British Journal of Anaesthesia CONTENTS JANUARY Comparison of effects of remifentanil and alfentanil on cardiovascular response to tracheal intubation in EDITORIALS hypertensive patients l I: Can we characterize the central nervous system actions 4. M. Maguire, N. Kumar, J. L. Parker, D. J. Rowbotham of &,-adrenergic agonists? and J. P. Thompson M. E. P. Jones and M. Maze Comparison of coagulation and blood loss during II: Publishing changes in 2001 anaesthesia with inhaled isoflurane or intravenous propofol G. Smith N. L. Law, K. F. J. Ne, M. G. Irwin and J. S. F. Man Decontamination of laryngoscopes in The Netherlands CLINICAL INVESTIGATIONS M. J. L. Bucx, J. Dankert, M. M. Beenhakker and 5 Sedative, analgesic, and cognitive effects of clonidine T. E. J. Harrison infusions in humans J. E. Hall, T. D. Uhrich and T. J. Ebert LABORATORY INVESTIGATION Model-based administration of inhalation anaesthesia. 103 Mechanical and electrophysiological effects of thiopental 1. Developing a system model on rat cardiac left ventricular papillary muscle J. G. C. Lerou and L. H. D. J. Booij A. Descorps-Declére, M. P. Sauviat, K. Samii and Y. Lecarpentier Model-based administration of inhalation anaesthesia. 2. Exploring the system model REVIEW ARTICLE J. G. C. Lerou and L. H. D. J. Booij 110 Lazaroids: efficacy and mechanism of action of the Effects of sevoflurane and propofol on pulmonary shunt 21-aminosteroids in neuroprotection fraction during one-lung ventilation for thoracic surgery R. J. Kavanagh and P. C. A. Kam D. H. Beck, U. R. Doepfmer, C. Sinemus, A. Bloch, M. R. Schenk and W. J. Kox SHORT COMMUNICATIONS Recovery and neurological examination after 120 Pharmacokinetic profile of epidurally administered remifentanil—desflurane or fentanyl—desflurane methylnaltrexone, a novel peripheral opioid antagonist in anaesthesia for carotid artery surgery a rabbit model W. Wilhelm, N. Schlaich, J. Harrer, S. Kleinschmidt, D. B. Murphy, H. El Behiery, V.W . Chan and J. F. Foss M. Miiller and R. Larsen Influence of head and neck position on cuff position and Comparison of changes in electroencephalographic oropharyngeal sealing pressure with the laryngeal mask measures during induction of general anaesthesia: airway in children influence of the gamma frequency band and K. Okuda, G. Inagawa, T. Miwa and K. Hiroki electromyogram signal Waste gas exposure to sevoflurane and nitrous oxide J. W. Sleigh, D. A. Steyn-Ross, M. L. Steyn-Ross, during anaesthesia using the oesophageal—tracheal M. L. Williams and P. Smith Combitube Small Adult™ Effects of different concentrations of sevoflurane and K. H. Hoerauf, T. Hartmann, S. Acimovic, A. Kopp desflurane on subcortical somatosensory evoked G. Wiesner, B. Gustorff, H. Jellinek and P. Krafft responses in anaesthetized, non-stimulated patients Effect of two anaesthetic regimens on airway nitric oxide D. J. A. Vaughan, C. Thornton, D. R. Wright, production in horses J. R. Fernandes, P. Robbins, C. Doré and M .D. Brunner D. J. Marlin, L. E. Young, R. McMurphy, K. Walsh and P. Dixon Pre-existing cognitive impairment as a factor influencing outcome after cardiac surgery Use of cisatracurium during fast-track cardiac surgery K. Millar, A. J. Asbury and G. D. Murray 4. Ouattara, L. Richard, J. M. Charriére, H. Lanquetot, P. Corbi and B. Debaene Fast-track cardiac anaesthesia in the elderly: effect of two different anaesthetic techniques on mental recovery CASE REPORTS N. P. Dowd, J. M. Karski, D. C. Cheng, S. Gajula, 133 Successful epidural anaesthesia for Caesarean section in a P. Seneviratne, J. A. Carroll Munro and D. Fiducia patient with spondyloepiphyseal dysplasia Intrathecal midazolam increases the analgesic effects of H. D. de Boer, A. Hemelaar, R. van Dongen and spinal blockade with bupivacaine in patients undergoing M. J. M. Gielen haemorrhoidectomy Use of remifentanil in a patient with peripartum M. H. Kim and Y. M. Lee cardiomyopathy requiring Caesarean section Comparison of two neurostimulation techniques for C. P. McCarroll, L. D. Paxton, P. Elliott and axillary brachial plexus blockade D. B. Wilson D. M. Coventry, K. F. Barker and M. Thomson Reduction of vasopressor requirement by hydrocortisone Dexamethasone is a cost-effective alternative to administration in a patient with cerebral vasospasm ondansetron in preventing PONV after paediatric J. A. Alhashemi strabismus repair Paradoxical changes in bispectral index during nitrous B. Subramaniam, R. Madan, S. Sadhasivam, B. Sennaraj, oxide administration P. Tamilselvan, S. Rajeshwari, D. Jagan and D. Shende G. D. Puri British Journal of Anaesthesia Therapeutic embolization of an internal mammary artery D. J. Greenblatt and J. A. J. Martyn damaged by placement of a central venous catheter Epidural analgesia and arterial reconstructive surgery to G. Abbott and P. Evans the leg: effects on fibrinolysis and platelet degranulation S. A. Bew, A. E. Bryant, J. P.D esborough and G. M. Hall CORRESPONDENCE Intrathecal sufentanil and morphine for post-thoracotomy pain relief BOOK REVIEWS N. Mason, R. Gondret, A. Junca and F. Bonnet Spinal anaesthesia with ropivacaine 5 mg ml’! in glucose ERRATUM 10 mg mI! or 50 mg mI! J. B. Whiteside, D. Burke andJ . A. W. Wildsmith Rate of injection through Whitacre needles affects distribution of spinal anaesthesia FEBRUARY L. Anderson, J. Walker, C. Brydon and M. G. Serpell EDITORIALS LABORATORY INVESTIGATION 161 I. Peri-operative B-blockade: a useful treatment that 249 Comparison of relaxant effects of propofol on should be greeted with cautious enthusiasm methacholine-induced bronchoconstriction in dogs with S. J. Howell, J. W. Sear and P. Foex and without vagotomy 164 II. Is peri-operative renal dysfunction of no consequence? S. Kabara, K. Hirota, E. Hashiba, H. Yoshioka, T. Kudo, M. L. Cittanova T. Sato and A. Matsuki 166 ILI. A breakthrough in the genetic diagnosis of malignant REVIEW ARTICLE hyperthermia R. L. Robinson and P. M. Hopkins 254 Anaesthesia and sleep apnoea J. A. Loadsman and D. R. Hillman CLINICAL INVESTIGATIONS 169 Haemodynamic and renal effects of intravenous SHORT COMMUNICATIONS enalaprilat during coronary artery bypass graft surgery in 267 Renal effects of inhaled nitric oxide in humans patients with ischaemic heart dysfunction W. M. Wraight andJ . D. Young F. Ryckwaert, P. Colson, J. Ribstein, G. Boccara 269 Can isoflurane mimic ischaemic preconditioning in and G. Guillon isolated rat heart? Is pulmonary resistance constant, within the range of tidal N. Martini, B. Preckel, V. Thdéimer and W. Schlack volume ventilation, in patients with ARDS? Post-operative recovery: day surgery patients’ preferences G. Mols, V. Kessler, A. Benzing, M. Lichtwarck-Aschoff, K. Jenkins, D. Grady, J. Wong, R. Correa, S. Armanious K. Geiger and J. Guttmann and F. Chung Gender differences in the pharmacokinetics of propofol in Attenuation of haemodynamic responses to tracheal elderly patients during and after continuous infusion intubation by the StyletScope J. Vuyk, C. J. Oostwouder, A. A. Vletter, A. G. L. Burm T. Kitamura, Y. Yamada, M. Chinzei, H. L. Du