Lecture Notes in Bioinformatics 6620 Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong Subseries of Lecture Notes in Computer Science Ana T. Freitas Arcadi Navarro (Eds.) Bioinformatics for Personalized Medicine 10th Spanish Symposium, JBI 2010 Torremolinos, Spain, October 27-29, 2010 Revised Selected Papers 13 Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Ana T. Freitas INESC-ID/Instituto Superior Técnico R. Alves Redol 9 1000-029 Lisboa, Portugal E-mail: Preface This volume contains the papers presented at JBI 2010: the 10th Spanish Symposium on Bioinformatics held in Torremolinos, M´alaga, Spain, during October 27–29, 2010. After 10 years of conferences (the JBI conference series was started in 2000) JBI 2010 centered on the topic “Bioinformatics for Person- alized Medicine” and was hosted by the University of Ma´laga, co-organized by the National Institute of Bioinformatics, Spain and the Portuguese Bioinformat- ics Network chaired by Oswaldo Trelles, Arcadi Navarro, Federico Mor´an and Pedro Fernandes and took place in the Hotel Son Don Pablo, at Paseo Mar´ıtimo, Torremolinos. This year, 18 papers were accepted for presentation out of more than 100 submissions. The papers presented were selected by the Program Committee (PC) assisted by a number of external reviewers. Each paper was reviewed by two members of the PC, or by external reviewers. JBI 2010 also introduced a Highlights Track, in which eight additional presentations were chosen from jour- nal papers published in 2009 or 2010. This made a total of 26 presentations. Authors were invited to submit a revised version of their work to be considered for publication in Lecture Notes in Bioinformatics after a second reviewing pro- cess by independent reviewers. This volume contains the papers that were finally selected. JBI 2010 invited several distinguished speakers as keynotes and for special sessions on Genomic Projects Design: Success Cases, Bioinformatics Challenges in Personalized Medicine, Bioinformatics Software Developments in Spain and Beyond, and Options and Priorities in Hands-On Training in Spain and Portugal. A special session to present the status of the ELIXIR ESFRI project also took place. Invited speakers and special sessions organizers included Ivo Gut (National Genome Analysis Center Barcelona), Sara Hunter (EMBL-EBI Hinxton), Julio Saez Rodriguez (EMBL Outstation - Hinxton, European Bioinformatics Insti- tute), Victoriano Valpuesta Ferna´ndez (University of Ma´laga), Alfonso Valencia (Centro Nacional de Investigaciones Oncolo´gicas), Jos´e Pereira Leal (Instituto Gulbenkian de Ciˆencia), Fernando Martin-Saˆnchez (Instituto de Salud Carlos III), Pedro Fernandes (Instituto Gulbenkian de Ciˆencia), Jose Mar´ıa Ferna´ndez (Centro Nacional de Investigaciones Oncolo´gicas), Jose Ramon Valverde (Centro Nacional de Biotecnologia), Victoria Mart´ın-Requena (Universidad de Ma´laga), Maximiliano Garc´ıa (Universidad de Ma´laga) and Allan Orozco (Centro Nacional de Investigaciones Oncol´ogicas). JBI 2010 was only possible through the dedication and hard work of many individuals and organizations. Special thanks go to the PC and external re- viewers for helping to improve the quality of the conference program, and the Organizing Committee, namely its Chair Oswaldo Trelles, for hosting the con- ference and providing the administrative, logistic, and financial support. We also VI Preface thank our sponsors, including the INB (Instituto Nacional de Bioinforma´tica), Bitlab (Bioinformatics and Information Technology Laboratory), Universidad de Ma´laga, Instituto de Salud Carlos III, Portuguese Bioinformatics Network, Life Sequencing, Integromics, UNIA, SEBIOT and Combiomed. Without them the conference would not have been financially viable. Finally, we thank all the authors who contributed papers and posters, as well as the attendees of the conference for their enthusiastic participation. May 2011 Anna Teresa Freitas Arcadi Navarro Conference Organization Honorary Committee Jos´e Antonio Grin˜a´n Mart´ınez (President of Andaluc´ıa) Francisco de la Torre (Mayor of Ma´laga, Spain) Pedro Ferna´ndez Montes (Mayor of Torremolinos, Spain) Adelaida de la Calle Mart´ın (Chancellor, University of Malaga, Spain) Scientific Committee Chairs Alfonso Valencia Centro Nacional de Investigaciones Oncol´ogicas Ana Teresa Freitas INESC-ID/Instituto Superior T´ecnico Committee M. Mar Alba` Universitat Pompeu Fabra Patrick Aloy Institute for Research in Biomedicine Jose Antonio A´ lvarez Universidad de Santiago de Compostela Julio R. Banga Instituto de investigaciones marinas de Vigo Ugo Bastolla Instituto de Investigaciones Biom´edicas Pedro Bernaola Galva´n Universidad de Ma´laga Miguel Blanca Hospital Carlos Haya Christian Blaschke BioAlma Jos´e Luis Caballero Universidad de Co´rdoba Jos´e Mar´ıa Carazo Centro Nacional de Biotecnolog´ıa Pedro Carpena Universidad de Ma´laga Joa˜o Carric¸o Universidade de Lisboa Robert Castelo Universitat Pompeu Fabra Pablo Chaco´n Centro de Investigaciones Biol´ogicas Julio Collados Vides Universidad Nacional Auto´noma de M´exico Ana Conesa Centro de Investigaciones Pr´ıncipe Felipe Francisco Couto Universidade de Lisboa Javier De Las Rivas Universidad de Salamanca Ramon Diaz-Uriarte Spanish National Cancer Centre Joaquin Dopazo Centro de Investigacio´n Pr´ıncipe Felipe Herna´n J. Dopazo Centro de Investigacio´n Pr´ıncipe Felipe VIII Conference Organization Julia´n Dorado Facultad de Humanidades Universidade da Corun˜a Eduardo Eyras ICREA and Universitat Pompeu Fabra Andr´e Falc˜ao Universidade de Lisboa Toni Gabaldon Centre for Genomic Regulation Gian Gaetano Tartaglia Center for Genomic Regulation Juan Antonio Garc´ıa Ranea Universidad de Ma´laga Francesco Gervasio Spanish National Cancer Research Centre Manuel J. Go´mez Centro de Astrobiolog´ıa INTA-CSIC M. Gonzalo Claros Universidad de Ma´laga Antonio Granell Instituto de Biolog´ıa Molecular y Celular de Plantas de Valencia Hugo Gutierrez de Teran Fundacio´n Pu´blica Galega de Medicina Xen´omica Michael Hackenberg Universidad de Granada Fyodor Kondrashov Center for Genomic Regulation Josep Lluis Gelpi Barcelona Supercomputing Center Paulino Go´mez-Puertas Centro de Biolog´ıa Molecular “Severo Ochoa” Nuria Lopez-Bigas Universitat Pompeu Fabra Juan Fernandez-Recio Barcelona Supercomputing Center Antonio Figueras Instituto de investigaciones Marinas Roderic Guigo´ Center for Genomic Regulation Roberto Marabini Universidad Auto´noma de Madrid Antonio Marin Universidad de Sevilla Miguel Angel Medina Torres University of Malaga Jordi Mestres Instituto Municipal de Investigaci´on M´edica Francisco Montero Universidad Complutense de Madrid Antonio Morreale Universidad Auto´noma de Madrid Andr´es Moya University of Valencia Juan Mun˜oz Universidad de Cordoba Arcadi Navarro Universitat Pompeu Fabra Cedric Notredame Centre de Regulacio Genomica Jos´e L. Oliver Universidad de Granada Jos´e Lu´ıs Oliveira Universidade de Aveiro Arlindo Oliveira INESC-ID/Instituto Superior T´ecnico Modesto Orozco Barcelona Supercomputing Center Alejandro Pazos Universidad de A Corun˜a Jos´e Pereira-Leal Instituto Gulbenkian de Ciˆencia Alberto Pascual Montano National Center for Biotechnology Florencio Pazos National Center for Biotechnology Antonio P´erez Pulido Universidad Pablo de Ola´vide Francisco Pinto Universidade de Lisboa Conference Organization IX David G. Pisano Spanish National Cancer Research Centre David Posada Universidad de Vigo Raul Rabadan Columbia University Pedro Reche Universidad Complutense de Madrid Cristian Robert Munteanu Universidade da Corun˜a Isabel Rocha Universidade do Minho Ana M. Rojas Institute for Predictive and Personalized Medicine of Cancer Armindo Salvador Universidade de Coimbra Kika Sa´nchez University of Malaga Javier Sancho Universidad de Zaragoza Ferran Sanz Institut Municipal d’Investigacio´ M`edica Cla´udio M. Soares Instituto de Tecnologia Qu´ımica e Biol´ogica Javier Tamames National Center for Biotechnology Oswaldo Trelles Universidad de Ma´laga Ana Tereza Vasconcelos Universidad Federal do R´ıo de Janeiro Enrique Viguera-M´ınguez Universidad de Ma´laga ordi Villa`-Freixa Universitat Pompeu Fabra Organizing Committee Chairs Pedro Fernandes Instituto Gulbenkian de Ciˆencia Federico Mora´n Universidad Complutense Madrid Arcadi Navarro Universitat Pompeu Fabra Oswaldo Trelles Universidad de Ma´laga Committee Maximiliano Garc´ıa Universidad de Ma´laga Johan Karlsson Universidad de Ma´laga Victoria Mart´ın-Requena Universidad de Ma´laga Alfredo Mart´ınez-L´opez Universidad de Ma´laga Jos´e Manuel Mateos Universidad de Ma´laga Antonio Mun˜oz-M´erida Universidad de Ma´laga Javier R´ıos P´erez Universidad de M´alaga Manuel Gonzalo Claros Universidad de Ma´laga Juan Falgueras Cano Universidad de Ma´laga Enrique Viguera M´ınguez Universidad de Ma´laga Allan Orozco Centro Nacional de Investigaciones Oncolo´gicas X Conference Organization JBI Past Editions Edition Date Organizing Committee I June 14-16, 2000 Universidad Politécnica de Cartagena II 30 May – 1 June, 2001 Universidad de Málaga III September 18-20, 2002 Centro de Investigación del Cancer, Universidad de Salamanca IV September 13-15, 2003 Facultad de Informática de la Universidad de Coruña V 29 November- 2 December, Universitat Politecnica de Catalunya 2004 VI 28 September-2 October, 2005 Centro Nacional de Investigaciones Oncológicas VII November 20-22, 2006 Universidad de Zaragoza VIII February 13-15, 2008 Centro de Investigaciones Príncipe Felipe IX November 2-6, 2009 Instituto Gulbenkian de Lisboa