VOLUME 78 - CONTENTS No 1 JANUARY 1994 Page Editorials 1 The treatment of chronic uveitic macular oedema Andrew D Dick 3 Setting the stage for onchocerciasis C Kupfer Original articles — Clinical science Reduction of macular oedema by acetazolamide in patients with chronic iridocyclitis: a randomised prospective crossover study Marilyn D Farber, Sheridan Lam, Howard H Tessler, ThomJ Jaennsing s, Andrew Cross, Mark M Rusin Distribution and aetiology of blindness and visual impairment in mesoendemic onchocercal communities, Kaduna State, Nigeria A Abiose, ] Murdoch, O Babalola, S Cousens, I Liman, JO nyema, J Evans, W Gregory, B Jones Exenteration for benign orbital disease Geoffrey E Rose, John E Wright Immunoscintigraphy with three step monoclonal pretargeting technique in diagnosis of uveal melanoma: preliminary results G Modorati, R Brancato, G Paganelli, P Magnani, R Pavoni, F Fazio Accurate vessel width measurement from fundus photographs: a new concept Salwan M B Rassam, Vinod Patel, Olaf Brinchmann-Hansen, Oddbjorn Engvold, Eva M Kohner Influence of apraclonidine and pilocarpine alone and in combination on post laser trabeculoplasty pressure rise R B Dapling, I A Cunliffe, S Longstaff Single intraoperative applications of 5-fluorouracil during filtration surgery: early results Lumina Lanigan, Jorg Stiirmer, Karin A Baez, Roger A Hitchings, Peng T Khaw The contralateral reduction of intraocular pressure by timolol Cynthia N Dunham, Richard F Spaide, Gerald Dunham Visual acuity and pupillary reactions after peribulbar anaesthesia S 7 Talks, N H V Chong, 7M Gibson, I R Francis An electrophysiological study on children and young adults with Alport’s syndrome Brett G Jeffrey, Mark Jacobs, Gabriella Sa, T Martin Barrau, David Taylor, Anthony Kriss Laboratory science Retinal blood flow after superior cervical ganglionectomy: a laser Doppler study in the cynomolgus monkey M F Ménage, 7 C Robinson, P L Kaufman, W E Sponsel Selective loss of vascular smooth muscle cells in the retinal microcirculation of diabetic dogs T A Gardiner, A W Stitt, H R Anderson, D B Archer Paraffin induced sclerosing lipogranuloma of eyelids and anterior orbit following endonasal sinus surgery Heinrich Witschel, Kathrin Geiger Perspective The management of cytomegalovirus retinitis in AIDS Baljean Dhillon Case reports Serpiginous choroiditis: an unusual presentation of ocular sarcoidosis C Edelsten, M R Stanford, E M Graham Pseudomonas conjunctival ulcer and secondary orbital cellulitis in a patient with AIDS Juan Cano-Parra, Enrique Espatia, Miguel Esteban, Manuel Diaz-L opis, Jose L Menezo Ocular melanocytosis and cavernous haemangioma of the optic disc Leonidas Zografos, Michel Gonvers Atypical cytomegalovirus retinitis: a clinicopathological correlation Hunter Maclean, James W Ironside, Baljean Dhillon, Sheila M Burns Congenital hereditary endothelial dystrophy associated with nail hypoplasia R Surling, FP itts, N R Galloway, K Robson, R Newbury-Ecob History of ophthalmology Letters to the editor Notices Correction No 2 FEBRUARY 1994 Editorials The scanning laser ophthalmoscope: a new view on the retina Barry R Masters Retinal pigment epithelium: lysosomal enzymes and aging Elaine R Berman Original articles - Clinical science Clinical investigation of an infrared digital scanning laser ophthalmoscope A Manivannan, JN P Kirkpatrick, P F Sharp, F V Forrester Changes in anterior chamber flare and cells following cataract surgery Sanjay M Shah, David FS palton Intraocular adrenaline maintains mydriasis during cataract surgery Melanie C Corbett, Andrew B Richards Shape of the neuroretinal rim and position of the central retinal vessels in glaucoma Jost B Jonas, Martin C Fernandez X linked progressive cone distrophy F M Meire, A A B Bergen, A De Rouck, M Leys, J W Delleman Impact of enucleation versus plaque radiotherapy in the management of juxtapapillary choroidal melanoma on patient survival Patrick De Potter, Carol L Shields, Ferry A Shields, Jacqueline R Cater, David F Tardio Aggressive management of an epidemic of chronic pseudophakic endophthalmitis: results and literature survey N K Rogers, P D Fox, B A Noble, K Kerr, T Inglis High dose intravitreal foscarnet in the treatment of cytomegalovirus retinitis in AIDS Manuel Diaz-L lopis, Enrique Espana, Gonzalo Mufioz, Amparo Navea, Enrique Chipont, Juan Cano, Jose L Menezo, Francisco JR omero Laboratory science Regional variation and age-related changes of lysomal enzymes in the human retinal pigment epithelium Mike Bouiton, Patrick Moriarty, John Jarvis-Evans, Borys Marcyniuk Increased lipid peroxides and inflammatory parameters in the retina adjacent to choroidal melanoma Albert 7A ugustin, Thorsten Boker, Winrich Breipohl Diabetic retinopathy: quantitative variation in capillary basement membrane thickening in arterial or venous environments A W Sritt, H R Anderson, T A Gardiner, D B Archer Effects of morphine on corneal sensitivity and epithelial wound healing: implications for topical ophthalmic analgesia G A Peyman, M H Rahimy, M L Fernandes An antimicrobial effect associated with rabbit primary aqueous humour J P Diamond, J P Leeming, A D Smart, P Duffus, A ¥ Hedges, D L Easty Perspective Human T lymphotropic virus type | uveitis Manabu Mochizuki, Kazuo Tajima, Toshiki Watanabe, Kazunari Yamaguchi Case reports Male choriocarcinoma with choroidal metastases K F Williamson, D R Barry, G A Sutton, E L Jones, S ¥ Crews Paecilomyces keratitis with corneal perforation salvaged by a conjunctival flap and delayed keratoplasty Satoshi Mizunoya, Yoshihiro Watanabe History of ophthalmology Letters to the editor Notices Correction No 3 MARCH 1994 Editorials Retroviruses — a clue to autoimmunity? Hamish Towler Changing concepts in ptosis surgery Ewan G Kemp Original articles — Clinical science Human T lymphotropic virus type | uveitis after Graves’ disease Kazunari Yamaguchi, Manabu Mochizuki, Toshiki Watanabe, Koichi Yoshimura, Makoto Shirao, Shinji Araki, Norio Miyata, Shigeo Mori, Tetsuyuki Kiyokawa, Kiyoshi Takatsuki i Adjustable sutures in eyelid surgery for ptosis and lid retraction 7R O Collin, B A O’Donnell A comparison of automated static dark stimuli with the Humphrey sTATPAC program in glaucomatous visual field loss Erkan Mutlukan Representation of the visual field in the occipital striate cortex Robert McFadzean, Donal Brosnahan, Donaid Hadley, Erkan Mutlukan Electroretinogram b/a wave ratio improvement in central retinal vein obstruction Yoshie Matsui, Osamu Katsumi, Hiroshi Sakaue, Tatsuo Hirose 193 nm excimer laser sclerostomy in pseudophakic patients with advanced open angle glaucoma Bruce D S Allan, Paul P van Saarloos, Richard L Cooper, lan JC onstable The treatment and follow up of adult chlamydial ophthalmia Francesco Carta, Stefania Zanetti, Antonio Pinna, Mano Sotgiu, Giovanni Fadda Percutaneous anaesthesia with a lignocaine-prilocaine cream (Emla) for eyelid skin surgery S S Gotsis, O M Volonaki, G P Theodossiadis Laboratory science Distribution and characterisation of rat choroidal mast cells R 7 Steptoe, P G McMenamin, C McMenamin Cytokeratin-containing cells in proliferative diabetic retinopathy membranes P Hiscott, R Gray, I Grierson, Z Gregor HLA-DRBI typing of Vogt-Koyanagi-Harada’s disease by PCR-RFLP and the strong association with DRB1*0405 and DRB1*0410 Yumiko Shindo, Hidetoshi Inoko, Takuji Yamamoto, Shigeaki Ohno Perspective Infectious endophthalmitis after cataract surgery D S Hughes, R F Hill Case reports Periorbital necrotising fasciitis 7S uharwardy Ocular complications associated with bungee jumping D B David, T Mears, M P Quinlan Bungee jumping and intraocular haemorrhage B K Fain, E M Talbot History of ophthalmology Letters to the editor Bookreviews Notices No 4 APRIL 1994 Editorials Imaging posterior uveal melanomas Jan Rennie What is the best intraocular lens? John Bolger Indexing British Journal of Ophthalmology Original articles — Clinical science Possibilities and limitations of radioimmunoscintigraphy and conventional diagnostic modalities in choroidal melanoma D F Schaling, 7A Oosterhuis, M FJ ager, H Kakebeeke-Kemme, E K 7 Pauwels Compared optical performances of multifocal and monofocal intraocular lenses (contrast sensitivity and dynamic visual acuity) W Williamson, L Poirier, P Coulon, Ph Verin Prognostic factors in primary