CONTENTS OF VOLUME 61 1 January 2001 61 Characterization of multidrug transporters in a nor- mal renal tubular cell line resistant to doxorubicin: Commentary multidrug transporters in the LLC-PK, cell line and its Uptake and mode of action of drugs used against resistant counterpart sleeping sickness Giuliana Decorti, Anna Rosati, Luigi Candussio, Hubert Denise and Michael P. Barrett Tullio Giraldi and Fiora Bartoli Klugmann Does the antitumor cyclopropylpyrroloindole antibi- MOLECULAR PHARMACOLOGY otic CC-1065 cross-link DNA in tumor cells? Andrzej Skladanowski, Marcin Koba and Jerzy Konopa Inhibitory effects of ruthenium red on inositol 1,4,5- trisphosphate-induced responses in rat megakaryo- cytes NEUROSCIENCE Masahiro Ikeda and Yoshio Maruyama Toxic effects of apomorphine on rat cultured neurons Prevention of c-Jun/activator protein-1 activation and glial C6 cells, and protection with antioxidants and microsomal epoxide hydrolase induction in the Ramon dos Santos El-Bachd, Jean-Luc Daval, Violette rat liver by cysteine during protein-calorie malnutri- Koziel, Patrick Netter and Alain Minn tion Min Kyung Cho, Yoon Gyoon Kim, Myung Gull Lee INFLAMMATION AND IMMUNOPHARMACOLOGY and Sang Geon Kim Differential regulation of protein kinase on free rad- Signaling pathways leading to the induction of orni- ical production, granule enzyme release, and cytokine thine decarboxylase: opposite effects of p44/42 mito- synthesis by activated murine peritoneal macrophages gen-activated protein kinase (MAPK) and p38 Young Ki Kim, Yoon Young Jang, Dong Hyun Kim, MAPK inhibitors Hyun Hee Ko, Eun Sook Han and Chung Soo Lee Flavio Flamigni, Annalisa Facchini, Emanuele Giordano, Benedetta Tantini and Claudio Stefanelli CARDIOVASCULAR AND PULMONARY PHARMACOLOGY Suppression of cell cycle progression by a fungal Pharmacological profile of F 12511, (S)-2',3’,5’- lectin: activation of cyclin-dependent kinase inhibi- trimethyl-4’-hydroxy-a-dodecylthioacetanilide, a tors powerful and systemic acylcoenzyme A: cholesterol Wing-keung Liu, Joyce C. K. Ho and Tze-bun Ng acyltransferase inhibitor Reduced cellular transport and activation of fluoro- Didier Junquero, Philippe Oms, Elisabeth Carilla- pyrimidine nucleosides and resistance in human lym- Durand, Jean-Marie Autin, Jean-Pierre Tarayre, phocytic cell lines selected for arabinosylcytosine Anne-Dominique Degryse, Jean-Francoise Patoiseau, resistance Francis C. Colpaert and André Delhon Ram P. Agarwal, Tieran Han and Marilyn Fernandez Potentiation by aminoethylisothiourea of the extra- Cell cycle phase specificity in the potentiation of cellular Ca”* component of norepinephrine-induced con- etoposide-induced DNA damage and apoptosis by traction in rat femoral arteries KN-62, an inhibitor of calcium-calmodulin-depen- M. Carmen Martinez, Voahanginirina dent enzymes Randriamboavonjy, Jean-Claude Stoclet and Masako Aoyama, Dale R. Grabowski, Katherine A. Ramaroson Andriantsitohaina Holmes, Lisa A. Rybicki, Ronald M. Bukowski, Prevention of human smooth muscle cell prolifera- Mahrukh K. Ganapathi and Ram Ganapathi tion without induction of apoptosis by the topoisom- Structure-activity relationships of neurokinin A (4- erase I inhibitor topotecan 10) at the human tachykinin NK, receptor: the role of Bernhard R. Brehm, Christina Bock, Sebastian natural residues and their chirality Wesselborg, Steffen Pfeiffer, Stefan Schiiler and Fiona J. Warner, Philip Mack, Alfio Comis, Robert C. Klaus Schulze-Osthoff Miller and Elizabeth Burcher Volume Contents, Author and Subject Index for Volume 61, 2001 1607 15 January 2001 199 Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell growth Commentary Oxidative activation of indole-3-acetic acids to cyto- Vladan Milovic, Lyudmila Turchanowa, toxic species—a potential new role for plant auxins in Alex R. Khomutov, Radii M. Khomutov, cancer therapy Wolfgang F. Caspary and Jiirgen Stein Lisa K. Folkes and Peter Wardman HORMONES AND GROWTH FACTORS MOLECULAR AND CELLULAR PHARMACOOLOGY The polyamine stress response: tissue-, endocrine-, and development-dependent regulation Different effects of the allosteric enhancer (2-amino- 4,5-dimethyl-trienyl)[3-trifluoromethyl) Varda H. Gilad, Jose M. Rabey, Ytzhak Kimiagar and phenyl]methanone (PD81,723) on agonist and antag- Gad M. Gilad onist binding and function at the human wild-type and a mutant (T277A) adenosine A, receptor GENE EXPRESSION AND DEVELOPMENT Angeliki Kourounakis, Corine Visser, Tryphostin AG879, a tyrosine kinase inhibitor: pre- Miriam de Groote and Ad P. IJzerman vention of transcriptional activation of the electro- Induction of nuclear transcription factors, cyto- phile and the aromatic hydrocarbon response ele- chrome P450 monooxygenases, and glutathione-S- ments transferase alpha gene expression in Aroclor 1254- Matthew Z. Dieter, Sarah L. Freshwater, treated rat hepatocyte cultures Willy A. Solis, Daniel W. Nebert and Jiirgen Borlak and Thomas Thum Timothy P. Dalton Inhibition of heart mitochondrial lipid peroxidation by non-toxic concentrations of carvedilol and its INFLAMMATION AND IMMUNOPHARMACOLOGY analog BM-910228 Inhibition of stimulated Jurkat cell adenosine 3’,5’- Dario J.$.L. Santos and Anténio J.M. Moreno cyclic monophosphate synthesis by the immuno- modulatory compound HR325 Involvement of glutathione metabolism in the cyto- toxicity of the phenethyl isothiocyanate and _ its Adam P. Curnock, T. Andrew Thomson, cysteine conjugate to human leukaemia cells in vitro Robert Westwood, Elizabeth A. Kuo, Richard A. Williamson, Christopher M. Yea and Ke Xu and Paul J. Thornalley Erik Ruuth Enzyme-catalyzed therapeutic agent (ECTA) design: Activation of the antitumor ECTA compound GASTROINTESTINAL AND RENAL PHARMACOLOGY NBI1O011 by thymidylate synthase Immunolocalisation of adenosine A, receptors in the David B. Lackey, Michael P. Groziak, rat kidney Maria Sergeeva, Malgorzata Beryt, Christopher Boyer, Robert M. Stroud, Peter Sayre, John W. Park, Jane A. Smith, Asipu Sivaprasadarao, Patrick Johnston, Dennis Slamon, H. Michael Shepard Timothy S. Munsey, Christopher J. Bowmer and and Mark Pegram Michael S. Yates Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4)(R)-carboxylic acid (CHEMOTHERAPY AND METABOLIC INHIBITORS in mice Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes Chandrika Srinivasan, Walter M. Williams, Mukunda B. Ray and Theresa S. Chen Zsolt Csapé, Maria Sasvdri-Székely, Tatjana Spasokoukotskaja, Ianis Talianidis, Staffan Eriksson and Maria Staub 1 February 2001 Commentary Angiogenesis: Regulators and clinical applications Sandra Liekens, Erik De Clercq and Johan Neyts Volume Contents, Author and Subject Index for Volume 61, 2001 MOLECULAR AND CELLULAR PHARMACOLOGY 343 Inorganic iron complexes derived from the nitric oxide donor nitroprusside: Competitive N-methyl-p- Selective inhibition of human mast cell tryptase by asparate receptor antagonists with nanomolar affinity gabexate mesylate, an antiproteinase drug Hans Neijt, Manuel Koller and Stephan Urwyler Fulvio Erba, Laura Fiorucci, Stefano Pascarella, Enea Menegatti, Paolo Ascenzi and Franca Ascoli (CHEMOTHERAPY AND METABOLIC INHIBITORS A two-state receptor model for the interaction be- Amplification of bleomycin-induced DNA cleavage tween angiotensin II] type 1 receptors and non- at cytosine residues 3’ to GGG sequences by pyrrole peptide antagonists triamide Georges Vanquelin, Peter Morsing, Frederik L. P. Yusuke Hiraku, Shinji Oikawa, Katsura Kuroki, Fierens, Jean-Paul De Backer and Patrick M. L. Hiroshi Sugiyama, Isao Saito and Shosuke Kawanishi Vanderheyden Structure—activity investigation of the inhibition of GENE EXPRESSION AND DEVELOPMENT 3-hydroxypyridin-4-ones on mammalian tyrosine hy- droxylase Differential induction of stearoyl-CoA desaturase and acyl-CoA oxidase genes by fibrates in HepG2 cells Zu Dong Liu, Michelle Lockwood, Sarah Rose, Anthony E. Theobald and Robert C. Hider Cristina Rodriguez, Agatha Cabrero, Niiria Roglans, Tomds Adzet, Rosa M. Sdncher, Manuel Vazquex, Detection of bradykinin B, receptors in rat aortic Carlos J. Ciudad and Juan C. Laguna smooth muscle cells Paul Schaeffer, Marie-Claude Laplace, Pierre Savi, INFLAMMATION AND IMMUNOPHARMACOLOGY Valérie Prabonnaud, Véronique Salel and Jean-Marc Herbert Suppressive effect of 1,25-dihydroxyvitamin D, and its analogues EB 1089 and K 1060 on T lymphocyte Apoptotic response of HL-60 human leukemia cells proliferation in active ulcerative colitis to the antitumor drug NB-506, a glycosylated indo- Maria Stio, Andrea G. Bonanomi, Giuseppe d’ Albasio locarbazole inhibitor of topoisomerase 1 and Cristina Treves Michael Facompre, Jean-Francois Goossens and Christian Bailly CARDIOVASCULAR AND PULMONARY PHARMACOLOGY Methylseleninic acid, a potent growth inhibitor of Calcium antagonists as inhibitors of in viro low