i Basic Medical Endocrinology Fourth Edition Basic Medical Endocrinology, Fourth Edition by H. Maurice Goodman Resources for Professors: ACADEMIC PRESS • All figures from the book available as PowerPoint slides • Links to web sites carefully chosen to supplement the content of the textbook To adopt this book for course use, visit http://textbooks.elsevier.com. Companion Web Site: http://books.elsevier.com/companions/9780123739759 T O O L S ALL NEEDS FOR YOUR textbooks.elsevier.com TEACHING Basic Medical Endocrinology Fourth Edition AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic Press is an imprint of Elsevier H. Maurice Goodman Department of Physiology University of Massachusetts Medical School Cover Credits: Background: FIGURE 3-2 Histology of the human thyroid. Simple cuboidal cells (arrows) make up the follicles. C _ thyroid colloid (thyroglobulin), which fi lls the follicles. (From Borysenko, M. and Beringer, T. (1979) Functional Histology, 312. Little, Brown, Boston by permission of Lippincott, Williams and Wilkins, Philadelphia.) Black/green: FIGURE 7-11 Confocal fl uorescent microscope images of cultured mouse adipocytes that were transfected with a GLUT4-enhanced green fl uorescent protein fusion construct and then incubated in the absence (A) or presence (B) of insulin for 30 min. Insulin stimulation results in the translocation of GLUT4 from intracellular storage sites to the plasma membrane. (From Watson, R.T., Kanzaki, M., and Pessin, J. (2004) Regulated membrane traffi cking of the insulin-responsive glucose transporter 4 in adipocytes. Endocr. Revs. 25: 177–204, by permission of Th e Endocrine Society.) Blue fi gure: FIGURE 10-14 Low-power photomicrograph of a portion of the thyroid gland of a normal dog. Parafollicular (C) cells are indicated in the walls of the follicles. (From Ham, A.W. and Cormack, D. H. (1979) Histology, 8th Edition, 802, by permission of Lippincott, Williams and Wilkins, Philadelphia.) Red, white and blue: FIGURE 11-3 Schematic representation of the tibial epiphyseal growth plate. (Modifi ed from Nilsson, O., Marino, R., De Luca, F., Phillip, M., and Baron, J. (2005) Endocrine regulation of the growth plate. Hormone Research 64: 157–165 by permission of S. Karger AG, Basel.) Pink, yellow, white: FIGURE 12-1 Histological section of human testis. Th e transected tubules show various stages of spermatogenesis. (From di Fiore, M.S.H. (1981) Atlas of Human Histology, 5th Edition, 209. Lea & Febiger, by permission of Lippincott, Williams and Wilkins, Philadelphia.) Academic Press is an imprint of Elsevier 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, California 92101-4495, USA 84 Th eobald’s Road, London WC1X 8RR, UK Copyright © 2009, Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone: ( � 44) 1865 843830, fax: ( � 44) 1865 853333, E-mail: