MICHAEL T. CRIMMINS SENIOR ASSOCIATE DEAN FOR NATURAL AND MATHEMATICAL SCIENCES MARY ANN SMITH DISTINGUISHED PROFESSOR DEPARTMENT OF CHEMISTRY, UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL CHAPEL HILL, NORTH CAROLINA 27599-3290 email: [email protected] ; (919)-966-5177; (919)-962-9277; FAX (919)-962-2388; EDUCATION: B.A., with Honors (1976) Hendrix College, Conway, Arkansas Ph.D., (1980) Duke University, Durham, North Carolina (with Steven W. Baldwin) Postdoctoral (1980-81) California Institute of Technology, Pasadena, CA (with David A. Evans) PROFESSIONAL EXPERIENCE: Graduate Assistant, Duke University, Durham, North Carolina (1976-80) Research Fellow, California Institute of Technology, Pasadena, California (1980-81) Assistant Professor of Chemistry, UNC, Chapel Hill, North Carolina (1981-88) Associate Professor of Chemistry, UNC, Chapel Hill, North Carolina (1988-93) Professor of Chemistry, UNC, Chapel Hill, North Carolina (1993-2003) Visiting Associate Professor, Duke University, Durham, North Carolina (1991) Vice Chair, Facilities, Department of Chemistry, UNC, Chapel Hill, North Carolina (1992-93) Vice Chair, Graduate Studies, Department of Chemistry, UNC, Chapel Hill, NC (1995-2000) George and Alice Welsh Distinguished Term Professor (2001-2003) Mary Ann Smith Distinguished Professor of Chemistry UNC, Chapel Hill, NC (2003-) Professor of Medicinal Chemistry-Natural Products, School of Pharmacy, UNC (2007-) Chair, Department of Chemistry, University of North Carolina at Chapel Hill, (2007-2009) Senior Associate Dean for Natural Sciences, University of North Carolina at Chapel Hill, (2009-) SELECTED HONORS AND PROFESSIONAL ACTIVITIES: M. J. McHenry Chemistry Prize, Hendrix College (1976) C. R. Hauser Fellow, Duke University (1979-80) NIH-NCI Postdoctoral Fellow, California Institute of Technology (1980-81) Alfred P. Sloan Fellow (1986-90) Research Development Award, University of North Carolina (1988) UNC-CH Foundation Leave (1991-92) Invited Expert Analyst ChemTracts Organic Chemistry (1993-2005) Chair, North Carolina Section of the American Chemical Society (1994) American Cyanamid Faculty Fellow (1994) Senior Class Favorite Faculty Award (1997) Tanner Faculty Award for Excellence in Undergraduate Teaching, UNC-CH (1999) Academy of Distinguished Teaching Scholars, UNC-CH (2000) Arthur C. Cope Scholar Award, American Chemical Society (2001) George and Alice Welsh Distinguished Term Professor (2001-2003) Lineberger Comprehensive Cancer Center, Member (2001-) Mary Ann Smith Distinguished Professor of Chemistry UNC, Chapel Hill, NC (2003-) Scientific Advisory Board, Chimerix Inc. (2002-2011) Editorial Advisory Board, Journal of Organic Chemistry, (2004-2007) Charles Holmes Herty Medal, Georgia Section, American Chemical Society (2004) NIH Synthetic and Biological Chemistry A Study Section, member (2005-2009) International Editorial Advisory Board, Organic & Biomolecular Chemistry (2007-2012) North Carolina ACS Section Distinguished Speaker Award (2008) Ernest Guenther Award in the Chemistry