocyte functions. 1999;66:415-24 Endrenyi L (see Kalow et al). 1999;66:445-7 (Commentary) Hase I (see Hamaoka et al). 1999;66:1 10-7 Ericksson O (see Mirghani et al). 1999;66:454-60 He N (see Qin et al). 1999;66:642-6 Hellgren U (see Mirghani et al). 1999;66:454-60 Herman BD, Fleishaker JC, Brown MT. Ketoconazole inhibits the clearance of the enantiomers of the antidepressant reboxetine in humans. 1999:66:374-9 Falk MC (see Johnseot anl ). 1999;66:492-500 Hermann C (see Hartung et al). 1999;66:415-24 Fantner F (see Hartung et al). 1999;66:415-24 Hillis WS (see Muir et al). 1999;66:85-90 Feinstein AR. Statistical reductionism and clinicians’ delinquencies Hinderling PH (see Barbey et al). 1999;66:91-9 in humanistic research. 1999;66:211-7 (Commentary) Hoffman BB (see Tangphao et al). 1999;66:232-8 Feldman RD (see Tan et al). 1999;66:275-81 Holroyd S, Seward RL. Psychotropic drugs in acute intermittent Ferron GM (see Ball et al). 1999;66:288-94 porphyria. 1999;66:323-5 Fisher DM (see Shangraw et al). 1999;66:380-90 Hopkins PJ (see Ball et al). 1999;66:288-94 Fleishaker JC (see Herman et al). 1999;66:374-9 Hotellier F (see Pariente-Khayat et al). 1999;66:136-9 Flockhart DA (see Donahue et al). 1999;66:563-68 Huang SL (see Qin et al). 1999;66:642-6 Flynn D (see Swanson et al). 1999;66:294-305 Hubert P (see Pariente-Khayat et al). 1999;66:136-9 Foote MA (see Hartung et al). 1999;66:415-24 Forrest A (see Luzier et al). 1999;66:594-601 Franzen K (see Johnson et al). 1999;66:492-500 Fruncillo R (see Ball et al). 1999;66:288-94 Fujimura A (see Tsuruoka et al). 1999:66:609-16 Fujita M (see Murayama et al). 1999;66:258-64 lida I (see Ikeda et al). 1999;66:265-74 inoue T (see Murayama et al). 1999;66:258-64 Funck-Brentano (see Tennezé et al). 1999;66:582-8 Furuta T, Ohashi K, Kobayashi K, lida I, Yoshida H, Shirai N, Ikeda Y (see Murayama et al). 1999;66:258-64 Takashima M, Kosuge K, Hanai H, Chiba K, Ishizaki T, Kaneko Ishizaki T (see Hamaoka et al). 1999;66:1 10-7 E. Effects of clarithromycin on the metabolism of omeprazole in Ishizaki T (see Ikeda et al). 1999;66:265-74 relation to CYP2C/9 genotype status in humans. 1999;66:265-74 G Jacob P (see Gelal et al). 1999;66:123-35 Gaedigk A (see Streetman et al). 1999;66:535-41 Jané F (see Barbanoj et al). 1999:66:485-91 Gagliano KD (see Rogers et al). 1999;66:358-66 Jannuzzo G (see Denolle et al). 1999;66:282-7 Garcia-Barcelo M (see Lam et al). 1999;66:647 (Letter) Jensen TS (see Sindrup et al). 1999;66:636-41 Gardner BM (see Poloyac et al). 1999;66:554-62 Jilma B (see Pernerstorfer et al). 1999;66:51-7 Garg R (see Dandona et al). 1999;66:58-65 Joensuu H (see Villikka et al). 1999;66:589-93 Gelal A, Jacob P, Yu L, Benowitz NL. Disposition kinetics and Johne A, Brockmdller J, Bauer S, Maurer A, Langheinrich M, Roots effects of menthol. 1999;66:128-35 I. Pharmacokinetic interaction of digoxin with a herbal extract Gerbeau C (see Kovarik et al). 1999:66:39 1-400 from St John’s wort (Hypericum perforatum). 1999;66:338-45 AL PHARMACOLOGY & THERAPEUTICS 66, NUMBER 6 Author index 661 Johnson AG, Rigby RJ, Taylor PJ, Jones CE, Allen J, Franzen K, am K, Chow L, Leung T, Wing YK, Chiu HFK, Garcia-Barcelo M Falk MC, Nicol D. The kinetics of mycophenolic acid and its glu Association between CYP2A6 and CYP2C/9 mutant alleles curonide metabolite in adult kidney transplant recipients 1999:66:647 (Letter) 1999:66:492-500 ; angheinrich M (see Johne et al). 1999:66:338- Jones CE (see Johnson et al). 1999;66:492-500 assek C (see Nau et al). 1999;66:25-32 Jouvet P (see Pariente-Khayat et al). 1999;66:136-9 eeder S (see Streetman et al). 1999:66:5 3 5 K emberger L. A flight through clinical pharmacology soar with the eagles. 1999;66:218-23 (Commentz : Kageyama H (see Koizumi et al). 1999;66:501-8 enz A (see Hartung et al). 1999;66:415-24 Kalow W, Ozdemir V, Tang BK, Tothfalusi L, Endrenyi L. The sci- erner M (see Swanson et al). 1999;66:294-305 ence of pharmacological variability: an essay. 1999;66:445-7 esko LJ (see Singh et al). 1999:66:346-57 (Commentary) esko LJ (see Yuan et al). 1999:66:9-15 Kaneko E (see Ikeda et al). 1999;66:265-74 eung T (see Lam et al). 1999;66:647 (Letter) Kao J (see Ball et al). 1999:66:288-94 ilja JJ (see Kivisté et al). 1999;66:444-53 Kapiotis S (see Pernerstorfer et al). 1999;66:51-7 ilja JL, Kivist6 KT, Neuvonen PJ. Grapefruit juice increases serum Karhunen LJ (see Vidgren et al). 1999;66:315-22 concentrations of atorvastatin and has no effect on pravastatin Kasuga M (see Tanigawara et al). 1999;66:528-34 1999:66:118-27 Katashima M (see Koizumi et al). 1999;66:501-8 indegard L (see Bergquist and Lindegard). 1999;66:201 (Letter) Katneni K (see Mamidi et al). 1999;66:193-200 Linder L (see Romerio et al). 1999;66:522-7 Kawaguc see Tsuruoka et al). 1999;66:609-16 iu L (see Rogers et al). 1999:66:358-66 Kayaalp O (see Aynaciouglu et al). 1999;66:185-92 ooareesuwan S (see Simpson et al). 1999;66:474-84 Kazierad DJ (see Luzier et al). 1999;66:594-601 uggen ME (see Mould et al). 1999;66:246-57 Kearns GL (see Marshall and Kearns). 1999;66:66-75 uzier AB, Killian A, Wilton JH, Wilson MF, Forrest A, Kazierad Kearns GL (see Streetman et al). 1999;66:535-41 DJ. Gender-related effects on metoprolol pharmacokinetics and Kearns Gl (see Streetman et al). 1999;66:535-41 pharmacodynamics in healthy volunteers. 1999:66:594-601 Killian A (see Luzier et al). 1999;66:594-601 Kim RB (see Kinirons et al). 1999;66:224-3 1 Kinirons MT, O’Shea D, Kim RB, Groopman JD, Thumn M Wood AJJ, Wilkinson RG. Failure of erythromycin breath test correlate vith midazolam clearance as a probe of cytocnre Macdonald CJ (see Tan et al). 1999;66:275-81 P4503A. 1999:66:224-31 Madsen C (see Sindrup et al). 1999;66:636-41 Kinitada S (see Murayama et al). 1999;66:258-64 Mdaenpaia H (see Villikka et al). 1999;66:589-93 Kita T (see Tanigawara et al). 1999;66:528-34 Maillard M (see Rossat et al). 1999;66:76-84 Kivist6 KT (see Backman et al). 1999;66:401 Malikian AP (see Barbey et al). 1999;66:91-9 Kivist6 KT Lilja et al). 1999:66:1 18-27 Mamidi RNVS, Satyavageeswaran S, Vakkalanka SVS, Chavluvdi Kivist6 KT (see Villikka et al). 1999;66:589-93 MR, Katneni K, Brahmadevara N, Damodarram G, S Kivist6 KT, Lilja JJ, Backman JT, Neuvonen PJ. Repeate S. Polymorphism of dextromethorphan oxidation in South Indian sumption of grapefruit juice considerably increases plasma subjects. 1999:66:193-200 centrations of cisapride. 1999;66:444-53 Mang C (see Belz et al). 1999;66:367-73 Kobayashi K (see Ikeda et al). 1999;66:265- 7A Manninen P( see Laine et al). 1999;66:602-8 Kober S (see Belz et al). 1999;66:367-73 Marroum P (see Yuan et al). 1999;66:9-15 Koizumi F, Murakami M, Kageyama H, Katashima M, Terakawa M Marshall JD, Kearns GL. Developmental pharmacodynamics of Ohnishi A. Smoking accelerates absorption of inhaled elastase cyclosporine. 1999;66:66-75 inhibitor FK706. 1999:66:501-8 Mathét RAA, Geus WP. Pharmacodynamic modeling of the acid Kolenda H (see Nau et al). 1999;66:25-32 inhibitory effect of ranitidine in patients in an intensive care unit Komada F (see Tanigawara et al). 1999;66:528-34 during prolonged dosing: characterization of tolerance Kortunay S (see Aynaciouglu et al). 1999;66: 185-92 1999-66:140-51 Kosuge K (see Ikeda et al). 1999:66:265-74 Maurer A( see Johne et al). 1999;66:338-45 Kovarik JM, Rigaudy L, Guerret M, Gerbeau C, Rost KL Mayer P (see Ball et al). 1999;66:288-94 Longitudinal assessment of a P-glycoprotein—mediated drug McCann GP (see Muir et al). 1999;66:85-90 interaction of valspodar on digoxin. 1999;66:391-400 Milwee S (see Hartung et al). 1999;66:415-24 Krecic-Shepard ME, Barnas CR, Slimko J, Gorski JC, Wainer IW, Minthorn EA (see Mould et al). 1999;66:246-57 Schwartz JB. In vivo comparison of putative probeso f CYP3A4/5 Mirghani RA, Hellgren U, Westerberg PA, Ericksson O, Bertilsson activity: erythromycin, dextromethorphan, verapamil L, Gustafsson LL. The roles of cytochrome P450 3A4 and 1 A2 in 1999:66:40-50 the 3-hydroxylation of quinine in vivo. 1999;66:454-60 Kubo S (see Takahashi et al). 1999;66:569-81 Mirochnick M, Capparelli E, Connor J. Pharmacokir Kumbkarni Y (see Dandona et al). 1999;66:58-65 zidovudine in infants: a population analysis across studies Kwok DC (see Mould et al). 1999;66:246-57 1999:66:16-24 Mizuntani K (see Hamaoka et al). 1999;66:110-7 Mohanty P (see Dandona et al). 1999;66:58-65 Mokhtari M (see Pariente-Khayat et al). 1999;66:136-9 Molzon JA (see Singh et al). 1999;66:346-57 Laine K, Palovaara S, Tapanainen P, Manninen P. Plasma tacrine Moore KE (see Atkinson et al). 1999:66:1 (Ci concentrations are significantly increased by concomitant hor Moreno HT (see Tangphao et al). 1999:66:2 32-8 mone replacement therapy. 1999;66:602-8 Morte A (see Barbanoj et al). 1999:66:485-91 CLINICAL PHARMACOLOGY & THERAPEUTICS 662 Author index DECEMBER 1999 Mould DR, Davis CB, Minthorn EA, Kwok DC, Elliott MJ, Luggen Pecquery R (see Alvarez et al). 1999;66:617-24 ME, Totoritis MC. A population pharmacokinetic-pharmacody- Pellizzoni C (see Denolle et al). 1999;66:282-7 namic analysis of single doses of clenoliximab in patients with Peraire C (see Barbanoj et al). 1999;66:485-91 rheumatoid arthritis. 1999;66:246-57 Perez-Diaz F (see Alvarez et al). 1999;66:617-24 Muir DF, McCann GP, Swan L, Clark AL, Hillis WS. Hemodynamic Pernerstorfer T, Schmid R, Bieglmayer C, Eichler HG, Kapiotis S, and coronary effects of intravenous eletriptan, a SHT | p/;p-recep- Jilma B. Acetaminophen has greater antipyretic efficacy than tor agonist. 1999;66:85-90 aspirin in endotoxemia: a randomized, double-blind, placebo- Muller-Oerlinghausen B (see Sachse et al). 1999;66:431-8 controlled trial. 1999;66:51-7 Mufioz A (see Barbangoj et al). 1999;66:485-91 Pershing LK (see Singh et al). 1999;66:346-57 Murakami M (see Koizumi et al). 1999;66:501-8 Perucca E (see Volosov et al). 1999;66:547-53 Murayama N, Tanaka M, Kunitada S, Yamada H, Inoue T, Terada Y, Petry NM, Bickel WK, Badger GJ. A comparison of four buprenor- Fjuita M, Ikeda Y. Tolerability, pharmacokinetics, and pharmaco- phine dosing regiment in the treatment of opioid dependence. dynamics of DX-906S5a, a new synthetic potent anticoagulant and 1999:66:306-14 specific factor Xa inhibitor, in healthy male volunteers. Poggesi I (see Denolle et al). 1999;66:282-7 1999:66:258-64 Poirier JM (see Tennezé et al). 1999;66:582-8 Mutschler E (see Belz et al). 1999;66:367-73 Poloyac SM, Tosheva RT, Gardner BM, Shedlofsky SI, Blouin RA. The effect of endotoxin administration on the pharmacokinetics of chlorzoxazone in humans. 1999;66:554-62 N Pons G (see Pariente-Khayat et al). 1999;66:136-9 Porras AG (see Rogers et al). 1999;66:358-66 Nacak M (see Aynaciouglu et al). 1999;66:185-92 Prange H (see Nau et al). 1999;66:25-32 Nafziger AN (see Streetman et al). 1999;66:535-41 Price R (see Simpson et al). 1999;66:474-84 Nakamoto T (see Hamaoka et al). 1999;66:110-7 Nau R, Desel H, Lassek C, Kolenda H, Prange H. Entry of tromethamine into the cerebrospinal fluid of humans after cere- Q brovascular events. 1999;66:25-32 Neuvonen PJ (see Backman et al). 1999;66:401-7 Qin XP, Xie HG, Wang W, He N, Huang SL, Xu ZH, Ou-Yang DS, Neuvonen PJ (see Kivist6 et al). 1999;66:444-53 Wang YJ, Zhou HH. Effect of the gene dosage of CYP2C/9 on Neuvonen PJ (see Lilja et al). 1999;66:118-27 diazepam metabolism in Chinese subjects. 1999;66:642-6 Neuvonen PJ (see Palkama et al). 1999;66:33-9 Quak CME (see van Lingen et al). 1999;66:509-15 Neuvonen PJ (see Villikka et al). 1999;66:589-93 Quintin P (see Alvarez et al). 1999;66:617-24 Nicol D (see Johnson et al). 1999;66:492-500 Nony P, Cucherat M, Boissel JP. Implication of evidence-based R medicine in prescription guidelines taught to French medical stu- dents: current status in the cardiovascular field. 1999;66:173-84 Reidenberg J. The case of the forgotten author: a mystery to editors. Nosten F (see Simpson et al). 1999;66:474-84 1999:66:333-5 (Commentary) Novakova I (see de Meijer et al). 1999;66:425-30 Reidenberg MM. Clinical pharmacology: the scientific basis of ther- Nussberger J (see Rossat et al). 1999;66:76-84 apeutics. 1999;66:1-8 (Commentary) 1999;66:624 (Correction) Rey E (see Pariente-Khayat et al). 1999;66:136-9 Rich B (see Hartung et al). 1999;66:415-24 O Rigaudy L (see Kovarik et al). 1999;66:391-400 Rigby RJ (see Johnson et al). 1999;66:492-500 O’Shea D (see Kinirons et al). 1999;66:224-31 Rissanen AM (see Vidgren et al). 1999;66:315-22 Obach R (see Barbanoj et al). 1999;66:485-91 Rogers HD, Zhao J, Liu L, Amin RD, Gagliano KD, Porras AG, Oda Y (see Hamaoka et al). 1999;66:110-7 Blum RA, Wilson ME, Stepanavage M, Vega JM. Grapefruit Oertel R (see Gramatté and Oertel). 1999;66:239-45 juice has minimal effects on plasma concentrations of lovastatin- Ohashi K (see Ikeda et al). 1999;66:265-74 derived 3-hydroxy-3-methylglutary] coenzyme A reductase Ohinishi A (see Koizumi et al). 1999;66:501-8 inhibitors. 1999;66:358-66 Ohmori M (see Tsuruoka et al). 1999;66:609-16 Romerio SC, Linder L, Haefeli WE. Neurokinin-1 receptor antago- Okken A (see van Lingen et al). 1999;66:509-15 nist R116301 inhibits substance P-induced venodilation. Okumura K (see Tanigawara et al). 1999;66:528-34 1999:66:522-7 Olive G (see Pariente-Khayat et al). 1999:66:136-9 Roots I (see Aynaciouglu et al). 1999;66:185-92 Olkkola KT (see Palkama et al). 1999;66:33-9 Roots I (see Johne et al). 1999;66:338-45 Ou-Yang DS (see Qin et al). 1999;66:642-6 Roots I (see Sachse et al). 1999;66:431-8 Ozdemir V (see Kalow et al). 1999;66:445-7 (Commentary) Rossat J, Maillard M, Nussberger J, Brunner HR, Burnier M. Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects. 1999;66:76-84 P Rost KL (see Kovarik et al). 1999;66:39 1-400 Ruschen S (see Sachse et al). 1999:66:431-8 Palkama VJ, Ahonen J, Neuvonen PJ, Olkkola KT. Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam. 1999:66:33-9 S Palovaara S (see Laine et al). 1999:66:602-8 Pariente-Khayat A, Tréluyer JM, Rey E, Mokhtari M, Werner E, Sachse C (see Aynaciouglu et al). 1999;66:185-92 Jouvet P, d’Athis P, Wood C, Hubert P, Hotellier F, olive G, Pons Sachse C, Ruschen S, Dettling M, Schley J, Bauer S, Muller- G. Pharmacokinetics and tolerance of flunitrazepam in neonates Oerlinghausen B, Roots I, BrockmGllerJ . Flavin monooxygenase and in infants. 1999;66:136-9 3 (FMO3) polymorphism in a white population: allele frequen- Parmelee T (see Yuan et al). 1999:66:9-15 cies, mutation linkage, and functional effects on clozapine and Peck CC (see Atkinson et al). 1999:66:1 caffeine metabolism. 1999;66:431-8 CLINICAL PHARMACOLOGY & THERAPEUTICS VOLUME 66, NUMBER 6 Author index 663 Saito T (see Tsuruoka et al). 1999;66:609-16 Tanigawara Y, Aoyama N, Kita T, Shirakawa K, Komada F, Kasuga Sale ME (see Barbey et al). 1999;66:91-9 M, Okumura K. CYP2C/9 genotype-related efficacy of omepra- Sato T (see Takahashi et al). 1999;66:569-81 zole for the treatment of infection caused by Helicobacter pylori Satyavageeswaran S (see Mamidi et al). 1999;66:193-200 1999:66:528-34 Scatnia JA (see Ball et al). 1999;66:288-94 Tapanainen P (see Laine et al). 1999;66:602-8 Schley J (see Sachse et al). 1999;66:431-8 Taylor PJ (see Johnson et al). 1999;66:492-500 Schmid R (see Pernerstorfer et al). 1999;66:51-7 Teja-Isavatharm P (see Simpson et al). 1999;66:474-84 Schroder T (see Aynaciouglu et al). 1999;66:185-92 Tennezé L, Verstuyft C, Becquemont L, Poirier JM, Wilkerson GR, Schwartz JB (see Krecic-Shepard et al). 1999;66:40-50 Funck-Brentano C. Assessment of CYP2D6 and CYP2C19 activ- Seward RL (see Holroyd and Seward). 1999;66:323-5 ity in vivo in humans: a cocktail study with dextromethorphan Shah VP (see Singh et al). 1999;66:346-57 and chloroguanide alone and in combination. 1999;66:582-8 Shangraw RE, Fisher DM. Pharmacokinetics and pharmacodynam- ter Kuile F (see Simpson et al). 1999;66:474-84 ics of dichloroacetate in patients with cirrhosis. 1999;66:380-90 Terada Y (see Murayama et al). 1999;66:258-64 Shedlofsky SI (see Poloyac et al). 1999;66:554-62 Terakawa M (see Koizumi et al). 1999;66:501-8 Shi J (see Barbey et al). 1999;66:91-9 Terzic A (see Waldman and Terzic). 1999;66:336-7 (Commentary) Shimizu T (see Takahashi et al). 1999;66:569-81 Terzic A. New frontiers of cardioprotection. 1999;66:105-9 Shimoyama Y (see Takahashi et al). 1999;66:569-8| (Commentary) Shioda N (see Takahashi et al). 1999;66:569-81 Thomas C (see de Meijer et al). 1999;66:425-30 Shirai N (see Ikeda et al). 1999;66:265-74 Thummel KE (see Kinirons et al). 1999;66:224-31 Shirakawa K (see Tanigawara et al). 1999;66:528-34 Tibboel D (see van Lingen et al). 1999;66:509-15 Shoulson I (see Swanson et al). 1999;66:294-305 Tosheva RT (see Poloyac et al). 1999;66:554-62 Simon B (see Hartung et al). 1999;66:415-24 Tothaflusi L (see Kalow et al). 1999;66:445-7 Simpson JA, Price R, ter Kuile F, Teja-Isavatharm P, Nosten F, Totoritis MC (see Mould et al). 1999;66:246-57 Chongsuphajaisiddhi T, Looareesuwan S, Aarons L, WHite NJ. Tréluyer JM (see Pariente-Khayat et al). 1999;66:136-9 Population pharmacokinetics of mefloquine in patients with acute Tsunoda SM, Velez RL, von Moltke LL, Greenblatt DJ. falciparum malaria. 1999;66:472-84 Differentiation of intestinal and hepatic cytochrome P450 3A Sindrup SH, Madsen C, Brgsen K, Jensen TS. The effect of tra- activity with use of midazolam as an in vivo probe: effect of keto- madol in painful polyneuropathy in relation to serum drug and conazole. 1999;66:461-71 metabolite levels. 1999;66:636-41 Tsuruoka S, Sugimoto K, Ohmori M, Kawaguchi A, Saito T, Singh GJP, Adams WP, Lesko LJ, Shah VP, Molzon JA, Williams Fujimura A. Chronotherapy of high-dose 1,25-dihydroxyvitamin RL, Pershing LK. Development of in vivo bioequivalence D; in hemodialysis patients with secondary hyperparathyroidism: methodology for dermatologic corticosteroids based on pharma- a single-dose study. 1999;66:609-16 codynamic modeling. 1999;66:346-57 Sintov A (see Volosov et al). 1999;66:547-53 Skovlund E (see Breivik et al). 1999;66:625-35 SlimkoJ (see Krecic-Shepard et al). 1999;66:40-50 Sola R M (see Barbanoj et al). 1999;66:485-91 Uppoor RS (see Yuan et al). 1999;66:9-15 Spreux-Varoquaux O (see Alvarez et al). 1999;66:617-24 Uusitupa MIJ (see Vidgren et al). 1999;66:315-22 Stepanavage M (see Rogers et al). 1999;66:358-66 Streetman DS, Ellis RE, Nafziger AN, Leeder S, Gaedigk A, Gotschall R, Kearns GL, Bertino JS. Dose dependency of dex- tromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyp- ing. 1999;66:535-41 Vakkalanka SVS (see Mamidi et al). 1999;66:193-200 Subramaniam S (see Mamidi et al). 1999;66:193-200 Vallés J (see Barbanoj et al). 1999;66:485-91 Sugimoto K (see Tsuruoka et al). 1999;66:609-16 Valve RS (see Vidgren et al). 1999;66:3 15-22 Swan L (see Muir et al). 1999;66:85-90 van Agtmael MA, Gupta V, van der Graaf CAA, van Boxtel CJ. The Swanson J, Guinta D, Flynn D, Agler D, Lerner M, Williams L, effect of grapefruit juice on the time-dependent decline of Shoulson I, Wigal S. Acute tolerance to methylphenidate in the artemether plasma levels in healthy subjects. 1999;66:408-14 treatment of attention deficit hyperactivity disorder in children. van Boxtel CJ (see van Agtmael et al). 1999;66:408-14 1999:66:294-305 van der Graaf CAA (see van Agtmael et al). 1999;66:408-14 van Lingen RA, Deinum HT, Quak CME, Okken A, Tibboel D. Multiple-dose pharmacokinetics of rectally administered aceta- minophen in term infants. 1999;66:509-15 Vega JM (see Rogers et al). 1999;66:358-66 Tainaka H (see Takahashi et al). 1999;66:569-8| Velez RL (see Tsunoda et al). 1999;66:461-71 Takahashi H, Sato T, Shimoyama Y, Shioda N, Shimizu T, Kubo S, Verbruggen B (see de Meijer et al). 1999;66:425-30 Tamura N, Tainaka H, Yasumori T, Echizen H. Potentiation of anti- Verstuyft C (see Tennezé et al). 1999;66:582-8 coagulant effect of warfarin caused by enantioselective metabolic Vidgren HM, Agren JJ, Valve RS, Karhunen LJ, Rissanen AM, inhibition by the uricosuric agent benzbromarone. 1999;66:569-8| Uusitupa MIJ. The effect of orlistat on the fatty acid composition Takashima M (see Ikeda et al). 1999;66:265-74 of serum lipid fractions in obese subjects. 1999;66:3 15-22 Tamura N (see Takahashi et al). 1999;66:569-8| Villikka K, Kivisté KT, Maenpaéai H, Joensuu H, Neuvonen PJ. Tan CM, Macdonald CJ, Chorazyczewski J, Burry AE, Feldman Cytochrome P450-inducing antiepileptics increase the clearance RD. Vandate stimulation of adenylyl cyclase: an index to tyrosine of vincristine in patients with brain tumors. 1999;66:589-93 kinase vascular effects. 1999;66:275-81 Volk HD (see Hartung et al). 1999;66:415-24 Tanaka M (see Murayama et al). 1999;66:258-64 Vollaard H (see de Meijer et al). 1999;66:425-30 Tang BK (see Kalow et al). 1999;66:445-7 (Commentary) Volosov A, Xiaodong S, Perucca E, Yagen B, Sintov A, Bialer M. Tangphao O, Chalon S, Moreno HT, Abiose AK, Blaschke TF, Enantioselective pharmacokinetics of 10-hydroxycarbazepine Hoffman BB. Heparin-induced vasodilation in human hand veins. after oral administration of oxycarbazepine to healthy Chinese 1999:66:232-8 subjects. 1999;66:547-53 CLINICAL PHARMACOLOGY & THERAPEUTICS 664 Author index DECEMBER 1999 von Aulock S (see Hartung et al). 1999;66:415-24 Wood AJJJ (see Kinirons et al). 1999;66:224-31 von Moltke LL (see Tsunoda et al). 1999;66:461-71 Wood C (see Pariente-Khayat et al). 1999;66: 136-9 Woosley RL (see Barbey et al). 1999;66:91-9 Ww X Wainer IW (see Krecic-Shepard et al). 1999;66:40-50 Waldman SA, Terzic A. The Molecular Therapeutics Section of the Xiaodong S (see Volosov et al). 1999:66:547-53 American Society for Clinical Pharmacology and Therapeutics. Xie HG (see Qin et al). 1999;66:642-6 1999:66:336-7 (Commentary) Xu ZH (see Qin et al). 1999;66:642-6 Wang JS (see Backman et al). 1999;66:401-7 Wang W (see Qin et al). 1999;66:642-6 Wang YJ (see Qin et al). 1999;66:642-6 Warner N (see Ball et al). 1999;66:288-94 Weinryb I (see Ball et al). 1999;66:288-94 Yagen B (see Volosov et al). 1999:66:547-53 Wen X (see Backman et al). 1999;66:401-7 Yamada H (see Murayama et al). 1999;66:258-64 Wendel A (see Hartung et al). 1999;66:415-24 Yasumori T (see Takahashi et al). 1999;66:569-81 Werner E (see Pariente-Khayat et al). 1999;66:136-9 Yoshida H (see Ikeda et al). 1999;66:265-74 Westerberg PA (see Mirghani et al). 1999;66:454-60 Yu L (see Gelal et al). 1999;66:123-35 White NJ (see Simpson et al). 1999;66:474-84 Yuan R, Parmelee T, Balian JD, Uppoor RS, Ajayi F, Burnett A, Wigal S (see Swanson et al). 1999;66:294-305 Lesko LJ, Marroum P. In vitro metabolic interaction studies Wilkinson GR (see Tennezé et al). 1999;66:582-8 experience of the Food and Drug Administration. 1999;66:915 Wilkinson RG (see Kinirons et al). 1999;66:224-31 Williams L (see Swanson et al). 1999;66:294-305 Williams RI (see Singh et al). 1999;66:346-57 Z Wilson MF (see Luzier et al). 1999;:66:594-601 Wilson MF (see Rogers et al). 1999;66:358-66 Zhang YD (see Cai et al). 1999;66:516-21 Wilton JH (see Luzier et al). 1999;66:594-601 Zhao J (see Rogers et al). 1999;66:358-66 Wing YK (see Lam et al). 1999:66:647 (Letter) Zhou Y (see Cai et al). 1999;66:516-21 Subject index American Society for Pharmacology and Experimental Therapeutics Abetimus sodium Cellular mechanisms and novel strategies for pain control ASPET-Ray Fuller Symposium. 1999;66:100 Abetimus sodium (USAN List No. 422). 1999;66:653 Amyotrophic lateral sclerosis Abortion Mecaserim (USAN List No. 419). 1999;66:331 Mifepristone (USAN List No. 419). 1999:66:330 Analgesics Acetaminophen Levobupivacaine hydrochloride (USAN List No. 417 Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled 66: 104 trial (Pernerstorfer et al). 1999;66:51-7 Analgesics, non-narcotic Combination of diclofenac with acetaminophen or aceta Acetaminophen has greater antipyretic efficacy than aspirin in minophen-codeine after oral surgery: a randomized, double endotoxemia: a randomized, double-blind, placebo-controlled blind single-dose study (Breivik et al). 1999;66:625-35 trial (Pernerstorfer et al). 1999;66:5 1-7 Multiple-dose pharmacokinetics of rectally administered aceta- Anesthetics, intravenous minophen in term infants (van Lingen et al). 1999;66:509-15 Propofol decreases the clearance of midazolam by inhibiting Adenosine triphosphate CYP3A¢4: an in vivo and in vitro study (Hamaoka et al). 1999 New frontiers of cardioprotection (Terzic et al). 1999;66:105-9 66:110-7 (Commentary) Angiotensin Adenylyl cyclase Time course and extent of angiotensin II antagonism after irbe- Vandate stimulation of adenylyl cyclase: an index to tyrosine sartan, losartan, and valsartan in humans assessed by kinase vascular effects (Tan et al). 1999;66:275-81 angiotensin II dose response and radioligand receptor assay (Belz et al). 1999;66:367-73 Adrenergic beta-antagonists Pharmacokinetic, pharmacodynamic, and safety evaluation of an Anidulafungin accelerated dose titration regimen of sotalol in healthy middle- Anidulafungin (USAN List No. 422). 1999;66:654 aged subjects (Barbey et al). 1999;66:91-9 Anti-anxiety agents, benzodiazepine Aldose reductase inhibitor Pharmacokinetics and tolerance of flunitrazepam in neonates and Zenarestat (USAN List No. 420). 1999;66:443 in infants (Pariente-Khayat et al). 1999;66:136-9 Alleles Anti-arrhythmia agents Association between CYP2A6 and CYP2C/9 mutant alleles (Lam Pharmacokinetic, pharmacodynamic, and safety evaluation of an et al). 1999;66:647 (Letter) accelerated dose titration regimen of sotalol in healthy middle- Flavin monooxygenase 3 (FMO3) polymorphism in a white pop- aged subjects (Barbey et al). 1999;66:91-9 ulation: allele frequencies, mutation linkage, and functional A nti-asthmatic agents effects on clozapine and caffeine metabolism (Sachse et al) Edodekin alfa (USAN List No. 418). 1999;66:206 1999:66:431-8 Anti-HIV agents Low frequency of defective alleles of cytochrome P450 enzymes Effect of saquinavir on the pharmacokinetics and pharmacody- 2C10 and 2D6 in the Turkish population (Aynacioglu et al) namics of oral and intravenous midazolam (Palkama et al) 1999;66:185-92 1999:66:33-9 Altinicline maleate Emitricitabine (USAN List No. 417). 1999;66:101 Altinicline maleate (USAN List No. 422). 1999;66:650 Pharmacokinetics of zidovudine in infants: a population analysis Alzheimer’s disease across studies (Mirochnick et al). 1999;66: 16-24 Levosimendan (USAN List No. 418). 1999;66:207 Anti-inflammatory agents American Society for Clinical Pharmacology and Therapeutics Celecoxib (USAN List No. 418). 1999;66:205 ASCPT moves to Alexandria, Virginia. 1999;66:328 Deracoxib (USAN List No. 418). 1999;66:208 Future meeting dates and sites of the ASCPT. 1999;66:32 Etanercept (USAN List No. 418). 1999;66:209 Nominations for awards. 1999;66:326-7, 542 Nepafenac (USAN List No. 418). 1999;66:208 Optimizing formulary decision making: core expertise for P & T Parecoxib sodium (USAN List No. 419). 1999;66:331 committees. 1999;66:649 Valdecoxib (USAN List No. 419). 1999:66:331 The Molecular Therapeutics Section of the American Society for Anti-inflammatory agents, steroidal Clinical Pharmacology and Therapeutics (Waldman and Effect of dexamethasone on reactive oxygen species generation Terzic). 1999;66:336-7 (Commentary) by leukocytes and plasma interleukin-10 concentrations: a Welcome new ASCPT members. 1999;66:648 pharmacodynamic study (Dandona et al). 1999;66:58-65 Anti-ulcer agents July, pp. 1-104; August, pp. 105-210; September, pp. 21 Pharmacodynamic modeling of the acid inhibitory effect of rani- October, pp. 333-444; November, pp. 445-546; December, pp. tidine in patients in an intensive care unit during prolonged 547-674. Index to the ASCPT meeting abstracts is located in the dosing: characterization of tolerance (Mathot et al).1999; February issue. 66:140-51 CLINICAL PHARMACOLOGY & THERAPEUTICS DECEMBER 1999 665 CLINICAL PHARMACOLOGY & THERAPEUTICS 666 Subject index DECEMBER 1999 Anticholesteremic agents Binetrakin Grapefruit juice increases serum concentrations of atorvastatin Binetrakin (USAN List No. 422). 1999;66:650 and has no effect on pravastatin (Lilija et al). 1999;66:118-27 Biricodar dicitrate Anticoagulants Biricodar dicitrate (USAN List No. 417). 1999;66:102 Tifacogin (USAN List No. 421). 1999;66:543 Body temperature Anticonvulsants Acetaminophen has greater antipyretic efficacy than aspirin in Cytochrome P450-inducing antiepileptics increase the clearance endotoxemia: a randomized, double-blind, placebo-controlled of vincristine in patients with brain tumors (Villikka et al) trial (Pernerstorfer et al). 1999;66:51-7 1999:66:589-93 Brain edema Antidepressive agents Entry of tromethamine into the cerebrospinal fluid of humans Igmesine hydrochloride (USAN List No. 417). 1999;66:104 after cerebrovascular events (Nau et al). 1999;66:25-32 Antidepressive agents, tricyclic Brasofensine maleate Clomipramine dose-effect study in patients with depression: clin Brasofensine maleate (USAN List No. 422). 1999;66:655 ical end points and pharmacokinetics (Danish University Buprenorphine Antidepressant Group). 1999;66: 152-65 4 comparison of four buprenorphine dosing regimens in the treat Antiepileptics; see Anticonvulsants of opioid dependence (Petry et al). 1999;66:306-14 Antilipemic agents Fenofibrate decreases plasma fibrinogen, improves lipid profile, and reduces uricemia (de la Serna et al). 1999;66:166-72 Antineoplastic agents Biricodar dicitrate (USAN List No. 417). 1999;66:102 Satraplatin (USAN List No. 420). 1999;66:440 Caffeine Antiviral agents Flavin monooxygenase 3 (FMO3) polymorphism in a white pop- Maribavir (USAN List No. 419). 1999;66:329 ulation: allele frequencies, mutation linkage, and functional Penciclovir sodium (USAN List No. 420). 1999;66:441 effects on clozapine and caffeine metabolism (Sachse et al). Saquinavir (USAN List No. 419). 1999;66:332 1999;66:431-8 Tremacamra (USAN List No. 421). 1999;66:544 Cardiovascular diseases Artemether Fenofibrate decreases plasma fibrinogen, improves lipid profile, The effect of grapefruit juice on the time-dependent decline of and reduces uricemia (de la Serna et al). 1999;66:166-72 artemether plasma levels in healthy subjects (van Agtmael et Implication of evidence-based medicine in prescription guide- lines taught to French medical students: current status in the al). 1999:66:408-14 cardiovascular field (Nony et al). 1999;66:173-84 Aspirin Caucasoid race Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled Low frequency of defective alleles of cytochrome P450 enzymes 2C10 and 2D6 in the Turkish population (Aynacioglu et al). trial (Pernerstorfer et al). 1999;66:51-7 1999:66:185-92 Attention deficit hyperactivity disorder Acute tolerance to methylphenidate in the treatment of attention Celecoxib deficit hyperactivity disorder in children (Swanson et al) Celecoxib (USAN List No. 418). 1999;66:205 1999:66:295-305 Cetuximab Cetuximab (USAN List No. 422). 1999;66:654 Authors Omission of authors. 1999;66:333 (Commentary) Cerebrovascular disorders The case of the forgotten author: a mystery to editors Entry of tromethamine into the cerebrospinal fluid of humans (Reidenberg). 1999;66:333-5 (Commentary) after cerebrovascular events (Nau et al). 1999;66:25-32 Axitirome Gavestinel (USAN List No. 417). 1999;66:103 Axitirome (USAN List No. 422). 1999;66:655 Children Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children (Swanson et al) 1999:66:295-305 Chinese Enantioselective pharmacokinetics of 10-hydroxycarbazepine after oral administration of oxycarbazepine to healthy Chinese Basiliximab subjects (Volosov et al). 1999:66:547-53 Basiliximab (USAN List No. 422). 1999;66:653 Fluoxetine impairs the CYP2D6-mediated metabolism of Benzbromarone propafenone enantiomers in healthy Chinese volunteers (Cai et Potentiation of anticoagulant effect of warfarin caused by enan- al). 1999:66:516-21 tioselective metabolic inhibition by the uricosuric agent Chloroguanide benzbromarone (Takahashi et al). 1999;66:569-81 Assessment of CYP2D6 and CYP2C19 activity in vivo in humans: Beverages a cocktail study with dextromethorphan and chloroguanide Grapefruit juice increases serum concentrations of atorvastatin alone and in combination (Tennezé et al). 1999;66:582-8 and has no effect on pravastatin (Lilija et al). 1999;66:118-27 Chlorzoxazone Bexlosteride The effect of endotoxin administration on the pharmacokinetics Bexlosteride (USAN List No. 422). 1999;66:653 of chlorzoxazone in humans (Poloyac et al). 1999;66:554-62 CLINICAL PHARMACOLOGY & THERAPEUTICS VOLUME 66, NUMBER 6 Subject index 667 Cholesterol Commentaries Fenofibrate decreases plasma fibrinogen, improves lipid profile, Commentaries. 1999;66:1-8, 105-9, 211-23, 333- , 445- and reduces uricemia (de la Serna et al). 1999;66:166-72 The science of pharmacological variability: an essay (Kalow et Chronotherapy al). 1999:66:445-7 Chronotherapy of high-dose 1,25-dihydroxyvitamin D in Contraceptives, oral hemodialysis patients with secondary hyperparathyroidism: a Mifepristone (USAN List No. 419). 1999;66:330 single-dose study (Tsuruoka et al). 1999;66:609-16 Coronary vessels Cirrhosis; see Liver cirrhosis Hemodynamic and coronary effects of intravenous eletriptan, a Cisapride SHT\p/;p-receptor agonist (Muir et al). 1999;66:85-90 Repeated consumption of grapefruit juice considerably increases Corrections plasma concentrations of cisapride (Kivist6 et al) Clinical pharmacology: The scientific basis of therapeutics 1999-66:448-53 (Reidenberg) (1999;66:1-8). 1999;66:624 (Correction) Citalopram hydrobromide Analysis of the CYP2D6 gene in relation to dextromethorphan O- Citalopram hydrobromide (USAN List No. 422). 1999;66:656 demethylation capacity in a Japanese population (Tateishi et al) (1999:65:570-5). 1999:66:581 (Correction) Citrus Corticosteroids Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A Development of in vivo bioequivalence methodology for derma- reductase inhibitors (Rogers et al). 1999;66:358-66 tologic corticosteroids based on pharmacodynamic modeling (Singh et al). 1999;66:346-57 Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin (Lilija et al). 1999;66: 118-27 Cyclooxygenase-2 inhibitors Repeated consumption of grapefruit juice considerably increases Celecoxib (USAN List No. 418). 1999:66:205 plasma concentrations of cisapride (Kivist6 et al) Parecoxib sodium (USAN List No. 419). 1999;66:331 1999:66:448-53 Renal effects of selective cyclooxygenase-2 inhibition in nor- The effect of grapefruit juice on the time-dependent decline of motensive salt-depleted subjects (Rossat et al). 1999;66:76-84 artemether plasma levels in healthy subjects (van Agtmael et Valdecoxib (USAN List No. 419). 1999;66:331 al). 1999:66:408-14 Cyclosporine Developmental pharmacodynamics of cyclosporine (Marshall Clarithromycin Effects of clarithromycin on the metabolism of omeprazole in and Kearns). 1999:66:66-75 relation to CYP2C/9 genotype status in humans (Furuta et al) Cytochrome P450 1999-66:265-74 Assessment of CYP2D6 and CYP2C19 activity in vivo in Clenoliximab humans: a cocktail study with dextromethorphan and chloroguanide alone and in combination (Tennezé et al). 1999; A population pharmacokinetic-pharmacodynamic analysis of sin- 66:582-8 gle doses of clenoliximab in patients with rheumatoid arthritis Association between CYP2A6 and CYP2C/9 mutant alleles (Lam (Mould et al). 1999:66:246-57 et al). 1999;:66:647 (Letter) Clevudine CYP2C/9 genotype-related efficacy of omeprazole for the treat- Clevudine (USAN List No. 422). 1999;66:656 ment of infection caused by Helicobacter pylori (Tanigawara et Clinical Pharmacology and Therapeutics al). 1999:66:528-34 Omission of authors. 1999:66:333 (Commentary) Cytochrome P450-inducing antiepileptics increase the clearance The case of the forgotten author: a mystery to editors of vincristine in patients with brain tumors (Villikka et al) (Reidenberg). 1999;66:333-5 (Commentary) 1999;66:589-93 Clomipramine Differentiation of intestinal and hepatic cytochrome P450 3A Clomipramine dose-effect study in patients with depression: clin activity with use of midazolam as an in vivo probe: effect of ical end points and pharmacokinetics (Danish University ketoconazole (Tsunoda et al). 1999;66:461-71 Antidepressant Group). 1999;66:152-65 Dose dependency of dextromethorphan for cytochrome P450 2D6 Decreased platelet serotonin transporter sites and increased (CYP2D6) phenotyping (Streetman et al). 1999;66:535-41 platelet inositol triphosphate levels in patients with unipolar Effect of the gene dosage of CYP2C/9 on diazepam metabolism depression: effects of clomipramine and fluoxetine (Alvarez et in Chinese subjects (Qin et al).-1999:66:642-6 al). 1999;66:617-24 Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C/9 genotype status in humans (Furuta et al) Clozapine 1999:66:265-74 Flavin monooxygenase 3 (FMO3) polymorphism in a white pop- Failure of erythromycin breath test to correlate with midazolam ulation: allele frequencies, mutation linkage, and functional clearance as a probe of cytochrome P4503A (Kinirons et al) effects on clozapine and caffeine metabolism (Sachse et al). 1999:66:224-31 1999:66:431-8 Fluoxetine impairs the CYP2D6-mediated metabolism of Codeine propafenone enantiomers in healthy Chinese volunteers (Cai et Combination of diclofenac with acetaminophen or aceta- al). 1999:66:516-21 minophen-codeine after oral surgery: a randomized, double- In vivo comparison of putative probes of CYP3A4/5 activity: ery- blind single-dose study (Breivik et al). 1999;66:625-35 thromycin, dextromethorphan, and verapamil (Krecic-Shepard Coenzyme A reductase inhibitors et al). 1999:66:40-50 Grapefruit juice has minimal effects on plasma concentrations of Low frequency of defective alleles of cytochrome P450 enzymes lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A 2C10 and 2D6 in the Turkish population (Aynacioglu et al). reductase inhibitors (Rogers et al). 1999;66:358-66 1999:66: 185-92 CLINICAL PHARMACOLOGY & THERAPEUTICS 668 Subject index DECEMBER 1999 Mibefradil but not isradipine substantially elevates the plasma Doxercalciferol concentrations of the CYP3A4 substrate triazolam (Backman Doxercalciferol (USAN List No. 422). 1999;66:655 et al). 1999;66:401-7 Drug interactions Population distribution and effects on drug metabolism of a In vitro metabolic interaction studies: experience of the Food and genetic variant in the 5° promoter region of CYP3A4 (Ball et Drug Administration (Yuan et al). 1999;66:9-15 al). 1999:66:288-94 Drug screening Propofol decreases the clearance of midazolam by inhibiting In vitro metabolic interaction studies: experience of the Food and CYP3A4: an in vivo and in vitro study (Hamaoka et al) Drug Administration (Yuan et al). 1999;66:9-15 1999:66:110-7 Dutasteride The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxyla Dutasteride (USAN List No. 417). 1999:66:101 tion of quinine in vivo (Mirghani et al). 1999;66:454-60 DX-9065a Cytokines Tolerability, pharmacokinetics, and pharmacodynamics of DX- Effect of filgrastim treatment on inflammatory cytokines and 9065a, a new synthetic potent anticoagulant and specific factor lymphocyte functions (Hartung et al). 1999;66:415-24 Xa inhibitor, in healthy male volunteers (Murayama et al). Cytomegalovirus infections 1999-66:258-64 Maribavir (USAN List No. 419). 1999;66:329 Edodekin alfa Depression, involutional Edodekin alfa (USAN List No. 418). 1999;66:206 Clomipramine dose-effect study in patients with depression: clin Education, medical ical end points and pharmacokinetics (Danish University Implication of evidence-based medicine in prescription guide- Antidepressant Group). 1999:66:152-65 lines taught to French medical students: current status in the Deracoxib cardiovascular field (Nony et al). 1999;66:173-84 Deracoxib (USAN List No. 418). 1999;66:208 Emitricitabine Dermatitis, atopic Emitricitabine (USAN List No. 417). 1999;66:101 Hydrocortisone probutate (USAN List No. 417). 1999;66:104 Endotoxin Dextromethorphan The effect of endotoxin administration on the pharmacokinetics Assessment of CYP2D6 and CYP2C19 activity in vivo in of chlorzoxazone in humans (Poloyac et al). 1999;66:554-62 humans: a cocktail study with dextromethorphan and Erythromycin chloroguanide alone and in combination (Tennezé et al). 1999; Failure of erythromycin breath test to correlate with midazolam 66:582-8 clearance as a probe of cytochrome P4503A (Kinirons et al) Dose dependency of dextromethorphan for cytochrome P450 2D6 1999:66:224-31 (CYP2D6) phenotyping (Streetman et al). 1999;66:535-41 In vivo comparison of putative probes of CYP3A4/5 activity: ery In vivo comparison of putative probes of CYP3A4/5 activity: ery thromycin, dextromethorphan, and verapamil (Krecic-Shepard thromycin, dextromethorphan, and verapamil (Krecic-Shepard et al). 1999;66:40-50 et al). 1999:66:40-50 Etanercept Polymorphism of dextromethorphan oxidation in South Indian Etanercept (USAN List No. 418). 1999;66:209 subjects (Mamidi et al). 1999:66:193-200 Evidence-based medicine Diabetes mellitus Clinical pharmacology: The scientific basis of therapeutics Mecaserim (USAN List No. 419). 1999;66:331 (Reidenberg) (1999;66:1-8). 1999;66:624 (Correction) Voglibose (USAN No 420). 1999:66:444 Implication of evidence-based medicine in prescription guide Diazepam lines taught to French medical students: current status in the Effect of the gene dosage of CYP2C/9 on diazepam metabolism cardiovascular field (Nony et al). 1999;66:173-84 in Chinese subjects (Qin et al). 1999;66:642-6 Dichloroacetate Pharmacokinetics and pharmacodynamics of dichloroacetate in patients with cirrhosis (Shangraw and Fisher). 1999;66:380-90 Diclofenac Combination of diclofenac with acetaminophen or aceta Fatty acids minophen-codeine after oral surgery: a randomized, double The effect of orlistat on the fatty acid composition of serum lipid blind single-dose study (Breivik et al). 1999;66:625-35 fractions in obese subjects (Vidgren et al). 1999;66:3 15-22 Digoxin Fever Longitudinal assessment of a P-glycoprotein—-mediated drug Acetaminophen has greater antipyretic efficacy than aspirin in interaction of valspodar on digoxin (Kovarik et al) endotoxemia: a randomized, double-blind, placebo-controlled 1999:66:39 1-400 trial (Pernerstorfer et al). 1999;66:51-7 Pharmacokinetic interaction of digoxin with a herbal extract from Fibrinogen St John’s wort (Hypericum perforatum) (Johne et al). Fenofibrate decreases plasma fibrinogen, improves lipid profile, 1999:66:338-45 and reduces uricemia (de la Serna et al). 1999;66: 166-72

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Clinical Pharmacology and Therapeutics 1999: Vol 66 Index PDF

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Preview Clinical Pharmacology and Therapeutics 1999: Vol 66 Index

Author index A Becquemont L (see Tennezé et al). 1999;66:582-8 Belz GG, Butzer R, Kober S, Mang C, Mutschler E. Time course Aarons L (see Simpson et al). 1999;66:474-84 and extent of angiotensin [I antagonism after irbesartan, losartan, Abernethy DR (see Donahue et al). 1999;66:563-68 and valsartan in humans assessed by angiotensin II dose response Abiose AK (see Tangphao et al). 1999;66:232-8 and radioligand receptor assay. 1999;66:367-73 Adams WP (see Singh et al). 1999;66:346-57 Benowitz NL (see Gelal et al). 1999;66:123-35 Agler D (see Swanson et al). 1999;66:294-305 Bergquist C, Lindegard L. Dosing recommendations in liver dis- Agren JJ (see Vidgren et al). 1999;66:3 15-22 ease. 1999;66:201 (Letter) Ahonen J (see Palkama et al). 1999;66:33-9 Bertilsson L (see Mirghani et al). 1999;66:454-60 Ajayi F (see Yuan et al). 1999;66:9-15 Bertino JS (see Streetman et al). 1999;66:535-41 Aljada A (see Dandona et al). 1999;66:58-65 Bialer M (see Volosov et al). 1999;66:547-53 Allen J (see Johnson et al). 1999;66:492-500 Bickel WK (see Petry et al). 1999;66:306-14 Alvarez JC, Gluck N, Arnulf I, Quintin P, Leboyer M, Pecquery R, Bieglmayer C (see Pernerstorfer et al). 1999:66:51-7 Launay JM, Perez-Diaz F, Spreux-Varoquaux O. Decreased Blaschke TF (see Tangphao et al). 1999;66:232-8 platelet serotonin transporter sites and increased platelet inositol Blouin RA (see Poloyac et al). 1999;66:554-62 triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine. 1999;66:617-24 Blum RA (see Rogers et al). 1999;66:358-66 Amin RD (see Rogers et al). 1999;66:358-66 Boissel JP (see Nony et al). 1999;66:173-84 Antonijoan R (see Barbanoj et al). 1999;66:485-91 Bozkurt A (see Aynaciouglu et al). 1999;66:185-92 Aoyama N (see Tanigawara et al). 1999;66:528-34 Brahmadevara N (see Mamidi et al). 1999;66:193-200 Arnulf I (see Alvarez et al). 1999;66:617-24 Breivik EK, Barkvoll P, Skovlund E. Combination of diclofenac Asada A (see Hamaoka et al). 1999;66:110-7 with acetaminophen or acetaminophen-codeine after oral surgery Atkinson AJ, Moore KE, Peck CC. Dr Marcus M. Reidenberg, a randomized, double-blind, single-dose study. 1999;66:625-35 recipient of the 1999 Harry Gold Award. 1999;66:1 BrockmillerJ (see Johne et al). 1999;66:338-45 (Commentary) BrockmillerJ (see Sachse et al). 1999;66:431-8 Aynacioglu AS, Sachse C, Bozkurt A, Kortunay S, Nacak M, Brockmiller J. (see Aynaciouglu et al). 1999;66:185-92 SchrédeTr, Kayaalp O, Roots I, Brockméller J. Low frequency of Brgsen K (see Sindrup et al). 1999;66:636-41 defective alleles of cytochrome P450 enzymes 2C19 and 2D6 in Brown MT (see Herman et al). 1999;66:374-9 the Turkish population. 1999;66:184-92 Brunner HR (see Rossat et al). 1999;66:76-84 Bulzer R (see Belz et al). 1999;66:367-73 Bundschuh D (see Hartung et al). 1999;66:415-24 B Burnett A (see Yuan et al). 1999;66:9-15 Burnier M (see Rossat et al). 1999;66:76-84 Backman JT (see Kivist6 et al). 1999;66:444-53 Burry AE (see Tan et al). 1999;66:275-81 Backman JT, Wang JS, Wen X, Kivisté KT, Neuvonen PJ. Mibeferadil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam. 1999; c 66:401-7 Badger GJ (see Petry et al). 1999;66:306-14 Cadarso C (see de la Serna and Cadarso). 1999;66: 166-72 Balian JD (see Yuan et al). 1999;66:9-15 Cai WM, Chen B, Zhou Y, Zhang YD. Fluoxetine impairs the Ball SE, Scatnia JA, Kao J, Ferron GM, Fruncillo R, Mayer P, CYP2D6-mediated metabolism of propafenone enantiomers in Weinryb I, Guida M, Hopkins PJ, Warner N, Hall J. Population healthy Chinese volunteers. 1999;66:516-21 distribution and effects on drug metabolism of a genetic variant in the 5° promoter region of CYP3A4. 1999;66:288-94 Capparelli E (see Mirochnick et al). 1999;66: 16-24 Barbanoj M, Antonijoan R, Morte A, Grinyé JM, Sola R, Vallés J, Chalon S (see Tangphao et al). 1999;66:232-8 Peraire C, Cordero JA, Mufioz A, Jané F, Obach R Chavluvdi MR (see Mamidi et al). 1999;66: 193-200 Pharmacokinetics of the somatostatin analog lanreotide in Chen B (see Cai et al). 1999;66:516-21 patients with severe chronic renal insufficiency. 1999;66:485-91 Chiba K (see Ikeda et al). 1999;66:265-74 Barbey JT, Sale ME, Woosley RL, Shi J, Melikian AP, Hinderling Chiu HFK (see Lam et al). 1999;66:647 (Letter) PH. Pharmacokinetic, pharmacodynamic, and safety evaluation Chongsuphajaisiddhi T (see Simpson et al). 1999;66:474-84 of an accelerated dose titration regimen of sotalol in healthy mid- Chorazyczewski J (see Tan et al). 1999;:66:275-81 dle-aged subjects. 1999;66:91-9 Chow L (see Lam et al). 1999;66:647 (Letter) Barkvoll P (see Breivik et al). 1999;66:625-35 Clark AL (see Muir et al). 1999;66:85-90 Barnas CR (see Krecic-Shepard et al). 1999;66:40-50 ConnorJ (see Mirochnick et al). 1999;66:16-24 Bauer S (see Johne et al). 1999;66:338-45 Cordero JA (see Barbanoj et al). 1999;66:485-91 Bauer S (see Sachse et al). 1999;66:431-8 Cucherat M (see Nony et al). 1999;66:173-84 July, pp. 1-104; August, pp. 105-210; September, pp. 211-332; D October, pp. 333-444; November, pp. 445-546; December, pp. 547-674. Index to the ASCPT meeting abstracts is located in the d’ Athis P (see Pariente-Khayat et al). 1999;66:136-9 February issue. Damodarram G (see Mamidi et al). 1999;66:193-200 CLINICAL PHARMACOLOGY & THERAPEUTICS DECEMBER 1999 659 CLINICAL PHARMACOLOGY & THERAPEUTICS 660 Author index DECEMBER 1999 Dandona P, Mohanty P, Hamouda W, Aljada A, Kumbkarni Y, Garg Geus WP (see Mathét and Geus). 1999;66:140-51 R. Effect of dexamethasone on reactive oxygen species genera- Gluck N (see Alvarez et al). 1999;66:617-2 tion by leukocytes and plasma interleukin-10 concentrations: a Gorski JC (see Krecic-Shepard et al). 1999;66:40-50 pharmacodynamic study. 1999;66:58-65 Gotschall R (see Streetman et al). 1999;66:535-41 Danish University Antidepressant Group. Clomipramine dose-effect Gramatté T, Oertal R. Intestinal secretion of intravenous talinolol is study in patients with depression: clinical end points and phar- inhibited by luminal R-verapamil. 1999;66:239-45 macokinetics. 1999;66:152-65 Greenblatt DJ (see Tsunoda et al). 1999;66:461-71 Davis DB (see Mould et al). 1999;66:246-57 Griny6é JM (see Barbanoj et al). 1999;66:485-91 de la Serna G, Cadarso C. Fenofibrate decreases plasma fibrinogen, Groopman JD (see Kinirons et al). 1999;66:224-31 improves lipid profile, and reduces uricemia. 1999;66: 166-72 Guerret M (see Kovarik et al). 1999;66:391-400 de Meijer A, Vollaard H, de Metz M, Verbruggen B, Thomas C, Guida M (see Ball et al). 1999;66:288-94 Novakova I. Meloxicam, 15 mg/day, spares platelet function in Guinta D (see Swanson et al). 1999;66:294-305 healthy volunteers. 1999;66:425-30 Gupta V (see van Agtmael et al). 1999;66:408-14 de Metz M (see de Meijer et al). 1999;66:425-30 Gustafsson LL (see Mirghani et al). 1999;66:454-60 Deinum HT (see van Lingen et al). 1999;66:509-15 Denolle T, Pellizzoni C, Jannuzzo G, Poggesi I. Hemodynamic effects of reboxetine in healthy male volunteers. 1999;66:282-7 H Desel H (see Nau et al). 1999;66:25-32 Dettling M (see Sachse et al). 1999;66:431-8 Haefeli WE (see Romerio et al). 1999;66:522-7 Doecek WD (see Hartung et al). 1999;66:415-24 Donahue S, Flockhart DA, Abernethy DR. Ticlopidine inhibits Hall J (see Ball et al). 1999;66:288-94 Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, phenytoin clearance. 1999;66:563-68 Asada A. Propofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study. 1999;66:110-7 Hamouda W (see Dandona et al). 1999;66:58-65 Hanai H (see Ikeda et al). 1999;66:265-74 Echizen H (see Takahashi et al). 1999;66:569-81 Hartung T, Doecek WD, Bundschuh D, Foote MA, Fantner F, Eichler HG (see Pernerstorfer et al). 1999;66:51-7 Hermann C, Lenz A, Milwee S, Rich B, Simon B, Vook HD, von Elliott MJ(see Mould et al). 1999;66:246-57 Aulock S, Wendel A. Effect of filgrastim treatment on inflamma- Ellis RE (see Streetman et al). 1999;66:535-41 tory cytokines and lymphocyte functions. 1999;66:415-24 Endrenyi L (see Kalow et al). 1999;66:445-7 (Commentary) Hase I (see Hamaoka et al). 1999;66:1 10-7 Ericksson O (see Mirghani et al). 1999;66:454-60 He N (see Qin et al). 1999;66:642-6 Hellgren U (see Mirghani et al). 1999;66:454-60 Herman BD, Fleishaker JC, Brown MT. Ketoconazole inhibits the clearance of the enantiomers of the antidepressant reboxetine in humans. 1999:66:374-9 Falk MC (see Johnseot anl ). 1999;66:492-500 Hermann C (see Hartung et al). 1999;66:415-24 Fantner F (see Hartung et al). 1999;66:415-24 Hillis WS (see Muir et al). 1999;66:85-90 Feinstein AR. Statistical reductionism and clinicians’ delinquencies Hinderling PH (see Barbey et al). 1999;66:91-9 in humanistic research. 1999;66:211-7 (Commentary) Hoffman BB (see Tangphao et al). 1999;66:232-8 Feldman RD (see Tan et al). 1999;66:275-81 Holroyd S, Seward RL. Psychotropic drugs in acute intermittent Ferron GM (see Ball et al). 1999;66:288-94 porphyria. 1999;66:323-5 Fisher DM (see Shangraw et al). 1999;66:380-90 Hopkins PJ (see Ball et al). 1999;66:288-94 Fleishaker JC (see Herman et al). 1999;66:374-9 Hotellier F (see Pariente-Khayat et al). 1999;66:136-9 Flockhart DA (see Donahue et al). 1999;66:563-68 Huang SL (see Qin et al). 1999;66:642-6 Flynn D (see Swanson et al). 1999;66:294-305 Hubert P (see Pariente-Khayat et al). 1999;66:136-9 Foote MA (see Hartung et al). 1999;66:415-24 Forrest A (see Luzier et al). 1999;66:594-601 Franzen K (see Johnson et al). 1999;66:492-500 Fruncillo R (see Ball et al). 1999;66:288-94 Fujimura A (see Tsuruoka et al). 1999:66:609-16 Fujita M (see Murayama et al). 1999;66:258-64 lida I (see Ikeda et al). 1999;66:265-74 inoue T (see Murayama et al). 1999;66:258-64 Funck-Brentano (see Tennezé et al). 1999;66:582-8 Furuta T, Ohashi K, Kobayashi K, lida I, Yoshida H, Shirai N, Ikeda Y (see Murayama et al). 1999;66:258-64 Takashima M, Kosuge K, Hanai H, Chiba K, Ishizaki T, Kaneko Ishizaki T (see Hamaoka et al). 1999;66:1 10-7 E. Effects of clarithromycin on the metabolism of omeprazole in Ishizaki T (see Ikeda et al). 1999;66:265-74 relation to CYP2C/9 genotype status in humans. 1999;66:265-74 G Jacob P (see Gelal et al). 1999;66:123-35 Gaedigk A (see Streetman et al). 1999;66:535-41 Jané F (see Barbanoj et al). 1999:66:485-91 Gagliano KD (see Rogers et al). 1999;66:358-66 Jannuzzo G (see Denolle et al). 1999;66:282-7 Garcia-Barcelo M (see Lam et al). 1999;66:647 (Letter) Jensen TS (see Sindrup et al). 1999;66:636-41 Gardner BM (see Poloyac et al). 1999;66:554-62 Jilma B (see Pernerstorfer et al). 1999;66:51-7 Garg R (see Dandona et al). 1999;66:58-65 Joensuu H (see Villikka et al). 1999;66:589-93 Gelal A, Jacob P, Yu L, Benowitz NL. Disposition kinetics and Johne A, Brockmdller J, Bauer S, Maurer A, Langheinrich M, Roots effects of menthol. 1999;66:128-35 I. Pharmacokinetic interaction of digoxin with a herbal extract Gerbeau C (see Kovarik et al). 1999:66:39 1-400 from St John’s wort (Hypericum perforatum). 1999;66:338-45 AL PHARMACOLOGY & THERAPEUTICS 66, NUMBER 6 Author index 661 Johnson AG, Rigby RJ, Taylor PJ, Jones CE, Allen J, Franzen K, am K, Chow L, Leung T, Wing YK, Chiu HFK, Garcia-Barcelo M Falk MC, Nicol D. The kinetics of mycophenolic acid and its glu Association between CYP2A6 and CYP2C/9 mutant alleles curonide metabolite in adult kidney transplant recipients 1999:66:647 (Letter) 1999:66:492-500 ; angheinrich M (see Johne et al). 1999:66:338- Jones CE (see Johnson et al). 1999;66:492-500 assek C (see Nau et al). 1999;66:25-32 Jouvet P (see Pariente-Khayat et al). 1999;66:136-9 eeder S (see Streetman et al). 1999:66:5 3 5 K emberger L. A flight through clinical pharmacology soar with the eagles. 1999;66:218-23 (Commentz : Kageyama H (see Koizumi et al). 1999;66:501-8 enz A (see Hartung et al). 1999;66:415-24 Kalow W, Ozdemir V, Tang BK, Tothfalusi L, Endrenyi L. The sci- erner M (see Swanson et al). 1999;66:294-305 ence of pharmacological variability: an essay. 1999;66:445-7 esko LJ (see Singh et al). 1999:66:346-57 (Commentary) esko LJ (see Yuan et al). 1999:66:9-15 Kaneko E (see Ikeda et al). 1999;66:265-74 eung T (see Lam et al). 1999;66:647 (Letter) Kao J (see Ball et al). 1999:66:288-94 ilja JJ (see Kivisté et al). 1999;66:444-53 Kapiotis S (see Pernerstorfer et al). 1999;66:51-7 ilja JL, Kivist6 KT, Neuvonen PJ. 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Failure of erythromycin breath test correlate vith midazolam clearance as a probe of cytocnre Macdonald CJ (see Tan et al). 1999;66:275-81 P4503A. 1999:66:224-31 Madsen C (see Sindrup et al). 1999;66:636-41 Kinitada S (see Murayama et al). 1999;66:258-64 Mdaenpaia H (see Villikka et al). 1999;66:589-93 Kita T (see Tanigawara et al). 1999;66:528-34 Maillard M (see Rossat et al). 1999;66:76-84 Kivist6 KT (see Backman et al). 1999;66:401 Malikian AP (see Barbey et al). 1999;66:91-9 Kivist6 KT Lilja et al). 1999:66:1 18-27 Mamidi RNVS, Satyavageeswaran S, Vakkalanka SVS, Chavluvdi Kivist6 KT (see Villikka et al). 1999;66:589-93 MR, Katneni K, Brahmadevara N, Damodarram G, S Kivist6 KT, Lilja JJ, Backman JT, Neuvonen PJ. Repeate S. Polymorphism of dextromethorphan oxidation in South Indian sumption of grapefruit juice considerably increases plasma subjects. 1999:66:193-200 centrations of cisapride. 1999;66:444-53 Mang C (see Belz et al). 1999;66:367-73 Kobayashi K (see Ikeda et al). 1999;66:265- 7A Manninen P( see Laine et al). 1999;66:602-8 Kober S (see Belz et al). 1999;66:367-73 Marroum P (see Yuan et al). 1999;66:9-15 Koizumi F, Murakami M, Kageyama H, Katashima M, Terakawa M Marshall JD, Kearns GL. Developmental pharmacodynamics of Ohnishi A. Smoking accelerates absorption of inhaled elastase cyclosporine. 1999;66:66-75 inhibitor FK706. 1999:66:501-8 Mathét RAA, Geus WP. Pharmacodynamic modeling of the acid Kolenda H (see Nau et al). 1999;66:25-32 inhibitory effect of ranitidine in patients in an intensive care unit Komada F (see Tanigawara et al). 1999;66:528-34 during prolonged dosing: characterization of tolerance Kortunay S (see Aynaciouglu et al). 1999;66: 185-92 1999-66:140-51 Kosuge K (see Ikeda et al). 1999:66:265-74 Maurer A( see Johne et al). 1999;66:338-45 Kovarik JM, Rigaudy L, Guerret M, Gerbeau C, Rost KL Mayer P (see Ball et al). 1999;66:288-94 Longitudinal assessment of a P-glycoprotein—mediated drug McCann GP (see Muir et al). 1999;66:85-90 interaction of valspodar on digoxin. 1999;66:391-400 Milwee S (see Hartung et al). 1999;66:415-24 Krecic-Shepard ME, Barnas CR, Slimko J, Gorski JC, Wainer IW, Minthorn EA (see Mould et al). 1999;66:246-57 Schwartz JB. 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Plasma tacrine Moore KE (see Atkinson et al). 1999:66:1 (Ci concentrations are significantly increased by concomitant hor Moreno HT (see Tangphao et al). 1999:66:2 32-8 mone replacement therapy. 1999;66:602-8 Morte A (see Barbanoj et al). 1999:66:485-91 CLINICAL PHARMACOLOGY & THERAPEUTICS 662 Author index DECEMBER 1999 Mould DR, Davis CB, Minthorn EA, Kwok DC, Elliott MJ, Luggen Pecquery R (see Alvarez et al). 1999;66:617-24 ME, Totoritis MC. A population pharmacokinetic-pharmacody- Pellizzoni C (see Denolle et al). 1999;66:282-7 namic analysis of single doses of clenoliximab in patients with Peraire C (see Barbanoj et al). 1999;66:485-91 rheumatoid arthritis. 1999;66:246-57 Perez-Diaz F (see Alvarez et al). 1999;66:617-24 Muir DF, McCann GP, Swan L, Clark AL, Hillis WS. Hemodynamic Pernerstorfer T, Schmid R, Bieglmayer C, Eichler HG, Kapiotis S, and coronary effects of intravenous eletriptan, a SHT | p/;p-recep- Jilma B. Acetaminophen has greater antipyretic efficacy than tor agonist. 1999;66:85-90 aspirin in endotoxemia: a randomized, double-blind, placebo- Muller-Oerlinghausen B (see Sachse et al). 1999;66:431-8 controlled trial. 1999;66:51-7 Mufioz A (see Barbangoj et al). 1999;66:485-91 Pershing LK (see Singh et al). 1999;66:346-57 Murakami M (see Koizumi et al). 1999;66:501-8 Perucca E (see Volosov et al). 1999;66:547-53 Murayama N, Tanaka M, Kunitada S, Yamada H, Inoue T, Terada Y, Petry NM, Bickel WK, Badger GJ. A comparison of four buprenor- Fjuita M, Ikeda Y. Tolerability, pharmacokinetics, and pharmaco- phine dosing regiment in the treatment of opioid dependence. dynamics of DX-906S5a, a new synthetic potent anticoagulant and 1999:66:306-14 specific factor Xa inhibitor, in healthy male volunteers. 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Effect of the gene dosage of CYP2C/9 on Neuvonen PJ (see Lilja et al). 1999;66:118-27 diazepam metabolism in Chinese subjects. 1999;66:642-6 Neuvonen PJ (see Palkama et al). 1999;66:33-9 Quak CME (see van Lingen et al). 1999;66:509-15 Neuvonen PJ (see Villikka et al). 1999;66:589-93 Quintin P (see Alvarez et al). 1999;66:617-24 Nicol D (see Johnson et al). 1999;66:492-500 Nony P, Cucherat M, Boissel JP. Implication of evidence-based R medicine in prescription guidelines taught to French medical stu- dents: current status in the cardiovascular field. 1999;66:173-84 Reidenberg J. The case of the forgotten author: a mystery to editors. Nosten F (see Simpson et al). 1999;66:474-84 1999:66:333-5 (Commentary) Novakova I (see de Meijer et al). 1999;66:425-30 Reidenberg MM. Clinical pharmacology: the scientific basis of ther- Nussberger J (see Rossat et al). 1999;66:76-84 apeutics. 1999;66:1-8 (Commentary) 1999;66:624 (Correction) Rey E (see Pariente-Khayat et al). 1999;66:136-9 Rich B (see Hartung et al). 1999;66:415-24 O Rigaudy L (see Kovarik et al). 1999;66:391-400 Rigby RJ (see Johnson et al). 1999;66:492-500 O’Shea D (see Kinirons et al). 1999;66:224-31 Rissanen AM (see Vidgren et al). 1999;66:315-22 Obach R (see Barbanoj et al). 1999;66:485-91 Rogers HD, Zhao J, Liu L, Amin RD, Gagliano KD, Porras AG, Oda Y (see Hamaoka et al). 1999;66:110-7 Blum RA, Wilson ME, Stepanavage M, Vega JM. Grapefruit Oertel R (see Gramatté and Oertel). 1999;66:239-45 juice has minimal effects on plasma concentrations of lovastatin- Ohashi K (see Ikeda et al). 1999;66:265-74 derived 3-hydroxy-3-methylglutary] coenzyme A reductase Ohinishi A (see Koizumi et al). 1999;66:501-8 inhibitors. 1999;66:358-66 Ohmori M (see Tsuruoka et al). 1999;66:609-16 Romerio SC, Linder L, Haefeli WE. Neurokinin-1 receptor antago- Okken A (see van Lingen et al). 1999;66:509-15 nist R116301 inhibits substance P-induced venodilation. Okumura K (see Tanigawara et al). 1999;66:528-34 1999:66:522-7 Olive G (see Pariente-Khayat et al). 1999:66:136-9 Roots I (see Aynaciouglu et al). 1999;66:185-92 Olkkola KT (see Palkama et al). 1999;66:33-9 Roots I (see Johne et al). 1999;66:338-45 Ou-Yang DS (see Qin et al). 1999;66:642-6 Roots I (see Sachse et al). 1999;66:431-8 Ozdemir V (see Kalow et al). 1999;66:445-7 (Commentary) Rossat J, Maillard M, Nussberger J, Brunner HR, Burnier M. Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects. 1999;66:76-84 P Rost KL (see Kovarik et al). 1999;66:39 1-400 Ruschen S (see Sachse et al). 1999:66:431-8 Palkama VJ, Ahonen J, Neuvonen PJ, Olkkola KT. Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam. 1999:66:33-9 S Palovaara S (see Laine et al). 1999:66:602-8 Pariente-Khayat A, Tréluyer JM, Rey E, Mokhtari M, Werner E, Sachse C (see Aynaciouglu et al). 1999;66:185-92 Jouvet P, d’Athis P, Wood C, Hubert P, Hotellier F, olive G, Pons Sachse C, Ruschen S, Dettling M, Schley J, Bauer S, Muller- G. Pharmacokinetics and tolerance of flunitrazepam in neonates Oerlinghausen B, Roots I, BrockmGllerJ . Flavin monooxygenase and in infants. 1999;66:136-9 3 (FMO3) polymorphism in a white population: allele frequen- Parmelee T (see Yuan et al). 1999:66:9-15 cies, mutation linkage, and functional effects on clozapine and Peck CC (see Atkinson et al). 1999:66:1 caffeine metabolism. 1999;66:431-8 CLINICAL PHARMACOLOGY & THERAPEUTICS VOLUME 66, NUMBER 6 Author index 663 Saito T (see Tsuruoka et al). 1999;66:609-16 Tanigawara Y, Aoyama N, Kita T, Shirakawa K, Komada F, Kasuga Sale ME (see Barbey et al). 1999;66:91-9 M, Okumura K. CYP2C/9 genotype-related efficacy of omepra- Sato T (see Takahashi et al). 1999;66:569-81 zole for the treatment of infection caused by Helicobacter pylori Satyavageeswaran S (see Mamidi et al). 1999;66:193-200 1999:66:528-34 Scatnia JA (see Ball et al). 1999;66:288-94 Tapanainen P (see Laine et al). 1999;66:602-8 Schley J (see Sachse et al). 1999;66:431-8 Taylor PJ (see Johnson et al). 1999;66:492-500 Schmid R (see Pernerstorfer et al). 1999;66:51-7 Teja-Isavatharm P (see Simpson et al). 1999;66:474-84 Schroder T (see Aynaciouglu et al). 1999;66:185-92 Tennezé L, Verstuyft C, Becquemont L, Poirier JM, Wilkerson GR, Schwartz JB (see Krecic-Shepard et al). 1999;66:40-50 Funck-Brentano C. Assessment of CYP2D6 and CYP2C19 activ- Seward RL (see Holroyd and Seward). 1999;66:323-5 ity in vivo in humans: a cocktail study with dextromethorphan Shah VP (see Singh et al). 1999;66:346-57 and chloroguanide alone and in combination. 1999;66:582-8 Shangraw RE, Fisher DM. Pharmacokinetics and pharmacodynam- ter Kuile F (see Simpson et al). 1999;66:474-84 ics of dichloroacetate in patients with cirrhosis. 1999;66:380-90 Terada Y (see Murayama et al). 1999;66:258-64 Shedlofsky SI (see Poloyac et al). 1999;66:554-62 Terakawa M (see Koizumi et al). 1999;66:501-8 Shi J (see Barbey et al). 1999;66:91-9 Terzic A (see Waldman and Terzic). 1999;66:336-7 (Commentary) Shimizu T (see Takahashi et al). 1999;66:569-81 Terzic A. New frontiers of cardioprotection. 1999;66:105-9 Shimoyama Y (see Takahashi et al). 1999;66:569-8| (Commentary) Shioda N (see Takahashi et al). 1999;66:569-81 Thomas C (see de Meijer et al). 1999;66:425-30 Shirai N (see Ikeda et al). 1999;66:265-74 Thummel KE (see Kinirons et al). 1999;66:224-31 Shirakawa K (see Tanigawara et al). 1999;66:528-34 Tibboel D (see van Lingen et al). 1999;66:509-15 Shoulson I (see Swanson et al). 1999;66:294-305 Tosheva RT (see Poloyac et al). 1999;66:554-62 Simon B (see Hartung et al). 1999;66:415-24 Tothaflusi L (see Kalow et al). 1999;66:445-7 Simpson JA, Price R, ter Kuile F, Teja-Isavatharm P, Nosten F, Totoritis MC (see Mould et al). 1999;66:246-57 Chongsuphajaisiddhi T, Looareesuwan S, Aarons L, WHite NJ. Tréluyer JM (see Pariente-Khayat et al). 1999;66:136-9 Population pharmacokinetics of mefloquine in patients with acute Tsunoda SM, Velez RL, von Moltke LL, Greenblatt DJ. falciparum malaria. 1999;66:472-84 Differentiation of intestinal and hepatic cytochrome P450 3A Sindrup SH, Madsen C, Brgsen K, Jensen TS. The effect of tra- activity with use of midazolam as an in vivo probe: effect of keto- madol in painful polyneuropathy in relation to serum drug and conazole. 1999;66:461-71 metabolite levels. 1999;66:636-41 Tsuruoka S, Sugimoto K, Ohmori M, Kawaguchi A, Saito T, Singh GJP, Adams WP, Lesko LJ, Shah VP, Molzon JA, Williams Fujimura A. Chronotherapy of high-dose 1,25-dihydroxyvitamin RL, Pershing LK. Development of in vivo bioequivalence D; in hemodialysis patients with secondary hyperparathyroidism: methodology for dermatologic corticosteroids based on pharma- a single-dose study. 1999;66:609-16 codynamic modeling. 1999;66:346-57 Sintov A (see Volosov et al). 1999;66:547-53 Skovlund E (see Breivik et al). 1999;66:625-35 SlimkoJ (see Krecic-Shepard et al). 1999;66:40-50 Sola R M (see Barbanoj et al). 1999;66:485-91 Uppoor RS (see Yuan et al). 1999;66:9-15 Spreux-Varoquaux O (see Alvarez et al). 1999;66:617-24 Uusitupa MIJ (see Vidgren et al). 1999;66:315-22 Stepanavage M (see Rogers et al). 1999;66:358-66 Streetman DS, Ellis RE, Nafziger AN, Leeder S, Gaedigk A, Gotschall R, Kearns GL, Bertino JS. Dose dependency of dex- tromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyp- ing. 1999;66:535-41 Vakkalanka SVS (see Mamidi et al). 1999;66:193-200 Subramaniam S (see Mamidi et al). 1999;66:193-200 Vallés J (see Barbanoj et al). 1999;66:485-91 Sugimoto K (see Tsuruoka et al). 1999;66:609-16 Valve RS (see Vidgren et al). 1999;66:3 15-22 Swan L (see Muir et al). 1999;66:85-90 van Agtmael MA, Gupta V, van der Graaf CAA, van Boxtel CJ. The Swanson J, Guinta D, Flynn D, Agler D, Lerner M, Williams L, effect of grapefruit juice on the time-dependent decline of Shoulson I, Wigal S. Acute tolerance to methylphenidate in the artemether plasma levels in healthy subjects. 1999;66:408-14 treatment of attention deficit hyperactivity disorder in children. van Boxtel CJ (see van Agtmael et al). 1999;66:408-14 1999:66:294-305 van der Graaf CAA (see van Agtmael et al). 1999;66:408-14 van Lingen RA, Deinum HT, Quak CME, Okken A, Tibboel D. Multiple-dose pharmacokinetics of rectally administered aceta- minophen in term infants. 1999;66:509-15 Vega JM (see Rogers et al). 1999;66:358-66 Tainaka H (see Takahashi et al). 1999;66:569-8| Velez RL (see Tsunoda et al). 1999;66:461-71 Takahashi H, Sato T, Shimoyama Y, Shioda N, Shimizu T, Kubo S, Verbruggen B (see de Meijer et al). 1999;66:425-30 Tamura N, Tainaka H, Yasumori T, Echizen H. Potentiation of anti- Verstuyft C (see Tennezé et al). 1999;66:582-8 coagulant effect of warfarin caused by enantioselective metabolic Vidgren HM, Agren JJ, Valve RS, Karhunen LJ, Rissanen AM, inhibition by the uricosuric agent benzbromarone. 1999;66:569-8| Uusitupa MIJ. The effect of orlistat on the fatty acid composition Takashima M (see Ikeda et al). 1999;66:265-74 of serum lipid fractions in obese subjects. 1999;66:3 15-22 Tamura N (see Takahashi et al). 1999;66:569-8| Villikka K, Kivisté KT, Maenpaéai H, Joensuu H, Neuvonen PJ. Tan CM, Macdonald CJ, Chorazyczewski J, Burry AE, Feldman Cytochrome P450-inducing antiepileptics increase the clearance RD. Vandate stimulation of adenylyl cyclase: an index to tyrosine of vincristine in patients with brain tumors. 1999;66:589-93 kinase vascular effects. 1999;66:275-81 Volk HD (see Hartung et al). 1999;66:415-24 Tanaka M (see Murayama et al). 1999;66:258-64 Vollaard H (see de Meijer et al). 1999;66:425-30 Tang BK (see Kalow et al). 1999;66:445-7 (Commentary) Volosov A, Xiaodong S, Perucca E, Yagen B, Sintov A, Bialer M. Tangphao O, Chalon S, Moreno HT, Abiose AK, Blaschke TF, Enantioselective pharmacokinetics of 10-hydroxycarbazepine Hoffman BB. Heparin-induced vasodilation in human hand veins. after oral administration of oxycarbazepine to healthy Chinese 1999:66:232-8 subjects. 1999;66:547-53 CLINICAL PHARMACOLOGY & THERAPEUTICS 664 Author index DECEMBER 1999 von Aulock S (see Hartung et al). 1999;66:415-24 Wood AJJJ (see Kinirons et al). 1999;66:224-31 von Moltke LL (see Tsunoda et al). 1999;66:461-71 Wood C (see Pariente-Khayat et al). 1999;66: 136-9 Woosley RL (see Barbey et al). 1999;66:91-9 Ww X Wainer IW (see Krecic-Shepard et al). 1999;66:40-50 Waldman SA, Terzic A. The Molecular Therapeutics Section of the Xiaodong S (see Volosov et al). 1999:66:547-53 American Society for Clinical Pharmacology and Therapeutics. Xie HG (see Qin et al). 1999;66:642-6 1999:66:336-7 (Commentary) Xu ZH (see Qin et al). 1999;66:642-6 Wang JS (see Backman et al). 1999;66:401-7 Wang W (see Qin et al). 1999;66:642-6 Wang YJ (see Qin et al). 1999;66:642-6 Warner N (see Ball et al). 1999;66:288-94 Weinryb I (see Ball et al). 1999;66:288-94 Yagen B (see Volosov et al). 1999:66:547-53 Wen X (see Backman et al). 1999;66:401-7 Yamada H (see Murayama et al). 1999;66:258-64 Wendel A (see Hartung et al). 1999;66:415-24 Yasumori T (see Takahashi et al). 1999;66:569-81 Werner E (see Pariente-Khayat et al). 1999;66:136-9 Yoshida H (see Ikeda et al). 1999;66:265-74 Westerberg PA (see Mirghani et al). 1999;66:454-60 Yu L (see Gelal et al). 1999;66:123-35 White NJ (see Simpson et al). 1999;66:474-84 Yuan R, Parmelee T, Balian JD, Uppoor RS, Ajayi F, Burnett A, Wigal S (see Swanson et al). 1999;66:294-305 Lesko LJ, Marroum P. In vitro metabolic interaction studies Wilkinson GR (see Tennezé et al). 1999;66:582-8 experience of the Food and Drug Administration. 1999;66:915 Wilkinson RG (see Kinirons et al). 1999;66:224-31 Williams L (see Swanson et al). 1999;66:294-305 Williams RI (see Singh et al). 1999;66:346-57 Z Wilson MF (see Luzier et al). 1999;:66:594-601 Wilson MF (see Rogers et al). 1999;66:358-66 Zhang YD (see Cai et al). 1999;66:516-21 Wilton JH (see Luzier et al). 1999;66:594-601 Zhao J (see Rogers et al). 1999;66:358-66 Wing YK (see Lam et al). 1999:66:647 (Letter) Zhou Y (see Cai et al). 1999;66:516-21 Subject index American Society for Pharmacology and Experimental Therapeutics Abetimus sodium Cellular mechanisms and novel strategies for pain control ASPET-Ray Fuller Symposium. 1999;66:100 Abetimus sodium (USAN List No. 422). 1999;66:653 Amyotrophic lateral sclerosis Abortion Mecaserim (USAN List No. 419). 1999;66:331 Mifepristone (USAN List No. 419). 1999:66:330 Analgesics Acetaminophen Levobupivacaine hydrochloride (USAN List No. 417 Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled 66: 104 trial (Pernerstorfer et al). 1999;66:51-7 Analgesics, non-narcotic Combination of diclofenac with acetaminophen or aceta Acetaminophen has greater antipyretic efficacy than aspirin in minophen-codeine after oral surgery: a randomized, double endotoxemia: a randomized, double-blind, placebo-controlled blind single-dose study (Breivik et al). 1999;66:625-35 trial (Pernerstorfer et al). 1999;66:5 1-7 Multiple-dose pharmacokinetics of rectally administered aceta- Anesthetics, intravenous minophen in term infants (van Lingen et al). 1999;66:509-15 Propofol decreases the clearance of midazolam by inhibiting Adenosine triphosphate CYP3A¢4: an in vivo and in vitro study (Hamaoka et al). 1999 New frontiers of cardioprotection (Terzic et al). 1999;66:105-9 66:110-7 (Commentary) Angiotensin Adenylyl cyclase Time course and extent of angiotensin II antagonism after irbe- Vandate stimulation of adenylyl cyclase: an index to tyrosine sartan, losartan, and valsartan in humans assessed by kinase vascular effects (Tan et al). 1999;66:275-81 angiotensin II dose response and radioligand receptor assay (Belz et al). 1999;66:367-73 Adrenergic beta-antagonists Pharmacokinetic, pharmacodynamic, and safety evaluation of an Anidulafungin accelerated dose titration regimen of sotalol in healthy middle- Anidulafungin (USAN List No. 422). 1999;66:654 aged subjects (Barbey et al). 1999;66:91-9 Anti-anxiety agents, benzodiazepine Aldose reductase inhibitor Pharmacokinetics and tolerance of flunitrazepam in neonates and Zenarestat (USAN List No. 420). 1999;66:443 in infants (Pariente-Khayat et al). 1999;66:136-9 Alleles Anti-arrhythmia agents Association between CYP2A6 and CYP2C/9 mutant alleles (Lam Pharmacokinetic, pharmacodynamic, and safety evaluation of an et al). 1999;66:647 (Letter) accelerated dose titration regimen of sotalol in healthy middle- Flavin monooxygenase 3 (FMO3) polymorphism in a white pop- aged subjects (Barbey et al). 1999;66:91-9 ulation: allele frequencies, mutation linkage, and functional A nti-asthmatic agents effects on clozapine and caffeine metabolism (Sachse et al) Edodekin alfa (USAN List No. 418). 1999;66:206 1999:66:431-8 Anti-HIV agents Low frequency of defective alleles of cytochrome P450 enzymes Effect of saquinavir on the pharmacokinetics and pharmacody- 2C10 and 2D6 in the Turkish population (Aynacioglu et al) namics of oral and intravenous midazolam (Palkama et al) 1999;66:185-92 1999:66:33-9 Altinicline maleate Emitricitabine (USAN List No. 417). 1999;66:101 Altinicline maleate (USAN List No. 422). 1999;66:650 Pharmacokinetics of zidovudine in infants: a population analysis Alzheimer’s disease across studies (Mirochnick et al). 1999;66: 16-24 Levosimendan (USAN List No. 418). 1999;66:207 Anti-inflammatory agents American Society for Clinical Pharmacology and Therapeutics Celecoxib (USAN List No. 418). 1999;66:205 ASCPT moves to Alexandria, Virginia. 1999;66:328 Deracoxib (USAN List No. 418). 1999;66:208 Future meeting dates and sites of the ASCPT. 1999;66:32 Etanercept (USAN List No. 418). 1999;66:209 Nominations for awards. 1999;66:326-7, 542 Nepafenac (USAN List No. 418). 1999;66:208 Optimizing formulary decision making: core expertise for P & T Parecoxib sodium (USAN List No. 419). 1999;66:331 committees. 1999;66:649 Valdecoxib (USAN List No. 419). 1999:66:331 The Molecular Therapeutics Section of the American Society for Anti-inflammatory agents, steroidal Clinical Pharmacology and Therapeutics (Waldman and Effect of dexamethasone on reactive oxygen species generation Terzic). 1999;66:336-7 (Commentary) by leukocytes and plasma interleukin-10 concentrations: a Welcome new ASCPT members. 1999;66:648 pharmacodynamic study (Dandona et al). 1999;66:58-65 Anti-ulcer agents July, pp. 1-104; August, pp. 105-210; September, pp. 21 Pharmacodynamic modeling of the acid inhibitory effect of rani- October, pp. 333-444; November, pp. 445-546; December, pp. tidine in patients in an intensive care unit during prolonged 547-674. Index to the ASCPT meeting abstracts is located in the dosing: characterization of tolerance (Mathot et al).1999; February issue. 66:140-51 CLINICAL PHARMACOLOGY & THERAPEUTICS DECEMBER 1999 665 CLINICAL PHARMACOLOGY & THERAPEUTICS 666 Subject index DECEMBER 1999 Anticholesteremic agents Binetrakin Grapefruit juice increases serum concentrations of atorvastatin Binetrakin (USAN List No. 422). 1999;66:650 and has no effect on pravastatin (Lilija et al). 1999;66:118-27 Biricodar dicitrate Anticoagulants Biricodar dicitrate (USAN List No. 417). 1999;66:102 Tifacogin (USAN List No. 421). 1999;66:543 Body temperature Anticonvulsants Acetaminophen has greater antipyretic efficacy than aspirin in Cytochrome P450-inducing antiepileptics increase the clearance endotoxemia: a randomized, double-blind, placebo-controlled of vincristine in patients with brain tumors (Villikka et al) trial (Pernerstorfer et al). 1999;66:51-7 1999:66:589-93 Brain edema Antidepressive agents Entry of tromethamine into the cerebrospinal fluid of humans Igmesine hydrochloride (USAN List No. 417). 1999;66:104 after cerebrovascular events (Nau et al). 1999;66:25-32 Antidepressive agents, tricyclic Brasofensine maleate Clomipramine dose-effect study in patients with depression: clin Brasofensine maleate (USAN List No. 422). 1999;66:655 ical end points and pharmacokinetics (Danish University Buprenorphine Antidepressant Group). 1999;66: 152-65 4 comparison of four buprenorphine dosing regimens in the treat Antiepileptics; see Anticonvulsants of opioid dependence (Petry et al). 1999;66:306-14 Antilipemic agents Fenofibrate decreases plasma fibrinogen, improves lipid profile, and reduces uricemia (de la Serna et al). 1999;66:166-72 Antineoplastic agents Biricodar dicitrate (USAN List No. 417). 1999;66:102 Satraplatin (USAN List No. 420). 1999;66:440 Caffeine Antiviral agents Flavin monooxygenase 3 (FMO3) polymorphism in a white pop- Maribavir (USAN List No. 419). 1999;66:329 ulation: allele frequencies, mutation linkage, and functional Penciclovir sodium (USAN List No. 420). 1999;66:441 effects on clozapine and caffeine metabolism (Sachse et al). Saquinavir (USAN List No. 419). 1999;66:332 1999;66:431-8 Tremacamra (USAN List No. 421). 1999;66:544 Cardiovascular diseases Artemether Fenofibrate decreases plasma fibrinogen, improves lipid profile, The effect of grapefruit juice on the time-dependent decline of and reduces uricemia (de la Serna et al). 1999;66:166-72 artemether plasma levels in healthy subjects (van Agtmael et Implication of evidence-based medicine in prescription guide- lines taught to French medical students: current status in the al). 1999:66:408-14 cardiovascular field (Nony et al). 1999;66:173-84 Aspirin Caucasoid race Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled Low frequency of defective alleles of cytochrome P450 enzymes 2C10 and 2D6 in the Turkish population (Aynacioglu et al). trial (Pernerstorfer et al). 1999;66:51-7 1999:66:185-92 Attention deficit hyperactivity disorder Acute tolerance to methylphenidate in the treatment of attention Celecoxib deficit hyperactivity disorder in children (Swanson et al) Celecoxib (USAN List No. 418). 1999;66:205 1999:66:295-305 Cetuximab Cetuximab (USAN List No. 422). 1999;66:654 Authors Omission of authors. 1999;66:333 (Commentary) Cerebrovascular disorders The case of the forgotten author: a mystery to editors Entry of tromethamine into the cerebrospinal fluid of humans (Reidenberg). 1999;66:333-5 (Commentary) after cerebrovascular events (Nau et al). 1999;66:25-32 Axitirome Gavestinel (USAN List No. 417). 1999;66:103 Axitirome (USAN List No. 422). 