The British Journal of Clinical Pharmacology Volume 35 1993 Published for The British Pharmacological Society by Blackwell Scientific Publications © 1993 Blackwell Scientific Publications Osney Mead, Oxford OX2 0OEL 25 John Street, London WCIN 2BL 23 Ainslie Place, Edinburgh EH3 6AJ Suite 500, Sth Floor, 238 Main Street, Boston, MA 02142, USA 54 University Street, Carlton, Victoria 3053, Australia Other Editorial Offices: Arnette SA 2, rue Casimir-Delavigne 75006 Paris France Blackwell Wissenschaft Meinekestrasse 4 D-1000 Berlin 15 Germany Blackwell MZV Feldgasse 13 A-1238 Wien Austria Published on behalf of The British Pharmacological Society All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of the copyright owner. Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Blackwell Scientific Publications for libraries and other users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the base fee of $10.00 per copy is paid directly to CCC, 27 Congress Street, Salem, MA 01970, USA. 0306-5251/93 $10.00/0. (For copying beyond that permitted by Sections 107 or 108 of the US Copyright Law). This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Special requests should be addressed to the Editor. Typeset by Oxprint Ltd, Oxford Printed in Great Britain at the University Press, Cambridge Contents Number 1, January 1993 Review Isoenzyme selective phosphodiesterase inhibitors: study using the euglycaemic hyperinsulinaemic potential clinical uses: J. P. Hall clamp: A. D. Morris, R. Donnelly, J. M. C. Connell & J. L. Reid Papers Therapeutic consultation: a necessary adjunct to A comparison of the effects of captopril and independent drug information: C. Rodriguez, enalapril on skin responses to intradermal J. M. Arnau, X. Vidal & J. R. Laporte bradykinin and skin blood flow in the human forearm: T. C. Li Kam Wa, E. D. Cooke & Short reports P. Turner Evening vs morning isradipine sustained release in Impairment of psychomotor function at modest essential hypertension: a double-blind study with plasma concentrations of carbamazepine after 24 h ambulatory monitoring: R. Fogari, E. Malacco, administration of the liquid suspension to naive F. Tettamanti, A.E. Gnemmi & M. Milani subjects: J. D. Wildin, B. J. Pleuvry & Effect of an inhaled histamine H3-receptor agonist G. E. Mawer on airway responses to sodium metabisulphite in The concentration-dependent disposition of asthma: B. J. O’Connor, J. M. Lecomte & intravenous p-aminohippurate in subjects with P. J. Barnes normal and impaired renal function: L. F. Prescott, Paracetamol elimination in patients with non-insulin S. Freestone & J. A. N. McAuslane dependent diabetes mellitus: F. Kamali, Inhibition of human cytochrome P450 2D6 S. H. L. Thomas & R. E. Ferner (CYP2D6) by methadone: D. Wu, S.V. Otton, The effects of liver and renal disease on B.A. Sproule, U. Busto, T. Inaba, W. Kalow & stereoselective serum binding of flurbiprofen: E. M. Sellers R. Blouin, I. Chaudhary, K. Nishihara & S. Cox The lipolytic effect of B;- and B2-adrenoceptor activation in healthy human volunteers: Proceedings C. A. Haffner, M. J. Kendall, S. Maxwell & Proceedings of the British Pharmacological Society B. Hughes (Queen Mary and Westfield College, University of Metabolic effects of lacidipine: a placebo-controlled London, 9-11 September 1992) Number 2, February 1993 Review 93 Treatment of vasculitis: H. G. Taylor & A. Samanta Patient knowledge about diuretic prescription: E. G. Bevan, E. M. Currie, S. M. McGhee & Papers G. T. McInnes The effects of anti-hypertensive medication on A study of the interaction between omeprazole and learning and memory: J. Powell, A. Pickering, cyclosporine in renal transplant patients: /. Blohmé, M. Wyke & T. Goggin J.