Gretchen G. Kimmick · Daniel J. Lenihan Douglas B. Sawyer · Erica L. Mayer Dawn L. Hershman Editors Cardio-Oncology The Clinical Overlap of Cancer and Heart Disease 123 Cardio-Oncology Gretchen G. Kimmick (cid:129) Daniel J. Lenihan Douglas B. Sawyer (cid:129) Erica L. Mayer Dawn L. Hershman Editors Cardio-Oncology The Clinical Overlap of Cancer and Heart Disease Editors GretchenG.Kimmick,MD,MS DanielJ.Lenihan,MD DukeCancerInstitute VanderbiltHeartandVascularInstitute DukeUniversityMedicalCenter VanderbiltUniversityMedicalCenter Durham,NC,USA Nashville,TN,USA DouglasB.Sawyer,MD EricaL.Mayer,MD,MPH MaineMedicalCenter Dana-FarberCancerInstitute CardiovascularInstitute HarvardMedicalSchool Portland,ME,USA Boston,MA,USA DawnL.Hershman,MD,MS HerbertIrvingComprehensiveCancerCenter ColumbiaUniversityMedicalCenter NewYork,NY,USA Additional material to this book can be downloaded from http://www.springerlink.com/ 978-3-319-43096-6 © 2016 Genevieve Kimmick, “Rhythm in Nature”, Watercolor on paper (photographed byRodgerD.Israel) ISBN978-3-319-43094-2 ISBN978-3-319-43096-6 (eBook) DOI10.1007/978-3-319-43096-6 LibraryofCongressControlNumber:2017932686 ©SpringerInternationalPublishingSwitzerland2017 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilarmethodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthis book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained hereinorforanyerrorsoromissionsthatmayhavebeenmade. Printedonacid-freepaper ThisSpringerimprintispublishedbySpringerNature TheregisteredcompanyisSpringerInternationalPublishingAG Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland For the inspiration and support to write this truly collaborative book, we thank our families and loved ones, those for whom we have the honor of providing care, our colleagues/collaborators, mentors, and students. ©2016GenevieveKimmick,“RhythminNature”, Watercoloronpaper(photographedbyRodgerD.Israel) Preface Asweseetheexplosionofnewtreatmentapproachesformanydiseases,medicine becomes moreandmoresubspecialized,andsubsequently thereis increased frag- mentation. As a result of this progressive partitioning of medical care, close collaboration between medical subspecialties becomes an essential component to effective health care. The emerging medical discipline of cardio-oncology is a prime instance when such cooperation is paramount. In adults, cancer and heart diseasehaveremarkablesimilaritiesinepidemiology. Thesetwodiseases,cardio- vascular disease and cancer, account for at least half of the reasons for death in developed countries. It is no surprise that these diseases may coexist in many patients,emphasizingtheneedfortheretobeclosecollaborationbetweenoncology andcardiologyspecialists. With this textbook, we hope to provide a clinically useful volume containing knowledge about cardiac complications of cancer therapy, treatment of cancer in patients with cardiovascular disease, and treatment of cardiovascular disease in patientswithcancerforpracticingcardiologists,medicalandradiationoncologists, andtraineesinthesefields.Thebookhasbeeneditedbythreeoncologistsandtwo cardiologistswiththepurposeofintegratingthetwomedicinesubspecialtiestobe clinicallyusefultotheoncologistandthecardiologist incaring forthese patients. Eachchapteriscoauthoredbyatleastoneoncologistandonecardiologist,inorder to include the perspective of each discipline and make the text user-friendly and clinicallyapplicabletobothspecialtiesaswellasothers.Webelievethatthisisthe first textbook of cardio-oncology to provide this comprehensive coverage from a truly multidisciplinary standpoint. Combined, the chapters provide a clinically relevant overview of the epidemiology, basic science, and clinical knowledge in theever-expandingspaceinwhichcardiologyandoncologyoverlap. This textbook adds to available learning resources in that it expands the topic from one focused only on heart failure caused by cancer therapies to a more inclusive one, where multiple cardiovascular issues, including coronary artery disease, hypertension, and vascular complications, among others, are thoroughly considered. We also asked the authors to generally include practical management vii viii Preface approaches to common clinical problems in order be a useful guide to clinicians encountering these potentially difficult decisions. We hope that you find this text engaging and informative, but we also recognize this is a rapidly changing disci- pline.Perhapsbyreadingthistext,apractitionerwillbestimulatedtocontributeto ourcombinedknowledgeandadvancetheresearchinthisinvigoratingdisciplineto continuouslyimprovepatientcare. Durham,NC,USA GretchenG.Kimmick,MD,MS Nashville,TN,USA DanielJ.Lenihan,MD Portland,ME,USA DouglasB.Sawyer,MD Boston,MA,USA EricaL.Mayer,MD,MPH NewYork,NY,USA DawnL.Hershman,MD,MS Acknowledgements Great thanks to the leadership and staff at the American Society of Clinical Oncologyfortheirenthusiasmaboutthisfield.ParticularthankstoTeresaGilewski, MD,wholedtheEducationCommitteeforthePatientandSurvivorshipCareTrack during2012,whentheideaforthebookwasconceived. WeacknowledgeJulieHughesattheDukeCancerInstitute,whoseadministra- tiveassistancewasinvaluableincompletingthiswork. Wealsowouldliketothankthepublisher,Springer,andourprojectcoordinator inbookproduction,SusanWestendorf,fortheirpatienceandguidancethroughthe publicationprocess. ix Contents 1 EpidemiologyofCardio-Oncology. . . . . . . . . . . . . . . . . . . . . . . . . 1 CarrieGeisbergLenneman,GretchenG.Kimmick, andDouglasB.Sawyer 2 CardiotoxicityofAnticancerTherapies. . . . . . . . . . . . . . . . . . . . . 15 RabihSaid,MylesNickolich,DanielJ.Lenihan, andApostoliaM.Tsimberidou 3 ScreeningandMonitoringforCardiotoxicityDuring CancerTreatment. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . .. . . . 43 MichelG.Khouri,IgorKlem,ChetanShenoy,JeffreySulpher, andSusanF.Dent 4 ManagementofChemotherapy-Associated Cardiomyopathy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 LaurenGilstrap,MikeHarrison,GretchenG.Kimmick, andAnjuNohria 5 TreatmentofHypertensioninPatientsReceiving CancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105 AaronP.Kithcart,GiuseppeCurigliano,andJoshuaA.Beckman 6 PreoperativeandPre-transplantCardiacEvaluation intheCancerPatient. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 StaceyGoodman,RobertFrankCornell,GreggF.Rosner, andDanielS.O’Connor 7 RadiationTherapyandCardiotoxicity. . . . . . . . . . . . . . . . . . . . . . 161 ManishaPalta,Chang-LungLee,SyedWamiqueYusuf, andDavidG.Kirsch xi xii Contents 8 ManagementofPatientswithCoronaryDiseaseandCancer: InteractionsBetweenCancer,CancerTreatment, andIschemia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175 RonaldJ.Krone,PreetPaulSingh,andChiaraMelloni 9 VascularComplicationsofCancerandCancerTherapy. . . . . . . . 215 GaryH.Lyman,AnnaCatino,andBonnieKy 10 BreastCancerCardio-Oncology. . . . . . . . . . . . . . . . . . . . . . . . . . . 241 AngelaEsposito,CarmenCriscitiello,DouglasB.Sawyer, andGiuseppeCurigliano 11 CardiacToxicChemotherapyandCancerSurvivorship. . . . . . . . . 253 DavaSzalda,MonicaAhluwalia,andJosephR.Carver 12 GeriatricCardio-oncology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281 AnneBlaesandChetanShenoy 13 FutureClinicalandProfessionalDirections inCardio-oncology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303 AnaBaracandEricaL.Mayer Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311