of Natural Products, American Chemical Society (2010) Lectureships: Roche Distinguished Lecturer, Colorado State University (2000), Merck Sharpe and Dohme Distinguished Visiting Lecturer, UK (2001), Abbott Labs Student Select Lecturer, U. of Notre Dame (2001), Merck-Frosst Lecturer, U. of Ottawa (2002), Student Select Lecturer, U. of Pennsylvania (2002), Roche Distinguished Lecturer, U. of Colorado (2002), Closs Lecturer, U. of Chicago (2004), Abbott Lecturer, Massachusetts Institute of Technology (2009) PUBLICATIONS 1. "A Convenient Preparation of α-Methylene-δ-valerolactones," Baldwin, S. W.; Crimmins, M. T.; Cheek, V. I. Synthesis 1978, 210-211. 2. “A Facile Synthesis of δ-Valerolactones by Photoannelation,” Baldwin, S. W.; Crimmins, M. T. Tetrahedron Lett. 1978, 4197-4200. 3. "Synthesis of the Alleged Genipic Acid by Photoannelation," Baldwin, S. W.; Crimmins, M. T. J. Am. Chem. Soc. 1980, 102, 1198-1199. 4. "Total Synthesis of (±) and (-) Sarracenin by Photoannelation," Baldwin, S. W.; Crimmins, M. T. J. Am. Chem. Soc. 1982, 104, 1132-1133. 5. "Addition of 1-Methoxy-1-butene-3-yne to Lactones: Synthesis of Substituted Spiroketals," Crimmins, M. T.; Bankaitis, D. M. Tetrahedron Lett. 1983, 24, 4551-4554. 6. "Synthesis of 5-Alkyl-2, 3-dihydropyrones from 1-Methoxy-1-butene-3-yne," Crimmins, M. T.; Bankaitis, D. M. Tetrahedron Lett. 1983, 24, 5303-5304. 7. "Intramolecular Photocycloaddition-Cyclobutane Fragmentation: A Highly Stereoselective Total Synthesis of Pentalenic Acid," Crimmins, M. T.; DeLoach, J. A. J. Org. Chem. 1984, 49, 2076-2077. 8. "Conjugate Addition-Cycloacylation of Acetylenic Diesters: Synthesis of Highly Functionalized Cyclopentenones," Crimmins, M. T.; Mascarella, S. W.; DeLoach, J. A. J. Org. Chem. 1984, 49, 3033-3035. 9. "Intramolecular Photocycloadditions: Synthesis of Sterically Congested Substituted [4.5.5.5] Fenestranes.: Models for the Synthesis of Laurenene and Silphinene. Crimmins, M. T.; Mascarella, S. W.; Bredon, L. D. Tetrahedron Lett. 1985, 26, 997-1000. 10. "Intramolecular Photocycloadditons: Total Synthesis of (±)-Pentalenene, (±)-Pentalenic Acid, and (±)-Deoxypentalenic Acid," Crimmins, M. T.; DeLoach, J. A. J. Am. Chem. Soc. 1986, 108, 800-806. 11. "Synthesis of the Hexahydrobenzofuran Subunit of the Milbemycins and the Avermectins," Crimmins, M. T.; Lever, J. G. Tetrahedron Lett. 1986, 27, 291-294. 12. "Intramolecular Photocycloadditions-Cyclobutane Fragmentation: Total Synthesis of (±)- Silphinene," Crimmins, M. T.; Mascarella, S. W. J. Am. Chem. Soc. 1986, 108, 3435-3438. 13. "Synthesis and Electropolymerization of Distyrylbipyridine and Methyldistyrylbipyridine Complexes of Iron, Ruthenium, Osmium, Rhenium, and Cobalt," Leidner, C. R.; Sullivan, B. P.; Reed, R. A.; White, B. A.; Crimmins, M. T.; Murray, R. W.; Meyer, T. J. Inorganic Chemistry 1987, 26, 882-891. 14. "Intramolecular Photocycloaddition-Cyclobutane Fragmentation: Total Synthesis of the Fenestrane (±)-Laurenene," Crimmins, M. T.; Bredon, L. D. J. Am. Chem Soc. 1987, 109, 6199-6200. 