malignant melanoma of the conjunctiva: a clinicopathological study of 256 cases A DA Paridaens, D C Minassian, AC E McCartney, 7L Hungerford Clinicopathological review of 1146 enucleations (1980-90) Philippe de Gottrau, Leonard M Holbach, Gottfried O H Naumann Fibrous dysplasia of the orbit K Bibby, R McFadzean Surgical correction of ptosis in ocular fibrosis syndrome Christopher Liu, Rita Ohri, Giovanni Frongia, Richard Collin Prevalence of blindness and low vision of people over 30 years in the Wenchi district, Ghana, in relation to eye care programmes A C Moll, A J H van der Linden, M Hogeweg, W E Schader, 7H ermans, R 7 W de Keizer Superior oblique tendon lengthening for acquired superior oblique overactions Ruth M Manners, Elizabeth O’ Flynn, Robert JM orns Localised wedge shaped defects of the retinal nerve fibre layer in glaucoma Jost B Jonas, Dennis Schiro Correlation of peripheral displacement thresholds and optic disc parameters in ocular hypertension Simon Ruben, Fred Fitzke Oculocutaneous manifestations in xeroderma pigmentosa 7L Goyal, Vasudev Anand Rao, Renuka Srinivasan, Karoon Agrawal Laboratory science Genetic and clinical determinants for the T cell mediated immune response against the cornea specific protein BCP 54 M 7 Jager, K J Vilker-Dieben, L de Waal, F G Kok, L Broersma, R van der Gaag Effects of irrigation solutions on corneal endothelial function Mohamed I Yagoubi, W John Armitage, Jeremy Diamond, David L Easty Perspective Fuchs’ heterochromic cyclitis: review of the literature on the pathogenetic mechanisms E La Hey, P T V M de Fong, A Kylstra Case reports Papilloedema and hydrocephalus in spinal cord ependymoma Anat Kesler, Riri S Manor Metastatic prostatic adenocarcinoma presenting as complete ophthalmoplegia from pituitary apoplexy David Frederick Anderson, Farhad Afshar, Namir Toma Contents Conjunctival melanoma after excision of a lentigo maligna melanoma in the ipsilateral eyelid skin C Hicks, C Liu, M Hiranandani, A Garner, 7 Hungerford Aggressive orbital lymphoma in AIDS Firas M Rahhal, Daniel F Rosberger, Murk-Hein Heinemann Ocular pulse measurements to assess pulsatile blood flow in carotid artery disease K G Claridge, C B James History of ophthalmology Notices No 5 MAY 1994 Editorials Infantile strabismus: what is it? where is it? Creig S Hoyt, William V Good What is the use of ocular blood flow measurement? Tom H Williamson Original articles —- Clinical science Sensitivity of nasal and temporal hemiretinas in latent nystagmus and strabismus evaluated using the light reflex Haruhisa Sektya, Sachiko Hasegawa, Kazuo Mukuno, Satoshi Ishikawa Aetiology of severe visual impairment and blindness in microphthalmos Mark J Elder Regional retinal blood flow reduction following half fundus photocoagulation treatment Naoki Fujio, Gilbert T Feke, Douglas G Goger, J Wallace McMeel Ophthalmic findings in dyslexic schoolchildren M-L Latvala, T T Korhonen, M Penttinen, P Laippal. Epidemiology of blindness and visual impairment in the kingdom of Tonga H S Newland, A 7 Woodward, L A Taumoepeau, N S Karunaratne, 1 G M Duguid Ocular motor behaviour of monozygotic twins with tyrosinase negative oculocutaneous albinism R V Abadi, E Pascal Ocular manifestations in autosomal dominant retinitis pigmentosa with a Lys-296-Glu rhodopsin mutation at the retinal binding site Sarah L Owens, Frederick W Fitzke, Christopher F Inglehearn, Marcelle Jay, T Jeffrey Keen, Geoffrey B Arden, Shomi S Bhattacharya, Alan C Bird Pattern electroretinogram and automated perimetry in patients with glaucoma and ocular hypertension Christopher Neoh, Stephen B Kaye, Malcolm Brown, Alec M Ansons, Peter Wishart Estimation of optic disc size using indirect biomicroscopy Simon Ruben A double blind placebo controlled group comparative study of ophthalmic sodium cromoglycate and nedocromil sodium in the treatment of vernal keratoconjunctivitis Medhat El Hennawi Laboratory science Expression of intercellular adhesion molecule-i (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on proliferating vascular endothelial cells in diabetic epiretinal membranes Shibo Tang, Kim Chi Le-Ruppert, Veu-Peter Gabel Effect of