Annual Reports in MEDICINAL CHEMISTRY VOLUME43 Sponsored by the Division of Medicinal Chemistry of the American Chemical Society Editor-in-Chief JOHN E. MACOR Neuroscience Discovery Chemistry Bristol-Myers Squibb Wallingford, CT, United States Section Editors ROBICHAUD � STAMFORD � BARRISH � MYLES � PRIMEAU � LOWE � DESAI Amsterdam � Boston � Heidelberg � London � New York � Oxford Paris � San Diego � San Francisco � Singapore � Sydney � Tokyo Academic Press is an imprint of Elsevier ACADEMIC PRESS Academic Press is an imprint of Elsevier 32 Jamestown Road, London NW1 7BY, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands Linacre House, Jordan Hill, Oxford OX2 8DP, UK 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2008 Copyright r 2008 Elsevier Inc. All rights reserved No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (+44) (0) 1865 843830; fax (+44) (0) 1865 853333; email: