h Annual Review of Biochemistry Volume 75, 2006 Wandering so fa DNA Enzymologist: From DNA Polymerase to Viral Signaling Pathways in Skeletal Muscle Remodeling Rhoi da Bassel-Duby and Eric N. Olson Biosynthesis and \ssembly of Capsular Polysaccharides in ( [yrphostins and Other ‘Tyrosine Kinase Inhibitors llexand ]y tzki and Eyal Mishani duced Replication and Recombinational Telomere Elongation j. McEachern and James E. Haber LKBI-D«s g Pathways oy Dai and fose R. Bayascas Energy Transduction: Proton Transfer Through the Respiratory ( omple x es n P. Hosler, Shelagh Fereuson-Miller, and Denise A. Mills Associated Protein Kinases: Stru ture, Function, and Bevond Shani Bialik vl Adi Kimehi Mechanisms for Chromosome and Plasmid Segregation Sai tanu Kumar Ghosh, Sujata Hajra Indrew Paek, and Makkuni Fayaram Chromatin Modifications by Methylation and Ubiquitination Implications in the Regulation of Gene Expression {/i Shilatifard Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery Laurence H. Pearl and Chrisostomos Prodromou Biochemistry of Mammalian Peroxisomes Revisited Ronald 7.A. Wanders and Hans R. Waterham Protein Misfolding, Functional Amyloid, and Human Disease Fabrizio Chiti and Christopher M. Dobson .. Obesity-Related Derangements in Metabolic Regulation Deborah M. Muoio and Christopher B. Newgard . Cold-Adapted Enzymes Khawar Sohail Siddiqui and Ricardo Cavicchioli lhe Biochemistry of Sirtuins Inthony A. Sauve, Cynthia Wolberger, Vern L. Schramm, and Jef D. Boeke Dynamic Filaments of the Bacterial Cytoskeleton Katharine A. Michie and Jan Lowe Che Structure and Function of ‘Telomerase Reverse Transcriptase Chantal Autexier and Neal F. Lue Relating Protein Motion to Catalysis Sharon Hammes-Schiffer and Stephen7 . Benkovic \nimal Cytokinesis: From Parts List to Mechanisms Ulrike S. Eggert, Timothy 7. Mitchison, and Christine M. Field Mechanisms of Site-Specific Recombination Nigel D.F- Grindley, Katrine L. Whiteson, and Phoebe A. Rice Axonal! Transport and Alzheimer’s Disease Gorazd B. Stokin and Lawrence S.B. Goldsteiz \sparagine Synthetase Chemotherapy Nigel G.}. Richards and Michael S. Kilberg Domains, Motifs, and Scaffolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits Roby P. Bhattacharyya, Attila Reményi, BrianF . Yeh, and Wendell A. Lim Ribonucleotide Reductases Par Nordlund and Peter Reichard Introduction to the Membrane Protein Reviews: The Interplay of Structure, Dynamics, and Environment in Membrane Protein Function Jonathan N. Sachs and Donald M. Engelman Relations Between Structure and Function of the Mitochondrial ADP/ATP Carrier H. Nury, C. Dahout-Gonzalez, V. Trézéguet, G.7.M. Lauquin, G. Brandolin, and E. Pebay-Peyroula G Protein—Coupled Receptor Rhodopsin Krzysztof Palczewski Transmembrane Traffic in the Cytochrome b, f Complex William A. Cramer, Huamin Zhang, fFiusheng Yan, Genji Kurisu, and Janet L. Smith INDEXES Subject Index Author Index ERRATA \n online log of corrections to Annual Review of Biochemistry chapters (if any, 19 the present) may be found at http://biochem.annualreviews.org/errata.shtml