“AN AGTECH DEVELOPMENT COMPANY ENABLING THE NEXT GENERATION OF SAFER INSECTICIDES THAT ADDRESS INSECTICIDE RESISTANCE” Investor Briefing November 2017 1 For Information Only BIO-GENE SNAPSHOT Data shows initial products Flavocide™ & Qcide™ can be highly effective for insect control management Potentially suitable for commercialisation into multiple targeted insecticides BETA-TRIKETONES Platform Technology Collaborate with multinational AgChem partners to bring multiple An insecticide Key technology enabling the insect indications to market technology and IP next generation of safe development insecticides to address the company increasing problem of insecticide resistance Targeting public health, animal health & crop protection verticals 2 For Information Only EXECUTIVE SUMMARY Novel insecticide • Unique (new) mode of action identified – alternative chemistry to current platform leading to incumbent insecticides in a market seeking new products opening new potential products multiple market segments with multiple revenue sources • Significant test results (and new tests underway with world leading Strong test data institutions) demonstrate effectiveness of Flavocide™ at controlling resistant pests, as well as product safety • Strategic testing partnership finalised with Virbac, a leading multinational Initial multinational animal health company with significant Virbac investment in product partnership secured development supports Bio-Gene’s partnership strategy Manufacturing optimisation project • To produce Flavocide™ at commercial rates and pricing underway with CSIRO Established global • Growing IP portfolio with additional applications filed patents Appointment of new • Diverse skill set with significant industry experience board members 3 For Information Only BOARD & MANAGEMENT DON BRUMLEY RICHARD JAGGER ROBERT KLUPACS Non-Exec. Chairman Exec. Director & Executive Director CEO - Elect • 25+ years as a senior partner and leader • 20+ years working in Agriculture Globally • 30+ years corporate experience in of Ernst & Young - Oceania international tech development • Most recently employed as Managing • Significant experience across IPOs, Director of Sinochem Australia • Previously, MD and CEO of ASX-listed transactions, audit and advising growing Circadian Technologies Ltd • Previously spent 15+ years at Monsanto in entrepreneurial companies. various management roles • Previously, MD & CEO of ES Cell • Currently NED, Chairman of Audit and International Pte Ltd Risk Committee of Murray River Organics • Registered Australian patent attorney PETER MAY KEVIN RUMBLE ROGER MCPHERSON Non-Exec. Director Non-Exec. Director Chief Financial Officer & Company Secretary • 20+ years experience in crop protection • Founding Director of Bio-Gene • 15+ years experience as CFO and market with companies Orica & Crop Care Company Secretary across both listed • 20+ years experience in new plant Aus. (now Nufarm) and unlisted companies propagation, farming and live plant • Founded Xavca, providing consulting transport techniques • Experience in the Pharma Manufacturing, services to companies such as Syngenta Biotech, Biopharma industries • Involved in the development of QcideTM & & Sorex (BASF) development of Flavesone as a first step • Previously CFO and Co-Sec of TPI • Former CEO of BioProspect in the commercialisation of FlavocideTM Enterprises (ASX:TPI) 4 For Information Only GLOBAL PROBLEM: RESISTANCE & TOXICITY Global Problems Humans contract vector-borne diseases Resistance – 700,000 lives claimed per year Some targets are Zika virus has emerged Overuse resistant, survive Insecticide and dengue fever has + misuse and produce applied re-emerged Kills majority populations that of targets are insecticide resistant Reduced food production from vector-borne diseases in animals Toxicity Insects destroy an estimated 18-26 % of annual crop production worldwide 5 For Information Only THE CHALLENGE FOR AGCHEM No. of molecules that need to be screened to discover a new molecule for No. of species resistant to at least one product use insecticide class 586 insect species now resistant to at least one 700 160,000 insecticide class 140,000 600 Hundreds of thousands 120,000 of molecules need to be 500 screened now to find a 100,000 new product 400 80,000 300 AgChem requires new 60,000 chemistries but there is a challenge to finding new 200 chemistries 40,000 100 20,000 Bio-Gene has a novel 0 0 chemistry that it seeks 1930 1940 1950 1960 1970 1980 1990 2000 2010 2014 1950 1960 1970 1980 1990 2000 2010 to bring to market Data: GT Brooks 1974, RL Metcalf 1980, W Klassen 1995, P McDougal 2003, CropLife 2011 6 For Information Only NOVEL MODE OF ACTION (EXAMPLE CROP PROTECTION) 2017 Novel 31 Qcide™ & 1944 1968 1970 1977 1985 1990 2002 2005 2008 Flavocide™ Significant market potential Novel 11 Novel 4 based on MICROBIAL (NACHR) performance of DISRUPTORS OF COMPETITIVE other classes INSECT MIDGUT MODULATORS coming to market MEMBRANES (NEONICOTINOIDS) Novel 17 Novel 28 Novel 23 Novel 12 MOULTING INHIBITORS RYANODINE INHIBITORS OF DISRUPTOR, OF ACETYL RECEPTOR MITOCHONDRIAL DIPTERAN COA MODULATORS (DIAMIDES) ATP SYNTHASE CARBOXYLAS E Novel 3 Novel 29 SODIUM CHANNEL CHORDOTONA Novel 1 MODULATORS L ORGAN ACETYLCHOLINESTERA (PYRETHROIDS) MODULATORS SE (ACHE) INHIBITORS (ORGANOPHOSPHATES) Still US$1.7B in sales per US$2.7B in sales US$4.6B in sales Taken 8% market share and annum today per annum today per annum today US$1.4B sales per annum today (Source: IRAC) 7 For Information Only LARGE GLOBAL, GROWING MARKETS Sprays, Baits, Stable industry dominated by Repellants multi-national AgChem companies Consumer Applications $5.1B Animal Health $6.0B Seeking, Safe New Solutions to complement off-patent insecticides Livestock, Pets Crop Public Health Protection AgTech with access $4.0B $16.0B to new technology platform leading to Food, fibre, Malaria, Zika, Dengue new insecticides grain storage 8 For Information Only BIO-GENE TECHNOLOGY APPROACH Synthetic = Replicable at BETA-TRIKETONES: PLATFORM TECHNOLOGY commercial quantities (SCALABLE) FLAVOCIDETM QCIDETM SYNTHETIC COMPOUND, NATURAL OIL PRODUCT, FLAVESONE TASMANONE CONSUMER ANIMAL HEALTH PUBLIC HEALTH CROP PROTECTION APPLICATIONS Targeted pest/animal Targeted pest/vector Targeted pest/crop Targeted applications combinations combination combinations AIM: BRING TO MARKET A BROAD PORTFOLIO OF TARGETED INSECT CONTROL MANAGEMENT SOLUTIONS Near-term consumer opportunities available with QCide™ 9 For Information Only FLAVOCIDE™: A UNIQUE MODE OF ACTION Comparison of the effects of Flavocide with other known insecticides on rat DRG membrane potential Our collaborators have 80 elucidated Flavesone MOA IT DOES NOT act via mechanisms listed by IRAC 60 ** 40 “Flavocide clearly exhibits ** ) a completely different V m ( m 20 profile compared to all V ∆ other tested compounds in rat DRG neurones” – 0 NeuroSolutions, August 2017 -20 ** ** -40 10 For Information Only