2004 Contents Volume 68 Number 1 January 2004 | Isolation by Language and Distance in Belgium I. Barrai, A. Rodriguez-Larralde, RFM anni, V. Ruggiero, D. Tartari and C. Scapoli Molecular Analysis of Myophosphorylase Deficiency in Dutch Patients with McArdle’s Disease M. A. Martin, J. C. Rubio, R. A. Wevers, B. G. M. Van Engelen, G. C. H. Steenbergen, O. P. Van Diggelen, M. De Visser, C. De Die-Smulders, A. Blazquez, A. L. Andreu and J. Arenas Mitochondrial DNA Sequence Diversity in a Sedentary Population from Egypt A. Stevanovitch, A. Gilles, E. Bouzaid, R. Kefi, EK Paris, R. P. Gayraud, J. L. Spadoni, F. El-Chenawi and E. Béraud-Colomb Pattern of mtDNA Variation in Three Populations from Sio Toma e Principe M. J. Trovoada, L. Pereira, L. Gusmao, A. Abade, A. Amorim and M. J. Prata Tests of Gene-Environment Interaction for Case-Parent Triads with General Environmental Exposures S. L. Lake and N. M. Laird Short Communication On the Power of Affected Relative Pair Designs for Linkage Studies Z. Li and J. L. Gastwirth Review Meta-Analysis of Linkage Studies for Complex Diseases: An Overview of Methods and a Simulation Study A. Dempfle and S. Loesgen Volume 68 Number 2 March 2004 85 DNMIDN: a new class of paralogous genomic segments (duplicons) with highly conserved copies on chromosomes Y and 15 E. Makrinou, M. Fox,J . Wolfe, J. Cameron, K.Taylor and Y. H. Edwards The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination H. Oota, A. J. Pakstis, B. Bonne-Tamir, D. Goldman, E. Grigorenko, S. L. B. Kajuna, N. J. Karoma, S. Kungulilo, R.-B. Lu, K. Odunsi, EFO konofua, O. V. Zhukova,J . R. Kidd and K. K. Kidd Population differences in DNA sequence variation and linkage disequilibrium at the PON1 gene Y. Koda, H. Tachida, M. Soejima, O. Takenaka and H. Kimura Alu insertion polymorphisms in the Balkans and the origins of the Aromuns D. Comas, H. Schmid, S. Braeuer, C. Flaiz, A. Busquets, F. Calafell,J .B ertranpetit, H.-G. Scheil, W. Hucken- beck, L. Efremovska and H. Schmidt Genetic structure and affinities among tribal populations of southern India: a study of 24 autosomal DNA markers H. Vishwanathan, E. Deepa, R. Cordaux, M. Stoneking, M. V. Usha Rani and P. P. Majumder Admixture in the Hispanics of the San Luis Valley, Colorado, and its implications for complex trait gene mapping C. Bonilla, E. J. Parra, C. L. Pfaff, S. Dios, J. A. Marshall, R. EKH amman, R. E. Ferrell, C. L. Hoggart, P. M. McKeigue and M. D. Shriver Complex segregation analyses of bone mineral density in Chinese P. Y. Liu, Y. J. Qin, Q. Zhou, R. R. Recker and H. W. Deng A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm D. A. Tregouet, S. Escolano, L. Tiret, A. Mallet and J. L. Golmard Volume 68 Number 3 May 2004 U79 Heritability of C-Reactive Protein and Association with Apolipoprotein E Genotypes in Japanese Americans M. A. Austin, C. Zhang, S. E. Humphries, W. L. Chandler, P. J. Talmud, K. L. Edwards, D. L. Leonetti, M. J. Mcneely and W. Y. Fujimoto © University College London 2004 Annals of Human Genetics (2004) 68,i-iv 189 Molecular Analysis of GAA Repeats and Four Linked Bi-allelic Markers in and Around the Frataxin Gene in Patients and Normal Populations from India B. Chattopadhyay, S. Gupta, P. K. Gangopadhyay, S. K. Das, T. Roy, S. C. Mukherjee, K. K. Sinha, B. S. Singhal and N. P. Bhattacharyya Age Related Changes in 5-methylcytosine Content in Human Peripheral Leukocytes and Placentas: an HPLC-based Study C. Fuke, M. Shimabukuro, A. Petronis, J.S ugimoto, T. Oda, K. Miura, T. Miyazaki, C. Ogura, Y. Okazaki and Y. Jinno Mitochondrial DNA and Y-Chromosome Variation in the Caucasus I. Nasidze, E. Y. S. Ling, D. Quinque, I. Dupanloup, R. Cordaux, S. Rychkov, O. Naumova, O. Zhukova, N. Sarraf-Zadegan, G. A. Naderi, S. Asgary, S. Sardas, D. D. Farhud, T. Sarkisian, C. Asadov, A. Kerimov and M. Stoneking Mitochondrial DNA