BREAST CANCER: BIOLOGICAL AND CLINICAL PROGRESS Developments in Oncology 49. K.H. Hollmann and J.M. Verley (eds.): New Frontiers in Mammary Pathology. 1986 ISBN 0-89838-852-X 50. DJ. Ruiter, GJ. Fleuren and S.O. Wamaar (eds.): Application ofM onoclonal Antibodies in Tumor Pathology. 1987 ISBN 0-89838-853-8 51. A.H.G. Paterson and A.W. Lees (eds.): Fundamental Problems in Breast Cancer. 1987 ISBN 0-89838-863-5 52. M. Chatel, E Darcel and J. Pecker (eds.): Brain Oncology. Biology, Diagnosis and Therapy. 1987 ISBN 0-89838-954-2 53. M.P. Hacker, J.S. Lazo and T.R. Tritton (eds.): Organ Directed Toxicities ofA nticancer Drugs. 1988. ISBN 0-89838-356-0 54. M. Nicolini (ed.): Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. 1988 ISBN 0-89838-358-7 55. J.R. Ryan and L.O. Baker (eds.): Recent Concepts in Sarcoma Treatment. 1988 ISBN 0-89838-376-5 56. M.A. Rich, J.C. Hager and D.M. Lopez (eds.): Breast Cancer. Scientific and Clinical Aspects.1988 ISBN 0-89838-387-0 57. B.A StoU (ed.): Women at High Risk to Breast Cancer. 1989 ISBN 0-89838-416-8 58. M.A. Rich, J.C. Hager and I. Keydar (eds.): Breast Cancer. Progress in Biology, Clinical Management and Prevention. 1989 ISBN 0-7923-0507-8 59. P.I. Reed, M. Carboni, BJ. Johnston and S. Guadagni (eds.): New Trends in Gastric Cancer. Background and Videosurgery. 1990 ISBN 0-7923-8917-4 60. H.K. Awwad: Radiation Oncology: Radiobiological and Phsyiological Perspectives. The Boundary-Zone between Clinical Radiotherapy and Fundamental Radiobiology and Physiology.1990 ISBN 0-7923-0783-6 61. J.L. Evelhoch, W. Negendank, F.A. Valeriote and L.H. Baker (eds.): Magnetic Resonance in Experimental anii Clinical Oncology. 1990 ISBN 0-7923-0935-9 62. B.A. StoU (ed.): Approaches to Breast Cancer Prevention. 1991 ISBN 0-7923-0995-2 63. MJ. Hill and A. Giacosa, (eds.): Causation and Prevention ofH uman Cancer. ISBN 0-7923-1084-5 64. J.R.W. Masters (ed.): Human Cancer in Primary Culture. A Handbook. 1991 ISBN 0-7923-1088-8 65. N. Kobayashi, T. Akera and S. Mizutani (eds.): Childhood Leukemia. Present Problems and Future Prospects. 1991 ISBN 0-7923-1138-8 66. P. Paoletti, K. Takakura, M.D. Wa1ker, G. Butti and S. Pezzotta (eds.): Neuro-oncology. 1991 ISBN 0-7923-1215-5 67. K.V. Honn, LJ. Mamett, S. Nigam and T. Walden Jr. (eds.): Eicosanoids and Other Bioactive Lipids in Cancer and Radiation lnjury. 1991 ISBN 0-7923-1303~8 68. EA. Valeriote, T.H. Corbett and L.H. Baker (eds.): Cytotoxic Antican(;er Drugs: Models and Concepts for Drug Discovery and Development. 1992 ISBN 0-7923-1629-0 SPRINGER SCIENCE+BUSINESS MEDIA, LLC BREAST CANCER: BIOLOGICAL ANO CLINICAL PROGRESS Proceedings of the Conference of the International Association for Breast Cancer Research, st. Vincent, Aosta Valley, Italy, May 26-29, 1991 Edited by: L. Oogliotti A. Sapino G. Bussolati ~. Springer Science+Business Media, LLC " Library of Congress Cataloging-in-Publication Data International Association for Breast Cancer Research. Conference (1991: Saint-Vmcent, ltaIy) Breast cancer: biological and clinical progress : proceedings of the Conference of the International Association for Breast Cancer Research, SI. Vmcent Aosta Valley, Italy, May 26-29, 1991/ edited by L. Dogliotti, A. Sapino, G. Bussolati. p. cm. - (Developments in oncology ; 69) ISBN 978-1-4613-6549-5 ISBN 978-1-4615-3494-5 (eBook) DOI 10.1007/978-1-4615-3494-5 1. Breast-Cancer-Congresses. 1. Dogliotti, Luigi. ll. Sapino, A. ill. Bussolati, G. IV. TItle. V. Series. [DNI.M: 1. Breast NeopIasms-pathology-congresses. 2. Breast Neoplasms-physiopathology-congresses. 3. Breast Neoplasms- -therapy-congresses. WI DE998N v. 69/ WP 870 1578b 1991] RC280.B8I54 1991 616.99'449-dc20 DNI.MlDLC for Library of Congress 92-7660 CIP Copyright © 1992 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 1992 Softcover reprint ofthe hardcover lst edition 1992 AlI rights reserved. No pari of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Springer Science+Business Media, LLC. CONTENTS Contributors ix Preface xvii I. ACTIVATION OF CELLULAR ONCOGENES 1 1. The Role of Oncogenes and Onco-Suppressor Genes in Human Breast Cancer. 3 D.A. Spandidos 2. Expression of the MET Oncogene in Human Tumors 11 M.F. Di Renzo, M. Prat, M. Olivero, T. Crepaldi, and P.M. Comoglio 3. c-erbB-2, a Tyrosine Kinase Growth Factor Receptor and its Role in Breast Cancer 23 F.J. Lofts and w.J. Gullick 4. Mammary Morphogenesis and Oncogenes 41 R.D. Cardiff, D. Ornitz, F. Lee, R. Moreadith, E. Sinn, W. Muller, and P. Leder II . POLYPEPTIDES AND GROWTH FACTORS EXPRESSION 57 5. Interdependence of Hormones and Growth Factors in Lobulo-Alveolar Development of the Mammary Gland and Tumorigenesis 59 B.K. Vonderhaar and K. Plaut VI 6. The Role of Estrogen Regulated Secreted Proteins for Growth Regulation of Human Breast Cancer 81 A. Lykkesfeldt, I. Laursen, and P. Briand 7. The Prolactin-Inducible Protein I Gross Cystic Disease Fluid Protein (PIP/GCDFP-15): Genetic Analysis and Hormonal Regulation of Gene Expression 93 R.P.G. Shiu, Y. Myal, D. Tsuyuki, D. Robinson, B. Iwasiow, A. Yarmill, and P. Watson III. MAMMARY EPITHELIUM AND STROMA IN VIVO AND IN 103 VITRO 8. Role of RAS Oncogene in Human Breast Cancer: an Experimental Approach 105 J. Russo, G. Galaf, J. Ochieng, I.H. Russo, Q. Tahin, and P. -L. Zhang 9. Interactions Between Malignant and Non-Malignant Components of the Breast 119 WR. Miller 10. Involvement of Heparanase and Extracellular Matrix-Bound Fibroblast Growth Factor in Tumor Progression 137 I. Vlodavsky, R. Ishai-Michaeli, M. Mohsen, G. Korner, and R. Gatane Vll IV. HORMONE RESPONSIVENESS AND ORAL CONTRACEPTIVES 151 11. Estrogen and Progesterone Receptor Activity in Breast Cancer Cells 153 S. Bettuzzi, A. Robinson, R. Fuchs-Young, and G. Greene 12. Oral Contraceptives and Breast Cancer: the Scope for a Hypothesis-Oriented Approach 169 C. La Vecchia V. RISK FACTORS; MONITORING OF BREAST CANCER PROGRESSION AND REGRESSION 179 13. Benign Breast Disease: Links to Risk of Cancer 181 D.L. Page and W. D. Dupont 14. Proliferation Rate in Different Cell Types in Benign Breast Disease 195 A. Sapino, L. Macri, P. Gugliotta, C. Manini, and G. Bussolati 15. Aspects of Cell Mediated Immunity in Monitoring Breast Cancer 207 U. Koldovsky 16. New Approaches to the Study of Selenium's Chemopreventive Properties 225 D. Medina, R. Mukhopadhyay, and M. Bansal Vlll VI. BIOLOGICAL FACTORS OF PROGNOSIS; THE METASTATIC PHENOTYPE 233 17. Cell Kinetics as an Indicator for Prognosis and Therapy 235 R. Silvestrini 18. Cathepsin D and Breast Cancer Metastasis: Biological and Clinical Significance 243 M. Garcia, G. Capony, and H. Rochefort 19. Diagnostic tools and prognostic factors in human breast cancer evaluated by morphological and immunohistochemical methods 255 A. Schauer, D. Marx, I. Lipp, M. Schumacher, W. Sauerbrei, H. Rauschecker, and R. Sauer VII.THERAPEUTIC STRATEGIES IN BREAST CANCER TREATMENT 277 20. Oestrogen-Deprivation in Breast Cancer: Clinical and Experimental Observations 279 R.I. Nicholson and D.L. Manning 21. Polyamines and Growth Factors as Possible Targets for Antitumor Therapy in Breast Cancer 291 A. Manni 22. New Diagnostic Methods and Treatment Modalities in Breast Cancer 301 J.G.M. Klijn, P.M.J.J. Berns, M. Bontenbal, J. Alexieva-Figusch, and J.A. Foekens CONTRIBUTORS J. Alexieva-Figusch, Dept. of Medical Oncology, The Dr. Daniel den Hoed, Cancer Center, PO Box 5201, 3008 AE Rotterdam, The Netherlands M. Bansal, Dept. of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston, Texas 77030, USA P.M.J.J. Berns, Dept. of Medical Oncology, The Dr. Daniel den Hoed, Cancer Center, PO Box 5201, 3008 AE Rotterdam, The Netherlands S. BeUuzzi, Universita di Modena, Istituto Chimica Biologica, 41100 Modena, Italy M. Bontenbal, Dept. of Medical Oncology, The Dr. Daniel den Hoed, Cancer Center, PO Box 5201, 3008 AE Rotterdam, The Netherlands P. Briand, Lab. of Tumor Endocrinology, The Fibiger Institute, The Danish Center Society, DK- 2100, Conpenhagen, Denmark G. Bussolati, Dept. of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Torino, Italy G. Calaf, Dept. of Pathology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA G. Capony, Universite de Montpellier, INSERM U 148, 60 rue de Navacelles, 34100 Montpellier Cedex, France x R.D. Cardiff, Department of Pathology, University of California Medical School, Room 3453, Med. Sci. 1-A, Davis, CA 95616, USA R. Catane, Dept. Radiation and Clinical Oncology, Hadassah University Hospital, Jerusalem, 91120 Israel P. Comoglio, Dept. Biomedical Sciences, C.so Massimo d'Azeglio 52, 10126 Torino, Italy T. Crepaldi, Dept. Biomedical Sciences, C.so Massimo d'Azeglio 52, 10126 Torino, Italy M.F. Di Renzo, Dept. Biomedical Sciences, C.so Massimo d'Azeglio 52, 10126 Torino, Italy W.O. Dupont, Dept. of Pathol. and Preventive Medicine, Vand erbilt, University Medical Center, C-3321, Nashville, Tennessee 37232, USA J.A. Foekens, Dept. of Medical Oncology, The Dr. Daniel den Hoed, Cancer Center, PO Box 5201, 3008 AE Rotterdam, The Netherlands R. Fuchs-Young, The Ben May Lab. for Cancer Research, 950 East 59th Street, Chicago, Illinois 60637, USA M. Garcia, Universite de Montpellier, INSERM U 148, 60 rue de Navacelles, 34100 Montpellier Cedex, France G. Greene, The Ben May Lab. for Cancer Research, 950 East