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G VIDEO CONTENTS R Videos available at expertconsult.inkling.com V 37-1 Shave biopsy 37-2 Punch biopsy d 37-3 Narrow hole lipoma excision e 37-4 Excision t 37-5 Fusiform excision i n 37-6 Transposition flap U 37-7 Split thickness skin graft 37-8 Mohs surgery - 38-1 Full face ablative resurfacing 39-1 Filler, lips 9 39-2 Botulinum t9oxin, glabella 39-3 Botulinum toxin, frontalis r 39-4 Starich iodine test for hyperhidrosis h 39-5 Botulinum toxin, hyperhidrosis axilla a 39-6 Sclerotherapy t 39-7 Foam sclerotherapy This page intentionally left blank Andrews’ Diseases G Skin of the R V CLINICAL DERMATOLOGY d e t i n U - 9 9 r i h a t Executive Content Strategist: Russell Gabbedy Senior Content Development Specialist: Ailsa Laing Publishing Services Manager: Patricia Tannian Senior Project Manager: John Casey Designer: Christian Bilbow Original cover images: Upper left: Dr. Donald Adler (deceased); Upper right: Dr. Shyam Verma; Center: Dr. Debabrata Bandyopadhyay; Lower right: Dr. William D. James. G Andrews’ DiseasR es V d Skin e of the t i n U CL INICAL DERMATOLOGY - 9 Twelfth Edition 9 William D. Jamres, MD Timothy G. Berger, MD Paul R Gross Professior of Dermatology Professor of Clinical Dermatology h Department of Dermatology Executive Vice Chair and Residency University of Pennsylvania School of Medicine Program Director a Philadelphia, Pennsylvania Chair in Dermatology Medical Student t Education Dirk M. Elston, MD University of California, San Francisco San Francisco, California Professor and Chairman Department of Dermatology tahir99 (blink99) and Dermatologic Surgery Medical University of South Carolina UnitedVRG, Original Release. Charleston, South Carolina; https://kat.cr/user/Blink99/ Former Director Ackerman Academy of Dermatopathology New York, New York 1600 John F. Kennedy Blvd. Ste. 1800 Philadelphia, PA 19103-2899 ANDREWS’ DISEASES OF THE SKIN: CLINICAL DERMATOLOGY, TWELFTH EDITION ISBN: 978-0-323-31967-6 International Edition ISBN: 978-0-323-31968-3 Copyright © 2016 by Elsevier, Inc. All rights reserved. 11th edition © 2011 by Elsevier, Inc. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. International Standard Book Number: ISBN: 978-0-323-31967-6 Printed in China Last digit is the print number: 9 8 7 6 5 4 3 2 1 CONTENTS 1 Skin: Basic Structure and Function 1 20 Parasitic Infestations, Stings, and Bites 418 2 Cutaneous Signs and Diagnosis 11 21 Chronic Blistering Dermatoses 451 3 Dermatoses Resulting from 22 Nutritional Diseases 471 Physical Factors 18 23 Diseases of Subcutaneous Fat 480 G 4 Pruritus and Neurocutaneous Dermatoses 45 24 Endocrine Diseases 491 R 5 Atopic Dermatitis, Eczema, and 25 Abnormalities of Dermal Fibrous Noninfectious Immunodeficiency Disorders 62 V and Elastic Tissue 500 6 Contact Dermatitis and Drug Eruptions 90 d 26 Errors in Metabolism 509 e 7 Erythema and Urticaria 136 27 Genodermatoses and t 8 Connective Tissue Diseases 153 iCongenital Anomalies 542 n 9 Mucinoses 179 28 Dermal and Subcutaneous Tumors 579 U 10 Seborrheic Dermatitis, Psoriasis, 29 Epidermal Nevi, Neoplasms, and Cysts 625 Recalcitrant Palmoplantar Eruptions, - 30 Melanocytic Nevi and Neoplasms 680 Pustular Dermatitis, and Erythroderma 185 9 31 Macrophage/Monocyte Disorders 699 11 Pityriasis Rosea, Pityriasis Rubra 9 Pilaris, and Other Papulosquamrous 32 Cutaneous Lymphoid Hyperplasia, and Hyperkeratotic Diseasesi 199 Cutaneous T-Cell Lymphoma, h Other Malignant Lymphomas, and 12 Lichen Planus and Realated Conditions 209 Allied Diseases 726 13 Acne t 225 33 Diseases of the Skin Appendages 747 14 Bacterial Infections 245 34 Disorders of the Mucous Membranes 789 15 Diseases Resulting from Fungi 35 Cutaneous Vascular Diseases 807 and Yeasts 285 36 Disturbances of Pigmentation 856 16 Mycobacterial Diseases 319 37 Dermatologic Surgery 874 17 Hansen’s Disease 331 38 Cutaneous Laser Surgery 901 18 Syphilis, Yaws, Bejel, and Pinta 343 39 Cosmetic Dermatology 913 19 Viral Diseases 359 v This page intentionally left blank