topical fs blockers on corneal epithelial wound healing in the rabbit James FR eidy, Joseph Zarzour, Hilary W Thompson, Roger W Beuerman Cells perpetuating the inflammatory response in scleritis Wolfgang Bernauer, Peter G Watson, Basil Daicker, Susan Lightman Toxic side effects of local anaesthetics on the human cornea M Boljka, G Kolar, 7 Vidensek Argon laser suture lysis with different suture materials. An experimental study C E Hugkulstone, A F Spencer, S A Vernon A comparative study of the elastic properties ef continuous tear curvilinear capsulorhexis versus capsulorhexis produced by radiofrequency endodiathermy 7 Luck, A K Brahma, B A Noble Schwannoma of the ciliary body treated by block excision Michael Kiichle, Leonard Holbach, Ursula Schlétzer-Schrehardt, Gottfried O H Naumann Perspective Corneal epithelial wound healing H S Dua, 7 A P Gomes, A Singh Case reports Anterior segment ischaemia following segmental scleral buckling Jeffrey Kwartz, Stephen Charles, Paul McCormack, Alan Jackson, Michael Lavin Posterior scleritis with retinal vasculitis and choroidal and retinal infarction N Andrew Frost, John M Sparrow, A Ralph Rosenthal Ocular albinism with unilateral sectorial pigmentation in the fundus Takashi Shiono, Tsutomu Mutoh, Yasushi Chida, Makoto Tamai Restrictive myopic myopathy: computed tomography, magnetic resonance imaging, echography, and histological findings Siileyman Kaynak, Ismet Durak, Ding Ozaksoy, Tiilay Canda Trisomy 4p and ocular defects Josif W Lurie, Vladimir A Samochvalov Meningitis as a complication of dacryocystorhinostomy /tzchak Beiran, Josef Pikkel, Michael Gilboa, Benjamin Miller Acute corneal erosion from the use of anti-misting agent in swimming goggles S 7 Doyle History of ophthalmology Letters Bookreviews Inmemoriam Notices No 6 JUNE 1994 Editorials Trigeminal sensory loss in orbital disease Jack Rootman Dark adaptation in retinal abnormalities F W Fitzke Original articles - Clinical science Trigeminal sensory loss in orbital disease Geoffrey E Rose, John E Wright Dark adaptation in patients with Best vitelliform macular dystrophy Wendy Baca, Gerald A Fishman, Kenneth R Alexander, Andrew M Glenn Early vitrectomy for progressive diabetic proliferations covering the macula Ralf Grewing, Ulrich Mester Visual function and course of basal laminar drusen combined with vitelliform macular detachment S Y Cohen, I Meunier, G Soubrane, A Glacet-Bernard, G ¥ Coscas Increased prevalence of disciform macular degeneration after cataract extraction with implantation of an intraocular lens Theo L van der Schaft, Cornelia M Mooy, Wim C de Bruijn, Paul G H Mulder, Jan H Pameyer, Paulus T V M de Fong Evidence for a new role of natriuretic peptides: control of intraocular pressure T J Wolfensberger, D R F Singer, T Freegard, N D Markandu, M G Buckley, G A MacGregor Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma P Hamard, H Hamard, 7 Dufaux, S Quesnot Excimer laser superficial keratectomy for proud nebulae in keratoconus Lalitha Moodaley, Christopher Liu, E Geoffrey Woodward, David'O’Brart, Malcolm Kerr Muir, Roger Buckley Herpes simplex keratitis in children Bijan Beigi, Kais Algawi, Aisling Foley-Nolan, Michael O’Keefe Laboratory science Regulation of ocular blood flow during increases of arterial blood pressure Georg Michelson, Martina Groh, Anselm Griindler Racial differences in the results of glaucoma filtration surgery: are racial differences in the conjunctival cell profile important? David Broadway, lan Grierson, Roger Hitchings Argon laser photocoagulation of fluorescein stained retina —- an unrecognised hazard? S Parks, D Aitken, D Keating, GN Dution Perspective Ultraviolet radiation and cataract: a review of the epidemiological evidence Paul F Dolin Case reports Proliferative activity in bilateral paraneoplastic melanocytic proliferation and bilateral uveal melanoma C M Mooy, PTV M de Fong, C Strous Adenoma of the pigmented ciliary epithelium Jan G Rennie, Michael K Faulkner, M Andrew Parsons Ophthalmic manifestations of neonatal proteinC deficiency A Cassels-Brown, A M B Minford, S L Chatfield, J A Bradbury Conjunctival involvement in classic (indolent) HIV negative