15. Selenium Initiated Cyclization-2, 3-Sigmatropic Rearrangement: Synthesis of the C1 to C10 Fragment of the Milbemycins and the Avermectins," Crimmins, M. T.; Lever, J. G.; Hollis, W. G., Jr.; Tetrahedron Lett. 1987, 28, 3647-3650. 16. "Studies Directed Toward the Total Synthesis of the Milbemycins: Synthesis of the C11 to C31 Fragment of Milbemycin D," Crimmins, M. T.; Hollis, W. G., Jr.; Bankaitis-Davis, D. M. Tetrahedron Lett. 1987, 28, 3651-3654. 17. "Radical Cleavage of Cyclobutanes: Alternate Routes to (±)-Silphinene," Crimmins, M. T.; Mascarella, S. W. Tetrahedron Lett. 1987, 28, 5063-5066. 18. "ChemIntosh and ChemPanion," Software Review, Crimmins, M. T. J. Am. Chem. Soc. 1987, 109, 6905. 19. "Studies Directed Toward the Total Synthesis of the Milbemycins and Avermectins" in "Studies in Natural Products Chemistry," Crimmins, M. T.; Hollis, W. G., Jr.; O'Mahony, R. Elsevier, 1988; Atta-Ur-Rahman, Ed., p.435-485. 20. "A Total Synthesis of Milbemycin β3," Crimmins, M. T.; Bankaitis-Davis, D. M.; Hollis, W. G., Jr. J. Org. Chem. 1988, 53, 652-657. 21. "Intramolecular [2 + 2] Enone Olefin Photocycloadditions in Natural Product Synthesis," Crimmins, M.T. Chemical Reviews, 1988, 88, 1453-1473. 22. "A Synthesis of (-)-Talaromycin A," Crimmins, M. T.; O'Mahony, R. J. Org. Chem. 1989, 54, 1157-1161. 23. "Synthesis of the Spiroketal Fragment of Avermectin B ," Crimmins, M. T.; O'Mahony, 1b R. Tetrahedron Lett. 1989, 30, 5993-5996. 24. "Enone-Furan Photocycloadditions; A Model for the Synthesis of the Ginkgolides," Crimmins, M. T.; Thomas, J. B. Tetrahedron Lett. 1989, 30, 5997-6000. 25. "Formal 3+2 Cycloaddition by Addition of Zinc Homoenolates to Acetylenic Esters," Crimmins, M. T.; Nantermet, P. G. J. Org. Chem. 1990, 55, 4235-4236. 26. "Synthesis of Spiroketals: A General Approach," Crimmins, M. T.; O'Mahony, R. J. Org Chem. 1990, 55, 5894-5900. 27. "Photochemical [2+2] Cycloadditions" in "Comprehensive Organic Synthesis" Vol. 3, Pergamon Press, Oxford, 1991, B.M. Trost, Ed. 28. "Protocols for the Preparation of the Four Possible Stereoisomeric α-Alkyl-β-hydroxy Carboxylic Acids From a Single Chiral Aldol Reagent," Van Draanen, N. A.; Arseniyadis, S.; Crimmins, M. T.; Heathcock, C. H. J. Org. Chem. 1991, 56, 2499-2506. 29. "Total Synthesis of Bilobalide," Crimmins, M. T.; Jung, D. K.; Gray, J.L. J. Am. Chem. Soc. 1992, 112, 5445-5447. 30. "An Unusual Radical Fragmentation-Ring Expansion Sequence of Cyclobutyl Carbinyl Radicals," Crimmins, M. T.; Dudek, C. M.; Cheung, A. W.- H Tetrahedron Lett. 1992, 33, 181-184. 31. "Cerium Chloride Catalyzed Addition of Grignard Reagents to Vinylogous Esters: An Improved Route to 3-Substituted Cyclopentenones," Crimmins, M. T.; Dedopoulou, D. Synthetic Commun. 1992, 1953-1958. 32. "Enone-Alkene Photocycloaddition Reactions," Crimmins, M.T.; Reinhold, T.L. Organic Reactions, John Wiley and Sons, Inc. Vol. 44 1993, 297-588. 33. "Synthetic Studies on the Ginkgolides: Total Synthesis of (±)-Bilobalide," Crimmins, M. T.; Gray, J. L.; Jung, D. K. J. Am. Chem. Soc. 1993, 115, 3146-3155. 