synchronized mouse mammary epithelial tumor cells density lipoprotein oxidation and glycation in vitro Grazyna Sobal, Ernst Johannes Menzel and Helmut Raghu Sinha, Emmanual Unni, Howard E. Ganther Sinzinger and Daniel Medina Signal transduction system for interleukin-6 and in- terleukin-11 synthesis stimulated by epinephrine in 15 February 2001 human osteoblasts and human osteogenic sarcoma cells Commentary Ayami Kondo, Makio Mogi, Yasuko Koshihara and Role of Bcl-2 and its post-transcriptional modifica- Akifumi Togari tion in response to antitumor therapy Inositol 1,4,5-triphosphate receptor isoform expres- Graziella Pratesi, Paola Perego and Franco Zunino sion in mouse pancreatic islets: Effects of carbachol Bumsup Lee and Suzanne G. Laychock MOLECULAR AND CELLULAR PHARMACOLOGY Muscarinic receptor subtypes and calcium signaling Lack of toxic effects of F 12511, a novel potent in Fischer rat thyroid cells inhibitor of acyl-coenzyme A: cholesterol O-acyl- transferase, on human adrenocortical cells in culture Eugenio Jiménez, José Pavia, Valentina Morell, Elisa Martin and Mercedes Montiel Didier Junquero, Antoine Pilon, Elizabeth Carilla- Durand, Jean-Francois Patoiseau, Jean-Pierre Tarayre, Gérard Torpier, Bart Staels, Jean-Charles Fruchart, Francis C. Colpaert, Véronique Clavey and André Delhon Volume Contents, Author and Subject Index for Volume 91, 2001 1609 399 Induction of cytochrome P450 1A1 gene expression, 467 Increased efficacy of antileishmanial antisense phos- oxidative stress, and genotoxicity by carbaryl and phorothioate oligonucleotides in Leishmania ama- thiabendazole in transfected human HepG2 and lym- zonensis overexpressing ribonuclease H phoblastoid cells Manjari Mishra, Jabbar R. Bennett and Chantal Delescluse, Nathalie Ledirac, Rouya Li, Gautam Chaudhuri Marie P. Piechocki, Ronald N. Hines, Xavier Gidrol 477 Hypoxanthine transport in human tumour cell lines: and Roger Rahmani Relationship to the inhibition of hypoxanthine res- 409 The role of glutathione in the neurotoxicity of cue by dipyridamole artemisinin derivatives in vitro Emma Marshman, Gordon A. Taylor, Sharon L. Smith, Claire J. Sadler, Charlotte C. Dodd, Huw D. Thomas, David R. Newell Geoffrey Edwards, Stephen A. Ward, B. Kevin Park and Nicola J. Curtin and W’. Graham McLean Extracellular adenosine-induced apoptosis in mouse CARDIOVASCULAR AND PULMONARY PHARMACOLOGY neuroblastoma cells: Studies on involvement of aden- 485 Lack of involvement of pertussis toxin-sensitive G- osine receptors and adenosine uptake proteins in norepinephrine-induced vasoconstriction S. Mariette Schrier, Erica W. van Tilburg, Hans van of rat aorta smooth muscle der Meulen, Ad P. Ijzerman, Gerald J. Mulder Marie-Anne Petitcolin, Catherine Vandeputte, and J. Fred Nagelkerke Esther Spitzbarth-Régrigny, Jean-Luc Bueb, 427 Induction of cell poliferation by cyclosporine A in Christine Capdeville-Atkinson and Eric Tschirhart primary cultures of rat hepatocytes 493 Cell-specific loss of cytochrome P450 2B1 in rat lung David Andrés, Carmen Diez-Ferndndez, following treatment with pneumotoxic and non- Asuncion Zaragoza, Alberto Alvarez pneumotoxic trialkyphosphorothioates and Maria Cascales David Dinsdale and Richard D. Verschoyle 437 A functional link between heme oxygenase and 903 Inhibition by ginkgolides and bilobalide of the pro- cyclo-oxygenase activities in cortical rat astrocytes duction of nitric oxide in macrophages (THP-1) but Mauro Vairano, Cinzia Dello Russo, Giacomo Pozzoli, not in endothelial cells (HUVEC) Giuseppe Tringali, Paolo Preziosi and Pierluigi Navarra Filly Cheung, Yaw L. Siow and Karmin O 443 Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells 1 March 2001 Bertil B. Fredholm, Eva Irenius, Bjérn Kull and Gunnar Schulte Commentary 911 Repression of cytochrome P450 1A1 gene expression by oxidative stress: mechanisms and biological impli- (CHEMOTHERAPY AND METABOLIC INHIBITORS cations 449 In situ kinetic characterization of methylthioad- Robert Barouki and Yannick Morel enosine transport by the adenosine transporter (P >) of the African Trypanosoma brucei brucei and Trypano- soma brucei rhodesiense MOLECULAR AND CELLULAR PHARMACOLOGY Burt Goldberg, Donna Rattendi, David Lloyd, 017 Ca’*t-dependent production of reactive oxygen me- Janice R. Sufrin and Cyrus J. Bacchi tabolites by human neutrophils in response to fluor- inated propranolol analogues 459 Coupling of 