Kaposi’s sarcoma Jlan G Ron, Israel Kremer, Anat Lowenstein, Samario Chaitchik Acinetobacter exposure keratitis A Marcovich, S Levartovsky Serious eye injuries caused by rotating wire brushes P Hassett, P E Cleary Exogenous Helminthosporium endophthalmitis Taraprasad Das, Usha Gopinathan, Savitri Sharma Aicardi syndrome — the elusive mild case Allison V Menezes, Robert W Enzenauer, }R aymond Buncic Elevation of the right ptotic eyelid with clenching the teeth Hiroko Kurome, Seyi Hayasaka Conjunctival h giopericytoma S Sujatha, R Sampath, R E Bonshek, A B Tullo Treatment of aphakic malignant glaucoma using Nd: YAG laser posterior capsulotomy B C Little Nasolacrimal obstruction and facial bone histopathology in craniodiaphyseal dysplasia Dominic A McHugh, Geoffrey E Rose, Alec Garner An unusual form of blink reflex induced by pressing on a frontal burr hole Avinoam B Safran, Gian Luca Laffi, Bertrand Demierre Fuchs’ heterochromic uveitis associated with retinitis pigmentosa in a father and son L Ingeborgh van den Born, MaryJ van Schooneveld, Paulus T V M de Fong, Elisabeth M Bleeker-Wagemakers Two step recovery of vision in the amblyopic eye after visual loss and enucleation of the fixing eye Corina Klaeger-Manzanell, Creig SH oyt, Wiiliam V Good History of ophthalmology Referees Letters to the editor Bookreview Notices No 7 JULY 1994 Editorials Computerised perimetry — the emperor’s new clothes? 7L Fay Conjunctival melanoma A B Tullo, R Bonshek Original articles — Clinical science Evaluation of the Humphrey FAsTPac threshold program in glaucoma C O’Brien, D Poinoosawmy, 7W u, R Hitchings Orbital exenteration in 95 cases of primary conjunctival malignant melanoma A D A Paridaens, AC E McCartney, DC Minassian, 7 L Hungerford Acute angle closure glaucoma: relative failure of YAG iridotomy in affected eyes and factors influencing outcome S A Buckley, B Reeves, M Burdon, C Moorman, S Wheatcroft, C Edelsten, L Benjamin Retinal arteriolar macroaneurysms: long term visual outcome David M Brown, Warren M Sobol, James C Folk, Thomas A Weingeist Carrier detection in X linked ocular albinism using linked DNA polymorphisms S 7 Charles, A T Moore, Y Zhang, R McMahon, D E Barton, JR W Yates Relation between iridopathy and retinopathy in diabetes Francesco Bandello, Rosario Brancato, Rosangela Lattanzio, Marcello Galdim, Bruno Falcomata Ocular penetration of topical ciprofloxacin and norfloxacin drops and their effect upon eyelid flora John P Leeming, Jeremy P Diamond, Romane Trigg, Les White, H Bing Hoh, David L Easty Long term results of pars plana vitrectomy in the management of complicated uveitis Arnd Heiligenhaus, Norbert Bornfeld, Michael H Foerster, Achim Wessing Laboratory science Muscarinic receptor M1 and M2 subtypes in the human eye: QNB, pirenzipine, oxotremorine, and AFDX-116 in vitro autoradiography Neeru Gupta, Rob McAllister, Stephen M Drance, Jack Rootman, Max S Cynader Studies on a novel series of acyl ester prodrugs of prostaglandin F,,, A Cheng-Bennett, M F Chan, G Chen, T Gac, M E Garst, C Gluchowski, L J Kaplan, C E Protzman, M B Roof, G Sachs, L A Wheeler, L S Williams, D F Woodward A case of corneal keloid: clinical, surgical, pathological, and ultrastructural characteristics Jose Miguel Risco, Antonio Huaman, Sobhi R Antonios Definition of thresholds for stereoscopic depth Manfred Fahle, Sigrid Henke-Fahle, John Harris Perspective Bacillus cereus endophthalmitis Don B David, Graham R Kirkby, Bruce A Noble Case Crystalline nature of the iridescent particles in hypermature cataracts Anne M V Brooks, Ross H Drewe, Glenys B Grant, Timothy Billington, William E Gillies Use of the polymerase chain reaction in the diagnosis of acquired ocular toxoplasmosis in an immunocompetent adult Ruth M Manners, Susan O’Connell, Edward CG uy, DavH Mi Fodynso n, Christopher RC anning, DavidE Etchells Aspergillus niger as an unusual cause of scleritis and endophthalmitis Mart7i Janger , James Chodosh, Andrew 7 W Huang, Eduardo C Alfonso, William W Culbertson, Richard K Forster Superficial epithelioid schwannoma presenting as a subcutaneous upper eyelid mass Z Butt, J W Ironside Bilateral abducens nerve lesions