34. "Homoenolates and Other Functionalized Organometallics. A Review," Crimmins, M. T.; Nantermet, P. G. Organic Preparations and Procedures International 1993, 25, 41-81. 35. "Formal 3+2 Cycloaddition by Addition of Zinc Homoenolates to Acetylenic Esters and Amides," Crimmins, M. T.; Nantermet, P. G.; Trotter, B. W.; Vallin, I.M.; Watson, P. S.; McKerlie, L. A.; Reinhold, T. L.; Cheung, A. W. H.; Stetson, K. A.; Dedopoulou, D.; Gray, J. L. J. Org. Chem. 1993, 58, 1038-1047. 36. "Stereoselective Intramolecular Enone-Olefin Photocycloadditions of 1,7-Dienes: Model Studies on the Synthesis of Lycopodium Alkaloids," Crimmins, M. T.; Watson, P. S. Tetrahedron Lett. 1993, 34, 199-202. 37. "Siloxanes as Temporary Tethers in [2+2] Photocycloadditions," Crimmins, M. T.; Guise, L. E. Tetrahedron Lett. 1994, 35, 1657-1660. 38. "Allene" Crimmins, M. T. in Encyclopedia of Reagents for Organic Synthesis, Pergamon Press, Oxford, 1994, L.A. Paquette, Ed. 39. "Ketene Diethyl Acetal" Crimmins, M. T. in Encyclopedia of Reagents for Organic Synthesis, Pergamon Press, Oxford, 1994, L.A. Paquette, Ed. 40. "Ethylene" Kim-Meade, A.S.; Crimmins, M. T. in Encyclopedia of Reagents for Organic Synthesis, Pergamon Press, Oxford, 1994, L.A. Paquette, Ed. 41. "Isobutene" Kim-Meade, A.S.; Crimmins, M. T. in Encyclopedia of Reagents for Organic Synthesis, Pergamon Press, Oxford, 1994, L.A. Paquette, Ed. 42. "Asymmetric Synthesis of 3',4'-Di-O-(-)-Camphanoyl-(+)-Cis-Khellactone (DCK), A Potent Anti-HIV Agent," Xie, L.; Crimmins, M. T.; Lee, K. H. Tetrahedron Lett. 1995, 36, 4529-4532. 43. "Addition of Functionalized Zinc Copper Reagents to Acetylenic Esters: Synthesis of 2- Carboalkoxy Cyclohexenones," Crimmins, M. T.; Guise, L. E.; Lacy, D. B.; Huang, S. J. Tetrahedron Lett. 1995, 36, 7061-7065. 44. "Trapping of the 1,4-Biradicals with Hydrogen Selenide in the Intermolecular and Intramolecular Photochemical Cycloaddition Reaction," King, B. W., Crimmins, M. T. ChemTracts Organic 1995, 8, 344-350. 45. "An Efficient Asymmetric Approach to Carbocyclic Nucleosides: Asymmetric Synthesis of 1592U89, a Potent Inhibitor of HIV Reverse Transcriptase," Crimmins, M. T., King, B. W. J. Org. Chem. 1996, 61, 4192-4193. 46. "Asymmetric Total Synthesis of (+)-Milbemycin D," Crimmins, M. T.; Al-awar, R. S.; Vallin, I. M.; O'Mahony, R.; Hollis, W. G., Jr.; Bankaitis-Davis, D. M.; Lever, J. G. J. Am. Chem. Soc. 1996, 119, 7513-7528. 47. "Regioselective and Stereoselective Reductive Cleavages of Spiroketal Alcohols," Crimmins, M. T.; Rafferty, S. W. Tetrahedron Lett. 1996, 37, 5649-5652. 48. "Synthesis of Medium Rings by Radical Fragmentation of Cyclobutylcarbinyl Radicals," Crimmins, M. T.; Huang, S. J.; Guise, L. E. Tetrahedron Lett. 1996, 37, 6519-6522. 49. "A Convenient Synthesis of Unsymmetrical, Substituted γ-Pyrones from Meldrum's Acid," Zawacki, F. J.; Crimmins, M. T. Tetrahedron Lett. 1996, 37, 6499-6502. 50. "Rearrangement of Cyclobutylcarbinyl Radicals. The Total Synthesis of the Spirovetivane Phytoalexin, (±)-Lubiminol," Crimmins, M. T.; Wang, Z.; McKerlie, L. A. Tetrahedron Lett. 1996, 37, 8703-8706. 