5-fluoro 2'-deoxyuridine to lactosami- nated poly-L-sine: An approach to a regional, non- Soad Salech, Hassan Aboul-Enein, Ranjit Parhar, invasive chemotherapy of liver micrometastases Kate Collison and Futwan Al-Mohanna Giuseppina Di Stefano, Corrado Busi, 927 Specific desensitization of sulfonylurea- but not imi- Alessandro Camerino, Massimo Derenzini, dazoline-induced insulin release after prolonged tol- Davide Treré and Luigi Fiume butamide exposure Neville H. McClenaghan, Andrew J. Ball and Peter R. Flatt | : 1610 Volume Contents, Author and Subject Index for Volume 61, 2001 537. Determination of in vivo adducts of disulfiram with INFLAMMATION AND IMMUNOPHARMACOLOGY mitochondrial aldehyde dehydrogenase Effects of melanocortin peptides on lipopolysaccha- Maryann L. Shen, Kenneth L. Johnson, ride/interferon-gamma-induced NF-kappaB DNA Dennis C. Mays, James J. Lipsky and Stephen Naylor binding and nitric oxide production in macrophage- like RAW 264.7 cells: evidence for dual mechanisms Inhibitory effect of a-lipoic acid and its positively of action charged amide analogue on nitric oxide production in RAW 264.7 macrophages Ilona Madrika, Ruta Muceniece and Jarl E.S. Wikberg Qiong Guo, Oren Tirosh and Lester Packer CARDIOVASCULAR AND PULMONARY PHARMACOLOGY Differential sensitivities of the MRP gene family and y-glutamylcysteine synthetase to prooxidants in hu- Physiological evidence for a P2Y receptor responsive man colorectal carcinoma cell lines with different to diadenosine polyphosphates in human lung via p53 status Ca’* release studies in bronchial epithelial cells Yen-Chin Lin-Lee, Shigeru Tatebe, Niramol Savaraj, Werner Laubinger, Gundula Streubel and Georg Reiser Toshihisa Ishikawa and M. Tien Kuo Comparative effects of indomethacin on cell prolif- 15 March 2001 eration and cell cycle progression in tumor cells grown in vitro and in vivo Commentary Yaniv Eli, Fiorenza Przedecki, Galit Levin, Where is the evidence that cyclooxygenase inhibi- Na’am Kariv and Amiram Raz tion is the primary cause of nonsteroidal anti-inflam- Ultrastructural morphology and localisation of cispla- matory drug (NSAID)-induced gastrointestinal in- tin-induced platinum-DNA adducts in a cisplatin- jury? Topical injury revisited sensitive and -resistant human small cell lung cancer Lenard M. Lichtenberger cell using electron microscopy Coby Meijer, Marja, J.A. van Luyn, MOLECULAR AND CELLULAR PHARMACOLOGY Edith F. Nienhuis, Nel Blom, Nanno H. Mulder and Elisabeth G.E. de Vries Growth reduction in glioma cells after treatment with tetradecylthioacetic acid: changes in fatty acid me- Adrenergic stimulation of osteoclastogenesis medi- tabolism and oxidative status ated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cells Karl J. Tronstad, Kjetil Berge, Endre Dyroy, Lise Madsen and Rolf K. Berge Toshimitsu Takeuchci, Takahiro Tsuboi, Michitsugu Arai and Akifumi Togavri Expression of rat liver long-chain acyl-CoA syn- thetase and characterization of its role in the metab- Ajoene, a natural product with non-steroidal anti- olism of R-ibuprofen and other fatty acid-like xeno- inflammatory drug (NSAID)-like properties? biotics Verena M. Dirsch and Angelika M. Vollmar Roland Brugger, Christine Reichel, Begonia Garcia Alia, Kay Brune, Tokuo Yamamoto, (CHEMOTHERAPY AND METABOLIC INHIBITORS Irmgard Tegeder and Gerd Geissinger Conjugative metabolism of 1,2-dibromoeethane in [HIJMRS 1754, a selective antagonist radioligand for mitochondria: disruption of oxidative phosphoryla- A>p adenosine receptors tion and alkylation of mitochondrial DNA Xiao-duo Ji, Yong-Chul Kim, David G. Ahern, Carin Thomas, Yvonne Will, Saundra L. Schoenberg, Joel Linden and Kenneth A. Jacobson Dawn Sanderlin and Donald J. Reed Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene GENE EXPRESSION AND DEVELOPMENT expression in methotrexate-resistant K562 human Regulation of transcription of the glutathione S- erythroleukemia cells transferase Pl gene by methylation of the minimal Bee Ching Ding, Teah L.Witt, Bharati Hukku, promoter in human leukemia cells Henry Heng, Long Zhang and Larry H. Matherly Patricia Borde-Chiché, Marc Diederich, Franck Morceau, Alvaro Puga, Maria Wellman and Mario Dicato Volume Contents, Author and Subject Index for Volume 61, 2001 1611 677 Enhancement of antioxidant and anti-inflammatory Stimulation of stress-activated but not mitogen- activities of bioflavonoid rutin