Baran & Dawber’s Diseases of the Nails and their Management Chapter No.: 1 Title Name: <TITLENAME> ffirs.indd Comp. by: <USER> Date: 27 Nov 2018 Time: 10:14:45 AM Stage: <STAGE> WorkFlow:<WORKFLOW> Page Number: i Chapter No.: 1 Title Name: <TITLENAME> ffirs.indd Comp. by: <USER> Date: 27 Nov 2018 Time: 10:14:45 AM Stage: <STAGE> WorkFlow:<WORKFLOW> Page Number: ii Baran & Dawber’s Diseases of the Nails and their Management Fifth Edition Edited by Robert Baran, MD, PhD Hon. Pr. of the University of Franche‐Comté; Nail Disease Centre, Cannes, France David de Berker, BA, MBBS, MRCP, PhD Bristol Dermatology Centre, Bristol Royal Infirmary, Bristol, UK Mark Holzberg, MD, PhD Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA Bianca Maria Piraccini, MD, PhD Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy Bertrand Richert, MD, PhD Department of Dermatology, Brugmann, St Pierre and Queen Fabiola University Hospitals, Université Libre de Bruxelles, Brussels, Belgium Luc Thomas, MD, PhD Department of Dermatology, Centre Hospitalier Lyon Sud; Lyon Cancer Research Center (Pr Puisieux); Lyon 1 Claude Bernard University, Lyon, France Chapter No.: 1 Title Name: <TITLENAME> ffirs.indd Comp. by: <USER> Date: 27 Nov 2018 Time: 10:14:45 AM Stage: <STAGE> WorkFlow:<WORKFLOW> Page Number: iii This edition first published 2019 © 2019 John Wiley & Sons Ltd Edition History John Wiley & Sons Ltd (4e, 2012); (3e, 2001); (2e, 1994); (1e, 1984) All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions. The right of Robert Baran, David de Berker, Mark Holzberg, Bianca Maria Piraccini, Bertrand Richert, and Luc Thomas to be identified as the authors of the editorial material in this work has been asserted in accordance with law. Registered Office(s) John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial Office 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com. 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Other titles: Baran and Dawber’s diseases of the nails and their management | Diseases of the nails and their management Description: Fifth edition. | Hoboken, NJ : Wiley-Blackwell, 2019. | Includes bibliographical references and index. | Identifiers: LCCN 2018038792 (print) | LCCN 2018039737 (ebook) | ISBN 9781119324256 (Adobe PDF) | ISBN 9781119324225 (ePub) | ISBN 9781119323358 (hardback) Subjects: | MESH: Nail Diseases | Nails–physiology | Nails, Malformed Classification: LCC RL165 (ebook) | LCC RL165 (print) | NLM WR 475 | DDC 616.5/47–dc23 LC record available at https://lccn.loc.gov/2018038792 Cover Design: Wiley Cover Images: On the top row, image 1, courtesy of Bianca Maria Piraccini; images 2 and 3, courtesy of Luc Thomas; images 4 and 5, courtesy of Bertrand Richert. On the bottom row, image 6, courtesy of Archana Singal; images 7 and 8, courtesy of Bianca Maria Piraccini; image 9, courtesy of Robert Baran Set in 10/12pt Warnock by SPi Global, Pondicherry, India 10 9 8 7 6 5 4 3 2 1 Chapter No.: 1 Title Name: <TITLENAME> ffirs.indd Comp. by: <USER> Date: 27 Nov 2018 Time: 10:14:45 AM Stage: <STAGE> WorkFlow:<WORKFLOW> Page Number: iv v Contents List of Contributors vii List of Abbreviations ix Foreword xi Preface xiii About the Companion Website xiv Part I The Normal Nail and Nail Signs 1 1 Science of the Nail Apparatus 1 David de Berker, Beth S. Ruben, and Robert Baran 2 Physical Signs 59 Adam Rubin, Mark Holzberg, and Robert Baran Part II Imaging of the Nail