-P. Idstrém & T. Andersson CNS-related performance and haemodynamics of Molecular heterogeneity of the Xbal defined 44kb metoprolol-Oros and propranolol after single and 3 allele of the CYP2D locus within the Caucasian days dosing in healthy volunteers: A. L. van population: C. Mura, N. Gerard, M. Vincent-Viry, Steveninck, M. S. M. Pieters, H. C. Schoemaker, M. M. Galteau, E. Jacqz-Aigrain & D. D. Breimer & A. F. Cohen R. Krishnamoorthy Comparison of quinapril and atenolol as single drugs The time course of action of three differing doses of or in combination with hydrochlorothiazide in noberastine, a novel H,-receptor antagonist, on moderate to severe hypertensives, using automated histamine-induced skin wheals and the relationship ambulatory monitoring: Y. Lacourcieére, to plasma drug concentrations in normal human J. Lefebvre, P. Provencher & L. Poirier volunteers: R. Wood-Baker, M. B. Emanuel, Effect of renal function on the pharmacokinetics and K. Hutchinson & P. H. Howarth pharmacodynamics of trandolapril: E. G. Bevan, Plasma concentrations and urinary excretion of G. T. McInnes, J. C. Aldigier, J. J. Conte, histamine after inhalation and subcutaneous J. P. Grunfeld, S. J. Harper, B. H. Meyer, N. Pauly injection of histamine: R. D. Murdoch, L. J. F. & R. Wilkinson Youlten, A. J. Williams & K. Howland The bioavailability of digoxin from three oral Capsaicin-densensitization to the human nasal formulations measured by a specific h.p.l.c. assay: mucosa selectively reduces pain evoked by citric A. F. Cohen, R. Kroon, H. C. Schoemaker, acid: P. Geppetti, M. Tramontana, E. Del Bianco & D. D. Breimer, A. Van Vliet-Verbeek & B. M. Fusco H. C. Brandenburg Modulation of capsaicin induced airway reflexes in Effects of an oral dose of isosorbide dinitrate on humans: effect of monoamine oxidase inhibition: platelet function and fibrinolysis in healthy N. B. Choudry, J. Studham, D. Harland & volunteers: N. H. Wallén, P. T. Larsson, R. W. Fuller A. Bréijersén, A. Andersson & P. Hjemdahl Assessment of the precorneal residence of an ophthalmic ointment in healthy subjects: E. G. Bevan, L. C. Chee, S. M. McGhee & J. L. Greaves, C. G. Wilson & A. T. Birmingham G. T. McInnes Interactions among primaquine, malaria infection and other antimalarials in Thai subjects: Short report G. Edwards, C. §. McGrath, S. A. Ward, Effect of B-adrenoceptor blockade on atrial W. Supanaranond, S. Pukrittayakamee, natriuretic peptide levels during exercise in angina T. M. E. Davis & N. J. White pectoris: M. Riley, J. S. Elborn, G. Onuoha, 199 The measurement of a new antimicrobial quinolone C. Erwin, C. Shaw, M. M. Khan, C. F. Stanford & in hair as an index of drug exposure: 7. Uematsu, D. P. Nicholls M. Nakano, H. Akiyama & M. Nakashima 204 Patients’ attitudes to participation in clinical trials: Erratum Number 3, March 1993 Personal view A A great thirst for knowledge: H. McGavock Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, Review an orally active nonpeptide angiotensin II receptor 219 The gastrointestinal toxicity of aspirin: an overview antagonist, in humans: M. Ohtawa, F. Takayama, of randomised controlled trials: P. J. Roderick, K. Saitoh, T. Yoshinaga & M. Nakashima H. C. Wilkes & T. W. Meade Short reports Papers Haemodynamics and hormonal responses to oral The differential effect of aspirin on human platelet enalapril in salt depleted normotensive man: activation in aspirin-sensitive asthmatics and normal R. J. MacFadyen, H. L. Elliott, P. A. Meredith & subjects: M. L. Taylor, G. A. Stewart & J. L. Reid P. J. Thompson The influence of chronic administration of calcium Equipotent inhibition by R(—)-, S(+)- and racemic carbonate on the bioavailability of oral ibuprofen of human polymorphonuclear cell ciprofloxacin: J. Sahai, D. P. Healy, J. Stotka & function in vitro: M. Villanueva, R. Heckenberger, R. E. Polk H. Strobach, M. Palmér & K. Schrér The reproducibility of quinine bioavailability: The effect of L-leucine on the absorption of G. Paintaud, G. Alvén & O. Ericsson levodopa, studied by regional jejunal perfusion in Food intake increases the relative oral man: H. Lennernds, D. Nilsson, S.-M. Aquilonius, bioavailability of vanoxerine: S. H. Ingwersen, O. Ahrenstedt, L. Knutson & L. K. Paalzow T. G. K. Mant & J. J. Larsen Endogenous digoyin-like immunoreactivity during A simple collection method for saliva in children: pregnancy and at birth: J. M. Lupoglazoff, potential for home monitoring of carbamazepine E. Jacqz-Aigrain, B. Guyot, O. Chappey & therapy: K. Y. Chee, D. Lee, D. Byron, D. Naidoo Ph. Blot & A. Bye Pharmacokinetics of 2-fluorodideoxycytidine Morphine glucuronidation in premature neonates: (2FddC) in patients infected with human R. Hartley, M. Quinn, M. Green & M. I. Levene immunodeficiency virus: P. E. O. Williams, Bronchodilating effects of the novel potassium G. J. Muirhead, D. Sereni, F. S. Rousseau, channel opener HOE 234 in human airways in vitro: K. Edelman & M. Hooker M. Miura, M. G. Belvisi, J. K. Ward, Comparison of the effect of oral sulphasalazine, S. Tadjkarimi, M. H. Yacoub & P. J. Barnes sulphapyridine and 5-amino-salicylic acid on the in Potentiation of the hypoglycaemic response to vivo antibody response to oral and systemic glipizide in diabetic patients by histamine H,- antigen: P. Sheldon & P. Pell receptor antagonists: J. Feely, W. C. J. Collins, A comparison of the pharmacokinetic and M. Cullen, A. H. El Debani, R. S. MacWalter, pharmacodynamic properties of quinine and N. R. Peden & I. H. Stevenson quinidine in healthy Thai males: J. Karbwang, Magnesium sulphate increases lymphocyte T. M. E. Davis, §. Looareesuwan, P. Molunto, adenosine 3’:5’-cyclic monophosphate in humans: D. Bunnag & N. J. White U. von Mandach, M. Biirgi, R. Huch & A. Huch Diazepam effects on the performance of healthy High clearance of (S)-warfarin in a warfarin- subjects are not enhanced by treatment with the resistant subject: H. O. Hallak, P. J. Wedlund, antihistamine ebastine: M. J. Mattila, K. Aranko & M. W. Modi, I. H. Patel, G. L. Lewis, B. Woodruff T. Kuitunen & A. A. Trowbridge A placebo controlled double-blind evaluation of the The N-demethylation of imipramine correlated with pharmacodynamics of fengabine vs amitriptyline the oxidation of S-mephenytoin (S/R-ratio). A following single and multiple doses in elderly population study: E. Skjelbo, L. F. Gram & volunteers: D. B. Fairweather, J. S. Kerr, S. Hilton K. Br@sen & I. Hindmarch The pharmacokinetics and pharmacodynamics of The effects of simvastatin and pravastatin on dermatan sulphate MF701 during haemodialysis for objective and subjective measures of nocturnal chronic renal failure: F. Gianese, sleep: a comparison of two structurally different M. T. Nurmohamed, B. P. Imbimbo, H. R. Biiller, HMG CoA reductase inhibitors in patients with R. J. Berckmans & J. W. Ten Cate primary moderate hypercholesterolaemia: S.-A. Eckernds, B.-E. Roos, P. Kvidal, Book review L.-O. Eriksson, G. A. Block, R. P. Neafus & Adverse reactions to non-steroidal anti- J. R. M. Haigh inflammatory drugs: clinical pharmacoepidemiology, edited by M. Kurowski: 7. Pullar Number 4, April 1993 Leading article 341 The role of clinical pharmacology in the performance and the EEG: C. G. G. Link, development and assessment of drugs for T. J. Leigh & J. K. Dennison cerebrovascular disease and stroke: J. L. Reid A population based case-cohort study of drug- induced anaphylaxis: M. M. Van Der Klauw, Review B. H. Ch. Stricker, R. M. C. Herings, W. S. Cost, Non-steroidal anti-inflammatory drugs and H. A. Valkenburg & J. H. P. Wilson angiotensin converting enzyme inhibitors: a The pharmacokinetics of methotrexate and its commonly prescribed combination with variable 7-hydroxy metabolite in patients with rheumatoid effects on renal function: N. D. C. Sturrock & arthritis: P. Seideman, O. Beck, S. Eksborg & A. D. Struthers M. Wennberg Stereoselective sulphate conjugation of salbutamol Methods in humans: comparison of hepatic, intestinal and Disagreement between standard transthoracic platelet activity: U. K. Walle, G. R. Pesola & impedance cardiography and the automated T. Walle transthoracic electrical bioimpedance method in The pharmacokinetics, tolerability and estimating the cardiovascular responses to pharmacodynamics of tucaresol (589C80; 4[2-formyl- phenylephrine and isoprenaline in healthy man: 3-hydroxyphenoxymethyl] benzoic