Biotechnology Bioengineering INDEX TO VOLUME 71 Biotechnology and Bioengineering Editor Douglas S. Clark ers Associate Editors Editorial Board lames D. Brvers e R lames E. Bailey Maria-Regina Kul FF CTH _Viirich _H I, if uric riety Uf der KFA Jiilich, Ger PaInuilviernsei ty Doran | Douglas A. Lauttenburger \ ulty ! é ‘ ‘ I tut } | Pp IPOUTSAKIkS , , ava ; i , Citta le Bernhard “ Pal| sso sao K arube Todd M. Przyvbycien ersit | irned V1 } miper : 00. 2 lohn Villadsen 7 lechbnical U Founding Editor: Elme: Postmaster Advertising Sales Reprints Manuscripts All Other Correspondence Subscription Price Editorial Production, John Wiley *, This paper meets the requirement of ANSI/NISO Z39.48-1992 (Permanence of Paper Biotechnology and Bioengineering Combined Author Index to Volume 71 This index covers Combinatorial Chemistry and Biotechnology and Bioengineering issues, for Volume 71, 2000/2001. The Issue in which a Combinatorial Chemistry item appears is indicated by a C, following the page number. Aslan, D.C. See Wipf, P., 58¢ de Miguel, Y.R. Hubel, A. Shearer, A.S Infrared Spectroscopy in Conroy, M.: Darr, T.B Influence of Solid-Phase Synthesis, 1 19¢ Preculture on the Prefreeze and Bakiené, E. See Daugelavicius, R., 2 Dhanoa, D.S. See Wu, Z., 87¢ Postthaw Characteristics of Hepatocy Bamford, D.H. See Daugelavicius Dice, T.A. See South. M.S., 51¢ 173 Bandel, H. See Schmid, D.G., 149¢ Dixon, C.E. See Organ, M.G., 71¢ Berzinskiené, J. See Daugelavicius, R., 208 Borth, N. Ikebukuro, K. See Oyama, M., 2 Zeyda, M Katinger, H.: Efficient Edwards, J.S. See Schilling, ¢ Ikeda, T. See Oyama. M.. 217 Selection ¢ f High-Producing Subclones Ewing, B. See Xiao, X.-Y., 44¢ During Gene Amplification of Jerome, K.D. See Hamper B.C... 28¢ Recombinant Chinese Hamster Ovary Fang, L. Jung, G. See Schmid, D.G., 149¢ Cells by Flow Cytometry and Cell Pan, J.: Yan, B.: High-Throughput Sorting, 266 Determination of Identity, Purity, and Bray, A.M. See Bui, C.T., 91¢ Quantity of Combinatorial Library Karube, I. See Oyama, M.. 21 Karunaratne, K. See Xiao, X.-Y., 444 Brown, R. See Xiao, X.-Y., 44¢ Members Using LC/MS/UV/ELSD Katinger, H. See Borth, N., 266 Bui, C.T. 162¢ Kay, C. Maeji, N.J.: Bray, A.M.: Novel Feng, Y. a-Hydroxyethyl-Polystyrene Burgess, K.: Resin Effects In Solid Lorthioir, O.E.; Parr, N.J.: Cong a-Chloroethyl-Polystyrene and Phase S,Ar and S ? Macrocyclizations M.: McKeown, S.( Scicinski Ley. S.V.: Solid-Phase Reaction onx -Atmhei noM-uolxtyieptihny™l -PSoollyisd tySruepnpeo rt Lifnokr ers Ferna4(n dez, E.J. See Tobler, S.A Monitoring—Chemical Derivatiza Solid-Phase Organic Synthesis, 91¢ Freedman, D.L. See Verce, M.I and Off-Bead Analysis, | 10( Kim, J. See Wu, Z.. 87¢ Burgess, K. See Feng. Y.. 3¢ Freitag, R. See Garret-Flaudy. | Kim, N.S. Friichtel, J.S. Lee, G.M Overexpression of be Chen, C. See Munoz, B., 78¢ Pflugseder, K.: Gstach, H Symmetric Inhibits Sodium Butyrate-Induced Chott, R.C. See Hamper, B.C., 28¢ Building Blocks and Combinatorial Apoptosis in Chinese Hamster Ovary Functional Group Transformation as Congreve, M. See Kay, C., 1 100 Cells Resulting in Enhanced Humanized Conroy, M. See Hubel, A Versatile Strategies in Combinatorial Antibody Production, 184 Chemistry, 94¢ Correll, M.J. Kulkarni, B.A. See Li, Z., 104¢ Wu, Y.: Weathers, P.J.: Controlling Hyperhydration of Carnations (Diant Ganesan, A. See Li, Z., 104¢ Labadie, J.W. See Porco, J.A.. Jr caryophyllus L.) Grown in a Mist Gao, C. Lazo, J.S. See Wipf. P.. 58¢ Reactor, 307 Mayon, P.: MacManus, D.A.: Vulfson Lee, G.M. See Kim, N.S.. 184 Crespo, J.G. See Velizarov, S., 245 E.N.: Novel Enzymatic \pproach to the Letscher, D. See Schilling, C.H Crundwell, F.K. Synthesis of Flavonoid Glycosides and Leung, S.S.W. See Yun. Y.K Modeling Simulation and Optimization Their Esters, 235 Ley, S.V. See Kay. C., 1100 of Bacterial Leaching Reactors, 25 Garret-Flaudy, F. Li, R. See Xiao, X.-Y., 44 Freitag, R.: Use of the Avidin is, Zz. Darr, T.B. See Hubel. A.. 17 (Imino)biotin System as a General Kulkarni, B.A.: Ganesan, A.: A Selenide Daugelavicius, R. Approach to Affinity Precipitation Linker for “Traceless” Solid-Phase Gounarides, J.S. See Shapiro, M.J., 130 Organic Synthesis, 104¢ Bakiene, | BerZinskiene, J.: Bamtord Grosche, P. See Schmid. D.G.. 149¢ Lillig, J. See Xiao. X.-Y., 44¢ D.H.: Use of Lipophilic Anions for Gstach, H. See Friichtel, J.S.. 94¢ Lim, T.-k. See Oyama, M., 217 Estimation of Biomass and Cell Viability, 208 Lorthioir, O.E. See Kay. ¢ Davis, P.W. Hamper, B.C. Luci, D.K. See Wipf. P Swayze Ef Automated Solid-Phase Jerome, K.D.: Yalamanchili, G Walker Synthesis of Linear Nitrogen-Linked D.M.: Chott, R.C.: Mischke, D.A MacManus, D.A. See Gao. ¢ Compounds, 19¢ Synthesis of Highly Substituted Maeji, N.J. See Bui, C.T., 91¢ de Miguel, Y. 5-(Trifluoromethy] )ketoimidazoles Using Marchioro, C. See Missio, A.. 38¢ Analytical Methods for the i Mixed-Solid/Solution Phase Mout Masuda, Y. See Oyama. M 17 Combinatorial Sciences, 109¢ 2> s Mayon, P. See Gao, C.. 2 35 Biotechnology and Bioengineering, Vol. 71, Pp. 317-318 (2000/2001) McDonald, L.A. See Munoz, B., 78C Reis, M.A. See Velizarov, S., 245 Removal in an lon Exchange Membrane McKeown, S.C. See Kay, C., 1 10C Rodrigues, C.M. See Velizarov. S., 245 Bioreactor: Drinking Water Mischke, D.A. See Hamper, B.C., 28€ Rossi, T. See Missio, A., 38C Dentrification, 245 Missio, A. Verce, M.F. Marchioro, C.; Rossi, 1 Panunzio, M.: Schilling, C.H. ; Freedman, D.L.: Modeling the Kinetics Selva, S.; Seneci, P Polymer-Supported . Edwards, J.S.; Letscher, D.; Palsson, of Vinyl Chloride Cometabolism by an Silyl Cyanide and Silyl Azide: Useful B.0.: Combining Pathway Analysis with Ethane-Grown Pseudomonas sp., 274 Reagents for Solid-Phase Applications, Flux Balance Analysis for the Vulfson, E.N. See Gao, C., 235 IRC Comprehensive Study of Metabolic Munoz, B. Systems, 286 Walker, D.M. See Hamper, B.C., 28¢ : Chen, C.: McDonald, LA.: Resin Schmid, D.G. Weathers, P.J. See Correll, M.J., 307 Activation Capture Technology ; Grosche, P.; Bandel, H.; Jung, G Wipf, P. Libraries from Stabilized FTICR-Mass Spectrometry for ; Aslan, D.C.; Luci, D.K.; Southwick, Acyl-Pyridinium on Solid Support, 78C High-Resolution Analysis in E.C.; Lazo, J.S.: Synthesis and Combinatorial Chemistry, 149¢ Biological Evaluation of a Targeted Scicinski, J.J. See Kay, C., 110C Library of Protein Phosphatase Nicolaou, K.C. See Xiao, X.-Y., 44C Selva, S. See Missio, A., 38C Inhibitors, 58C Seneci, P. See Missio, A., 38C Wu, Y. See Correll, M.J., 307 Organ, M.G. Shapiro, M.J. Wu, Z. ; Dixon, C.E.: The Preparation of ; Gounarides, J.S.: High Resolution : Kim, J.; Soll, R.M.; Dhanoa, D.S Amino-Substituted Biary! Libraries: The MAS-NMR in Combinatorial Chemistry, Solid-Phase Synthesis of 130C Application of Solid-Supported 2,4-Diaminoquinazolines, 87C Shearer, A.S. See de Miguel, Y.R., 119C Reagents to Streamline Solution-Phase Sherman, N.E. See Tobler, S.A., 194 Synthesis, 71C Xiao, X.-Y. Soll, R.M. See Wu, Z., 87C Oyama, M. ; Li, R.; Zhuang, H.; Ewing, B.:; South, M.S. Ikeda, T.; Lim, T.-k.; Ikebukuro, K.; Karunaratne, K.; Lillig, J.; Brown, R.: ; Dice, T.A.; Parlow, J.J Masuda, Y.; Karube, I.: Detection of Toxic Chemicals with High Sensitivity Polymer-Assisted Solution-Phase CNoimcoblianoaut,o riKa.lC. : SySnotlhieds-iPsh asUes ing by Measuring the Quantity of Induced (PASP) Library Synthesis of MicroKan Reactors, Rf Tagging, and P450 mRNAs Based on Surface a-Ketoamides, 51¢ Directed Sorting, 44C Southwick, E.C. See Wipf, P.. 58C Plasmon Resonance, 217 Swayze, E.E. See Davis, P.W., 19C Yalamanchili, G. See Hamper, B.C Palsson, B.O. See Schilling, C.H., 286 lobler, S.A. Yan, B. See Fang, L., 162C Pan, J. See Fang, L., 162¢ ; Sherman, N.E.; Fernandez, E.J Yun, Y.K. Panunzio, M. See Missio, A., 38C Tracking Lysozyme Unfolding During ; Leung, S.S.W.; Porco, J.A., Jr Parlow, J.J. See South, M.S., 51C Salt-Induced Precipitation with Streamlined Synthesis of Substituted Parr, N.J. See Kay, C., 110C Hydrogen Exchange and Mass 2-Aminothiazoles Using Tandem Pflugseder, K. See Friichtel, J.S.. 94C Spectrometry, 194 Precipitative and Polymer-Assisted Porco, J.A., Jr. Reactions, 9C ; Labadie, J.W Polymer Supports for Velizaroy, S. Streamlined Organic Synthesis, 1C ; Rodrigues, C.M.; Reis, M.A.; Crespo, Zeyda, M. See Borth, N., 266 : See Yun, Y.K., 9C J.G.: Mechanism of Charged Pollutants Zhuang, H. See Xiao, X.-Y., 44¢ AUTHOR INDEX Biotechnology and Bioengineering Combined Subject Index to Volume 71 This index covers Combinatorial Chemistry and Biotechnology and Bioengineering issues, for Volume 71, 2000/2001. The Issue in which a Combinatorial Chemistry item appears is indicated by a C, following the page number. a-amino-oxyethyl-polystyrene, 91¢ Glycosidase, 2 Polymer-assisted solution-phase (PASP) a,B-unsaturated ketones, 94C ( ilycosides, 2 35 chemical library synthesis, 51¢ a-chloroethyl-polystyrene, 91C Glycosylation, 235 Polymer-supported cyanohydrins, 38¢ 274 Aerobic, Polymer-supported reagents, 9¢ a-hydroxyethyl-polystyrene, 91C Hepatocyte, 173 Polymer-supported silyl azide, 38¢ a-ketoamides, 51C Heterocyclic synthesis, 9¢ Polymer-supported silyl cyanide, 38¢ Alkylation of sulfonamides, 58¢ High-resolution magic angle-spinning NMR Polymyxin B, 208 Amide coupling, 51¢ 130¢ Protein precipitation, 194 Analytical FT-IR, 119C Human antibody, 266 Pyrimidine synthesis, 94C Apoptosis, 184 Humanized antibody, 184 Atrazine, 217 Hybrid process, 245 Quinazolines, 87¢ Automated preparative chromatography, 28¢ Hydrogen exchange, 194 Automated solid-phase synthesis, 19¢ Radiofrequency tagging, 44€ In vitro culture, 173 Recombinant Chinese hamster ovary (CHO) Bacterial leaching, 255 Infrared analysis, 119C cells, 266 Bcl-2, 184 lon exchange membrane bioreactor, 245 Reductive amination, 58(€ Biaryl, 71C Resin effects, 3¢ Bioconjugates, 227 2 Kinetics, 27 Resin loading determination, | 1 0¢ Bioreactor, 307 Review, 149C Bic separation, 22+3 LCMS purification, 28C RNA-binding molecules, 19C B-turn mimics, 3C List, 223 os Leaching, 255 Saccharomyces cerevisiae ( atechin, 235 Libraries from libraries, 94C Scavenger resins, 9¢ ( ‘de25 dual-specificity phosphatases, 58C Library, 149C Selenides, 104C ( ell sorting, 266 Linear programming, 286 Simulation, 255 ( ell viability, 208 Linker, 91¢ Single bead analysis, 149¢ ( ‘hinese hamster ovary (CHO), 184 Lipase, 235 Single-bead IR, 119C ( ‘laisen-Schmidt reaction 94C Lysozyme, 194 Small molecule libraries 87C ( ‘olor tests, 1 10C 3 At: 3S ( ‘ombinatorial chemistry, 87C, 130C, 149C Macrocyclizations, 3C Sodium butyrate (NaBu), 184 ( ‘ombinatorial functional group Mass spectrometry, 149C, 194 Solid-phase organic chemistry. 130 transformation, 94C Metabolic modeling, 286 Solid-phase organic synthesis, 28¢ ‘ombinatorial library, 119C Metabolic pathways, 286 id-phase reaction, 119C ‘ometabolism, 2~ 74 MicroKan reactor, 44C id-phase reaction monitoring, | 10¢ ‘onformational changes, 194 Micropropagation, 307 id-phase synthesis, 44C, 87C, 91C, 104¢ ( ‘onvex analysis, 286 Modeling, 274 id-phase—solution-phase motif, 28¢ ( ‘ryopreservation, 17 Multi-step library synthesis, 51¢ Solic-supported reagents, 71(€ Solution-phase synthesis, 71¢ 2-D NMR, 130C Nitrogen-linked compounds, 19C Split & pool, 44C Denitrification, 245 Nucleic acid sequence-based amplification Stimulus-responsive material, 223 Diffusion-weighted MAS-NMR, 130C (NASBA), 217 Supersaturated solutions, 235 Directed sorting, 44C Surface plasmon resonance (SPR), 217 Donnan dialysis, 245 On-resin reaction monitoring, | 30( Symmetric building blocks, 94¢ Drinking water, 245 Optimization, 255 Drug discovery, 87C Oxidation modeling, 255 Tandem reactions, 71¢ TFMK imidazoles, 28C E nvelope permeability, 208 P450 14DM, 217 Thermoprecipitation, 223 E thane, 274 Parallel precipitation, 9C Traceless linkers, 104C Parallel synthesis, 9C, 44C, 7 Transesterification, 235 Feed rate, 307 Periodinane oxidation, 51C rrifluoromethylketoimidazoles, 28¢ }- lavonoid, 235 Phenyldicarbaundecaborane, 208 F lavonoid glycosides, 235 Phosphatase inhibitors, 58C Vinyl chloride, 274 Flux balance analysis, 286 Polymer support, 119C I TICR-MS, 149C Polymer-assisted reactions, 9C Wang resin, 58C Biotechnology and Bioengineering, Vol. 71 , P. 319 (2000/2001)