Unit 105 3 Nail Photography 105 Paola Pasquali 4 Dermoscopy 113 Luc Thomas, Sébastien Debarbieux, and Amélie Boespflug 5 Ultrasound and Other Imaging Methods 140 Ximena Wortsman, Gregor B.E. Jemec, and Axel Villani 6 Magnetic Resonance Imaging 175 Jean‐Luc Drapé 7 Nail Fold Capillary Microscopy or Capillaroscopy 201 Gregor B.E. Jemec 8 Confocal Microscopy 204 Sébastien Debarbieux, Amélie Boespflug, Bruno Labeille, and Luc Thomas Part III Nail Disorders Occurring Principally in Childhood 213 9 Hereditary and Congenital Nail Disorders 213 Smail Hadj‐Rabia, Rudolf Happle, Bianca Maria Piraccini, and Robert Baran 10 Nail Disorders in Childhood 297 David de Berker, Bianca Maria Piraccini, Beth S. Ruben, and Robert Baran Chapter No.: 1 Title Name: <TITLENAME> ftoc.indd Comp. by: <USER> Date: 27 Nov 2018 Time: 10:15:43 AM Stage: <STAGE> WorkFlow:<WORKFLOW> Page Number: v vi Contents Part IV Nail Disorders in the Elderly 337 11 The Aging Nail and Related Disorders 337 Bertrand Richert Part V Nail Infections 349 12 Fungal (Onychomycosis) and Other Infections Involving the Nail Apparatus 349 Roderick J. Hay, Boni Elewski, Bianca Maria Piraccini, Nikki Sullivan, Casey Wang, and Robert Baran 13 Bacterial, Viral, and Other Infections 390 Archana Singal and Bertrand Richert Part VI The Nail in Dermatological Conditions 409 14 Dermatological Disorders 409 Bianca Maria Piraccini, Mark Holzberg, Marcel Pasch, and Dimitrios Rigopoulos Part VII The Nail in Systemic Conditions 481 15 The Nail in Systemic Disease 481 Mark Holzberg and Bianca Maria Piraccini 16 Drug‐induced Nail Disorders 574 Bianca Maria Piraccini 17 Anticancer Therapies 604 Vincent Sibaud, Robert Baran, Bianca Maria Piraccini, Mario E. Lacouture, and Caroline Robert Part VIII The Nail in Occupational, Podiatric, and Cosmetic Conditions 617 18 Occupational Abnormalities and Contact Dermatitis 617 Robert Baran and An Goossens 19 Cosmetics: the Care and Adornment of the Nail 646 Douglas Schoon and Robert Baran 20 Trauma from Footwear and Pedal Deformities 662 Bertrand Richert Part IX Nail Tumors and Surgery 675 21 Tumors of the Nail Apparatus and Adjacent Tissues 675 Marcel Pasch, Eckart Haneke, Robert Baran, Luc Thomas, and Bertrand Richert 22 Nail Surgery 825 Bertrand Richert, Eckart Haneke, Elvin G. Zook, and Robert Baran Appendix 896 Mark Holzberg Index 949 vii List of Contributors Robert Baran, MD, PhD Rudolf Happle, MD Hon. Pr. of the University of Franche‐Comté; Universitaets‐Hautklinik, Freiburg, Germany Nail Disease Centre, Cannes, France Roderick J. Hay, DM, FRCP Amélie Boespflug, MD, PhD King’s College London, London, UK Department of Dermatology, Centre Hospitalier Lyon Sud; Lyon Cancer Research Center (Pr Puisieux); Mark Holzberg, MD, PhD Lyon 1 Claude Bernard University, Lyon, France Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA Sébastien Debarbieux, MD Department of Dermatology, Centre Hospitalier Lyon Gregor B.E. Jemec, MD, DMSc Sud; Lyon Cancer Research Center (Pr Puisieux); Department of Dermatology, Zealand University Lyon 1 Claude Bernard University, Lyon, France Hospital, Roskilde; Health Sciences Faculty, David de Berker, BA, MBBS, MRCP, PhD University of Copenhagen, Copenhagen, Denmark Bristol Dermatology Centre, Bristol Royal Infirmary, Bruno Labeille, MD Bristol, UK Dermatology Department, Hôpital Nord, Saint Etienne, Jean‐Luc Drapé, MD, PhD France Department of Radiology, Hôpital Cochin, University Paris Descartes, Sorbonne Paris Centre, France Mario E. Lacouture, MD, PhD Dermatology Service, Memorial Sloan Kettering Boni Elewski, MD Cancer Center, New York, NY, USA Department of Dermatology, The University of Alabama at Birmingham, Birmingham, AL, USA Marcel Pasch, MD, PhD Department of Dermatology, Radboud University An Goossens, RPharm, PhD Medical Center, Nijmegen, The Netherlands Professor Emeritus, Contact Allergy Unit, University Hospital K.U. Leuven, Leuven, Belgium Paola Pasquali, MD Pius Hospital de Valls, Tarragona, Spain Smail Hadj‐Rabia, MD, PhD Department of Dermatology and Reference Center for Bianca Maria Piraccini, MD, PhD Genodermatoses and Rare Skin Diseases; University Dermatology, Department of Experimental, Diagnostic Paris Descartes - Sorbonne Paris Cité; Institut Imagine, and Specialty Medicine, University of Bologna, Paris, France Bologna, Italy Eckart Haneke, MD, PhD Bertrand Richert, MD, PhD Department of Dermatology, University of Bern, Bern, Switzerland; Centro de Dermatología Epidermis, Porto, Department of Dermatology, Brugmann, St Pierre and Portugal; Department of Dermatology, University of Queen Fabiola University Hospitals, Université Libre de Ghent, Ghent, Belgium Bruxelles, Belgium Chapter No.: 1 Title Name: <TITLENAME> fbetw.indd Comp. by: <USER> Date: 27 Nov 2018 Time: 10:15:48 AM Stage: <STAGE> WorkFlow:<WORKFLOW> Page Number: vii viii List of Contributors Dimitrios Rigopoulos, MD Archana Singal, MD, MNAMS National and Kapodistrian University of Athens; Department of Dermatology and STD, University Medical School, University Hospital “A. Sygros”, College of Medical Sciences, Delhi, India Department of Dermatology and Venereology, Athens, Greece Nikki Sullivan, MD Department of Dermatology, University of Michigan, Caroline Robert, MD, PhD Ann Arbor, MI, USA Department of Dermatology, Institut Gustave Roussy, Villejuif; Department of Dermatology, Paris‐Sud Luc Thomas, MD, PhD University, Orsay, France Department of Dermatology, Centre Hospitalier Lyon Sud; Lyon Cancer Research Center (Pr Puisieux); Lyon 1 Beth S. Ruben, MD Claude Bernard University, Lyon, France Dermatology/Dermatopathology, University of California, San Francisco; Dermatopathology, Palo Alto Axel Villani, MD Medical Foundation, Palo Alto, CA, USA Dermatology Department, Edouard Herriot Hospital, Lyon 1 Claude Bernard University, Lyon, France Adam Rubin, MD Departments of Dermatology, Pediatrics, and Pathology Casey Wang, MD and Laboratory Medicine, Hospital of the University Department of Dermatology, The University of of Pennsylvania; Children’s Hospital of Philadelphia, Alabama at Birmingham, Birmingham, AL, USA Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Ximena Wortsman, MD Institute for Diagnostic Imaging and Research of the Douglas Schoon, MS Skin and Soft Tissues; Departments of Dermatology, Schoon Scientific + Regulatory Consulting LLC, Dana University of Chile and Pontifical Catholic University of Point, CA, USA Chile, Santiago, Chile Vincent Sibaud, MD Elvin G. Zook, MD (Deceased) Department of Oncodermatology, Institut Universitaire Formerly, Plastic Surgery Institute, Southern Illinois du Cancer – Toulouse Oncopole, Toulouse, France University, School of Medicine, Springfield, IL, USA Chapter No.: 1 Title Name: <TITLENAME> fbetw.indd Comp. by: <USER> Date: 27 Nov 2018 Time: 10:15:48 AM Stage: <STAGE> WorkFlow:<WORKFLOW> Page Number: viii