by complexation with activated protein kinases by tumour necrosis factor transition metals receptor subtypes in airway smooth muscle Igor B. Afanas’ev, Elena A. Ostrakovitch, Shona M. McFarlane, Orla J. Elena V. Mikhal’chik, Galina A. Ibragimova and Jupp, Hannah J. Cobban, Irene Hunter, Ludmila G. Korkina Helen M. Anderson, Peter Vandenabeele , Graeme F. Nixon and David J. MacEwan Enzymatic activation of a new antitumour drug, 5-diethylaminoethylamino-8-hydroxyimidazoacridi- none, C-1311, observed after its intercalation into GASTROINTESTINAL AND RENAL PHARMACOLOGY DNA Blocking action of cytochalasin D on protein kinase Zofia Mazerska, Jaroslaw Dziegielewski and A stimulation of a stretch-activated cation channel Jerzy Konopa in renal epithelial A6 cells Peripheral-type benzodiazepine receptor ligands: mi- Naomi Niisato and Yoshinori Marunaka tochondrial permeability transition induction in rat Additions and Corrections cardiac tissue Beatric Chelli, Alessandra Falleni, Francesca Salvetti, 1 April 2001 Vittorio Gremigni, Antonio Lucacchini and Claudia Martini Effect of the glutathione/glutathione disulfide redox Commentary couple on thiopurine methyltransferase Molecular targets for pharmacological cytoprotection Roy A. Lysaa, David J. Warren, Ingebrigt Sylte and Andras Balla, Balazs Toth Gyorgy Timdr, Judit Bak Jarle Aarbakke and Peter Krajcsi No reduction of a-tocopherol quinone by glutathione in rat liver microsomes MOLECULAR AND CELLULAR PHARMACOLOGY Rachel I. M. van Haaften, Chris T. A. Evelo, Protective effects of morphine in peroxynitrite-in- Guido R. M. M. Haenen and Aalt Bast duced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphati- dylinositol 3-kinase (P13 kinase) (CHEMOTHERAPY AND METABOLIC INHIBITORS Myung-Sunny Kim, Young-Pyo Cheong, Debenzylation of O°-benzyl-8-oxogauanine in human Hong-Seob So, Kang-Min Lee, Tai-Yo Kim, liver: implications for O°-benzylguanine metabolism Jaymin-Oh, Yeon-Tai Chung, Yong Son, Lina Long, Robert C. Moschel and M. Eileen Dolan Bok-Ryang Kim and Raekil Park 2’-O-Acyl/alkyl-substituted arabinosyl nucleosides as Noncompetitive inhibition by camphor of nicotinic inhibitors of human mitochondrial thymidine kinase acetylcholine receptors Jan Balzarini, Bart Degréve, Chaoyong Zhu, Tae-Ju Park, Hyuck-Kyo Seo, Byung-Jo Kang and Elisa Durini, Luca Porcu, Erik De Clerq, Kyong-Tai Kim Anna Karlsson and Stefano Manfredini Role of proteasomal degradation in the cell cycle- dependent regulations of DNA topoisomerase Ila INFLAMMATION AND IMMUNOPHARMACOLOGY expression Investigation of nicotine binding to THP-1 cells: Leonardo Salmena, Viengthong Lam, evidence for a non-cholinergic binding site J. Peter McPherson and Gerald J. Goldenberg Deri Morgan, Mike E. Parsons and Cliff J. Whelan Modulation of inositol 1,4,5-triphosphate binding to the various inositol 1,4,5-triphosphate receptor iso- forms by thimerosal and cyclic ADP-ribose CARDIOVASCULAR AND PULMONARY PHARMACOLOGY Sara Vanlingen, Henk Sipma, Patrick De Smet, Geert 2-Bromoethylamine as a potent selective suicide in- Callewaert, Ludwig Missiaen, Humbert De Smedt and hibitor for semicarbazide-sensitive amine oxidase Jan B. Parys Peter H. Yu, Bruce A. Davis and Yulin Deng 1612 Volume Contents, Author and Subject Index for Volume 61, 2001 811 The effect of high molecular phospholipase A, inhib- HORMONES AND GROWTH FACTORS itors on 3T6 fibroblast proliferation Metabolism of a 20-methyl substituted series of vita- Teresa Sanchez and Juan J. Moreno min D analogs by cultured human cells: apparent reduction of 23-hydroxylation of the side chain by Chorpromazine-induced increase in dipalmitoylphos- the 20-methyl group phatidylserine surface area in monolayers at room temperature V. Narayanaswamy Shankar, Valarie Byford, David W. Prosser, Neil J. Schroeder, Armelle Varnier Agasosler, Laila M. Tungodden, Hugh L.J. Makin, Herbert Wiesinger, Giinter Neef, Daniel Cejka, Einar Bakstad, Leiv K. Sydnes and Andreas Steinmeyer and Glenville Jones Holm Holmsen Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phyco- INFLAMMATION AND IMMUNOPHARMACOLOGY toxin Suppression of a sesquiterpene lactone from Carpe- sium divaricatum of inducible nitric oxide synthase by Laura A. de la Rosa, Amparo Alfonso, Natalia inhibiting nuclear factor-KB activation Vilarifio, Mercedes R. Vieytes and Luis M. Botana Eun Ju Kim, Hye Kyoung Jin, Yong Kee Kim, Potency and selectivity of RXP407 on human, rat, Hoi Young Lee, Seok Yong Lee, Kang Ro Lee, and mouse angiotensin-converting enzyme Ok Pyo Zee, Jeung Whan Han and Hyang Woo Lee Gille Vazeux, Joél Cotton, Philippe Cuniasse and Evidence for bradykinin mediation of carrageenin- Vincent Dive induced inflammatory pain: a study using kininogen- Role of cytochrome P450 1A2 in bilirubin degrada- deficient Brown Norway Katholiek rats tion: studies in Cypla2(—/—) mutant mice Yuri Ikeda, Akinori Ueno, Hiroaki Naraba and Cinzia Zaccaro, Sarah Sweitzer, Sandra Pipino, Nadia Sachiko Oh-ishi Gorman, Peter R. Sinclair, Jacqueline F. Sinclair, Daniel W. Nebert and Francesco De Matteis CARDIOVASCULAR AND PULMONARY PHARMACOLOGY Potentiation of okadaic acid-induced ceramide eleva- Proteolytic activation of membrane-bound guanylate tion but not apoptosis by inhibition of glucosylcer- cyclase amide synthase in human neuroepithelioma cells Zi-Jiang Chen, Dong-Li Song, Zhenhua Miao and Sabrina Di Bartolomeo and Angelo Spinedi Chung-Ho Chang Possible involvement of G;, protein in augmented (CHEMOTHERAPY AND METABOLIC INHIBITORS contraction of bronchial smooth muscle from antigen- Marked suppression of the activity of some, but not induced airway hypperesponsive rats all, antifolate compounds by augmentation of folate Yoshihiko Chiba, Hiroyasu Sakai and Miwa Misawa cofactor polls within tumor cells Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic Rongbao Zhao, Feng Gao and I. David Goldman acid on extrahepatic sulfhydryl levels in mice treated Cytotoxic synergism of methioninase in combination with acetaminophen with 5-fluroroacil and folinic acid Chandrika Srinivasan, Walter M. Williams, David Machover, Jacqueline Zittoun, Phillipe Broét, Herbert T. Nagasawa and Theresa S. Chen Gérard Metzger, Mireille Orrico, Emma Goldschmidt, Alfred Schilf, Carole Tonetti, Yuying Tan, Béatrice Delmas-Marsalet, Catherine Luccioni, 15 April 2001 Bruno Falissard and Robert M. Hoffman Commentary NEUROSCIENCE Role of the sugar moiety in the pharmacological Vinpocetine-induced stimulation of calcium-acti- activity of anthracyclines: development of a novel vated potassium currents in rat pituitary GH; cells series of disaccharide analogs Sheng-Nan Wu, Hui-Fang Li and Hung-Ting Chiang Franco Zunino, Graviella Pratesi and Paola Perego Volume Contents, Author and Subject Index for Volume 61, 2001 1613 MOLECULAR AND CELLULAR PHARMACOLOGY 1029 Inhibition of Kvl.3 channels by H-89 (N-[2-(p- bromocinnamylamino)ethyl]-5-isoquinolinesulfon- Broussochalcone A, a potent antioxidant and effec- amide) independent of protein kinase A tive suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages Jin-Sung Choi, Bok Hee Choi, Sang June Hahn, Shin Hee Yoon, Do Sik Min, Yang-Hyeok Jo and Zhi-Jiao Cheng, Chun-Nan Lin, Tsong-Long Hwang Myung-Suk Kim and Che-Ming Teng Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor (CHEMOTHERAPY AND METABOLIC INHIBITORS in Hep3B cells Involvement of oxygen radicals in cytarabine-in- duced apoptosis in human polymorphonuclear cells Yang-Sook Chun, Eun-Jin Yeo, Eunjoo Choi, Che- Ming Teng, Jae-Moon Bae, Myung-Suk Kim and Metello Iacobini, Adriana Menichelli, Jong-Wan Park Giuseppe Palumbo, Giuseppe Multari, Beate Werner and Domenico Del Principle Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines INFLAMMATION AND IMMUNOPHARMACOLOGY Asher Begleiter, Marsha K. Leith, Geoffrey P. Doherty, Role of petasin in the potential anti-inflammatory Tyler J. Digby and Sushu Pan activity of a plant extract of petasites hybridus Stimulation of cyclooxygenase-2-activity by nitric Olivier A.R. Thomet, Ulrich N. Wiesmann, oxide-derived species in rat chondrocyte: lack of Andreas Schapowal, Christian Bizer and contribution to loss of cartilage anabolism Hans-Uwe Simon Emmanuelle Nédélec, Amr Abid, Christine Cipolletta, Nathalie Presle, Bernard Terlain, Patrick Netter and 1 May 2001 Jean-Yves Jouzeau Effects of genistein on cell proliferation and cell cycle Commentary arrest in nonneoplastic human mammary epithelial A unitfied theory of enzyme kinetics based upon the cells: involvement of Cdc2, aio. p27*'?! |a nd systematic analysis of the variations of k,,,, Ky, and Cdc25C expression K..,/K, and the relevant AG°* values—possible impli- Randall S. Frey, Jiyuan Li and Keith W. Singletary cations in chemotherapy and biotechnology Differential effect of simvastatin on various signal Carlo Bauer, Ahmed M. Osman, Giovanni