Angiogenesis Key Principles - Science - Technology - Medicine Edited by Rudolf Steiner Paul B. Weisz Robert Langer Birkhauser Verlag Basel . Boston . Berlin Editor's addresses: Dr. R. Steiner Dr. P. B. Weisz Research Division University of Pennsylvania Dept. of Surgery Dept. of Chemical and Bioengineering University Hospital Zurich Room 312, Towne Building/D3 8091 Zurich Philadelphia, PA 19104 Switzerland USA Dr. R. Langer Dept. of Chemical Engineering and Harvard - MIT Division of Health, Science and Technology Massachusetts Institute of Technology Building E 25 Room 342 Cambridge, MA 02139 USA The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher cannot assume any legal responsibility for given data, especially as far as directions for the use and the handling of chemicals and drugs are concemed. This informa tion can be obtained from the manufacturers. Library of Congress Cataloging-in-Publication Data Angiogenesis: key principles - science, technology, medicine/edited by R. Steiner, P. B. Weisz, R. Langer. (Experientia. Supplementum; v. 61) Inc1udes bibliographical references and index. ISBN 978-3-0348-7003-0 ISBN 978-3-0348-7001-6 (eBook) DOI 10.1007/978-3-0348-7001-6 1. Neovascularization. I. Steiner, R. (RudoIO, 1945- . H. Weisz, Paul B., 1921- . III. Langer, Robert S. IV. Series. QPI06.6.A53 1992 612.l'3-dc20 Deutsche Bibliothek Cataloging-in-Publication Data Angiogenesis: key principles - science - technology - medicine/ed. by R. Steiner ... - Basel; Boston; Berlin: Birkhäuser, 1992 (Experientia: Supplementum; Vol. 61) ISBN 978-3-0348-7003-0 NE: Steiner, Rudolf [Hrsg.]; Experientia/Supplementum This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concemed, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under §54 of the German Copyright Law, where copies are made for other than private use, a fee is payable to 'Verwertungsgesellschaft Wort', Munich. © 1992 Birkhäuser Verlag Softcover reprint of the hardcover Ist edition 1992 P.O. Box 133 4010 Basel Switzerland ISBN 978-3-0348-7003-0 To Judah Folkman for his many services to the experimental physiology and pathology of angiogenesis To Paul Calabresi in admiration of his interdisciplinary spirit Editorial Note The book on Angiogenesis is a witness to history of the emergence of new scientific insight of a universally important basic phenomenon, and the concept of controlling it with respect to health and disease. It is an initial textbook of current and pertinent knowledge for readers of nearly all scientific branches providing material background for education and for research, much of which could easily be considered as obligatory reading in the study of medicine, molecular biology, chemistry and engineering. Thus the context of this book does not fit into the narrow niche of a single compartment. It shouldn't. On the contrary it is relevant to many. The most challenging editorial concern was to effectively report major developments at the forefront of angiogenesis research and to reflect with short introductories the complex and inextricable interdependence of key principles in science, technology and medicine. Rudolf Steiner Paul B. Weisz Robert Langer Contents Introductories: R. Steiner Angiogenesis - Historical perspective 1 J. Folkman Angiogenesis - Retrospect and outlook ...................... 4 P. B. Weisz Angiogenesis - The interdisciplinary challenge 14 L. Sachs Angiogenesis - Cytokines as part of a network 20 R. Langer Angiogenesis - Biomedical technology ....................... 23 K. Hellmann Angiogenesis - Time to review progress ...................... 26 G. K. Uhlschmid Angiogenesis - A new fascinating enigma for surgeons?! 29 Morphology P. H. Burri Intussusceptive microvascular growth, a new mechanism of capillary network formation .............................. 32 M. A. Konerding, C. van Ackern, F. Steinberg and C. Streffer Combined morphological approaches in the study of network formation in tumor angiogenesis .......................... 40 T. Ishibashi and S. J. Ryan Maturation of newly-formed subretinal vessels ................ 59 H. C. Bauer, M. Steiner and H. Bauer Embryonic development of the CNS microvasculature in the mouse: new insights into the structural mechanisms of early angiogenesis ....................................... 64 D. Virgintino, D. Ribatti, B. Nico, M. Bertossi and L. Roncali Vascular supply in embryonic neural transplants .............. 69 J. R. Less, T. C. Skalak, E. M. Sevick and R. K. Jain Microvascular network architecture in a mammary carcinoma 74 I. Freitas, G. F. Baronzio, S. Barni, V. Bertone, O. Griffini, P. Accossato and P. Pontiggia Tumor angiogenesis: evidence of new blood vessel channels from plasma infiltrations ................................... 