Cardiac Management of Oncology Patients Clinical Handbook for Cardio-Oncology Gonzalo Báron-Esquivias Riccardo Asteggiano Editors 123 Cardiac Management of Oncology Patients Gonzalo Baron Esquivias (cid:129) Riccardo Asteggiano Editors Cardiac Management of Oncology Patients Clinical Handbook for Cardio-Oncology Editors Gonzalo Baron Esquivias Riccardo Asteggiano Cardiology Department Azienda Sanitaria Locale Torino 3 Hospital Universitario Virgen del Rocio Out-of-Hospital Cardiology Service Sevilla Torino Spain Italy ISBN 978-3-319-15807-5 ISBN 978-3-319-15808-2 (eBook) DOI 10.1007/978-3-319-15808-2 Library of Congress Control Number: 2015941515 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. T he use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com) Acknowledgements Special thanks to: Elena Asteggiano, MD, for her help in the revision of the manuscript G abriele Destefanis, Computer Scientist, for his help in electronic post- processing of the pictures v Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Riccardo Asteggiano and Gonzalo Baron Esquivias 2 Physiopathology and Toxic Heart Effects of Chemotherapy Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Riccardo Asteggiano 3 Radiotherapy Heart Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 Riccardo Asteggiano 4 Cardiac Imaging Technology in Cardio-oncology . . . . . . . . . . . . . . . . 129 Christopher Tillmanns 5 Evaluation of the Oncologic Patient Before, During, and After Chemotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157 Iris Parrini and Alessandro Bonzano 6 Specifi c Clinic Problems in Cancer Therapy Cardiac Toxicity Complications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 Iris Parrini, Alessandro Bonzano, Gonzalo Baron Esquivias, and Xavier Garcia-Moll 7 Synthetic Tables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 Iris Parrini and Alessandro Bonzano Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253 vii Contributors Riccardo Asteggiano , MD, FESC Out-of-Hospital Cardiology Service , Azienda Sanitaria Locale Torino 3 , Regione Piemonte , Turin, Italy Gonzalo Baron Esquivias , MD, PhD, FESC Cardiology Department , Hospital Universitario Virgen del Rocio, Universidad de Sevilla , Sevilla , Spain Alessandro Bonzano , MD Cardiology Unit, Service Department , IRCCS Candiolo , Turin , Italy Xavier Garcia-Moll , MD, FESC Cardiology Department , Hospital de la Santa Creu i Sant Pau, University Hospital , Barcelona , Spain Iris Parrini , MD Cardiology Department , Mauriziano Hospital , Turin , Italy Christopher Tillmanns , MD Division of Cardiology , Diagnostikum Berlin , Berlin , Germany ix