acid), a potential C. De Mey & D. Enterling anti-sickling agent, following oral administration to healthy subjects: P. E. Rolan, J. E. Parker, Papers S. J. Gray, B. C. Weatherley, J. Ingram, Responsiveness of human isolated bronchial W. Leavens, R. Wootton & J. Posner segments and its relationship to epithelial loss: The metabolism of aprindine in relation to the T. I. Omari, M. P. Sparrow & H. W. Mitchell sparteine/debrisoquine polymorphism: 7. Ebner & Partial mediation by nitric oxide of the relaxation of M. Eichelbaum human isolated detrusor strips in response to Inhibitory effect of grapefruit juice and its bitter electrical field stimulation: M. J. James, principal, naringenin, on CYP1A2 dependent A. T. Birmingham & S. J. Hill metabolism of caffeine in man: U. Fuhr, K. Klittich A comparison of the potassium and magnesium- & A. Horst Staib sparing properties of amiloride and spironolactone in diuretic-treated normal subjects: D. L. Murdoch, Short reports G. Forrest, D. L. Davies & G. T. McInnes The effect of tocainide on theophylline metabolism: Defining small differences in efficacy between anti- C-M. Loi, X. Wei, B. M. Parker, M. R. Korrapati Parkinsonian agents using gait analysis: a &R. E. Vestal comparison of two controlled release formulations The pharmacokinetics of intravenous ondansetron of levodopa/decarboxylase inhibitor: C. Weller, in patients with hepatic impairment: J. C. Blake, C. J. A. O'Neill, A. Charlett, S. G. Bowes, J. L. Palmer, N. A. Minton & A. K. Burroughs A. Purkiss, P. W. Nicholson, R. J. Dobbs & The pharmacokinetics of quinine in patients with S. M. Dobbs hepatitis: J. Karbwang, A. Thanavibul, P. Molunto Human studies on abecarnil, a new B-carboline & K. Na Bangchang anxiolytic: safety, tolerability and preliminary pharmacological profile: 7. Duka, B. Schiitt, Letter to the Editors W. Krause, R. Dorow, S. McDonald & K. Fichte In vitro interaction between cyclosporin A and The effects of BRL 46470A, a novel 5-HT3 receptor macrolide antibiotics: F. Marre, G. de Sousa, antagonist, and lorazepam on psychometric A. M. Orloff& R. Rahmani Number 5, May 1993 Leading article 449 Good Clinical Practice: a question of balance: M. Van Den Biggelaar-Martea, C. P. W. G. M. A. E. Wallnofer & A. F. Cohen Verwey-Van Wissen, M. L. Vree & P. J. M. Guelen The effects of 5-HT and m-chlorophenylpiperazine Papers (m-CPP) on the efflux of [?]-5-HT from human The use of proprietary medicines by patients perfused platelets: J. G. Carver, D. G. Grahame- presenting with peptic ulcer haemorrhage: Smith, E. S. Johnson & Z. Madgwick J. F. Marriott, P. A. Asquith & C. J. Shorrock Plasma concentrations and ocular effects of Non-steroidal anti-inflammatory drugs and cyclopentolate after ocular application of three hypertension in the elderly: a community-based formulations: K. Lahdes, R. Huupponen, T. Kaila, cross-sectional study: A. G. Johnson, L. A. Simons, D. Monti, M. F. Saettone & L. Salminen J. Simons, Y. Friedlander & J. McCallum Neutrophils and mononuclear cells from patients Dose-dependent heart rate reducing effect of with chronic granulomatous disease release nitric nizatidine, a histamine H>-receptor antagonist: oxide: A. Condino-Neto, M. N. Muscard, H. Hinrichsen, A. Halabi, G. Fuhrmann & A. §. Grumach, M. M. S. Carneiro-Sampaio & W. Kirch G. De Nucci The pharmacokinetics of naproxen, its metabolite A comparison of amlodipine with enalapril in the O-desmethylnaproxen, and their acyl glucuronides treatment of moderate/severe hypertension: in humans. Effect of cimetidine: T. B. Vree, G. Fowler, J. Webster, D. Lyons, K. Witte, W. A. Crichton, T. A. Jeffers, E. A. Wickham, Short reports S. S. Sanghera, R. Cornish & J. C. Petrie Lack of effect of enalaprilat on the action of A comparison of amlodipine with enalapril in the vasoactive intestinal polypeptide in the human treatment of isolated systolic hypertension: forearm: J. R. Cockcroft, P. Chowienczyk, J. Webster, G. Fowler, T. A. Jeffers, D. Lyons, T. G. Elliott & J. M. Ritter