in unilateral type 3 Duane’s retraction syndrome Mark Mulhern, Catherine Keohane, Gerard O’Connor History of ophthalmology Letters to the editor Bookreviews Notices No 8 AUGUST 1994 Editorials Pathogenesis of the ICE syndrome R 7 Buckley Mechanisms governing the passage of aqueous humour through the trabecular meshwork Gordon Ruskell Original articles - Clinical science Strict metabolic control and retinal blood flow in diabetes mellitus Juan E Grunwald, Alexander JB rucker, Seth N Braunstein, Stanley SS chwartz, Lester Baker, Benno L Petrig, Charles E Riva Effect on intraocular pressure of local anaesthesia in eyes undergoing intraocular surgery E O’ Donoghue, M Batterbury, T Lavy Vision related daily life problems in patients waiting for a cataract extraction Mats Lundstrém, Gunvor Fregell, Anita Sjéblom Refractive outcome following diode laser versus cryotherapy for eyes with retinopathy of prematurity Kais Algawi, Michael Goggin, Michael O’Keefe Peripheral retinal vasculature in normal Jamaican children Alan Penman, John F Talbot, Elaine L Chuang, Alan C Bird, Graham R Serjeant Prediction of enophthalmos by computed tomography after ‘blow out’ orbital fracture R W Whitehouse, M Batterbury, A Fackson, F L Noble Oral albendazole in the management of extraocular cysticercosis Ramanyit Sihota, Santosh G Honavar Laboratory science Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome W R Lee, G E Marshall, C M Kirkness Localisation of «(2,3) and (2,6) linked terminal sialic acid groups in human trabecular meshwork S A Chapman, RE Bonshek, R W Stoddart, K R Mackenzie, D McLeod Production of IGF-I and IGF binding proteins by retinal cells in vitro Patrick Moriarty, Mike Boulton, Alan Dickson, David McLeod Deformation of the lamina cribrosa by elevated intraocular pressure D B Yan, F M Coloma, A Metheetrairut, G E Trope, F G Heathcote, C R Ethier Perspective Corneal allograft rejection D F P Larkin Case reports Corneal ulceration in a patient with a, antitrypsin deficiency R M Manners, M L Donaldson, C Low, P J Fenton Progressive corneal vascularisation as a previously unreported complication of neonatal herpes simplex infection Christopher }H ammond, Alec F Harden Bilateral angle closure glaucoma and accelerated cataract formation in a patient with AIDS Naresh Joshi, Peter H Constable, Todd P Margolis, Creig SH oyt, Timothy ¥K Leonard Isolated xanthogranuloma of the limbus in an adult P Harvey, 7A Lee, ¥ F Talbot, 7R Goepel Fundus albipunctatus-like lesions in juvenile retinoschisis Mary Jv an Schooneveld, Yozo Miyake Notices Correction No 9 SEPTEMBER 1994 Editorials A rational approach to the patient with floppy/lax eyelids Myron Tanenbaum The minified Goldmann applanation tonometer Eamonn O’ Donoghue Original articles — Clinical science The lax eyelid syndrome Willem A van den Bosch, Hans G Lemij Intraocular pressure measurement after penetrating keratoplasty: minified Goldmann applanation tonometer, pneumatonometer, and Tono-Pen versus manometry Mitchel ¥M énage, Paul L Kaufman, Mary Ann Croft, Stuart P Landay Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS Shiva K Akula, Patrick E Ma, Gholam A Peyman, Mohamad H Rahimy, Newton E Hyslop Fr, Aileen Janney, Paul Ashton New classification of peripheral retinal vascular changes in sickle cell disease Alan D Penman, John F Talbot, Elaine L Chuang, Peter Thomas, Graham R Serjeant, Alan C Bird Blindness from uveitis in a hospital population in Sierra Leone M 7 H Ronday, 7 S Stilma, R F Barbe, A Kijlstra, A Rothova Laser flare intensity in diabetics: correlation with retinopathy and aqueous protein concentration Masanori Ino-ue, Atsushi Azumi, Hisamitsu Shirabe, Yasutomo Tsukahara, Misao Yamamoto Unilateral retinoblastoma: new intraocular tumours after treatment David H Abramson, Lisa S Gamell, Robert M Ellsworth, Erik F Kruger, Camille A Servodidio, Liebert Turner, David Sussman Problems with the hydroxyapatite orbital implant: experience with 250 consecutive cases Carol L Shields, Jerry A Shields, Patrick De Potter, Arun D Singh Mathematical analysis and experiment on the corneal reflex test in spectacle wearers Yoshikazu Hatsukawa, Hitoshi