51. "Synthesis and Intramolecular Photocycloadditions of 2-Acyloxy-3-Hexenoyl Cyclohexenones: Diastereoselectivity in the Intramolecular [2+2] Photocycloadditions of Alkenes and Cyclohexenones Tethered by Four Atoms," Crimmins, M. T.; Watson, P. S.; King, B. W.; Guise, L. E. Tetrahedron 1997, 53, 8963-8974. 52. "Enantioselective Synthesis of Cyclopentenes," U.S. Patent Serial No. 60/017,510 Filed March 10, 1996, Issued July, 1999, Crimmins, Michael T. 53. "A Mechanism of Carbon Monoxide Production from Volatile Anesthetics and Anhydrous Soda Lime in Anesthetic Circuits," Huh, B. K.; Passannante, A. N.; Crimmins M. T. Anesthesiology 1997 Suppl. S 87, A1138-A1138. 54. "Effects of Hydrogen Bonding on the Diastereoselectivity in Intramolecular Enone-alkene Photocycloadditions," Crimmins, M. T.; Choy, A. L. J. Am. Chem. Soc. 1997, 119, 10237- 10238. 55. "Asymmetric Aldol Condensations with Titanium Enolates of Acyloxazolidinethiones: Dependence of Selectivity on Amine Base and Lewis Acid Stoichiometry," Crimmins, M. T.; King, B. W.; Tabet, E. A. J. Am. Chem. Soc. 1997, 119, 7883-7884. 56. "An Asymmetric Aldol - Ring Closing Metathesis Strategy for the Enantioselective Construction of Six to Nine Membered Oxygen Heterocycles," Crimmins, M. T.; Choy, A. L. J. Org. Chem. 1997, 62, 7548-7549. 57. "The Synthesis of 2-Alkyl-4-Pyrones from Meldrum's Acid," Crimmins, M. T.; Washburn, D. G.: Zawacki, F. J. Organic Syntheses 1999. 58. "Double Diastereoselection in Intramolecular Photocycloadditions: A Radical Rearrangement Approach to the Total Synthesis of the Spirovetivane Phytoalexin, (±)- Lubiminol," Crimmins, M. T.; Wang, Z.; McKerlie, L. A. J. Am. Chem. Soc. 1998, 120, 1747-1756. 59. "Recent Advances in the Asymmetric Synthesis of Carbocyclic Nucleosides," Crimmins, M. T. Tetrahedron 1998, 54, 9229-9272. 60. "Addition of Metalated Pyrones to β-Alkoxy Aldehydes. Synthesis of Hydroxylated Spiroketals,” Crimmins, M. T.; Washburn, D. G.; Katz, J. D.; Zawacki, F. J. Tetrahedron Lett. 1998, 39, 3439-3442. 61. "A Convenient Synthesis of 3-Butenal," Crimmins, M. T.; Kirincich, S. J.; Wells, A. J.; Choy, A.L. Synthetic Commun. 1998, 28, 3675-3679. 62. "Synthesis of the AB Spiroketal Subunit of Spongistatin 1 (Altohyrtin A): The Pyrone Approach," Crimmins, M.T.; Washburn, D.G. Tetrahedron Lett. 1998, 39, 7487-7490. 63. "Asymmetric Total Synthesis of Callystatin A: Asymmetric Aldol Additions with Titanium Enolates of Acyloxazolidinethiones," Crimmins, M. T.; King, B. W. J. Am. Chem. Soc. 1998, 120, 9084-9085. 64. "Pinacol-Type Rearrangements of Intramolecular Photocycloadducts: Application of the 2,2-Dimethyl-4-Pentenoate Protecting Group," Crimmins, M. T., Carroll, C. A.; Wells, A. J. Tetrahedron Lett. 1998, 39, 7005-7008. 65. "An Asymmetric Aldol - Ring Closing Metathesis Strategy for the Enantioselective Construction of Six to Nine Membered Oxygen Heterocycles: A Formal Total Synthesis of (+)-Laurencin," Crimmins, M. T.; Choy, A. L. J. Am. Chem. Soc. 1999, 121, 5663-5660. 66. "Total Synthesis of (±)-Ginkgolide B," Crimmins, M. T.; Pace, J. M.; Nantermet, P. G.; Kim-Meade, A. S.; Thomas, J. B.; Wagman, A. S.; Watterson, S. H. J. Am. Chem. Soc. 1999, 121, 10249-10250. 67. "Total Synthesis of (+)-Laurencin: An Asymmetric Alkylation - Ring Closing Metathesis Approach to the Synthesis of Medium Ring Ethers," Crimmins, M. T.; Emmitte, K. A. Organic Lett. 1999, 1, 2029-2032. 68. "A Solution to the Preparation of Crossed Photocycloadducts in Intramolecular [2+2] Photocycloadditions," Crimmins, M. T.; Hauser, E. B. Organic Lett. 2000, 2, 281-284. 69. "Synthesis of the C1 to C13 Fragment of Leucascandrolide A," Crimmins, M. T.; Carroll, C. A.; King, B. W. Organic Lett. 2000, 2, 597-599. 70. "Titatium Enolates of Thiazolidinethione Chiral Auxiliaries: Versatile Tools for Asymmetric Aldol Additions," Crimmins, M. T.; Chaudhary, K. Organic Lett. 2000, 2, 775-777. 71. “Solid Phase Synthesis of Carbocyclic Nucleosides,” Crimmins, M. T.; Zuercher, W. J. Organic Lett. 2000, 2, 1065-1067. 72. "Synthesis of the CD Spiroketal Subunit of Spongistatin 1 (Altohyrtin A): The Pyrone Approach," Crimmins, M. T.; Katz, J. D. Organic Lett. 2000, 2, 957-960. 73. “Total Synthesis (+)-Prelaureatin and (+)-Laurallene," Crimmins, M. T.; Tabet, E. A. J. Am. Chem. Soc. 2000, 122, 5473-5476. 74. "Ring-Closing Metathesis for the Synthesis of Medium Ring Ethers: Confomational Effects on the Rates of Ring Closure," Crimmins, M. T.; Emmitte, K. A. Synthesis 2000, 899-903. 75. "Total Synthesis of (±)-Ginkgolide B," Crimmins, M. T.; Pace, J. M.; Nantermet, P. G.; Kim-Meade, A. S.; Thomas, J. B.; Wagman, A. S.; Watterson, S. H. J. Am. Chem. Soc. 2000, 122, 8453-8463. 76. "Asymmetric Glycolate Alkylations: A Useful Extension of the Evans Asymmetric Alkylation," Crimmins, M. T.; Emmitte, K. A., Katz, J.D. Organic Lett. 2000, 2, 2165- 2167. 77. "An Efficient Enantioselective Approach to Nucleoside Analogs," Crimmins, M. T.; King, B. W., Zuercher, W. J.; Choy, A. L. J. Org. Chem. 2000, 64, 8499-8509. 78. "Asymmetric Aldol Additions: Use of Titanium Tetrachloride and (–)-Sparteine for the Soft Enolization of N-Acyl Oxazolidinones, Oxazolidinethiones and Thiazolidinethiones," Crimmins, M. T.; King, B. W.; Tabet, E. A., Chaudhary, K. J. Org. Chem. 2001, 65, 894- 902. 79. "Asymmetric Total Synthesis of (–)-Isolaurallene," Crimmins, M. T.; Emmitte, K. A. J. Am. Chem. Soc. 2001, 123, 1533-1534. 80. "An Aldol Approach to the Synthesis of the EF Fragment of Spongistatin 1," Crimmins, M. T.; Katz, J. D.; Captain, L. F.; Tabet, E. A.; Kirincich, S. J. Organic Lett. 2001, 3, 949-952. 81. "Total Synthesis of (-) - Trehazolin via an Asymmetric Aldol - Ring Closing Metathesis Strategy," Crimmins, M. T.; Tabet, E. A. J. Org. Chem. 2001, 65, 4012-4108. 82. "Ring Closing Metathesis for the Formation of Medium Ring Ethers: Total Synthesis of Isolaurallene," Crimmins, M. T.; Emmitte, K. A.; Choy, A. L. Tetrahedron 2002, 58 1817- 1834. 83. "Regioselectivity in the Palladium Catalyzed Addition of Carbon Nucleophiles to Carboyclic Derivatives," Hoke, M. E.; Brescia, M.-R.; Bogaczyk, S; DeShong, P.; King, B. W.; Crimmins, M. T. J. Org. Chem. 2002, 66, 327-335. 84. "Asymmetric Total Synthesis of (–)-Laulimalide. Exploiting the Asymmetric Glycolate Alkylation," Crimmins, M. T.; Stanton, M. G.; Allwein, S. P. J. Am. Chem. Soc. 2002, 124, 5958-5959. 85. "Asymmetric Total Synthesis of Spongistatins 1 and 2,” Crimmins, M. T.; Katz, J. D.; Washburn, D. G.; Allwein, S. P.; MacAtee, L. F. J. Am. Chem. Soc. 2002, 124, 5661-5663. 86. “Synthetic Approaches to the Microtubule Stabilizing Agent (–)-Laulimalide,” Crimmins, M. T. Current Opinion in Drug Discovery and Development 2002, 5, 944-959. 87. “Anti Selective Aldol Reactions with Titanium Enolates of N-Glycolyloxazolidinethiones,” Crimmins, M. T.; McDougall, P. J. Organic Lett. 2003, 5, 591-594. 88. “Enantioselective Synthesis of (+)-Obtusenyne,” Crimmins, M. T.; Powell, M. T. J. Am. Chem. Soc. 2003, 125, 7592-7595. 89. “Enantioselective Total Synthesis of Rogioloxepane A,” Crimmins, M. T.; Debaillie, A. Org. Lett. 2003, 5, 3009-3011. 90. “Enantioselective Total Synthesis of (+)-Leucascandrolide A Macrolactone,” Crimmins, M. T.; Siliphivanh, P. Org. Lett. 2003, 5, 4641-4644. 91. “Enantioselective Synthesis of the G-Ring of Brevetoxin A," Crimmins, M. T.; Cleary, P. A. Heterocycles 2003, 61, 87-92. 92. “A Unified Approach to the Enantioselective Synthesis of 2,6-Cis and Trans Disubstituted Tetrahydropyranones," Crimmins, M. T.; Diaz, C. J.; Emmitte, K. A. Heterocycles 2004, 62, 179-183. 93. “An Improved Procedure for Asymmetric Aldol Additions with N-Acyl Oxazolidinones, Oxazolidinethiones and Thiazolidinethiones,” Crimmins, M. T.; She, J. SynLett 2004, 1371-1374. 94. “An Intramolecular Diels-Alder Strategy for the Construction of Eunicellin Diterpenes, Enantioselective Total Synthesis of Ophirin B,” Crimmins, M. T.; Brown, B. H. J. Am. Chem. Soc. 2004, 126, 10264-10266. 95. “Enantioselective Total Synthesis of Gigantecin: Exploiting the Asymmetric Glycolate Aldol Reaction,” Crimmins, M. T.; She, J. J. Am. Chem. Soc. 2004, 126, 12790-12791. 96. “A Convergent Coupling Strategy for the Formation of Polycyclic Ethers: Stereoselective Synthesis of the BCDE fragment of Brevetoxin A," Crimmins, M. T.; McDougall, P. J.; Emmitte, K. A. Org. Lett. 2005, 7, 4033-4036. 97. “Enantioselective Synthesis of Apoptolidin Sugars,” Crimmins, M. T.; Long, A., Org. Lett. 2005, 7, 4157-4160. 98. “Enantioselective Synthesis of Apoptolidinone: Exploiting the Versatility of Thiazolidinethione Chiral Auxiliaries,” Crimmins, M. T.; Christie, H. S.; Chaudhary, K.; Long, A. J. Am. Chem. Soc. 2005, 127, 13810-13812. 99. “Establishing the Absolute Configuration of the Asbestinins: Enantioselective Total Synthesis of 11-Acetoxy-4-deoxyasbestinin D,” Crimmins, M. T.; Ellis, J. M. J. Am. Chem. Soc. 2005, 127, 17200-17201. 100. “An Intramolecular Diels-Alder Approach to the Eunicellins: Enantioselective Total Syntheses of Ophirin B and Astrogorgin,” Crimmins, M. T.; Brown, B. H.; Plake, H. R. J. Am. Chem. Soc. 2006, 128, 1371-1378. 101. “Stereoselective Synthesis of the GHIJ fragment of Brevetoxin A," Crimmins, M. T.; Zuccarello, J. L.; Cleary, P. A.; Parrish, J. D. Org. Lett. 2006, 8, 159-162. 102. “Enantioselective Total Synthesis of FD-891,” Crimmins, M. T.; Caussanel, F. J. Am. Chem. Soc. 2006, 129, 3128-3129. 103. “A Hetero-Diels-Alder Approach to Complex Pyrones: An Improved Synthesis of the Spongistatin AB Spiroketal,” Crimmins, M. T.; Smith, A. C. Org. Lett. 2006, 8, 1003- 1006. 104. “Total Synthesis of Bistramide A,” Crimmins, M. T.; DeBaillie, A. C. J. Am. Chem. Soc., 2006, 129, 4936-4937. 105. “An Iterative Aldol Approach to the Erythromycins: A Formal Synthesis of 6- Deoxyerythronolide B,” Crimmins, M. T.; Slade, D. J. Org. Lett. 2006, 8, 2191-2194. 106. “Selective Olefin Cross-Metathesis; Total Synthesis of Mucocin,” Crimmins, M. T.; Zhang, Y.; Diaz, F. Org. Lett. 2006, 8, 2369-2372. 107. “Total Synthesis of SCH-351448," Crimmins, M. T.; Smalley, G.A. Org. Lett. 2006, 8, 2887-2890. 108. “An Improved Synthesis of the ABCDE fragment of Brevetoxin A," Crimmins, M. T.; McDougall, P. J.; Ellis, J. M. Org. Lett. 2006, 8, 4079-4082. 109. “Synthesis of the C29-C37 Bicyclic ether Core of (+)-Sorangicin A,” Crimmins, M. T.; Haley, M. W. Org. Lett. 2006, 8, 4223-4225. 110. Lampe, John W.; Plourde, Robert; She, Jin; Vittitow, Jason L.; Watson, Paul S.; Crimmins, Michael T.; Slade, David J. “Preparation of 2-(2-oxothiazolidin-4-yl)tetrahydropyran-2-ol derivatives related to Latrunculin A or Latrunculin B as cytoskeletal active compounds for use against disorders involving actin polymerization.” U.S. Pat. Appl. Publ. (2006), 45pp. 111. “Highly Selective Acetate Aldol Additions Using Mesityl Substituted Chiral Auxiliaries,” Crimmins, M. T.; Shamszad, M. Org. Lett. 2007, 9, 149-152. 112. “Enantioselective Total Synthesis of 11-Acetoxy-4-deoxyasbestinin D and Asbestinin 12” Crimmins, M. T.; Ellis, J. M. J. Org. Chem. 2008, 73, 1649-1660. 113. “Total Synthesis of C2-C11 Cyclized Cembranoids,” Ellis, J. M.; Crimmins, M. T. Chem. Rev. 2008, 5278-5298. 114. “Total Synthesis of Brevetoxin A,” Crimmins, M. T.; Zuccarello, J. L.; Ellis, J. M.; McDougall, P. J.; Haile, P. C.; Emmitte, K. A.; Parrish, J. D. Org. Lett. 2009, 11, 489-492. 115. “Enantioselective Total Synthesis of Apoptolidin A,” Crimmins, M. T.; Christie, H. C.; Chaudhary, K.; Long, A. Org. Lett. 2009, 11, 831-834. 116. “Enantioselective Total Synthesis of (-)-Pironetin: Iterative Aldol Reactions of Thiazolidinethiones, “Crimmins, M. T.; Dechert, A.-M. R. Org. Lett. 2009, 11, 1635-1638. 117. “Enantioselective total Synthesis of (+)-Pyranicin,” Crimmins, M. T.; Jacobs, D. L. Org. Lett. 2009, 11, 2695-2698. 118. “Total Synthesis of Irciniastatin A (Psymberin),” Crimmins, M. T.; Stevens, J. M.; Schaaf, G. M. Org. Lett. 2009, 11, 3990-3993. 119. "Enantioselective Total Synthesis of Brevetoxin A: Unified Strategy for the B, E, G, and J Subunits," Crimmins, M. T.; Ellis, J. M.; Emmitte, K. A.; Haile, P. A. McDougall, P. J.; Parrish, J. D.; Zucarello, J. L. Chem. Eur. J. 2009, 15, 9223-9234.