Heterogeneity in Tunisian Berbers K. Fadhlaoui-Zid, S. Plaza, F. Calafell, M. Ben Amor, D. Comas and A. Bennamar El gaaied Standardizing a Composite Measure of Linkage Disequilibrium D. C. Hamilton and D. E. C. Cole Further Investigation of Linkage Disequilibrium Between SNPs and their Ability to Identify Associated Susceptibility Loci B. V. North, D. Curtis, E. R. Martin, E. H. Lai, A. D. Roses and P. C. Sham The Sib TDT Adjusted For Age Of Disease Onset Saurabh Ghosh and Theodore Reich Notes on the Maximum Likelihood Estimation of Haplotype Frequencies S. Mano, N. Yasuda, T. Katoh, K. Tounai, H. Inoko, T. Imanishi, G. Tamiya and T. Gojobori Short Communication Ancestral Founder Mutation of the Nude (FOXN1) Gene in Congenital Severe Combined Immunodeficiency Associated with Alopecia in Southern Italy Population M. Adriani, A. Martinez-Mir, F Fusco, R. Busiello, J. Frank, S. Telese, E. Matrecano, M. V. Ursini, A. M. Christiano and C. Pignata Review The Genetic Basis for Sex Differences in Human Behaviour: Role of the Sex Chromosomes Ian W. Craig, Emma Harper and Caroline S. Loat Volume 68 Number 4 July 2004 285 Single Nucleotide Polymorphisms in the Coding Region of the Apolipoprotein H (62-Glycoprotein I) Gene and their Correlation with the Protein Polymorphism, Anti-B2 Glycoprotein I Antibodies and Cardiolipin Binding: Description of Novel Haplotypes and Their Evolution M. I. Kamboh, D. K. Sanghera, H. Mehdi, C. S. Nestlerode, Q. Chen, O. Khalifa, A. Naqvi, S. M. and C. H. Bunker Polymorphisms in TDG and MGMT Genes — Epidemiological and Functional Study in Lung Cancer Patients from Poland M. KrzeSniak, D. Butkiewicz, A. Samojedny, M. Chorazy and M. Rusin Tracing the Origin of the Most Common Thiopurine Methyltransferase (TPMT) Variants: Preliminary Data from the Patterns of Haplotypic Association with Two CA Repeats S. Alves, J. Rocha, A. Amorim and M. J. Prata Mutagenesis by Transient Misalignment in the Human Mitochondrial DNA Control Region B. A. Malyarchuk and I. B. Rogozin MtDNA Profile of West Africa Guineans: Towards a Better Understanding of the Senegambia Region A. Rosa, A. Brehm, T. Kivisild, E. Metspalu and R. Villems Identification and Molecular Characterization of a de novo Supernumerary Ring Chromosome 18 in a Patient with Klippel-Trenaunay Syndrome A. A. Timur, A. Sadgephour, M. Graf, S. Schwartz, E. D. Libby, D. J. Driscoll and Q. Wang il Annals of Human Genetics (2004) 68.1-iv © University College London 2004 TNR/11q#1 Trinucleotide (GCC)n Repeat Alleles and Predisposition to Acute and Chronic Leukemia A. A. Klinkov, E. A. Nikitin, O. V. Maiorova, M. A. Ivanov, V. V. Strelnikov, O. V. Babenko, V. V. Zemlyakova, E. B. Kuznetsova and D. V. Zaletayev Short Communications A Note on the Asymptotic Properties of Affected-sib-pair Linkage Tests K. Wang A Note on the Genome Scan Meta-Analysis Statistic J. A. Koziol and A. C. Feng Review Molecular Genetics of Late-Onset Alzheimer’s Disease M. Ilyas Kamboh Volume 68 Number 5 September 2004 405 Exploration of Multilocus Effects in a Highly Polymorphic Gene, the Apolipoprotein (APOB) Gene, in Relation to Plasma apoB Levels N. Tahri-Daizadeh, D. A. Tregouet, V. Nicaud, O. Poirier, K Cambien and L. Tiret Contribution of Chromosome 1|q21-q23 to Familial Combined Hyperlipidemia in Mexican Families A. Huertas-Vazquez, J. P. del Rincon, S. Canizales-Quinteros, L. Riba, G. Vega-Hernandez, S. Ramirez- Jiménez, M. Aurén-Gomez, F. J. Gomez—Pérez, C. A. Aguilar-Salinas and M. T. Tusié-Luna Compound Haplotypes at Xp11.23 and Human Population Growth in Eurasia S. Alonso and J. A. L. Armour Y Chromosome and Mitochondrial DNA Variation in Lithuanians D. Kasperaviciite, V. Kucinskas and M. Stoneking Mitochondrial DNA Diversity in Tribal and Caste Groups of Maharashtra (India) and its Implication on Their Genetic Origins M. M. Baig, A. A. Khan and K. M. Kulkarni Inferring the Most Likely Geographical Origin of mtDNA Sequence Profiles T. Egeland, H. M. Bovelstad, G. O. Storvik and A. Salas Genetic Dissection of Human Stature in a Large Sample of Multiplex Pedigrees Y.