Koike, Saki Sugimoto, Keiko Kasai, Peter Fells Laboratory sciences Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathy Bhartiben Patel, Paul Hiscott, David Charteris, Joanne Mather, David McLeod, Mike Boulton Correlation between electroretinogram findings and molecular analysis in the Duchenne muscular dystrophy phenotype Inge De Becker, D Christine Riddell, Joseph M Dooley, Francoise Tremblay Perspective Cognitive visual dysfunction Gordon N Dutton Case reports Ectopic conjunctivalisation in Stevens-Johnson syndrome Samuel E Navon, Peter AD Rubin Nerve sheath myxoma of the lower lid Yu Nakamura, Toshitaka Hirakata, Makio Mukai Fungal keratitis caused by Scopulariopsis brevicaulis: successful treatment with topical amphotericin B and chloramphenicol without the need for surgical debridement Andrew7 Lotery, Jonathan R Kerr, Brian A Page History of ophthalmology Letters Notices Contents No 10 OCTOBER 1994 Editorials Registration of blind and partially sighted people Richard Wormald, Jennifer Evans Combined trabeculotomy-trabeculectomy for congenital glaucoma Gerard O’Connor Original articles — Clinical science Unrecognised and unregistered visual impairment Rosemary Robinson, John Deutsch, Helen S Fones, Sandra Youngson-Reilly, Deborah M Hamlin, Leyland Dhurjon, Alistair R Fielder Loss of vision before ophthalmic referral in blind and partially sighted diabetics in Bristol 7B Clark, R H B Grey, K KT Lim, C 7 Burns-Cox Combined trabeculotomy-trabeculectomy compared with primary trabeculectomy for congenital glaucoma Mark 7 Elder Interferon alfa-2a modifies the course of subfoveal and juxtafoveal choroidal neovascularisation Claus Engler, Birgit Sander, Forgen Villumsen, Henrik Lund-Andersen Effect of diabetes associated increases in lens optical density on colour discrimination in insulin dependent diabetes KevinJ Hardy, John H B Scarpello, David H Foster, Jack D Moreland Retinal findings in Malawian patients with AIDS Susan Lewallen, Jonny Kumwenda, Dermot Maher, Anthony D Harries Optic nerve head analyser and Heidelberg retina tomograph: accuracy and reproducibility of topographic measurements in a model eye and in volunteers Peter Janknecht, Jens Funk Cryotherapy for trichiasis in ocular cicatricial pemphigoid Mark 7E lder, Wolfgang Bernauer Lack of effect of preoperative norfloxacin on bacterial contamination of anterior chamber aspirates after cataract surgery D K Chitkara, T Manners, F Chapman, M G Stoddart, D Hill, D Jenkins Optic disc measurement with the Zeiss four mirror contact lens A F Spencer, S A Vernon Biometry in X linked megalocornea: pathognomonic findings Francoise M Meire, J Willem Delleman Laboratory science Comparison of the expression of interferon y, IL2, IL4, and lymphotoxin mRNA in experimental autoimmune uveoretinitis David G Charteris, Susan L Lightman Low glutathione reductase and peroxidase activity in age-related macular degeneration Steven M Cohen, Katherine L Olin, William 7F euer, Leonard Hjelmeland, Carl L Keen, Lawrence S Morse Perspective Contrast sensitivity testing in clinical practice Merrick 7M oseley, Adrian R Hill Case reports Understanding of the retinal circulation provided by an anomalous retinal vein Tom H Williamson, Dai B Bar, Grant M Baxter Mechanism related to the lateral rectus muscle capable of retracting the outer canthus of the eye S 7 Lewis, H N Tasker Multiple vortex vein varices masquerading as choroidal secondaries L da Cruz, B James, R Gray, 7 Elston History of ophthalmology Letters Bookreview Notices No 11 NOVEMBER 1994 Editorials Perimetry — back to the future? R A Hitchings Traditional eye medicines — good or bad news? Allen Foster, Gordon G Fohnson Molecular epidemiology and ophthalmology Paul 7 Dolin Selective cell death in glaucoma: does it really occur? R A Hitchings Original articles — Clinical science Traditional eye medicine use among patients with corneal disease in rural Malawi Paul Courtright, Susan Lewallen, Steve Kanjalou, Dighton F Divala Molecular epidemiology of trachoma in a Gambian village R L Bailey, L Hayes, M Pickett, H C Whittle, M E Ward, DC W Mabey Effect of trabeculectomy on pulsatile ocular blood flow C B James First