Biochemistry and Biochimie et Cell Biology biologie cellulaire Contents Sommaire Volume 76, 1998 Volume 76, 1998 Number 1 / numéro 1 REVIEWS / SYNTHESES Terence E. Hébert and Michel Bouvier Structural and functional aspects of G protein-coupled receptor oligomerization Judy E. Anderson Studies of the dynamics of skeletal muscle regeneration: the mouse came back! ARTICLES Jie Pan and Nelly Auersperg Spatiotemporal changes in cytokeratin expression in the neonatal rat ovary Kelly L. Jordan-Sciutto and David J. Hall A mutant E2F-1 transcription factor that affects the phenotype of NIH3T3 fibroblasts inefficiently associates with cyclin A — cdk2 M.S. Ridyard and E.J. Sanders Cellular phenotypic transformation during early embryogenesis: a role for focal adhesion kinase? Pangala V. Bhat, Thomas Bader, Paul Nettesheim, and Anton M. Jetten Differentiation-dependent regulation of retinal dehydrogenase gene expression in the trachea Richard R. Desrosiers, France Gauthier, Wei Lin, and Richard Béliveau Guanine nucleotides protect Rho proteins from en- dogenous proteolytic degradation in renal membranes Hayfa A. Al-Mazidi, Leonard P. Kleine, and Douglas J. Franks The presence of an unusual PKC isozyme profile in rat liver cells Janice Mayne and John J. Robinson The sea urchin egg yolk granule is a storage compartment for HCL-32, an extracellular matrix protein Jing Zheng, Dale A. Redmer, S. Derek Killilea, and Lawrence P. Reynolds Characterization of heparin-binding endothelial mitogen(s) produced by the ovine endometrium during early pregnancy P.M. Ouimet and M. Kapoor Analysis of complex formation between Hsp80 and Hsp70, cytosolic molecular chaperones of Neurospora crassa, by enzyme-linked immunosorbent assays (ELISA) C. Stan Tsai and Q. Chen Purification and kinetic characterization of hexokinase and glucose-6-phosphate dehydrogenase from Schizosaccharomyces pombe Bartholomew A. Pederson, James D. Foster, and Robert C. Nordlie Low-X,, mannose-6-phosphatase as a criterion for microsomal integrity Huizhou Fan, Cristy Villegas, Arthur K. Chan, and Jim A. Wright Myc-epitope tagged proteins detected with the 9E10 anti- body in immunofluorescence and immunoprecipitation assays but not in Western blot analysis Kha D. Dang, Previn B. Dutt, and Donald R. Forsdyke Chargaff difference analysis of the bithorax complex of Drosophila melanogaster NOTE Paulo Caseiro Alves and Arnaldo Videira The membrane domain of complex I is not assembled in the stopper mutant E35 of Neurospora Instructions to Authors Recommendations aux auteurs Biochem. Cell Biol. Vol. 76, 1998 Number 2/3 / numéro 2/3 Thematic issue / Numéro thématique Canadian biological NMR spectroscopy Spectrocopie de RMN biologique au canada Introduction Brian D. Sykes and Hans J. Vogel Protein NMR methods / Méthodes de RMN protéique Lewis E. Kay Protein dynamics from NMR David S. Wishart and Alex M. Nip Protein chemical shift analysis: a practical guide David van der Spoel_ The solution conformations of amino acids from molecular dynamics simulations of Gly-X-Gly peptides: comparison with NMR parameters Alex D. Bain Blurring the distinction between slow and intermediate chemical exchange Jianxing Song and Feng Ni_ NMR for the design of functional mimetics of protein-protein interactions: one key is in the build- ing of bridges Kalle Gehring, Xiaochen Zhang, Jason Hall, Hiroshi Nikaido, and David E. Wemmer An NMR study of ligand binding by maltodextrin binding protein André H. Juffer Theoretical calculations of acid-dissociation constants of proteins James M. Aramini and Hans J. Vogel Quadrupolar metal ion NMR studies of metalloproteins Giilin Oz, Dean L. Pountney, and Ian M. Armitage NMR spectroscopic studies of / = % metal ions in biological systems Peptides and proteins / Peptides et protéines Peter M. Hwang and Hans J. Vogel Structure—function relationships of antimicrobial peptides Dyanne Brewer, Howard Hunter, and Gilles Lajoie NMR studies of the antimicrobial salivary peptides histatin 3 and histatin 5 in aqueous and nonaqueous solutions George Kotovych, John R. Cann, John M. Stewart, and Hitoshi Yamamoto NMR and CD conformational studies of bradykinin and its agonists and antagonists: application to receptor binding Annett Rozek, James T. Sparrow, Karl H. Weisgraber, and Robert J. Cushley Sequence-specific 'H NMR resonance assignments and secondary structure of human apolipoprotein C-I in the presence of sodium dodecyl] sulfate Jianjun Wang, Daisy Sahoo, Brian D. Sykes, and Robert O. Ryan NMR evidence for a conformational adaptation of apolipophorin III upon lipid association Frank D. Sénnichsen, Peter L. Davies, and Brian D. Sykes NMR structural studies on antifreeze proteins Michael S. Hammond, R. Scott Houliston, and Elizabeth M. Meiering Two-dimensional 'H and '°N NMR titration studies of hisactophilin Signal transduction proteins / Protéines de transduction d’un signal Stéphane M. Gagné, Monica X. Li, Ryan T. McKay, and Brian D. Sykes The NMR angle on troponin C Mingjie Zhang and Tao Yuan Molecular mechanisms of calmodulin’s functional versatility Steven P. Smith and Gary S. Shaw A change-in-hand mechanism for $100 signalling Irena Ekiel, Denis Banville, Shi Hsiang Shen, and Kalle Gehring Effect of peptide binding on amide proton exchange rates in the PDZ2 domain from human phosphatase hPTPIE Voula Kanelis, Neil A. Farrow, Lewis E. Kay, Daniela Rotin, and Julie D. Forman-Kay NMR studies of tandem WW do- mains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel Katherine L.B. Borden RING fingers and B-boxes: zinc-binding protein-protein interaction domains E. Bruce Waygood The structure and function of HPr DNA and DNA-binding proteins / ADN et protéines liant l'ADN Stefan Bagby, Cheryl H. Arrowsmith, and Mitsuhiko Ikura New perceptions of transcription factor properties from NMR Contents / Sommaire Carolyn M. Slupsky, Lisa N. Gentile, and Lawrence P. McIntosh Assigning the NMR spectra of aromatic amino acids in pro- teins: analysis of two Ets pointed domains Markus W. Germann, Bernd W. Kalisch, James M. Varnum, Hans J. Vogel, and Johan H. van de Sande NMR spectroscopic and enzymatic studies of DNA hairpins containing mismatches in the EcoRI recognition site James M. Aramini and Markus W. Germann’ NMR studies of DNA duplexes containing a-anomeric nucleotides and polarity reversals Solid-state NMR and NMR of membranes / RMN de |’état solide, RMN de membranes David J. Siminovitch Solid-state NMR studies of proteins: the view from static 7H NMR experiments Jennifer R. Garbutt, Gillian R. Goward, Christopher W. Kirby, and William P. Power Solid-state *H NMR_ study of methyl-d3;-cobalamin Gang Wu _ Recent developments in solid-state nuclear magnetic resonance of quadrupolar nuclei and applications to biological sys- tems R. Scott Prosser, V.B. Volkov, and I.V. Shiyanovskaya Solid-state NMR studies of magnetically aligned phospholipid mem- branes: taming lanthanides for membrane protein studies Peter M. Macdonald, Kevin J. Crowell, Carla M. Franzin, Peter Mitrakos, and Darlene J. Semchyschyn Polyelectrolyte-induced domains in lipid bilayer membranes: the deuterium NMR perspective Audrey Saint-Laurent, Nadine Boudreau, René C.-Gaudreault, Patrick Poyet, and Michéle Auger Interaction between lipid bilayers and a new class of antineoplastic agents derived from arylchloroethylurea: a 7H solid-state NMR study NMR spectroscopy in medicine / Spectroscopie de RMN en médecine Ian C.P. Smith and Dorothea E. Blandford Diagnosis of cancer in humans by 'H NMR of tissue biopsies Taro Kaibara, Randy L. Tyson, and Garnette R. Sutherland Human cerebral neoplasms studied using MR spectroscopy: a review K.L. Malisza, P. Kozlowski, and J. Peeling A review of in vivo 'H magnetic resonance spectroscopy of cerebral ischemia in rats Richard B. Thompson and Peter S. Allen The role of the N-acetylaspartate multiplet in the quantification of brain metabolites Hao Lei and James Peeling Effect of temperature on the kinetics of lactate production and clearance in a rat model of forebrain ischemia Roxanne Deslauriers and Valery V. Kupriyanoy Cardiac magnetic resonance spectroscopy Constance M. Campbell, Gerald Wisenberg, Jane Sykes, and R. Terry Thompson Noninvasive assessment of pharmaceuti- cal intervention during myocardial ischemia—reperfusion in a canine model using two-dimensional! 31P chemical shift imaging Laura M. McIntosh, Ross E. Baker, and Judy E. Anderson Magnetic resonance imaging of regenerating and dystrophic mouse muscle Manfred Brauer, Wuhua Lu, and Mingfu Ling Chronic ethanol administration alters hepatic rates of glycerol phosphorylation and glycerol 3-phosphate oxidation: a dynamic in vivo 3Ip magnetic resonance spectroscopy study Malcolm R. Ogborn, Evan Nitschmann, Neda Bankovic-Calic, Richard Buist, and James Peeling The effect of dietary flax- seed supplementation on organic anion and osmolyte content and excretion in rat polycystic kidney disease Ravi S. Menon, Joseph S. Gati, Bradley G. Goodyear, David C. Luknowsky, and Christopher G. Thomas Spatial and tem- poral resolution of functional magnetic resonance imaging Number 4 / numéro 4 REVIEW / SYNTHESE Mark R. Wilson Apoptotic signal transduction: emerging pathways ARTICLES Isabella DalleDonne, Aldo Milzani, and Roberto Colombo G-actin conformational change and polymerization induced by paraquat J.M. Stewart, T.E. English, and K.B. Storey Comparisons of the effects of temperature on the liver fatty acid binding proteins from hibernator and nonhibernator mammals C-4 Biochem. Cell Biol. Vol. 76, 1998 Linda S.M. Ooi, Hexiang Wang, T.B. Ng, and Vincent E.C. Ooi Isolation and characterization of a mannose-binding lectin from leaves of the Chinese daffodil Narcissus tazetta Volodymyr I. Lushchak, Ljudmyla P. Lushchak, Tetjana V. Bahnjukova, Alexei V. Spichenkov, and Kenneth B. Storey Comparative study of free and bound glycolytic enzymes from sea scorpion brain John C. Lau and M. George Cherian Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice Sven E. Sorensen, Jane M. Barrett, Alex K.C. Wong, and John H. Spencer Identification of the in vivo promoters of bacte- riophages $13 and 0X174 and measurement of their relative activities C. Stan Tsai and Q. Chen Purification and kinetic characterization of 6-phosphogluconate dehydrogenase from Schizosaccharomyces pombe NOTES C. Stan Tsai and Q. Chen Regulation of D-glucose-6-phosphate dehydrogenase from Schizosaccharomyces pombe Ross A. Ridsdale, Jennifer L. Semotok, Dawn E. Larson, Lawrence I. Rothblum, and George Harauz Topology of recombinant rat upstream binding factor Kenneth Hayataka, Mary-Frances O’Connor, Nancy Kinzler, John T. Weber, and Keith K. Parker A _ bioactive peptide from the transmembrane 5 - intracellular loop 3 region of the human 5HT1la receptor J. Wu, H. Sugiyama, L.-H. Zeng, D. Mickle, and T.-W. Wu _ Evidence of Trolox and some gallates as synergistic protectors of erythrocytes against peroxyl! radicals Nicholas W. Ohan, Ying Tam, Pasan Fernando, and John J. Heikkila Characterization of a novel group of basic small heat shock proteins in Xenopus laevis A6 kidney epithelial cells Obituary / Nécrologie In Memoriam — Dr. Robert Hall Haynes Number 5 / numéro 5 Proceedings of the Eighth Fisher Winternational Symposium of the Canadian Society of Biochemistry and Molecular & Cellular Biology: Membrane proteins in health and disease Actes du huitéme symposium internationeige Fisher de la SocitéteCanadienne de Biochimie et de Biologie Moléculaire et Cellulaire : Les protéines membranaires, la santé et les maladies REVIEWS / SYNTHESES Di Xia, Hoeon Kim, Chang-An Yu, Linda Yu, Anatoly Kachurin, Li Zhang, and Johann Deisenhofer A _ novel _ electron transfer mechanism suggested by crystallographic studies of mitochondrial cytochrome bc] complex Peng Leong and David H. MacLennan Complex interactions between skeletal muscle ryanodine receptor and dihydropyridine receptor proteins Frances J. Sharom, Ronghua Liu, and Yolanda Romsicki Spectroscopic and biophysical approaches for studying the structure and function of the P-glycoprotein multidrug transporter Joseph R. Casey and Reinhart A.F. Reithmeier Anion exchangers in the red cell and beyond James M. Salhany Mechanism of competition between chloride and stilbenedisulfonates for binding to human erythrocyte band 3 (AE1) Lesley J. Bruce, Robert J. Unwin, Oliver Wrong, and Michael J.A. Tanner The association between familial distal renal tu- bular acidosis and mutations in the red cell anion exchanger (band 3, AE/) gene Naotaka Hamasaki, Hiroyuki Kuma, Kazuhisa Ota, Masao Sakaguchi, and Katsuyoshi Mihara A new concept in polytopic membrane proteins following from the study of band 3 protein Larry Fliegel, Rakhilya Murtazina, Pavel Dibrov, Carmen Harris, Andrea Moor, and Francoise A. Fernandez-Rachubinski Regulation and characterization of the Na*/H* exchanger James L. Kinsella, Phillip Heller, and Jeffrey P. Froehlich Na*/H* exchanger: proton modifier site regulation of activity Katherine M. Hannan and Peter J. Little Mechanisms regulating the vascular smooth muscle Na/H exchanger (NHE-1) in dia- betes Carol E. Cass, James D. Young, and Stephen A. Baldwin Recent advances in the molecular biology of nucleoside transporters of mammalian cells Contents / Sommaire Marcal Pastor-Anglada, Antonio Felipe, F. Javier Casado, Belén Del Santo, Joao F. Mata, and Raquel Valdés Nucleoside transporters and liver cell growth Marek Michalak, Paola Mariani, and Michal Opas Calreticulin, a multifunctional Ca** binding chaperone of the endoplasmic reticulum ARTICLES Christopher Rensing, Bharati Mitra, and Barry P. Rosen A Zn(II)-translocating P-type ATPase from Proteus mirabilis Robert A. Edwards and Raymond J. Turner Alpha-periodicity analysis of small multidrug resistance (SMR) efflux transport- ers Seth L. Alper, Marina N. Chernova, Jon Williams, Michael Zasloff, Foon-Yee Law, and Philip A. Knauf Differential inhi- bition of AE] and AE2 anion exchangers by oxonol dyes and by novel polyaminosterol analogs of the shark antibiotic squalamine Michael L. Jennings, Jonathan Whitlock, and Anjali Shinde Pre-steady state transport by erythrocyte band 3 protein: uphill countertransport induced by the impermeant inhibitor H,DIDS Andrew M. Taylor and Anthony Watts Spin-label studies of lipid-protein interactions with reconstituted band 3, the human erythrocyte chloride—bicarbonate exchanger Homa Kameh, Carolina Landolt-Marticorena, Jeffrey H.M. Charuk, Harry Schachter, and Reinhart