81 Molecular Biology J. G. Beitz, I.-S. Kim, P. Calabresi and A. R. Frackelton Receptors for platelet-derived growth factor on microvascular endothelial cells ......................................... 85 J. Korhonen, J. Partanen, E. Eerola, S. Vainikka, R. A litalo , T. P. Makela, M. Sandberg, H. Hirvonen and K. Alitalo Five FGF receptors with distinct expression patterns .......... 91 A. Isacchi, L. Bergonzoni, M. Statuto, R. Chiesa, M. Rusnati, M. Presta, G. Ragnotti and P. Sarmientos Activation of the tyrosine kinase receptor is not sufficient for the full biological activity of bFGF ....................... 101 Chemical Engineering P. B. Weisz, H. C. Hermann, M. M. Joullie, K. Kumor, E. M. Levine, E. J. Macarak and D. B. Weiner Angiogenesis and heparin mimics ........................... 107 C. L. Stokes Endothelial cell migration and chemotaxis in angiogenesis 118 Cell Biology and Dynamics P. M. Gullino Microenvironment and angiogenic response 125 R. Montesano, M. S. Pepper, J-D. Vassalli and L. Orci Modulation of angiogenesis in vitro ......................... 129 M. S. Pepper, J-D. Vassalli, L. Orci and R. Montesano Proteolytic balance and capillary morphogenesis in vitro ....... 137 M. A. Moses and R. Langer Metalloproteinase inhibition as a mechanism for the inhibition of angiogenesis ................................ 146 M. P. Piechocki, S. Kantak and J. M. Onoda TPA-induced differentiation of rat aortic endothelial cells is substrate-specific and receptor mediated ...................... 152 A. E. Canfield, A. B. Sutton, S. L. Schor, M. E. Grant and A. M. Schor Aortic endothelial cells in culture: factors which modulate their morphological and biosynthetic phenotypes ................. 158 A. M. Schor, A. E. Canfield, A. B. Sutton, T. D. Allen, P. Sloan and S. L. Schor The behaviour of pericytes in vitro: relevance to angiogenesis and differentiation ...................................... 167 N. Sato, N. Tsuruoka, M. Yamamoto, T. Nishihara, T. Goto Identification of non heparin-binding endothelial cell growth factor from rat myofibroblasts ............................ 179 S. M. Albelda Differential expression of integrin cell-substratum adhesion receptors on endothelium ................................ 188 P. Defilippi, C. Bozzo, M. Geuna, P. Rossino, L. Silengo and G. Tarone Modulation of extracellular matrix receptors (integrins) on human endothelial cells by cytokines ...................... 193 C. Jackson, K. Jenkins and L. Schrieber Possible mechanisms of type I collagen-induced vascular tube formation ......................................... 198 M. Presta, M. Rusnati, C. Urbinati, E. Tanghetti, M. Statuto, A; Pozzi, A. Gualandris and G. Ragnotti Basic fibroblast growth factor bound to cell substrate promotes cell adhesion, proliferation, and protease production in cultured endothelial cells .................... 205 G. Taraboletti, D. Belotti and R. Giavazzi Thrombospondin modulates basic fibroblast growth factor activities on endothelial cells .............................. 210 W. F. Herblin and J. L. Gross Binding sites for basic fibroblast growth factor on solid tumors are associated with the vasculature ................. 214 M. Guthridge, J. Schmitt, J. Bertolini, J. Cowling, A. Runting, S. Katsahambas, A. E. Drummond and M. T. W. Hearn Studies on basic fibroblast growth factor (FGF-~) gene expression in the rat and pig ovary using in situ hybridisation and quantitative reverse transcriptase- polymerase chain reaction techniques ...................... 219 R. L. Smither and T.-P. D. Fan Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro ...................................... 230 J. Badet, F. Soncin and D. Barritault Angiogenin and endothelial cells ............................ 235 N. Mirsky and E. S. Lindenbaum Cultured endothelial cell mobilization induced by partially purified human uterine angiogenic factor ................... 239 A. Amberger, U. Tontsch, O. Lemykin, G. Gabbiani and H. C. Bauer Two cloned cerebral endothelial cell phenotypes: an in vitro model for angiogenesis? .................................. 244 M. L. Brandi Bone endothelial cells: A tool for analyzing cell to cell interactions in the skeletal tissue .......................... 250 H. S. Sharma, M. Wunsch, M. Schmidt, R. J. Schott, R. Kandolf and W. Schaper Expression of angiogenic growth factors in the collateralized swine myocardium ...................................... 255 H. C. Lichtenbeld and G. H. Blijham Tumor cell spheroids induce a mitogenic response in endothelial cells ......................................... 