experience with a new echographic contrast agent G Cennamo, N Rosa, G F Vailone, F Smaltino Retinal thickness change after focal laser treatment of diabetic macular oedema Mahnaz Shahidi, Yuichiro Ogura, Norman P Blair, Ran Zeimer Ocular findings associated with a 3 base pair deletion in the peripherin-RDS gene in autosomal dominant retinitis pigmentoJoshan 7W roblewski, John A Wells III, Anja Eckstein, Fred W Fitzke, Chris Jubb, T Jeffrey Keen, Chris F Inglehearn, Shomi S Bhattacharya, Geoffrey B Arden, Marcelle R Jay, Alan C Bird Sex differences in the left and right hemifieds of normal subjects with computerised static perimetry Howard Cohn, Maria DeAgostim, Daniéle Aron-Rosa, Laurent Laloum, Francois Boller 8 mm Bimedial rectus recession in infantile esotropia of 80-90 prism dioptres Alexandros G D. k Panagos G Arvanitis, loannis D Ladas, George P Theodossiadis Carbohydrate deficient glycoprotein syndrome type I: ophthalmic aspects in four Sicilian patients A Fiumara, R Barone, P Buttitta, M Di Pietro, A Scuderi, F NigrJo FJa,eke n Suppurative keratitis caused by Streptococcus pneumoniae after cataract surgery David G Charteris, Mark Batterbury, Malcolm Armstrong, Andrew B Tullo Laboratory science Immunogold study of non-collagenous matrix components in normal and exfoliative iris A Vogiatzts, G E Marshall, AG P Konstas, W R Lee Detection of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in donor eyes using polymerase chain reaction 7 Shimazaki, K Tsubota, M Sawa, S Kinoshita, T Ohkura, M Honda Improved preservation of human corneal basement membrane following freezing of donor tissue for epikeratophakia Robert D Young, W John Armitage, Paul Bowerman, Stuart D Cook, David L Easty Syntactic structure analysis in uveal melanomas Kate Coleman, Paul J van Diest, 7 P A Baak, Joan Mullaney Perspective Selective cell death in glaucoma: does it really occur? 7 E Morgan Commentary — Harry A Quigley Case reports Localised unilateral blepharochalasis R M Manners, 7 R O Collin Superior oblique myokymia — a topical solution? Kim Bibby, James S Deane, David Farnworth, John Cappin History of ophthalmology Letters Bookreviews Notices No 12 DECEMBER 1994 Editorials The role of cytokines in ocular inflammation Aize Kylstra Thromboxane in ocular pathophysiology M L Schwartzman Original articles — Clinical science Factors affecting the success rate of open lacrimal surgery Mark7 W alland, Geoffrey E Rose Long term results after probing for congenital nasolacrimal duct obstruction S M Sturrock, C7 MacEwen, 7 D H Young Clinical comparison of the ProTon and Tono-Pen tonometers with the Goldmann applanation tonometer Anna Midelfart, Andreas Wigers Additive effect of latanoprost, a prostaglandin F,, analogue, and timolol in patients with elevated intraocular pressure Alexander H Rulo, Erik L Greve, Philip F Hoyng Myopic shift and its mechanism in nephropathia epidemica or Puumala virus infection Matti Kontkanen, Tuomo Puusyjdrvi, Juhani L ihdevirta Extended wear soft contact lenses induce corneal epithelial changes Kazuo Tsubota, Ikuko Toda, Hiroshi Fujishima, Masakazu Yamada, Tokuaki SugawaraF,u n Shimazaki Vestibulo-ocular reflex abnormality in Vogt-Koyanagi-Harada syndrome Hidehiro Oku, Satoshi Ishikawa Laboratory science Effect of interleukin 1 receptor antagonist on the blood-aqueous barrier after intraocular lens implantation Ohkihiro Nishi, Kayo Nishi, Yasuichi Ohmoto Localisation of thromboxane A, receptors and the corresponding mRNAs in human eye tissue Zheng Chen, Shiv Prasad, Max Cynader S-antigen specific T cell clones from a patient with Behcet’s disease Joyce Hisae Yamamoto, Yujiro Fujino, Chiu Lin, Mie Nieda, Takeo Fuji, Kanjiro Masuda Rhodopsin mutations in a Scottish retinitis pigmentosa population, including a novel splice site mutation in intron four Christine Bell, Carolyn A Converse, Harold M Hammer, Aileen Osborne, Neva E Haites Perspective Ocular blood flow measurement Tom H Williamson, Alon Harris Case report Unusual funduscopic manifestations of an ethmoidal mucocele Louise E Allen, lain H Chisholm Letters to the editor Notices Correction History of ophthalmology Author Index Subject Index