THE FUTURE OF CELLULOSIC ETHANOL IS HERE New techologies and research for industrial scale-up: the formula for a sustainable bioethanol POUL RUBEN ANDERSEN, NOVOZYMES 3rd Bio-Ethanol Conference Turin, Italy March 2, 2010 2009 Novozymes sales by industry NOVOZYMES IN BRIEF 5% 3% 8% 32% GLOBAL PRESENCE 21% •  Global leader in Industrial Enzymes & Microorganisms 31% •  More than 700 products used in 130 countries within >30 different industries •  5,200 employees worldwide Detergent Technical Food Feed Microorganisms Biopharmaceuticals R&D 2009 market share of enzymes (industrial use) •  Market leader in all main industries •  47% global market share within industrial enzymes •  ~14% of sales invested in R&D 26% 47% •  >6,000 patents in place 6% PERFORMANCE 21% •  2009 global sales USD 1.6B (FY 2009) •  Operating profit margin 20% (FY2009) •  ROIC 20.3% (FY2009) Novozymes Danisco DSM Other 2 NOVOZYMES AND BIOFUELS LEADING THE WAY IN ENZYMES FOR EXISTING AND FUTURE BIOFUELS   Largest supplier of enzymes to the existing biofuel industry   Market share of more than 60% in this field   18% of total Novozymes sales in 2009   Continuously provide the enzymes giving the highest biofuel yields at the lowest total production cost and provide second- to-none customer support   Leading the way in development of 2nd generation / cellulosic ethanol in collaboration with industry leaders around the globe   150 people working on this development   Enzymes for commercial production of cellulosic ethanol ready by 2010 CELLULOSIC ETHANOL MEANS ECONOMIC GROWTH AND JOB CREATION 4 CELLULOSIC ETHANOL MEANS SUSTAINABILITY 5 CELLULOSIC ETHANOL MEANS ENERGY INDEPENDENCE 6 LARGE POTENTIAL WITH MANY CELLULOSIC FEEDSTOCKS Adjusted Feedstock India Corn Stover Corn Cobs China Wheat Straw Sugarcane Bagasse Brazil Wood EU US 0 100 200 300 400 500 MMT/Year Estimated Production MLtr/Year based on Adjusted Feedstock India Corn Stover China Corn Cobs Wheat Straw Brazil Sugarcane Bagasse EU Wood US Assumed 77% process conversion efficiency on all substrates utilizing C5 and C6 sugars Source cob:stover ratio used: 19.5: http://www.ars.usda.gov/research/ MLtr/Year publications/publications.htm?SEQ_NO_115=235194 A CELLULOSIC ETHANOL INDUSTRY IS EMERGING   Inbicon   Lignol   Greenfield   Poet   M&G   ADM   Fiberight   COFCO & Sinopec   ICM   PRAJ   CTC NOVOZYMES GLOBAL PARTNERS 8 NOVOZYMES CELLIC® CTEC2 DELIVERING ON OUR PROMISE The first commercially viable enzyme for cellulosic ethanol 9 CTEC2 PROVIDES SIGNIFICANT PERFORMANCE IMPROVEMENT OVER CTEC Hydrolysis of unwashed NREL PCS, 20% TS, 8-days 90,0% 80,0% 70,0% n o i 60,0% s r e v n 50,0% o C e s CTec2 o 40,0% l u CTec l l e C 30,0% % 20,0% 10,0% 0,0% 0,01 0,015 0,02 0,025 0,03 0,035 0,04 0,045 Enzyme Dosage (ml/g-cellulose) 10