and J. G. Bovill and K. Hanaoka Comparing the effects of stimulation and propofol infusion rate on implicit and explicit memory formation CASE REPORTS J. Andrade, L. Englert, C. Harper and N. D. Edwards 278 Unexplained acute severe methaemoglobinaemia in a Absence of memory for intra-operative information young adult during surgery with total intravenous anaesthesia M. Falkenhahn, S. Kannan and M. O'Kane I. F. Russell and M. Wang 280 Total spinal anaesthesia in association with insertion of a Psychomotor recovery in very old patients after total paravertebral catheter intravenous or balanced anaesthesia for cataract surgery B. Lekhak, C. Bartley, I. D.C onacher and S. M. Nouraei J. Kubitz, J. Epple, A. Bach, J. Motsch, E. Martin and COMMENTARY H. Schmidt 283 Guidelines for molecular genetic detection of EEG bispectral index and hypnotic component of susceptibility to malignant hyperthermia anaesthesia induced by sevoflurane: comparison between A. Urwyler, T. Deufel, T. McCarthy and S. West for the children and adults European Malignant Hyperthermia Group C.-S. Degoute, C. Macabeo, C. Dubreuil, R. Duclaux and V. Banssillon Sevoflurane EC., and EC, values for laryngeal mask CORRESPONDENCE insertion and tracheal intubation in children R. Aantaa, R. Takala and P. Muittari BOOK REVIEWS Effect of common airway manoeuvres on upper airway ACKNOWLEDGEMENT OF ASSESSORS dimensions and clinical signs in anaesthetized, spontaneously breathing children 301 ERRATA A. Reber, R. Paganoni and F. J. Frei Pharmacokinetics and pharmacodynamics of vecuronium ABSTRACTS in children receiving phenytoin or carbamazepine for 303P Proceedings of the Anaesthetic Research Society chronic anticonvulsant therapy Meeting, London, November 16-17, 2000 S. G. Soriano, L. J. Sullivan, K. Venkatakrishnan, British Journal of Anaesthesia MARCH 403 Evaluation and comparison of the pharmacokinetic and pharmacodynamic properties of allopregnanolone and EDITORIALS pregnanolone at induction of anaesthesia in the male rat 234277 ‘I. Right heart catheterization in intensive care D. Zhu, M. D. Wang, T. Bédckstraéndm G. Wahlstrém J. D. Young REVIEW ARTICLE 329 II. Codeine phosphate in children: time for re-evaluation? M. Cunliffe 413 Codeine phosphate in paediatric medicine D.G Williams D. J. Hatch and R. F. Howard CLINICAL INVESTIGATIONS SHORT COMMUNICATIONS Dose-dependent prophylactic effect of nicorandil, an ATP-sensitive potassium channel opener, on 422 Predicted effect compartment concentration of thiopenta intra-operative myocardial ischaemia in patients at loss of eyelash reflex undergoing major abdominal surgery T. A. Lim and K. Inbasegaran T. Kaneko, Y. Saito, Y. Hikawa, K. Yasuda and K. Makita Effects of hypoxia and isoflurane on liver blood flow: role Prediction of volatile anaesthetic solubility in blood and of adenosine priming fluids for extracorporeal circulation S. H. Cray, M. W. Crawford, N. Khayyam R.-G. Yu, J.-X. Zhou andJ . Liu and F. J. L. Carmichael Heterogeneous distribution of cardioplegic solution in Compound A production from sevoflurane is not less when KOH-free absorbent is used in a closed-circuit pigs lung model system J.-S. Han, D M. Soh, C.-W Joh, B.-I. Choi, Y.-S. Lee L. Versichelen, M. P. Bouche, M. Struys, J. Van Bocxlaer, C.