1999;66:655 Children Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children (Swanson et al) 1999:66:295-305 Chinese Enantioselective pharmacokinetics of 10-hydroxycarbazepine after oral administration of oxycarbazepine to healthy Chinese Basiliximab subjects (Volosov et al). 1999:66:547-53 Basiliximab (USAN List No. 422). 1999;66:653 Fluoxetine impairs the CYP2D6-mediated metabolism of Benzbromarone propafenone enantiomers in healthy Chinese volunteers (Cai et Potentiation of anticoagulant effect of warfarin caused by enan- al). 1999:66:516-21 tioselective metabolic inhibition by the uricosuric agent Chloroguanide benzbromarone (Takahashi et al). 1999;66:569-81 Assessment of CYP2D6 and CYP2C19 activity in vivo in humans: Beverages a cocktail study with dextromethorphan and chloroguanide Grapefruit juice increases serum concentrations of atorvastatin alone and in combination (Tennezé et al). 1999;66:582-8 and has no effect on pravastatin (Lilija et al). 1999;66:118-27 Chlorzoxazone Bexlosteride The effect of endotoxin administration on the pharmacokinetics Bexlosteride (USAN List No. 422). 1999;66:653 of chlorzoxazone in humans (Poloyac et al). 1999;66:554-62 CLINICAL PHARMACOLOGY & THERAPEUTICS VOLUME 66, NUMBER 6 Subject index 667 Cholesterol Commentaries Fenofibrate decreases plasma fibrinogen, improves lipid profile, Commentaries. 1999;66:1-8, 105-9, 211-23, 333- , 445- and reduces uricemia (de la Serna et al). 1999;66:166-72 The science of pharmacological variability: an essay (Kalow et Chronotherapy al). 1999:66:445-7 Chronotherapy of high-dose 1,25-dihydroxyvitamin D in Contraceptives, oral hemodialysis patients with secondary hyperparathyroidism: a Mifepristone (USAN List No. 419). 1999;66:330 single-dose study (Tsuruoka et al). 1999;66:609-16 Coronary vessels Cirrhosis; see Liver cirrhosis Hemodynamic and coronary effects of intravenous eletriptan, a Cisapride SHT\p/;p-receptor agonist (Muir et al). 1999;66:85-90 Repeated consumption of grapefruit juice considerably increases Corrections plasma concentrations of cisapride (Kivist6 et al) Clinical pharmacology: The scientific basis of therapeutics 1999-66:448-53 (Reidenberg) (1999;66:1-8). 1999;66:624 (Correction) Citalopram hydrobromide Analysis of the CYP2D6 gene in relation to dextromethorphan O- Citalopram hydrobromide (USAN List No. 422). 1999;66:656 demethylation capacity in a Japanese population (Tateishi et al) (1999:65:570-5). 1999:66:581 (Correction) Citrus Corticosteroids Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A Development of in vivo bioequivalence methodology for derma- reductase inhibitors (Rogers et al). 1999;66:358-66 tologic corticosteroids based on pharmacodynamic modeling (Singh et al). 1999;66:346-57 Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin (Lilija et al). 1999;66: 118-27 Cyclooxygenase-2 inhibitors Repeated consumption of grapefruit juice considerably increases Celecoxib (USAN List No. 418). 1999:66:205 plasma concentrations of cisapride (Kivist6 et al) Parecoxib sodium (USAN List No. 419). 1999;66:331 1999:66:448-53 Renal effects of selective cyclooxygenase-2 inhibition in nor- The effect of grapefruit juice on the time-dependent decline of motensive salt-depleted subjects (Rossat et al). 1999;66:76-84 artemether plasma levels in healthy subjects (van Agtmael et Valdecoxib (USAN List No. 419). 1999;66:331 al). 1999:66:408-14 Cyclosporine Developmental pharmacodynamics of cyclosporine (Marshall Clarithromycin Effects of clarithromycin on the metabolism of omeprazole in and Kearns). 1999:66:66-75 relation to CYP2C/9 genotype status in humans (Furuta et al) Cytochrome P450 1999-66:265-74 Assessment of CYP2D6 and CYP2C19 activity in vivo in Clenoliximab humans: a cocktail study with dextromethorphan and chloroguanide alone and in combination (Tennezé et al). 1999; A population pharmacokinetic-pharmacodynamic analysis of sin- 66:582-8 gle doses of clenoliximab in patients with rheumatoid arthritis Association between CYP2A6 and CYP2C/9 mutant alleles (Lam (Mould et al). 1999:66:246-57 et al). 1999;:66:647 (Letter) Clevudine CYP2C/9 genotype-related efficacy of omeprazole for the treat- Clevudine (USAN List No. 422). 1999;66:656 ment of infection caused by Helicobacter pylori (Tanigawara et Clinical Pharmacology and Therapeutics al). 1999:66:528-34 Omission of authors. 1999:66:333 (Commentary) Cytochrome P450-inducing antiepileptics increase the clearance The case of the forgotten author: a mystery to editors of vincristine in patients with brain tumors (Villikka et al) (Reidenberg). 1999;66:333-5 (Commentary) 1999;66:589-93 Clomipramine Differentiation of intestinal and hepatic cytochrome P450 3A Clomipramine dose-effect study in patients with depression: clin activity with use of midazolam as an in vivo probe: effect of ical end points and pharmacokinetics (Danish University ketoconazole (Tsunoda et al). 1999;66:461-71 Antidepressant Group). 1999;66:152-65 Dose dependency of dextromethorphan for cytochrome P450 2D6 Decreased platelet serotonin transporter sites and increased (CYP2D6) phenotyping (Streetman et al). 1999;66:535-41 platelet inositol triphosphate levels in patients with unipolar Effect of the gene dosage of CYP2C/9 on diazepam metabolism depression: effects of clomipramine and fluoxetine (Alvarez et in Chinese subjects (Qin et al).-1999:66:642-6 al). 1999;66:617-24 Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C/9 genotype status in humans (Furuta et al) Clozapine 1999:66:265-74 Flavin monooxygenase 3 (FMO3) polymorphism in a white pop- Failure of erythromycin breath test to correlate with midazolam ulation: allele frequencies, mutation linkage, and functional clearance as a probe of cytochrome P4503A (Kinirons et al) effects on clozapine and caffeine metabolism (Sachse et al). 1999:66:224-31 1999:66:431-8 Fluoxetine impairs the CYP2D6-mediated metabolism of Codeine propafenone enantiomers in healthy Chinese volunteers (Cai et Combination of diclofenac with acetaminophen or aceta- al). 1999:66:516-21 minophen-codeine after oral surgery: a randomized, double- In vivo comparison of putative probes of CYP3A4/5 activity: ery- blind single-dose study (Breivik et al). 1999;66:625-35 thromycin, dextromethorphan, and verapamil (Krecic-Shepard Coenzyme A reductase inhibitors et al). 1999:66:40-50 Grapefruit juice has minimal effects on plasma concentrations of Low frequency of defective alleles of cytochrome P450 enzymes lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A 2C10 and 2D6 in the Turkish population (Aynacioglu et al). reductase inhibitors (Rogers et al). 1999;66:358-66 1999:66: 185-92 CLINICAL PHARMACOLOGY & THERAPEUTICS 668 Subject index DECEMBER 1999 Mibefradil but not isradipine substantially elevates the plasma Doxercalciferol concentrations of the CYP3A4 substrate triazolam (Backman Doxercalciferol (USAN List No. 422). 1999;66:655 et al). 1999;66:401-7 Drug interactions Population distribution and effects on drug metabolism of a In vitro metabolic interaction studies: experience of the Food and genetic variant in the 5° promoter region of CYP3A4 (Ball et Drug Administration (Yuan et al). 1999;66:9-15 al). 1999:66:288-94 Drug screening Propofol decreases the clearance of midazolam by inhibiting In vitro metabolic interaction studies: experience of the Food and CYP3A4: an in vivo and in vitro study (Hamaoka et al) Drug Administration (Yuan et al). 1999;66:9-15 1999:66:110-7 Dutasteride The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxyla Dutasteride (USAN List No. 417). 1999:66:101 tion of quinine in vivo (Mirghani et al). 1999;66:454-60 DX-9065a Cytokines Tolerability, pharmacokinetics, and pharmacodynamics of DX- Effect of filgrastim treatment on inflammatory cytokines and 9065a, a new synthetic potent anticoagulant and specific factor lymphocyte functions (Hartung et al). 1999;66:415-24 Xa inhibitor, in healthy male volunteers (Murayama et al). Cytomegalovirus infections 1999-66:258-64 Maribavir (USAN List No. 419). 1999;66:329 Edodekin alfa Depression, involutional Edodekin alfa (USAN List No. 418). 1999;66:206 Clomipramine dose-effect study in patients with depression: clin Education, medical ical end points and pharmacokinetics (Danish University Implication of evidence-based medicine in prescription guide- Antidepressant Group). 1999:66:152-65 lines taught to French medical students: current status in the Deracoxib cardiovascular field (Nony et al). 1999;66:173-84 Deracoxib (USAN List No. 418). 1999;66:208 Emitricitabine Dermatitis, atopic Emitricitabine (USAN List No. 417). 1999;66:101 Hydrocortisone probutate (USAN List No. 417). 1999;66:104 Endotoxin Dextromethorphan The effect of endotoxin administration on the pharmacokinetics Assessment of CYP2D6 and CYP2C19 activity in vivo in of chlorzoxazone in humans (Poloyac et al). 1999;66:554-62 humans: a cocktail study with dextromethorphan and Erythromycin chloroguanide alone and in combination (Tennezé et al). 1999; Failure of erythromycin breath test to correlate with midazolam 66:582-8 clearance as a probe of cytochrome P4503A (Kinirons et al) Dose dependency of dextromethorphan for cytochrome P450 2D6 1999:66:224-31 (CYP2D6) phenotyping (Streetman et al). 1999;66:535-41 In vivo comparison of putative probes of CYP3A4/5 activity: ery In vivo comparison of putative probes of CYP3A4/5 activity: ery thromycin, dextromethorphan, and verapamil (Krecic-Shepard thromycin, dextromethorphan, and verapamil (Krecic-Shepard et al). 1999;66:40-50 et al). 1999:66:40-50 Etanercept Polymorphism of dextromethorphan oxidation in South Indian Etanercept (USAN List No. 418). 1999;66:209 subjects (Mamidi et al). 1999:66:193-200 Evidence-based medicine Diabetes mellitus Clinical pharmacology: The scientific basis of therapeutics Mecaserim (USAN List No. 419). 1999;66:331 (Reidenberg) (1999;66:1-8). 1999;66:624 (Correction) Voglibose (USAN No 420). 1999:66:444 Implication of evidence-based medicine in prescription guide Diazepam lines taught to French medical students: current status in the Effect of the gene dosage of CYP2C/9 on diazepam metabolism cardiovascular field (Nony et al). 1999;66:173-84 in Chinese subjects (Qin et al). 1999;66:642-6 Dichloroacetate Pharmacokinetics and pharmacodynamics of dichloroacetate in patients with cirrhosis (Shangraw and Fisher). 1999;66:380-90 Diclofenac Combination of diclofenac with acetaminophen or aceta Fatty acids minophen-codeine after oral surgery: a randomized, double The effect of orlistat on the fatty acid composition of serum lipid blind single-dose study (Breivik et al). 1999;66:625-35 fractions in obese subjects (Vidgren et al). 1999;66:3 15-22 Digoxin Fever Longitudinal assessment of a P-glycoprotein—-mediated drug Acetaminophen has greater antipyretic efficacy than aspirin in interaction of valspodar on digoxin (Kovarik et al) endotoxemia: a randomized, double-blind, placebo-controlled 1999:66:39 1-400 trial (Pernerstorfer et al). 1999;66:51-7 Pharmacokinetic interaction of digoxin with a herbal extract from Fibrinogen St John’s wort (Hypericum perforatum) (Johne et al). Fenofibrate decreases plasma fibrinogen, improves lipid profile, 1999:66:338-45 and reduces uricemia (de la Serna et al). 1999;66: 166-72

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