A RSENIC A MEDICAL DICTIONARY, BIBLIOGRAPHY, AND ANNOTATED RESEARCH GUIDE TO INTERNET REFERENCES JAMES N. PARKER, M.D. AND PHILIP M. PARKER, PH.D., EDITORS ii ICON Health Publications ICON Group International, Inc. 4370 La Jolla Village Drive, 4th Floor San Diego, CA 92122 USA Copyright ©2003 by ICON Group International, Inc. Copyright ©2003 by ICON Group International, Inc. All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without written permission from the publisher. Printed in the United States of America. Last digit indicates print number: 10 9 8 7 6 4 5 3 2 1 Publisher, Health Care: Philip Parker, Ph.D. Editor(s): James Parker, M.D., Philip Parker, Ph.D. Publisher's note: The ideas, procedures, and suggestions contained in this book are not intended for the diagnosis or treatment of a health problem. As new medical or scientific information becomes available from academic and clinical research, recommended treatments and drug therapies may undergo changes. The authors, editors, and publisher have attempted to make the information in this book up to date and accurate in accord with accepted standards at the time of publication. The authors, editors, and publisher are not responsible for errors or omissions or for consequences from application of the book, and make no warranty, expressed or implied, in regard to the contents of this book. Any practice described in this book should be applied by the reader in accordance with professional standards of care used in regard to the unique circumstances that may apply in each situation. The reader is advised to always check product information (package inserts) for changes and new information regarding dosage and contraindications before prescribing any drug or pharmacological product. Caution is especially urged when using new or infrequently ordered drugs, herbal remedies, vitamins and supplements, alternative therapies, complementary therapies and medicines, and integrative medical treatments. Cataloging-in-Publication Data Parker, James N., 1961- Parker, Philip M., 1960- Arsenic: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References / James N. Parker and Philip M. Parker, editors p. cm. Includes bibliographical references, glossary, and index. ISBN: 0-597-83743-0 1. Arsenic-Popular works. I. Title. iii Disclaimer This publication is not intended to be used for the diagnosis or treatment of a health problem. It is sold with the understanding that the publisher, editors, and authors are not engaging in the rendering of medical, psychological, financial, legal, or other professional services. 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ICON Group often grants permission for very limited reproduction of our publications for internal use, press releases, and academic research. Such reproduction requires confirmed permission from ICON Group International Inc. The disclaimer above must accompany all reproductions, in whole or in part, of this book. iv Acknowledgements The collective knowledge generated from academic and applied research summarized in various references has been critical in the creation of this book which is best viewed as a comprehensive compilation and collection of information prepared by various official agencies which produce publications on arsenic. Books in this series draw from various agencies and institutions associated with the United States Department of Health and Human Services, and in particular, the Office of the Secretary of Health and Human Services (OS), the Administration for Children and Families (ACF), the Administration on Aging (AOA), the Agency for Healthcare Research and Quality (AHRQ), the Agency for Toxic Substances and Disease Registry (ATSDR), the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), the Healthcare Financing Administration (HCFA), the Health Resources and Services Administration (HRSA), the Indian Health Service (IHS), the institutions of the National Institutes of Health (NIH), the Program Support Center (PSC), and the Substance Abuse and Mental Health Services Administration (SAMHSA). In addition to these sources, information gathered from the National Library of Medicine, the United States Patent Office, the European Union, and their related organizations has been invaluable in the creation of this book. Some of the work represented was financially supported by the Research and Development Committee at INSEAD. This support is gratefully acknowledged. Finally, special thanks are owed to Tiffany Freeman for her excellent editorial support. v About the Editors James N. Parker, M.D. Dr. James N. Parker received his Bachelor of Science degree in Psychobiology from the University of California, Riverside and his M.D. from the University of California, San Diego. In addition to authoring numerous research publications, he has lectured at various academic institutions. Dr. Parker is the medical editor for health books by ICON Health Publications. Philip M. Parker, Ph.D. Philip M. Parker is the Eli Lilly Chair Professor of Innovation, Business and Society at INSEAD (Fontainebleau, France and Singapore). Dr. Parker has also been Professor at the University of California, San Diego and has taught courses at Harvard University, the Hong Kong University of Science and Technology, the Massachusetts Institute of Technology, Stanford University, and UCLA. Dr. Parker is the associate editor for ICON Health Publications. vi About ICON Health Publications To discover more about ICON Health Publications, simply check with your preferred online booksellers, including Barnes & Noble.com and Amazon.com which currently carry all of our titles. Or, feel free to contact us directly for bulk purchases or institutional discounts: ICON Group International, Inc. 4370 La Jolla Village Drive, Fourth Floor San Diego, CA 92122 USA Fax: 858-546-4341 Web site: www.icongrouponline.com/health vii Table of Contents FORWARD..........................................................................................................................................1 CHAPTER 1. STUDIES ON ARSENIC....................................................................................................3 Overview........................................................................................................................................3 The Combined Health Information Database.................................................................................3 Federally Funded Research on Arsenic..........................................................................................4 E-Journals: PubMed Central.......................................................................................................59 The National Library of Medicine: PubMed................................................................................61 CHAPTER 2. NUTRITION AND ARSENIC........................................................................................107 Overview....................................................................................................................................107 Finding Nutrition Studies on Arsenic.......................................................................................107 Federal Resources on Nutrition.................................................................................................115 Additional Web Resources.........................................................................................................116 CHAPTER 3. ALTERNATIVE MEDICINE AND ARSENIC..................................................................119 Overview....................................................................................................................................119 National Center for Complementary and Alternative Medicine................................................119 Additional Web Resources.........................................................................................................133 General References.....................................................................................................................137 CHAPTER 4. DISSERTATIONS ON ARSENIC....................................................................................139 Overview....................................................................................................................................139 Dissertations on Arsenic............................................................................................................139 Keeping Current........................................................................................................................144 CHAPTER 5. CLINICAL TRIALS AND ARSENIC..............................................................................145 Overview....................................................................................................................................145 Recent Trials on Arsenic............................................................................................................145 Keeping Current on Clinical Trials...........................................................................................152 CHAPTER 6. PATENTS ON ARSENIC...............................................................................................155 Overview....................................................................................................................................155 Patents on Arsenic.....................................................................................................................155 Patent Applications on Arsenic.................................................................................................192 Keeping Current........................................................................................................................231 CHAPTER 7. BOOKS ON ARSENIC..................................................................................................233 Overview....................................................................................................................................233 Book Summaries: Online Booksellers.........................................................................................233 The National Library of Medicine Book Index...........................................................................238 Chapters on Arsenic...................................................................................................................239 CHAPTER 8. MULTIMEDIA ON ARSENIC.......................................................................................243 Overview....................................................................................................................................243 Bibliography: Multimedia on Arsenic........................................................................................243 CHAPTER 9. PERIODICALS AND NEWS ON ARSENIC....................................................................245 Overview....................................................................................................................................245 News Services and Press Releases..............................................................................................245 Academic Periodicals covering Arsenic.....................................................................................250 CHAPTER 10. RESEARCHING MEDICATIONS.................................................................................251 Overview....................................................................................................................................251 U.S. Pharmacopeia.....................................................................................................................251 Commercial Databases...............................................................................................................252 APPENDIX A. PHYSICIAN RESOURCES..........................................................................................255 Overview....................................................................................................................................255 NIH Guidelines..........................................................................................................................255 NIH Databases...........................................................................................................................257 Other Commercial Databases.....................................................................................................259 viii Contents APPENDIX B. PATIENT RESOURCES...............................................................................................261 Overview....................................................................................................................................261 Patient Guideline Sources..........................................................................................................261 Finding Associations..................................................................................................................265 APPENDIX C. FINDING MEDICAL LIBRARIES................................................................................267 Overview....................................................................................................................................267 Preparation.................................................................................................................................267 Finding a Local Medical Library................................................................................................267 Medical Libraries in the U.S. and Canada.................................................................................267 ONLINE GLOSSARIES................................................................................................................273 Online Dictionary Directories...................................................................................................273 ARSENIC DICTIONARY.............................................................................................................275 INDEX..............................................................................................................................................357 1 FORWARD In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."1 Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing. Since only the smallest fraction of information dealing with arsenic is indexed in search engines, such as www.google.com or others, a non- systematic approach to Internet research can be not only time consuming, but also incomplete. This book was created for medical professionals, students, and members of the general public who want to know as much as possible about arsenic, using the most advanced research tools available and spending the least amount of time doing so. In addition to offering a structured and comprehensive bibliography, the pages that follow will tell you where and how to find reliable information covering virtually all topics related to arsenic, from the essentials to the most advanced areas of research. Public, academic, government, and peer-reviewed research studies are emphasized. Various abstracts are reproduced to give you some of the latest official information available to date on arsenic. Abundant guidance is given on how to obtain free-of-charge primary research results via the Internet. While this book focuses on the field of medicine, when some sources provide access to non-medical information relating to arsenic, these are noted in the text. E-book and electronic versions of this book are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). If you are using the hard copy version of this book, you can access a cited Web site by typing the provided Web address directly into your Internet browser. You may find it useful to refer to synonyms or related terms when accessing these Internet databases. NOTE: At the time of publication, the Web addresses were functional. However, some links may fail due to URL address changes, which is a common occurrence on the Internet. For readers unfamiliar with the Internet, detailed instructions are offered on how to access electronic resources. For readers unfamiliar with medical terminology, a comprehensive glossary is provided. For readers without access to Internet resources, a directory of medical libraries, that have or can locate references cited here, is given. We hope these resources will prove useful to the widest possible audience seeking information on arsenic. The Editors 1 From the NIH, National Cancer Institute (NCI): http://www.cancer.gov/cancerinfo/ten-things-to-know.