A.F. Reithmeier Structural and functional consequences of an N-glycosylation mutation (HEMPAS) affecting human erythrocyte membrane glycoproteins Daniel Gebreselassie, Krishna Rajarathnam, and Larry Fliegel Expression, purification, and characterization of the carboxyl-terminal region of the Na*/H* exchanger Charles R. Crawford, Carol E. Cass, James D. Young, and Judith A. Belt Stable expression of a recombinant sodium- dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line Harry P. de Koning and Simon M. Jarvis A highly selective, high-affinity transporter for uracil in Trypanosoma brucei brucei: evidence for proton-dependent transport Sylvia Y.M. Yao, William R. Muzyka, Carol E. Cass, Christopher I. Cheeseman, and James D. Young Evidence that the transport-related proteins BAT and 4F2hc are not specific for amino acids: induction of Na*-dependent uridine and pyruvate trans- port activity by recombinant BAT and 4F2hc expressed in Xenopus oocytes Daniel N. Hebert, Jian-Xin Zhang, and Ari Helenius Protein folding and maturation in a cell-free system David H. Llewellyn and H. Llewelyn Roderick Overexpression of calreticulin fails to abolish its induction by perturbation of normal ER function Stephanie A. Fraser, Marek Michalak, William H. Welch, and Dorothy Hudig Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model system Number 6 / numéro 6 Thematic Issue: Cell Lineage Numéro thématique : Lignage cellulaire REVIEWS / SYNTHESES Kursad Turksen and Tammy-Claire Troy Epidermal cell lineage Jane E. Aubin Advances in the osteoblast lineage Shin-Ichi Hayashi, Toshiyuki Yamane, Akitomo Miyamoto, Hiroaki Hemmi, Hisashi Tagaya, Yasuko Tanio, Hidenobu Kanda, Hidetoshi Yamazaki, and Takahiro Kunisada Commitment and differentiation of stem cells to the osteoclast lineage Jean Victor Ruch Odontoblast commitment and differentiation Anne Eichmann, Catherine Corbel, and Nicole M. Le Douarin Segregation of the embryonic vascular and hemopoietic sys- tems Kyunghee Choi Hemangioblast development and regulation Jean-Noél Freund, Claire Domon-Dell, Michéle Kedinger, and Isabelle Duluc The Cdx-/ and Cdx-2 homeobox genes in the intestine David Warburton, Carol Wuenschell, Guillermo Flores-Delgado, and Kathryn Anderson Commitment and differentiation of lung cell lineages André Lochter Plasticity of mammary epithelia during normal development and neoplastic progression C-6 Biochem. Cell Biol. Vol. 76 Hannu Sariola and Kirsi Sainio Cell lineages in the embryonic kidney: their inductive interactions and signalling molecules Sergey Kupriyanov and Héléne Baribault Genetic control of extraembryonic cell lineages studied with tetraploid«*diploid chimeric concepti Kenji Kitajima and Takashi Takeuchi Mouse gene trap approach: identification of novel genes and characterization of their bi- ological functions Maya Sieber-Blum Growth factor synergism and antagonism in early neural crest development Anjali J. Kalyani and Mahendra S. Rao_ Cell lineage in the developing neural tube ARTICLES Cheng-Ming Chuong, Han-Sung Jung, Drew Noden, and Randall B. Widelitz Lineage and pluripotentiality of epithelial pre- cursor cells in developing chicken skin Boris Kablar, Atsushi Asakura, Kirsten Krastel, Chuyan Ying, Linda L. May, David J. Goldhamer, and Michael A. Rudnicki MyoD and Myf-5 define the specification of musculature of distinct embry- onic origin Karin Opdecamp, Lidia Kos, Heinz Arnheiter, and William J. Pavan’ Endothelin signalling in the development of neural crest-derived melanocytes Author index for volume 76 / Index des auteurs pour le volume 76 Contents for volume 76 / Sommaire pour le volume 76