transduction intermediates in cultured human Cercignani, Natalino Gialluca and Moreno Paolini smooth muscle cells Pascale Négre-Aminou, Monique van Erck, RAPID COMMUNICATION Rick E. W. van Leeuwen, John G. Collard Suppression of hepatocyte nuclear factor-4a by acyl- and Louis H. Cohen CoA thioesters of hypolipidemic peroxisome prolif- Prooxidant activity of B-hematin (synthetic malaria erators pigment) in arachidonic acid micelles and phospho- Rachel Hertz, Vered Sheena, Bella Kalderon, Ina lipid large unilamellar vesicles Berman and Jacob Bar-Tana Fausta Omodeo-Salé, Diego Monti, Piero Olliaro and Donatella Taramelli MOLECULAR AND CELLULAR PHARMACOLOGY Inhibition of nicotinic acetylcholine receptors and Structure-function relationship in the interaction of calcium channels by clozapine in bovine adrenal mastoparan analogs with neutrophil NADPH oxidase chromaffin cells Daphna Tisch-Idelson, Mati Fridkin, Frans Wientjes Tae-Ju Park, Seong-Il Bae, Se-Young Choi, and Irit Aviram Byung-Jo Kang and Kyong-Tai Kim Hydroxypropyl-B-cyclodextrin as delivery system for Specific involvement of G,;, with epidermal growth thyroid hormones, regulating glutathione S-trans- factor receptor signaling in rat hepatocytes, and the ferase expression in rat hepatocyte co-cultures inhibitory effect of chronic ethanol Tamara Vanhaecke, Marie-Paule Derde, Antoine Bao-Hong Zhang, Vikki Ho and Geoffery C. Farrell Vercruysse and Vera Rogiers Volume Contents, Author and Subject Index for Volume 61, 2001 Modulation of ligand responses by coupling of a ,- 1153 Regulation of TNFa and interleukin-10 production adrenoceptors to diverse G,-proteins by prostaglandins I, and E,: studies with prostaglandin receptor-deficient mice and prostraglandin E-receptor sub- Petrus J. Pauwels, Stéphanie Tardif, Francis C. type-selective synthetic agonists Colpaert and Thierry Wurch Shiho Shinomiya, Hiroaki Naraba, Akinori Ueno, Iku Stimulation of protein kinase C-dependent and -in- Utsunomiya, Takayuki Maruyama, Shuichi Ohuchida, dependent signaling pathways by bistratene A in Fumitaka Ushikubi, Koichi Yuki, Shuh Narumiya, intestinal epithelial cells Yukihiko Sugimoto, Atsushi Ichikawa and Sachiko Oh- Mark R. Frey, Olga Leontieva, Dianne J. Watters and ishi Jennifer D. Black Effects of phorbol ester and dexamethasone treatment CARDIOVASCULAR AND PULMONARY PHARMACOLOGY on histidine decarboxylase and ornithine decarboxyl- Inhibition of ATP-induced surfactant exocytosis by ase in basophilic cells dihydropyridine (DHP) derivatives: A non-stereospe- Ignacio Fajardo, Jose L. Urdiales, Miguel A. Medina cific, photoactivated effect and independent of L- and Francisca Sanchez-Jimenez type Ca** channels Influence of culture system and medium enrichment Manfred Frick, Gerlinde Siber, Thomas Haller, on sulfotransferase and sulfatase expression in male Norbert Mair and Paul Dietl rat hepatocyte cultures Role of G,-proteins in norepinephrine-mediated vasocon- Katrien Slaus, Michael W.H. Coughtrie, Sheila Sharp, striction in rat tail artery smooth muscle Tamara Vanhaecke, Antoine Vercruysse and Vera Marie-Anne Petitcolin, Esther Spitzbarth-Régrigny, Rogiers Jean-Luc Bueb, Christine Capdeville-Atkinson and Eric Tschirhart GENE EXPRESSION AND DEVELOPMENT The suppression of ornithine decarboxylase expres- Inhibition of liver methionine adenosyltransferase sion and cell proliferation at the promotion stage of gene expression by 3-methylcolanthrene: protective lung tumorigenesis in mice by a-tocopheryloxybu- effect of S-adenosylmethionine tyric acid M. Victoria Carretero, Maria U. Latasa, Elena R. Tomohiro Yano, Yoshihisa Yano, Shoko Yajima, Garcia-Trevijano, Fernando J. Corrales, Conrad Itumara Kumadaki, Tomio Ichikawa, Shuzo Otani and Wagner, Jose M. Mato and Matias A. Avila Kiyokazu Hagiwara STRUCTURAL BIOLOGY 15 May 2001 Inhibition of the preferential binding of actin to the N-terminal hydratase domain of the 78-kDa gastrin- Commentary binding protein by non-steroidal anti-inflammatory Guanidino-containing drugs in cancer chemother- drugs and gastrin receptor antagonists aphy: biochemical and clinical pharmacology Graham S. Baldwin Sara Ekelund, Peter Nygren and Rolf Larsson INFLAMMATION AND IMMUNOPHARMACOLOGY MOLECULAR AND CELLULAR PHARMACOLOGY Differential effects of pentoxifylline on the hepatic inflammatory response in porcine liver cell cultures: Effect of wogonin, a plant flavone from Scutellaria increase in inducible nitric oxide synthase expression radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in li- Kasper H.N. Hoebe, Nieves Gonzalez-Ramon, Sandra popolysaccharide-treated RAW 264.7 cells M. Nijmeijer, Renger F. Witkamp, Leo A.M.G. van Leengoed, Adelbert S.J.P.A.M. van Miert and Mario Yeon Sook Chi, Bong Sun Cheon and Hyun Pyo Kim Monshouwer Effects of structurally related flavonoids on cell cycle k-Opioid receptor agnoist suppression of HIV-1 ex- progression of human melanoma cells: regulation of pression in CD4* lymphocytes cyclin-dependent kinases CDK2 and CDK1 Fabrice Casagrande and Jean-Marie Darbon Phillip K. Peterson, Genya Gekker, James R. Lokensgard, Jean M. Bidlack, An-Chih Chang, Xingin Fang and Philip S. Portoghese Volume Contents, Author and Subject Index for Volume 61, 2001 1615 1217 Limitations of the single-cell gel electrophoresis assay 1293 Effects of epidermal growth factor on CYP inducibil- to monitor apoptosis in U937 and HepG2 cells ity by xenobiotics, DNA replication, and caspase exposed to 7B-hydroxycholesterol activations in collagen I gel sandwich cultures of rat hepatocytes Yvonne C. O’Callaghan, Julie A. Woods and Nora M. O’Brien Karen De Smet, Pascal Loyer, David Gilot, Antoine Vercruysse, Vera Rogiers and Tight binding of the angiotensin AT, receptor antag- Christiane Guguen-Guillouzo onist [*H]candesartan is independent of receptor internal- ization Frederik L. P. Fierens, Patrick M. L. Vanderheyden, INFLAMMATION AND IMMUNOPHARMACOLOGY Chantal Roggeman, Jean-Paul De Backer, Role of nitric oxide on the increased vascular perme- Thomas J. Thekkumkara and Georges Vauquelin ability and neutrophil accumulation induced by staphylococcal enterotoxin B into the mouse paw Structural damage to proteins caused by free radicals: assessment, protection by antioxidants, and influence Carla F. Franco-Penteado, Ivani Desouza, of protein binding Simone A. Teixeira, Glaci Ribeiro-DaSilva, Gilberto De Nucci and Edson Antunes Aline Salvi, Pierre-Alain Carrupt, Jean-Paul Tillement and Bernard Testa Inhibition of T-cell invasion across cultured fibro- blast monolayers by phenothiazine-related calmodu- lin inhibitors: impairment of lymphocyte motility by (CHEMOTHERAPY AND METABOLIC INHIBITORS trifluoperazine and chlorpromazine, and alteration of Alteration of nuclear factor-kB (NF-KB) expression the monolayer by pimozide in bone marrow stromal cells treated with etoposide Robert Grabski, Joelle Dewit, Jos De Braekeleer, Brett M. Hall, James E. Fortney and Laura F. Gibson Maria Malicka-Blaskiewicz, Patrick De Baetselier and Hendrik Verschueren NEUROSCIENCE The anti-inflammatory interactions of epinephrine Interaction of enkephalins with oxyradicals with human neutrophils in vitro are achieved by cyclic AMP- mediated accelerated resequestration of cytoso- Mario Fontana, Luciana Mosca and Maria Anna Rosei lic calcium Novel modified adenosine 5’-triphosphate analogues Gregory R. Tintinger, Annette J. Theron, pharmacologically characterized in human embryonic Ronald Anderson and James A. Ker kidney 293 cells highly expressing rat brain P2Y, receptor: biotinylated analogue potentially suitable for specific P2Y, receptor isolation 1 June 2001 Gregor Ziindorf, Rainer Schafer, Christian Vohringer, Efrat Halbinger, Bilha Fischer and Georg Reiser Commentary Inhibition of glutamine release by BIA 2-093 and Gy-like (GGL) domains: new frontiers in G-protein BIA 2-024, two novel derivatives of carbamazepine, signaling and B-propeller scaffolding due to blockade of sodium but not calcium channels John Sondek and David P. Siderovski Anténio F. Ambrésio, Ana p. Silva, Joao O. Malva, Patricio Soares-da-Silva, Arsélio Carvalho and MOLECULAR AND CELLULAR PHARMACOLOGY Caetana M. Carvalho Protein kinase C-mediated down-regulation of MDR3 and mRNA expression in Chang liver cells HORMONES AND GROWTH FACTORS Shinya Wakusawa, Ritsuko Ikeda, Yuhta Shiono and A dual role of protein kinase C in insulin signal Hisao Hayashi transduction via adenylyl cyclase signaling system in Involvement of all-trans-retinoic acid in the break- muscle tissues of vertebrates and invertebrates down of retinoic acid receptors a and y through Svetlana A. Plesneva, Alexander O. Shpakov, proteasomes in MCF-7 human breast cell cancer cells Ludmila A. Kuznetsova and Marianna N. Pertseva Takemi Tanaka, Maria Luisa Rodriguez de la Concepcién and Luigi M. De Luca