K. Witte, W. A. Crichton, E. A. Wickham, Inhibition of angiotensin converting enzyme with S. S. Sanghera, R. Cornish & J. C. Petrie enalapril maleate in infants with congestive heart Receptor occupancy in lumbar CSF as a measure of failure: J. P. Dutertre, E. M. Billaud, E. Autret, the antagonist activity of atenolol, metoprolol and A. Chantepie, I. Oliver & J. Laugier propranolol in the CNS: T. Kaila & R. Marttila The effect of captopril on the superior mesenteric artery and portal venous blood flow in normal man: Proceedings K. Ray-Chaudhuri, T. Thomaides, S. Maule, Proceedings of the British Pharmacological Society L. Watson, S. Lowe & C. J. Mathias (5-7 January 1993, University of Cambridge) Number 6, June 1993 Review 557 The treatment of heart failure —what next?: Effects of terbutaline on basal thermogenesis of R. H. Davies & D. J. Sheridan human skeletal muscle and Na-K pump after 1 week of oral use —a placebo controlled comparison with Methods series propranolol: B. Fagher, H. Liedholm, A. Sjégren & Diagnosis and treatment of human hydatidosis: M. Monti H. Wen, R. R. C. New & P. S. Craig Platelet activating factor, lyso-platelet activating factor and arachidonic acid release in normal human Leading article skin and the influence of topical steroid treatment: Bridging the gap between clinical pharmacology and R. M. Barr, F. Lawlor, M. R. Judge, P. Courtney, rational drug prescribing: L. E. Ramsay R. Barlow, A. Kobza Black, A. I. Mallet & M. W. Greaves Methods Cicaprost, an orally active prostacyclin analogue: its Presenting clinical pharmacology and therapeutics: effects on platelet aggregation and skin blood flow in general introduction: T. P. G. M. De Vries normal volunteers: J. J. F. Belch, M. McClaren, Presenting clinical pharmacology and therapeutics: C. S. Lau, I. R. MacKay, A. Bancroft, J. McEwen a problem based approach for choosing and & J. M. Thompson prescribing drugs: T. P. G. M. De Vries Presenting clinical pharmacology and therapeutics: the course in pharmacotherapeutics: T. P. G. M. Short reports De Vries Moclobemide treatment causes a substantial rise in Presenting clinical pharmacology and therapeutics: the sparteine metabolic ratio: L. F. Gram, K. Brosen evaluation of a problem based approach for choosing and the Danish University Antidepressant Group drug treatments: 7. P. G. M. De Vries The multiple dose pharmacokinetics of proguanil: N. A. Helsby, G. Edwards, A. M. Breckenridge & Papers S. A. Ward United Kingdom Product Licence applications Individual theophylline dosing based on bioelectrical involving new active substances, 1987-1989: their impedance analysis: J. S. Sidhu, E. J. Triggs, fate after appeals: M. D. Rawlins & D. B. Jefferys B. G. Charles & B. A. Smithurst Variability in the stereoselective disposition of Cimetidine does not influence the metabolism of the ibuprofen in patients with rheumatoid arthritis: H,-receptor antagonist ebastine to its active G. Geisslinger, K. P. Stock, D. Loew, G. L. Bach metabolite carebastine: J. Van Rooij, & K. Brune H. C. Schoemaker, R. Bruno, J. F. Reinhoudt, Studies on the renal excretion of the acyl D. D. Breimer & A. F. Cohen glucuronide, phenolic glucuronide and sulphate A clinical trial of a slow-release formulation of conjugates of diflunisal: R. G. Dickinson, acetylsalicylic acid in patients at risk for A. R. King, G. E. McKinnon, W. D. Hooper, preeclampsia: J. Shen, S. Wanwimolruk, M. J. Eadie & G. K. Herkes P. D. Wilson, R. J. Seddon & M. S. Roberts The pharmacokinetics of remoxipride and metabolites in patients with various degrees of renal function: G. Movin-Osswald, J. Boelaert, Letters to the Editors M. Hammarlund-Udenaes & L. R. Nilsson Back-estimation of blood alcohol concentration: Effects of dilevalol (R,R-labetalol) compared with A. W. Jones: I. H. Stevenson & T. A. Moreland nifedipine on heart rate, blood pressure and muscle blood flow at rest and on exercise in hypertensive patients: T. Walley, Y. Tsao, A. Scott, E. MacKay, Indexes M. Vandenburg & A. Breckenridge Author and subject indexes to Volume 35