-Z. Liu, E-H. Xu, H. Shen, Y.-J. Liu, L.-J. Zhao, J.-R. Long, Y.-Y. Zhang, P. Xiao, D.-H. Xiong, V. Dvornyk, J.-L. Li, T. Conway, K. M. Davies, R. R. Recker, H.-W. Deng Commingling Analysis of Intraocular Pressure and Glaucoma in an Older Australian Population A. C. Viswanathan, R. A. Hitchings, A. Indar, P. Mitchel, P. R. Healey, P. McGuffin and P. C. Sham Methods for Testing Familial Aggregation of Diseases in Population-based Samples: Application to Hodgkin Lymphoma in Swedish Registry Data R. M. Pfeiffer, L. R. Goldin, N. Chatterjee, S. Daugherty, K. Hemminki, D. Pee, L. I. X and M. H. Gail SHORT COMMUNICATIONS Novel HMBS Founder Mutation and Significant Intronic Polymorphism in Spanish Patients with Acute Intermittent Porphyria E. Guillén-Navarro, P. Carbonell, G. Glover, M. Sanchez-Solis and A. Fernandez-Barreiro Estimated Frequency of Genetic and Nongenetic Causes of Congenital Idiopathic Cerebral Palsy in West Sweden H. Costeff Volume 68 Number 6 November 2004 521 Evidence for Non-additive Influence of Single Nucleotide Polymorphisms within the Apolipoprotein E Gene S. C. Hamon,J . H. Stengard, A. G. Clark, V. Salomaa, E. Boerwinkle and C. F. Sing Susceptibility to Basal Cell Carcinoma: Associations with PTCH Polymorphisms R. C. Strange, N. El-Genidy, S. Ramachandran, T. J. Lovatt, A. A. Fryer, A. G. Smith, J. T. Lear, C. Wong, P. W. Jones, F. Ichii-Jones and P. R. Hoban ( University College London 2004 Annals of Human Genetics (2004) 68,i-iv_—sH Gene Expression Profile Analysis in Human T Lymphocytes from Patients with Down Syndrome S. Giannone, P. Strippoli, L. Vitale, R. Casadei, S. Canaider, L. Lenzi, P. D’Addabbo, F. Frabetti, EF.F acchin, A. Farina, P. Carinci and M. Zannotti Correlation Between the Allelic Distribution of STRs in a Finnish Population and Phenotypically Different Gastrointestinal Tumours: A Study Using Four X-Chromosomal Markers (DXS7423, DXS8377, ARA, DXS101) H. Vauhkonen, M. Vauhkonen, P. Sipponen and A. Sajantila Linkage Disequilibrium and Haplotype Architecture for two ABC Transporter Genes (ABCC 1 and ABCG2) in Chinese Population: Implications for Pharmacogenomic Association Studies H. Wang, B. Hao, K. Zhou, X. Chen, S. Wu, G. Zhou, Y. Zhu and F He DNA Sequence Variation and Haplotype Structure of the ICAM1 and TNF Genes in 12 Ethnic Groups of India Reveal Patterns of Importance in Designing Association Studies S. Sengupta, S. Farheen, N. Mukherjee, B. Dey, B. Mukhopadhyay, S. K. Sil, N. Prabhakaran, A. Ramesh, D. Edwin, M.V. Usha Rani, M. Mitra, C. Thakur Mahadik, S. Singh, S. C. Sehgal and P. P. Majumder 588 Genetic Evidence Concerning the Origins of South and North Ossetians I. Nasidze, D. Quinque, I. Dupanloup, S. Rychkov, O. Naumova, O. Zhukova, and M. Stoneking 600 A Tale of Aborigines, Conquerors and Slaves: Alu Insertion Polymorphisms and the Peopling of Canary Islands N. Maca-Meyer, J. Villar, L. Pérez-Méndez, A. Cabrera de Leén and C. Flores 606 Affected Sib Pair Tests in Inbred Populations W. Liu and B. S. Weir 620 Power of Variance Component Linkage Analysis—II. Discrete Traits J. T. WILLIAMS and J. BLANGERO Short Communications The FBN1 (R2726W) mutation is not fully penetrant S. Buoni, R. Zannolli, F Macucci, S. Ansaldi, M. Grasso, E. Arbustini and A. Fois Characterization of the loricrin (LOR) gene as a positional candidate for the PSORS4 psoriasis susceptibility locus E. Giardina, F Capon, MC. De Rosa, R. Mango, G. Zambruno, A. Orecchia, S. Chimenti, B. Giardina and G. Novelli Review Replication in genetic studies of complex traits M. J. Sillanpaa and K. Auranen Corrigendum 2004 Indexes Iv Annals of Human Genetics (2004) 68,i-iv © University College London 2004