-J. Lee and ¢ H. Park E. Mortier, A. P. de Leenheer and G. Rolly CASE REPORTS Arterial to end-tidal carbon dioxide tension difference in 431 Liver transplantation for massive hepatic haemangiomatosis children with congenital heart disease causing restrictive lung disease J. A. Short, S. T. Paris, P. D. Booker and R. Fletcher M. T. Keegan, G. S. Kamath, G. M. Vasdev, J. ¥ Findlay Biphasic EEG changes in relation to loss of consciousness G. J. Gores, J. L. Steers and D. J. Plevak during induction with thiopental, propofol, etomidate Undiagnosed cardiomyopathy in a neonate: significance midazolam or sevoflurane of low oxygen saturation during anaesthesia K. Kuizenga, J. M. K. H. Wierda and C. J. Kalkman W. Q. Smith and M. Abu-Harb Recovery from propofol anaesthesia supplemented with 437 Multiple acyl-CoA dehydrogenase deficiency remifentanil cause of acidosis with an increased anion gap R. A. O'Hare, R. K. Mirakhur, J. E. Reid, D. S. Breslin 4. S. Grice and T. E. Pech and A. Hayes 442 Subarachnoid haemorrhage following spinal anaesthesia Post-operative recovery after inguinal herniotomy in in an obstetric patient ex-premature infants: comparison between sevoflurane S. M. Eevert and K. A Eggers and spinal anaesthesia J. M. Williams, P. A. Stoddart, S. A R. Williams COMMENTARY andA . R. Wolf 445 Assessment instruments used during anaesthetic Evaluation of pre-emptive intramuscular phenylephrine simulation: review of published studies and ephedrine for reduction of spinal anaesthesia-induced 4. J. Byrne and J. D. Greaves hypotension during Caesarean section 451 CORRESPONDENCI B. T. Ayorinde, P. Buczkowski, J. Brown, J. Shah and D. J. Buggy 460 BOOK REVIEWS I.V. ketoprofen for analgesia after tonsillectomy comparison of pre- and post-operative administration A. Salonen, H. Kokki and K. Tuovinen APRIL Analysis of the French health ministry’s national register EDITORIALS of incidents involving medical devices in anaesthesia and 465 I. KISS and indices of pulmonary oxygen transfer intensive care C. E. W. Hahn L. Beydon, F. Conreux, R. Le Gall, D. Safran, J. B. Cazalaa and the members of the ‘Sous-commission 467 I]. Continuous cardiac output by pulse contour analysis de Materiovigilance’ for Anaesthesia and Intensive Care J. J. van Lieshout and K. H. Wesseling Ili. Lessons from Stafford LABORATORY INVESTIGATIONS J. R. Sneyd 388 Differential nitric oxide synthase activity, cofactor IV Local anaesthesia for eye surgery—no room for availability and cGMP accumulation in the central complacency nervous system during anaesthesia G. S. Thind and A. P. Rubin H. F. Galley, A. E. Le Cras, §. D. Logan and N. R. Webster CLINICAL INVESTIGATIONS Suppressive effect of nitrous oxide on motor evoked 477 Effect of changes in arterial-mixed venous oxygen potentials can be reversed by train stimulation in rabbits content difference (C(a—¥),.) on indices of pulmonary under ketamine/fentanyl anaesthesia, but not with oxygen transfer in a model ARDS lung additional propofol M. Nirmalan, T. Willard, M. O. Columb and T. Sakamoto, M. Kawaguchi, S. Inoue and H. Furuya P. Nightingale British Journal of Anaesthesia 486 Estimation of changes in cardiac output from the arterial 570 Small-dose selective spinal anaesthesia for short-duration blood pressure waveform in the upper limb outpatient gynaecological laparoscopy: recovery N. W. F. Linton and R. A. F. Linton characteristics compared with propofol anaesthesia 4. V. G. Stewart, H. Vaghadia, L. Collins Transoesophageal echocardiography in cardiac and and G. W. E. Mitchell vascular surgery: implications and observer variability ‘ D. Schmidlin, D. Bettex, E. Bernard, R. Germann, Analgesic efficacy of tramadol 2 mg g' for paediatric day-case adenoidectomy M. Tornic, R. Jenni and E. R. Schmid H. Viitanen and P. Annila Intercurrent drug therapy and perioperative cardiovascular Reduced haemostatic factor transfusion using heparinase- mortality in elective and urgent/emergency surgical modified thrombelastography during cardiopulmonary patients bypass J. W. Sear, S. J. Howell, Y. M. Sear, D. Yeates, D. Royston and S. von Kier M. Goldacre and P. Foex Circulating tetrahydrobiopterin concentrations in patients [he auditory evoked response as an awareness monitor with septic shock during anaesthesia H. F. Galley, A. E. Le Cras, K. Yassen, 1. S. Grant E. Loveman, J. C. Van Hooff and D. C. Smith and N. R. Webster Ocular microtremor: a tool for measuring depth of CASE REPORTS anaesthesia? 581 Review of management of purpura fulminans and two §. Bojanic, T. Simpson and C. Bolge case reports Effects of fentanyl, alfentanil, remifentanil and J. Nolan and R. Sinclair sufentanil on loss of consciousness and bispectral index Intra-operative and post-operative hypercapnia leading to during propofol induction of anaesthesia delayed respiratory failure associated with transanal C. Lysakowski, L. Dumont, M. Pellégrini, F. Clergue endoscopic microsurgery under general anaesthesia and E. Tassonyi K. Kerr and G. H. Mills \ntinociceptive properties of neurosteroids IV: pilot Acute respiratory and metabolic acidosis induced by study demonstrating the analgesic effects of alphadolone excessive muscle contraction during spinal evoked administered orally to humans stimulation Y. Tohdoh, S. Sumita, T. Kawamata, K. Omote, C. §. Goodchild, A. Robinson and R. Nadeson S. Kawana and A, Namiki Persistent back pain after spinal anaesthesia in the non- obstetric setting: incidence and predisposing factors 594 CORRESPONDENCE K. Schwabe and H.-B. Hopf 603 BOOK REVIEWS \BORATORY INVESTIGATIONS 605 ERRATA 540 Cytochrome P4502B6 and 2C9 do not metabolize midazolam: kinetic analysis and inhibition study with monoclonal antibodies N. Hamaoka, Y. Oda, I. Hase and A. Asada MAY Naloxone improves functional recovery of myocardial stunning in conscious dogs through its action on the EDITORIALS central nervous system 607 I. Mapping the anatomy of unconsciousness—imaging I. P. Weber, J. Stypmann, A. Meifiner, M. GroBe anaesthetic action in the brain Hartlage, D. K. Menon H. Van Aken and N. Rolf II. How can we improve the outcome of Effects of sevoflurane on dopamine, glutamate and oesophagectomy? K. M. Sherry aspartate release in an in vitro model of cerebral ischaemia III. Development of the concept of a liquid pulmonary C. C. Toner, K. Connelly, R. Whelpton, S. Bains, alveolar lining layer K. L. Dorrington and J. D. Young 1. T. Michael-Titus, D. P. McLaughlin and J. A. Stamford CLINICAL INVESTIGATIONS REVIEW ARTICLE 55 618 Correlating in vivo anaesthetic effects with ex vivo Neurofibromatosis: clinical presentations and anaesthetic receptor density data supports a GABAergic mechanism implications of action for propofol, but not for isoflurane N. P. Hirsch, A. Murphy and J. J. Radcliffe M. T. Alkire and R. J. Haier SHORT COMMUNICATIONS Clonidine decreases propofol requirements during anaesthesia: effect on bispectral index 565 Intrapartum epidural catheter migration: a comparative S. B. Fehr, M. P. Zalunardo, B. Seifert, K. M. Rentsch, study of three dressing applications R. G. Rohling, T. Pasch and D. R. Spahn S. M. Burns, C. M. Cowan, P. M. Barclay and R. G. Wilkes Peri-operative risk factors for acute lung injury after Choice of opioid for initiation of combined spinal elective oesophagectomy epidural analgesia in labour—fentany] or diamorphine S. Tandon, A. Batchelor, R. Bullock, A. Gascoigne, D. J. A. Vaughan, N. Ahmad, N. K. Lillywhite, N. Lewis, M. Griffin, N. Hayes, J. Hing, I. Shaw, I. Warnell and D. Thomas and P. N. Robinson S. V. Baudouin Comparison of pattern of breathing with other measures 3 BOOK REVIEWS of induction of anaesthesia, using propofol, methohexital, and sevoflurane ERRATUM T. L. Strickland and G. B. Drummond Uptake of isoflurane during prolonged clinical anaesthesia S. K. Pal, G. G. Lockwoaondd D. C. White Effects of dexmedetomidine on adrenocortical function JUNE and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in EDITORIALS the intensive care unit 7 43 ‘I. Circulating volume and clinical assessment of the R. M. Venn, A. Brvant, G. M. Hall and R. M. Grounds circulation Does the optimization of cardiac output by fluid loading M. Palazzo increase splanchnic blood flow 1 \ momentary pause S. G. Sakka, K. Reinhart and A. Meier-Hellmann VU 1. Groppe 663 Amrinone can accelerate the cooling rate of core III. Is it safe to artificially ventilate a paralysed patient temperature during deliberate mild hypothermia for through the laryngeal mask? The jury is still out neurosurgical procedures G. Sidaras and J. M. Hunter S. Inoue, M. Kawaguchi, T. Sakamoto, T. Iwata Y. Kawaraguchi, H. Furuyanad T. Sakaki CLINICAL INVESTIGATIONS 669 Autologous blood transfusion in total knee replacement 154 Clinical evaluation of circulating blood volume in surgery critically ill patients—contribution of a clinical scoring D. Thomas, K. Wareham, D. Cohen and H. Hutchings system 674 Double-blind comparison of ropivacaine 7.5 mg ml’ with F. Stépha“ae n, A. gies” Flahault, N. Dieudonné, J. Hollande bupivacaine 5 mg ml” for sciatic nerve block F. Paillard and F. Bonnet C. Connolly, D. M. Coventry and J. A. W. Wildsmith 3 Recovery after remifentanil and sufentanil for analgesia and sedation of mechanically ventilated patients after 678 Rocuronium: high risk for anaphylaxis? M. Rose and , M. Fisher t§. raSolutémsza,O r maA.j oBriS edlseeurr, g eryM . Silomon, I. Schépflin and LABORATORY INVESTIGATIONS G. P. Molter 683 Effects of haemoglobin-based oxygen carrier Hemoglobin 769 Monitoring level of sedation with bispectral EEG glutamer-200 (bovine) on intestinal perfusion and analysis: comparison between hypothermic and oxygenation in a canine hypovolaemia model normothermic cardiopulmonary bypass B. Driessen, J. S. Jahr, F. Lurie, 8. M. Griffey and D. Schmidlin, P. Hager and E. R. Schmid R. A. Gunther yf Inspiratory timing during anaesthesia: a model of 693 Tissue/blood and tissue/water partition coefficients for cardioventilatory coupling propofol in sheep D. C. Galletly and P. D. Larser B. M. Q. Weaver, G. E. Staddon and W. W. Mapleson 7 Survey of cancellation rate of hypertensive patients Antinociceptive properties of neurosteroids III undergoing anaesthesia and elective surgery experiments with alphadolone given intravenously P.> Dixs an. d j S. Howsaee ll iy intraperitoneally, and intragastrically 7 Oesophageal Doppler monitoring overestimates cardiac R. Nadeson and C. S. Goodchild output during lumbar epidural anaesthesia H. A. Leather and P. F. Wouters REVIEW ARTICLE The lumbar epidural space in pregnancy: visualization by 709 Hormone replacement therapy (HRT) and anaesthesia ultrasonography D. Brighouse IT’. Grau, R. W. Leipold, J. Horter, R. Conradi, E. Martin CCAASSEE REPORTSS and l J. Moottsscclh 471177 Abnormal pupillary activity in a brainstem-dead patient Spii nal anaersetrhee sia for Caegsareeans section with bu—p_iv—ac aine . ; 5 mg ml" in glucose 8 or 80 mg ml D. Shlugman, M. Parulekar, J. S. Elston and A. Farmery pagers é Subdural haematoma after dural puncture headache C. Connolly, G. A. McLeod and J. A. W. Wildsmith treated by epidural blood patch Does prior administration of enoxaparin influence the J. M. Davies, A. Murphy, M. Smith and G. O'Sullivan effects of levobupivacaine on blood clotting Assessment : using the Thrombelastograph Incremental spinal anaesthesia for elective Caesarean S. A. Leonard. A. Lydon. M. Walsh. C. Flemine. J. Bovlan section in a patient with Eisenmenger’s syndrome and G, D. Shorten P. J. Cole, M. H. Cross and M. Dresner Infusion of amino acid enriched solution hastens recovery Undiagnosed myasthenia gravis unmasked by from neuromuscular block caused by vecuronium neuromuscular blockade Y. Saitoh, K. Kaneda, Y. Tokunagaan d M. Murakawa M. F. Dunsire, S. G. Clarke and J. J. Stedmon What can be expected from risk scores for predicting Haemodynamic changes during retroperitoneoscopic postoperative nausea and vomiting? adrenalectomy for phaeochromocytoma C. C. Apfel, P. Kranke, C.-A. Greim and N. Roewer F. Atallah, T. Bastide-Heulin, M. Soulié, F. Crouzil, : : . tas Downward movement of syringe pumps reduces syringe A. Galiana, K. Samii and C. Virenque output H. Kern, A. Kuring, U. Redlich, U. R. Dépfmer CORRESPONDENCE N. M. Sims, C. D. Spies and W. J. Kox British Journal of Anaesthesia LABORATORY INVESTIGATIONS Influence of sepsis on sevoflurane minimum alveolar concentration in a porcine model B. Allaouchiche, F. Duflo, J.-P. Tournadre, R. Debon and D. Chassard Halothane potentiates effect of methamphetamine and nomifensine on extracellular dopamine levels in rat striatum: a microdialysis study Y. U. Adachi, K. Watanabe, T. Satoh and E. S. Vizi Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart D. Ebel, P. Lipfert, J. Frafdorf, B. Preckel., J. Miillenheim, V. Théimer and W. Schlack Propofol inhibits FMLP-stimulated phosphorylation of p42 mitogen-activated protein kinase and chemotaxis in human neutrophils T. Nagata, M. Kansha, K. lrita and S. Takahashi REVIEW ARTICLE 859 Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold—Jarisch reflex S. M. Kinsella andJ . P. Tuckey SHORT COMMUNICATIONS 869 Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents T. F. Zatman, J. E. Hall and M. Harmer Effect of intravenous magnesium on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers §. Mikkelsen, J. Dirks, P. Fabricius, K. L. Petersen, M. C. Rowbotham andJ . B. Dahl Orally administered clonidine significantly reduces pain during injection of propofol T. Yoshikawa, Z. Wajima, A. Ogura, T. Inoue and R. Ogawa Efficacy of varying concentrations of hyaluronidase in peribulbar anaesthesia C. Mantovani, A. E. Bryant and G. Nicholson Midazolam versus propofol for reducing contractility in fatigued canine diaphragm Y. Fujii and H. Tovooka REPORTS Xenon anaesthesia for laparoscopic cholecystectomy in a patient with Eisenmenger’s syndrome J. Hofland, I. Giiltuna and R. Tenbrinck Respiratory failure after tracheal extubation in a patient with halo frame cervical spine immobilization—rescue therapy using the Combitube airway M. Mercer Intramuscular ketamine in a parturient in whom pre-operative intravenous access was not possible W. C. Lum Hee and V. F. Metias Cranial subdural haematoma after spinal anaesthesia R. Acharya, S. S. Chhabra, M. Ratra and A. D. Sehgal 896 CORRESPONDENCE 905 BOOK REVIEWS 909. INDEX TO VOLUME 8&6 ees iese ae e