261 J. M. Wang, R. D. Hunter and S. Kumar A Monoclonal antibody (E-9) binds preferentially to the vasculatures of human tumours, embryonic and regenerating tissues ...................................... 266 D. Rusciano, P. Lorenzoni and M. M. Burger Liver or lung colonization by F9 teratocarcinoma cells follows specific interactions with the target organ .................. 272 St. Riedl, P. Moller, A. Faissner and P. Schlag Induction and altered distribution of tenascin in the basal lamina of colorectal adenomas and carcinomas ............. 277 Assays and Models K. Norrby On the quantitative rat mesenteric-window angiogenesis assay .................................................. 282 D. A. Cox, S. Kunz, N. Cerletti, G. K. McMaster and R. R. Burk Wound healing in aged animals - effects of locally applied transforming growth factor beta in different model systems ... 287 G. Weckbecker, R. Liu and L. Tolcsvai Intradermal angiogenesis in nude mice induced by human tumor cells or b-FGF ......................................... 296 L. B. G. B. Vieira, J. A. A. Rodriques, V. H. R. Leite and S. P. Andrade Angiogenic activity of PAF and inhibition of blood flow by Bothrops Jararaca venom in a mouse sponge model ......... 302 T-P. D. Fan, D-E. Hu, R. L. Smither and G. A. Gresham Furher studies on angiogenesis in a rat sponge model .......... 308 T-P. D. Fan, E. E. Frost and A. D. Wren A multichannel wounding device for the study of vascular repair in vitro .......................................... 315 R. Adatia, L. Poggi, E. W. Thompson, R. C. Gallo, G. F. Fassina, and A. Albini Assessment of angiogenic potential - the use of AIDS-KS cell supernatants as an in vitro model ......................... 321 Biomedical Technology R. Langer Delivery systems for angiogenesis stimulators and inhibitors .... 327 E. Wintermantel, L. Cima, B. Schloo and R. Langer Angiopolarity of cell carriers: directional angiogenesis in resorbable liver cell transplantation devices ................. 331 A. I. Skene, R. J. L. Williams, R. D. Goldin and R. D. Rosin Angiogenic vessels as a potential for targeted therapy in human liver metastases .................................. 335 D. J. Kerr, J. A. Goldberg, J.R. Anderson, N. Wilmott, A. T. Whatelely, C. S. McArdle and J. McKillop The effect of angiotensin II on tumor blood flow and the delivery of microparticulate cytotoxic drugs ................ 339 T. M. Lam, N. E. Whereat, S. C. Henderson, W. H. Burgess, A. Shaheen and H. P. Greisler Effects of hypercholesterolemia on mono kine induced smooth muscle cell proliferation .......................... 346 I. A. Burney, R. J. Maxwell, J. R. Griffiths and S. B. Field Deuterium nuclear magnetic resonance imaging of the developmental pattern of tumour blood flow ............... 357 C. Thomas, C. Counsell, J. Sansom, P. Wood,1. Stratford and G. Adams The perfluorocarbon emulsion PFOB: potential indicator of change in blood volume using fluorine 19 NMR spectroscopy ........................................... 362 M. Molls, H. J. Feldman and K. Sievers Clinical investigations on blood perfusion in human malignancies of the pelvis and abdomen: significance for tumor therapy 368 E. G. Salerud and S. Hellem A bone tissue integrated single fibre laser Doppler flowmeter probe ........................................ 373 Pharmacology and Medicine J. 1. Stagner and E. Samols Induction of angiogenesis by growth factors: relevance to pancreatic islet transplantation ............................ 381 v. Lindner and M. A. Reidy Role of basic fibroblast growth factor in proliferation of endothelium and smooth muscle after denuding injury in vivo ........................................... 386 M. D. Brown and O. Hudlicka Capillary growth in the heart ............................... 389 G. Imre and E. Csonka Angiogenic role of lactic acid in the mechanism of neovascularization ......................................... 395 D. G. S. Thilo-Korner, U. Marre, N. Savion, F. W. Hehrlein, and R. H. Bodecker Hyperoxia (145 mmHg p02) and tissue normoxia (20-40 mmHg p02) modulate human vascular cell functions .. 400 M. Kamler, H.-A. Lehr, J. H. Barker, R. K. Saetzler, E. Uhl and K. Messmer Impact of basic fibroblast growth factor (bFGF) on wound healing in chronically ischemic tissue ...................... 405 C. Mothersill, C. B. Semour, D. Mulvin and T. P. Hennessy Endothelial cell proliferation is induced by radiation in cultured explants of human urothelium and oesophageal mucosa 407 L. Ghali and M. Dyson The direct effect of light therapy on endothelial cell proliferation in vitro .................................... 411